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Search Results: 1 - 10 of 38051 matches for " Bingliang Lin "
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Pathophysiological Significance of Hepatic Apoptosis
Kewei Wang,Bingliang Lin
ISRN Hepatology , 2013, DOI: 10.1155/2013/740149
Abstract: Apoptosis is a classical pathological feature in liver diseases caused by various etiological factors such as drugs, viruses, alcohol, and cholestasis. Hepatic apoptosis and its deleterious effects exacerbate liver function as well as involvement in fibrosis/cirrhosis and carcinogenesis. An imbalance between apoptotic and antiapoptotic capabilities is a prominent characteristic of liver injury. The regulation of apoptosis and antiapoptosis can be a pivotal step in the treatment of liver diseases. 1. Apoptosis Apoptosis is a process of programmed cell death. Apoptotic cells are characterized by energy-dependent biochemical mechanisms and obvious morphological changes [1, 2]. These features include membrane blebbing, cell shrinkage, nuclear chromatin condensation, and chromosomal DNA fragmentation. The apoptotic process deletes single cell or small clusters of cells without inflammatory response [3]. Apoptotic cells die in a controlled and regulated fashion. This makes apoptosis distinct from other uncontrolled modes of cell death such as necrosis, necroptosis, autophagy, and cornification [4]. Uncontrolled cell death leads to cell lysis, inflammatory response, and serious health problems [5]. Apoptosis is associated with multiple pathophysiological functions. During the embryological stage of mammals, apoptosis is important for the normal development of organs [6]. In adults, apoptosis regulates physiological processes (e.g., removing aged cells) and maintains tissue homeostasis [7]. Dysfunction or dysregulation of the apoptotic program is implicated in a variety of congenital anomalies and pathological conditions such as tumorigenesis, autoimmune diseases, neurodegenerative disorders, and others [8]. 2. Hepatic Apoptosis Hepatic apoptosis, as name indicated, means cell suicide in liver. The hepatic apoptosis is different from hepatocyte apoptosis. The hepatocyte apoptosis describes the apoptotic cell death in only hepatocytes (one type of liver cells), but the hepatic apoptosis reflects the interaction of manifold cells in liver and represents a comprehensive outcome of multiple effects. The liver is an organ consisting of several phenotypically distinct cell types, for example, hepatocytes, cholangiocytes, stellate cells, sinusoidal endothelial cells, Kupffer cells, oval cells, and so forth [9]. Predominant hepatocytes make up 70–80% of the liver cells [10]. Hepatocytes manufacture critical circulating proteins, generate bile acid-dependent bile flow, detoxify endo- and xenobiotics, and regulate intermediary metabolism [11]. Hepatocyte injury results
The Association between Expression of NK Cells and Prognosis of Patients with HBV Acute-on-Chronic Liver Failure in Advanced Phase  [PDF]
Weizhen Weng, Yiming Shi, Xiaohua Peng, Jing Xiong, Huijuan Cao, Bingliang Lin
Advances in Infectious Diseases (AID) , 2017, DOI: 10.4236/aid.2017.74012
Abstract: Acute-on-chronic liver failure (Acute-on-chronic liver failure, ACLF) is acute liver function decompensation on the basis of chronic liver disease. The progression of ACLF develops from advanced phase, plateau phase to remission phase. The pathophysiological basis of ACLF in different phases is various. In advanced phase, immune imbalance and systemic inflammatory reaction plays key roles. In this study, we try to assess the association between expression of NK cells and its receptors and prognosis of patients with ACLF in advanced phase. A total of 35 inpatients with HBV acute-on-chronic liver failure in advanced phase were recruited. They were divided into case group (n = 18) and control group (n = 17) according to whether the patients was dead in the 12 weeks. PBMC were detected for the frequency and expression of NK cell receptors by flow cytometric analysis. Our results demonstrated that patients who died had lower expression of NK cells and inhibitory receptor KIR3DL1, higher levels of FASL. During 12-week follow-up in those case alive, we found that NK cells increased, while expression of FASL decreased. High short-term mortality of ALCF was associated with NK cell, especially related to KIR3DL1 and FASL (PNK = 0.036, PKIR3DL1 = 0.0265, PFasL = 0.0008).
