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Search Results: 1 - 10 of 15077 matches for " Bingyin Ren "
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Access Control for Manufacturing Process in Networked Manufacturing Environment  [PDF]
Ke Zhou, Min Lv, Gang Wang, Bingyin Ren
Journal of Service Science and Management (JSSM) , 2009, DOI: 10.4236/jssm.2009.22014
Abstract: The deficiencies of current access control techniques in solving the problems of manufacturing process access conflict in networked manufacturing environment were analyzed. An information model of manufacturing process was con-structed, and a case XML Schema of manufacturing task model was given. Based on the characteristic analysis of the access control for the information model, an improved access control model of manufacturing process was constructed, and the access control model based on manufacture tasks, roles and time limits and the relationships among the ele-ments were defined. The implementation mechanisms for access control model were analyzed, in which the access case matching strategy based on manufacture tasks and time limits, the authorization assignment mechanism based on manufacture tasks, roles, correlation degrees and time limits, XML based access control for transaction security and integrity were included. And the two-level detection architecture of transaction conflict was designed to find the con-flicts both in application and in the database. Finally the prototype system was developed based on these principles. Feasibility and effectiveness of the method were verified by an enterprise application.
Alteration of the Let-off and Take-up Machine of Loom SAURER 400
Bingyin Liu,Jianjun Sun
Modern Applied Science , 2009, DOI: 10.5539/mas.v3n11p75
Abstract: At present, many shuttleless looms in Chinese enterprises still use the mechanical let-off and take-up machine, and to fulfill the requirements of modern textile technology and consider the factor of saving cost, most enterprises begin to alter their old looms. Taking the rapier loom SAURER400 as the research object, the original let-off and take-up machine of loom SAURER400 was analyzed in the article, and the electric let-off and take-up system was designed, and the revs of the let-off input end and the take-up input end were respectively computed, which could provide some references for the alteration of future electric let-off and take-up control system.
A STUDY ON ECOLOGICAL DISTRIBUTION OF MICROOGANISMS AND SOME BIOCHEMICAL CHARACTERISTICS IN THE SPARTINA ALTERNIFLORA MARSH SOIL
互花米草(Spartina alterniflora)草场土壤微生物生态分布及某些酶活性的研究

Sun Bingyin,
孙炳寅

生态学报 , 1989,
Abstract: To find out the interrelationships between S,alterniflora and ils particular ecological environment, comparative studies on ecological distribution of soil microbes in one-,two- and three-year-old, S.altermflora marsh soil of Binghai,Jiangsu,were carried out in a 2-year-duration (1985-1986). Respiration Quotient(RQ), enzyme activity and their interrelationships were also determined. In the soil of S.alternif-lora planting salt marsh, numbers of bacteria, actinomycetcs and microfungi were found more than in ...
Association of promoter methylation with histologic type and pleural indentation in non-small cell lung cancer (NSCLC)
Meiju Ji, Yong Zhang, Bingyin Shi, Peng Hou
Diagnostic Pathology , 2011, DOI: 10.1186/1746-1596-6-48
Abstract: We determined the promoter methylation of 6 genes using quantitative methylation-specific PCR (Q-MSP) technique in 96 clinically well-characterized non-small cell lung cancer (NSCLC).Highly frequent promoter methylation was found in NSCLC. With 100% diagnostic specificity, high sensitivity, ranging from 44.9 to 84.1%, was found for each of the 6 genes. Our data also showed that promoter methylation was closely associated with histologic type. Most of genes were more frequently methylated in squamous cell carcinomas (SCC) compared to adenocarcinomas (ADC). Moreover, promoter methylation significantly increased the risk of pleural indentation in NSCLC.Our findings provided evidences that multiple genes were aberrantly methylated in lung tumorigenesis, and demonstrated the promoter methylation was closely associated with clinicopathologic characteristics of NSCLC. More importantly, we first revealed promoter methylation may be served as a potentially increased risk factor for pleural indentation of NSCLC patients.Lung cancer is a leading cause of cancer death worldwide, accounting for 30% of all cancer-related deaths [1]. The 5-year survival rate between 1996-2004 is 16%-significantly lower than that of other major cancers [2]. Owing to the rapid industrialization and increase in the smoking consumption in society, lung cancer presents as the number one cancer type of threats in China [3]. Epidemiological evidence has documented that approximately 41.8 men and 19.3 women per 100,000 Chinese individuals died of lung cancer in 2005 [4]. Lung cancer is generally classified into two major histological categories, small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). The latter accounts for approximately 85% of lung cancer [2]. Approximately 25-33% of NSCLC patients present with stage I or II disease, which permits surgical resection with curative intent. However, despite surgery, approximately 30-40% of patients with NSCLC who have discrete lesions and hist
Highly frequent promoter methylation and PIK3CA amplification in non-small cell lung cancer (NSCLC)
Meiju Ji, Haixia Guan, Cuixia Gao, Bingyin Shi, Peng Hou
BMC Cancer , 2011, DOI: 10.1186/1471-2407-11-147
Abstract: We determined the promoter methylation of 6 genes and PIK3CA amplification using quantitative methylation-specific PCR (Q-MSP) and real-time quantitative PCR, respectively, and explore the association of promoter methylation with PIK3CA amplification in a large cohort of clinically well-characterized non-small cell lung cancer (NSCLC).Highly frequent promoter methylation was observed in NSCLC. With 100% diagnostic specificity, excellent sensitivity, ranging from 45.8 to 84.1%, was found for each of the 6 genes. The promoter methylation was associated with histologic type. Methylation of CALCA, CDH1, DAPK1, and EVX2 was more common in squamous cell carcinomas (SCC) compared to adenocarcinomas (ADC). Conversely, there was a trend toward a higher frequency of RASSF1A methylation in ADC than SCC. In addition, PIK3CA amplification was frequently found in NSCLC, and was associated with certain clinicopathologic features, such as smoking history, histologic type and pleural indentation. Importantly, aberrant promoter methylation of certain genes was significantly associated with PIK3CA amplification.Our data showed highly frequent promoter methylation and PIK3CA amplification in Chinese NSCLC population, and first demonstrated the associations of gene methylation with PIK3CA amplification, suggesting that these epigenetic events may be a consequence of overactivation of PI3K/Akt pathway.Lung cancer is the number one cancer killer in China and soon will reach epidemic levels worldwide [1]. Epidemiological evidence has documented that approximately 41.8 men and 19.3 women per 100,000 Chinese individuals died of lung cancer in 2005 [2]. This disease is largely associated with smoking. While in developed countries smoking rates are decreasing, the use of tobacco products is increasing in the developing countries. In combination with a spike in the number of lung cancer cases in never smokers, this ensures that lung cancer will remain a major health problem [3]. Lung cancer is
Developmental study on the immunocytochemical localization of NOV protein-containing neurons in the rat brain
Bingyin Su,Wenqin Cai,Chenggang Zhang,B. Perbal
Chinese Science Bulletin , 1999, DOI: 10.1007/BF02885990
Abstract: The localization and development of nephroblastoma overexpressed gene (nov) protein-immunoreactive neurons in the brain of E8-P300 rats have been studied using immunocytochemistry and image analysis. Results are as follows: No NOV protein-immunoreactive cells were detected in the rat brain during prenatal development. A few of positive cells were detected at the early postnatal stage. However, the number and the immunoreactivity of these cells increased gradually at later stages. NOV-immunoreactive cells were widely distributed in the rat brain during P30–P60. The number of immunoreactive cells and their intensity also peaked within this stage. The number and staining intensity of NOV-positive cells decreased gradually with age. The positive cells were mainly located in cingulate cortex, striatum, hippocampus, hypothalamus, cerebellum and brain stem. The present results indicate thatnov may play an important role in the development and differentiation of brain as well as maintaining the function of brain.
Concomitant hypermethylation of multiple genes in non-small cell lung cancer (NSCLC)
Meiju Ji,Haixia Guan,Bingyin Shi,Peng Hou
Folia Histochemica et Cytobiologica , 2011, DOI: 10.5603/4154
Abstract: Primary lung cancer remains the leading cause of cancer death worldwide. Promoter hypermethylation is a major inactivation mechanism of tumor-related genes, and increasingly appears to play an important role in carcinogenesis. In the present study, we used quantitative methylation-specific PCR (Q-MSP) assays to analyze promoter hypermethylation of nine genes in a large cohort of well-characterized non-small cell lung cancer (NSCLC) and explore their associations with the clinicopathological features of tumor. We found that there were significant differences in methylation levels for six of nine gene promoters between cancerous and noncancerous lung tissues. More importantly, with 100% diagnostic specificity, high sensitivity, ranging from 44.9% to 84.1%, was found for each of the nine genes. Interestingly, promoter hypermethylation of most genes was closely associated with histologic type, which was more frequent in squamous cell carcinomas (SCC) than in adenocarcinomas (ADC). In addition, highly frequent concomitant methylation of multiple genes was found in NSCLC, particularly in SCC. Our data showed that multiple genes were aberrantly methylated in lung tumorigenesis, and that they were closely associated with certain clinicopathological features of NSCLC, particularly of the histologic type, suggesting that these hypermethylated genes could be potential biomarkers in early detection of NSCLC in high-risk individuals, as well as in evaluating the prognosis of NSCLC patients. (Folia Histochemica et Cytobiologica 2011, Vol. 49, No. 1, 132–141)
Emphysematous pyelonephritis treated with elective nephrectomy in a 75-year-old diabetic patient
Yayi He,Bingyin Shi,Xiaoyan Wu,Peng Hou
Clinics and Practice , 2012, DOI: 10.4081/cp.2012.e14
Abstract: We present a case of 75-year-old man with type 2 diabetes and emphysematous pyelonephritis (EPN). The patient presented with abdominal pain, fever of undetermined origin and progressive decrease in urine output. Computerized tomography scan revealed gas formation in the left renal parenchyma and capsule. A left nephrectomy was performed. He made a quick recovery. EPN should be taken into consideration in diabetic patients with symptoms of pyelonephritis who show a poor response to conventional treatment. Elective nephrectomy may be life saving in some patients.