Prevalence of primary biliary cirrhosis in adults referring hospital for annual health check-up in Southern China
Haiying Liu, Yunfeng Liu, Luxia Wang, Dexing Xu, Bingliang Lin, Renqian Zhong, Sitang Gong, Mauro Podda, Pietro Invernizzi
BMC Gastroenterology , 2010, DOI: 10.1186/1471-230x-10-100
Abstract: AMA and ANA were screened in 8,126 adults (mean age 44 ± 15 years, 48% females) by indirect immunofluorenscence (IIF). Positive sera were tested by ELISA/immunoblotting for AMA-M2, anti-sp100 and anti-gp210. A diagnosis of PBC was re-assessed six months after the initial testing.Out of 8,126 individuals 35 were positive for AMA and 79 positive for ANA. Nineteen, 4, and 3 of the subjects positive for AMA and/or ANA showed reactivity for AMA-M2, anti-sp100 or gp210, respectively, further tested with ELISA/immunoblotting. Fourteen in the 39 individuals positive for AMA at IIF, AMA-M2, anti-gp210, or anti-sp100 had abnormal cholestatic liver functional indices. One definite and 3 probable PBC diagnosis could be made in 4 cases including 3 females and 1 male after half a year.We found a point prevalence rate of PBC among Southern Chinese adults attending for yearly health check-up of 492 cases per million (95% CI, 128 to 1,093) and 1,558 cases per million (95% CI, 294 to 3,815) for women over 40, a finding similar to prevalence reported in other geographical areas.Primary biliary cirrhosis (PBC) is an autoimmune liver disease leading to progressive destruction of small intrahepatic bile ducts, development of cirrhosis, and liver failure [1]. PBC affects predominantly women over middle-age [2]. It has been reported that PBC is more prevalent in some geographic areas such as Northern Europe and Northern America but much less common in Eastern Asia, Africa, and Australia [3-6]. However, it is worth noting that a rising frequency in many areas may be due to a more widespread awareness of this disease among physicians. Case series of Chinese patients with PBC have been reported from Taiwan, Hong Kong, Singapore and, more recently, also from Mainland China [6-11], with a number of Chinese patients with PBC apparently to be increasing in recent years. However, no epidemiological data have accompanied these reports.PBC is serologically characterized by the presence of anti-mitoc
The Tumor Suppressor Gene TUSC2 (FUS1) Sensitizes NSCLC to the AKT Inhibitor MK2206 in LKB1-dependent Manner
Jieru Meng, Mourad Majidi, Bingliang Fang, Lin Ji, B. Nebiyou Bekele, John D. Minna, Jack A. Roth
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0077067
Abstract: TUSC2-defective gene expression is detected in the majority of lung cancers and is associated with worse overall survival. We analyzed the effects of TUSC2 re-expression on tumor cell sensitivity to the AKT inhibitor, MK2206, and explored their mutual signaling connections, in vitro and in vivo. TUSC2 transient expression in three LKB1-defective non-small cell lung cancer (NSCLC) cell lines combined with MK2206 treatment resulted in increased repression of cell viability and colony formation, and increased apoptotic activity. In contrast, TUSC2 did not affect the response to MK2206 treatment for two LKB1-wild type NSCLC cell lines. In vivo, TUSC2 systemic delivery, by nanoparticle gene transfer, combined with MK2206 treatment markedly inhibited growth of tumors in a human LKB1-defective H322 lung cancer xenograft mouse model. Biochemical analysis showed that TUSC2 transient expression in LKB1-defective NSCLC cells significantly stimulated AMP-activated protein kinase (AMPK) phosphorylation and enzymatic activity. More importantly, AMPK gene knockdown abrogated TUSC2-MK2206 cooperation, as evidenced by reduced sensitivity to the combined treatment. Together, TUSC2 re-expression and MK2206 treatment was more effective in inhibiting the phosphorylation and kinase activities of AKT and mTOR proteins than either single agent alone. In conclusion, these findings support the hypothesis that TUSC2 expression status is a biological variable that potentiates MK2206 sensitivity in LKB1-defective NSCLC cells, and identifies the AMPK/AKT/mTOR signaling axis as an important regulator of this activity.
Characteristics of neighborhood interaction in urban land-use changes: A comparative study between three metropolitan areas of Japan

ZHAO Yaolong,CUI Bingliang,MURAYAMA Yuji,

地理学报 , 2011,
Abstract: Local spatial interaction between neighborhood land-use categories (i.e. neighborhood interaction) is an important factor which affects urban land-use change patterns. Therefore, it is a key component in cellular automata (CA)-based urban geosimulation models towards the simulation and forecast of urban land-use changes. Purpose of this paper is to interpret the similarities and differences of the characteristics of neighborhood interaction in urban land-use changes of different metropolitan areas in Japan for providing empirical materials to understand the mechanism of urban land-use changes and construct urban geosimulation models. Characteristics of neighborhood interaction in urban land-use changes of three metropolitan areas in Japan, i.e. Tokyo, Osaka, and Nagoya, were compared using such aids as the neighborhood interaction model and similarity measure function. As a result, urban land-use in the three metropolitan areas was found to have had similar structure and patterns during the study period. Characteristics of neighborhood interaction in urban land-use changes are quite different from land-use categories, meaning that the mechanism of urban land-use changes comparatively differs among land-use categories. Characteristics of neighborhood interaction reveal the effect of spatial autocorrelation in the spatial process of urban land-use changes in the three metropolitan areas, which correspond with the characteristics of agglomeration of urban land-use allocation in Japan. Neighborhood interaction amidst urban land-use changes between the three metropolitan areas generally showed similar characteristics. The regressed neighborhood interaction coefficients in the models may represent the general characteristics of neighborhood effect on urban land-use changes in the cities of Japan. The results provide very significant materials for exploring the mechanism of urban land-use changes and the construction of universal urban geosimulation models which may be applied to any city in Japan.