The Effect of Dantonic Pill on β-Catenin Expression in a Rat Model of Streptozotocin-Induced Early Stage of Diabetic Nephropathy
Zhou Shuhong,Lv Hongjun,Cui Bo,Xu Li,Shi Bingyin
Journal of Diabetes Research , 2013, DOI: 10.1155/2013/848679
Abstract: Diabetic nephropathy (DN) is one of the most common causes of end-stage renal failure. This study was performed to determine the effect of Dantonic Pill (DP) treatment on β-catenin expression in a rat model of streptozotocin- (STZ-) induced early-stage DN, with irbesartan treatment as a positive control. Including an analysis of the general metabolic index and renal function, immunohistochemical staining and reverse transcription real-time PCR for β-catenin were performed in the renal cortex of the rat models every 4 weeks. After the treatments of DP and irbesartan, the albuminuria level, kidney weight/body weight, and thickness of the glomerular basement membrane were decreased, but the expression of β-catenin was not downregulated in the renal cortex. The effective drug target of DP to ameliorate albuminuria and renal hypertrophy should not inhibit the upregulated expression of β-catenin in rats with STZ-induced early-stage diabetic damage. 1. Introduction Diabetes mellitus presents a significant health concern because this disorder leads to long-term complications throughout the body involving the renal and other systems [1]. Diabetic nephropathy (DN) evolves into a progressive fibrosing kidney disease. Wnt pathway components have been reported to be associated with various kidney diseases including DN [2]. Regulating the -catenin protein levels to control the activation of Wnt-responsive target genes is referred to as the canonical Wnt/ -catenin pathway. Wnt proteins interact with receptor proteins and stabilize the downstream transcription regulator -catenin by inhibiting -catenin phosphorylation, which reportedly affects tubule formation and epithelial differentiation [3]. High glucose levels (HG) increased the phosphorylation of -catenin and reduced the nuclear -catenin levels. The destabilization of -catenin was correlated with the increased expression of other profibrotic factors in mesangial cells [4]. Impaired -catenin signaling is one prominent pathologic reaction responsible for the ECM metabolism induced by HG in mesangial cells [5]. “Herbal medicines’’ and ‘‘herbal remedies’’ are interchangeable terms that are used to refer to treatments containing various mixtures of herbs. People choose to take herbal medicines as alternatives to orthodox medicines due to their supposed low levels of toxicity and their ‘‘natural’’ origins. Thousands of years ofclinic practice in traditional Chinese medicine (TCM) have accumulated a considerable number of formulae that exhibit reliable in vivo efficacy and safety. The “Dantonic Pill” (DP), also known as
Aberrant DNA methylation of drug metabolism and transport genes in nodular goiter
Lihong Zhang, Jing Shi, Li Xu, Bingyin Shi, Peng Hou, Meiju Ji
Thyroid Research , 2011, DOI: 10.1186/1756-6614-4-15
Abstract: The genes encoding drug-metabolizing enzymes and transporters play an important role in transporting various kinds of molecules import or export the cells, which is closely associated with the development of various human diseases, mainly including solute carrier (SLC) superfamily, cytochrome P450 (CYP) superfamily and ATP binding cassette (ABC) superfamily [1]. To date, most of studies focused on investigating SNPs or gene mutation in these genes, however, it is has recently been reported that epigenetic mechanisms were involved in the regulation of these genes [2]. In the present study, we choose 11 drug metabolism and transport genes, including ABCB1, ABCB4, ABCG2, CYP1A1, CYP1B1, CYP24A1, CYP27B1, CYP39A1, SLC1A2, SLC19A3, and SLC26A2, to detect their methylation status of promoter region in a cohort of nodular goiter and normal thyroid tissues using methylation-specific PCR (MSP).Methylation analysis of thyroid tissues was carried out in a series of 27 nodular goiter and 23 normal thyroid paraffin-embedded tissues, which were obtained from the Department of Pathology of the First Affiliated Hospital of Xi'an Jiaotong University School of Medicine. All samples underwent histological examination by a senior pathologist. The genomic DNA was isolated from paraffin-embedded tissues using xylene to remove the paraffin and sodium dodecyl sulfate (SDS) and proteinase K to digest tissues, followed by standard phenol-chloroform extraction and ethanol precipitation of DNA. DNA was subsequently treated with sodium bisulfite to detect the methylation status of these 11 genes using methylation-specific PCR (MSP) as described previously [3]. Normal leukocyte DNA was methylated in vitro with Sss I methylase (New England Biolabs, Beverly, MA) to generate completely methylated DNA as a positive control. The primer sequences and their annealing temperatures were presented in Table 1. To examine the role of DNA methylation in the regulation of gene expression, we treated 3 thyroid
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