CVD Treatment of Carbon Fibers and Evaluation of Their Dispersion in CFRC  [PDF]
Chuang Wang, Bingliang Li, Lei Peng, Wenmin He, Liping Zhao, Kezhi Li
Materials Sciences and Applications (MSA) , 2017, DOI: 10.4236/msa.2017.88046
Abstract: Carbon-fiber-reinforced cement-based (CFRC) composites is a promising functional material which can be used both in the military and civil fields against electromagnetic interference. However, it is essential to make carbon fibers dispersed uniformly during the preparation of CFRC. In this work, short carbon fibers were treated through Chemical Vapor Deposition (CVD) process at high temperature between 900°C and 1200°C under the protection of diluted nitrogen gas N2 to modify the surface of carbon fibers to further strengthen the bonding between carbon fibers and cement matrix. Natural gas (98% CH4) was used as a precursor. It was decomposed to produce an uneven layer of pyrocarbon that was deposited on the surface of carbon fibers. CVD-treated carbon fibers were pre-dispersed by using ultrasonic wave. Both hydroxyethyl cellulose (HEC) and silicon fume were used as dispersants and as admixtures. They helped CVD-treated carbon fibers distribute uniformly. The mass fraction of HEC was around 1.78% in the aqueous solution. Four methods, namely, the simulation experiment (SE) method, the scanning electron microscopy (SEM) method, the fresh mixture (FM) method, and the electrical resistivity measurement (ERM) method were, respectively, applied to evaluate fiber dispersion degree. Each method indicated its own advantages and disadvantages and it therefore catered for different conditions. Of the four evaluation methods, the SE method was the most convenient way to determine the pre-dispersion state prior to the preparation of CFRC composites. This method was helpful for predicting the subsequent dispersion state of carbon fibers in the cement matrix because it economized a large quantity of raw materials and time.
Insulin-Like Growth Factor Binding Protein-2 Level Is Increased in Blood of Lung Cancer Patients and Associated with Poor Survival
Chengcheng Guo, Haibo Lu, Wen Gao, Li Wang, Kaihua Lu, Shuhong Wu, Apar Pataer, Maosheng Huang, Randa El-Zein, Tongyu Lin, Jack A. Roth, Reza Mehran, Wayne Hofstetter, Stephen G. Swisher, Xifeng Wu, Bingliang Fang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0074973
Abstract: Background We recently showed that IGFBP2 is overexpressed in primary lung cancer tissues. This study aims to determine whether IGFBP2 is elevated in blood samples of lung cancer patients and whether its level is associated with clinical outcomes. Methodology/Principal Findings Plasma IGFBP2 levels were determined blindly by enzyme-linked immunosorbent assay in 80 lung cancer patients and 80 case-matched healthy controls for comparison. We analyzed blood samples for IGFBP2 levels from an additional 84 patients with lung cancer and then tested for associations between blood IGFBP2 levels and clinical parameters in all 164 lung cancer patients. All statistical tests were two-sided and differences with p<0.05 were considered significant. The mean plasma concentration of IGFBP2 in lung cancer patients was significantly higher than that in healthy controls (388.12±261.00 ng/ml vs 219.30±172.84 ng/ml, p<0.001). IGFBP2 was increased in all types of lung cancer, including adenocarcinoma, squamous cell cancer, and small-cell cancer, regardless of patients’ age, sex, or smoking status. IGFBP2 levels were mildly but significantly associated with tumor size and were significantly higher in stage IV than stage I or III disease. A multivariate analysis showed that lung cancer patients whose blood IGFBP2 was higher than 160.9 ng/ml had a poor survival outcome, with a hazard ratio of 8.76 (95% CI 1.12-68.34, p=0.038 after adjustment for tumor size, pathology, and stage). The median survival time for patients with blood IGFBP2 >160.9 ng/ml is 15.1 months; whereas median survival time was 128.2 months for the patients whose blood IGFBP2 was ≤160.9 ng/ml (p =0.0002). Conclusions/Significance Blood IGFBP2 is significantly increased in lung cancer patients. A high circulating level of IGFBP2 is significantly associated with poor survival, suggesting that blood IGFBP2 levels could be a prognostic biomarker for lung cancer.
Transgenic rice homozygous lines expressing GNA showed enhanced resistance to rice brown planthopper
Sun Xiaofen,Tang Kexuan,Wan Bingliang,Qi Huaxiong,Lu Xinggui
Chinese Science Bulletin , 2001, DOI: 10.1007/BF02900655
Abstract: Mature seed-derived calli from two elite Chinese japonica rice (Oryza sativa L.) cultivars Eyi 105 and Ewan 5 were co-transformed with two plasmids, pWRG1515 and pRSSGNA1, containing the selectable marker hygromycin phosphotransferase gene (hpt), the reporter β-glucuronidase gene (gusA) and the snowdrop (Galanthus nivalis) lectin gene (gna) via particle bombardment. 61 independent transgenic rice plants were regenerated from 329 bombarded calli. 79% transgenic plants contained all the three genes, revealed by PCR/Southern blot analysis. Western blot analysis revealed that 36 out of 48 gna-containing transgenic plants expressed GNA (75%) at various levels with the highest expression being approximately 0.5% of total soluble protein. Genetic analysis confirmed Mendelian segregation of transgenes in progeny. From the R2 generations whose R1 parent plants showing 3:1 Mendelian segregation patterns, we identified five independent homozygous lines containing and expressing all the three transgenes. Insect bioassay and feeding tests showed that these homozygous lines had significant inhibition to rice brown planthopper (Nilaparvata lugens, BPH) by decreasing BPH survival and overall fecundity, retarding BPH development and declining BPH feeding. These BPH-resistant lines have been incorporated into rice insect resistance breeding program. This is the first report that homozygous transgenic rice lines expressing GNA, developed by genetic transformation and through genetic analysis-based selection, conferred enhanced resistance to BPH, one of the most damaging insect pests in rice.
Indirect Radiative Forcing and Climatic Effect of the Anthropogenic Nitrate Aerosol on Regional Climate of China

LI Shu,WANG Tijian,ZHUANG Bingliang,HAN Yong,

大气科学进展 , 2009,
Abstract: The regional climate model (RegCM3) and a tropospheric atmosphere chemistry model (TACM) were couplcd, thus a regional climate chemistry modeling system (RegCCMS) was constructed, which was applied to investigate the spatial distribution of anthropogenic nitrate aerosols, indirect radiative forcing, as well as its climatic effect over China. TACM includes the thermodynamic equilibrium model ISORROPIA and a condensed gas-phase chemistry model. Investigations show that the concentration of nitrate aerosols is relatively high over North and East China with a maximum of 29μg m-3 in January and 8 μg m-3 in July.Due to the influence of air temperature on thermodynamic equilibrium, wet scavenging of precipitation and the monsoon climate, there are obvious seasonal differences in nitrate concentrations. The average indirect radiative forcing at the tropopause due to nitrate aerosols is -1.63 W m-2 in January and -2.65 W m-2 in July, respectively. In some areas, indirect radiative forcing reaches -10 W m-2. Sensitivity tests show that nitrate aerosols make the surface air temperature drop and the precipitation reduce on the national level. The mean changes in surface air temperature and precipitation are -0.13 K and -0.01 mm d-1 in January and -0.09 K and -0.11 mm d-1 in July, respectively, showing significant differences in different regions.
Anthropogenic Halo Disturbances Alter Landscape and Plant Richness: A Ripple Effect
Bingliang Liu, Jinbao Su, Jianwei Chen, Guofa Cui, Jianzhang Ma
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0056109
Abstract: Although anthropogenic landscape fragmentation is often considered as the primary threat to biodiversity, other factors such as immediate human disturbances may also simultaneously threaten species persistence in various ways. In this paper, we introduce a conceptual framework applied to recreation landscapes (RLs), with an aim to provide insight into the composite influences of landscape alteration accompanying immediate human disturbances on plant richness dynamics. These impacts largely occur at patch-edges. They can not only alter patch-edge structure and environment, but also permeate into surrounding natural matrices/patches affecting species persistence–here we term these “Halo disturbance effects” (HDEs). We categorized species into groups based on seed or pollen dispersal mode (animal- vs. wind-dispersed) as they can be associated with species richness dynamics. We evaluated the richness of the two groups and total species in our experimental landscapes by considering the distance from patch-edge, the size of RLs and the intensity of human use over a six-year period. Our results show that animal-dispersed species decreased considerably, whereas wind-dispersed species increased while their richness presented diverse dynamics at different distances from patch-edges. Our findings clearly demonstrate that anthropogenic HDEs produce ripple effects on plant, providing an experimental interpretation for the diverse responses of species to anthropogenic disturbances. This study highlights the importance of incorporating these composite threats into conservation and management strategies.
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