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Search Results: 1 - 10 of 127040 matches for " Bingliang Li "
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CVD Treatment of Carbon Fibers and Evaluation of Their Dispersion in CFRC  [PDF]
Chuang Wang, Bingliang Li, Lei Peng, Wenmin He, Liping Zhao, Kezhi Li
Materials Sciences and Applications (MSA) , 2017, DOI: 10.4236/msa.2017.88046
Abstract: Carbon-fiber-reinforced cement-based (CFRC) composites is a promising functional material which can be used both in the military and civil fields against electromagnetic interference. However, it is essential to make carbon fibers dispersed uniformly during the preparation of CFRC. In this work, short carbon fibers were treated through Chemical Vapor Deposition (CVD) process at high temperature between 900°C and 1200°C under the protection of diluted nitrogen gas N2 to modify the surface of carbon fibers to further strengthen the bonding between carbon fibers and cement matrix. Natural gas (98% CH4) was used as a precursor. It was decomposed to produce an uneven layer of pyrocarbon that was deposited on the surface of carbon fibers. CVD-treated carbon fibers were pre-dispersed by using ultrasonic wave. Both hydroxyethyl cellulose (HEC) and silicon fume were used as dispersants and as admixtures. They helped CVD-treated carbon fibers distribute uniformly. The mass fraction of HEC was around 1.78% in the aqueous solution. Four methods, namely, the simulation experiment (SE) method, the scanning electron microscopy (SEM) method, the fresh mixture (FM) method, and the electrical resistivity measurement (ERM) method were, respectively, applied to evaluate fiber dispersion degree. Each method indicated its own advantages and disadvantages and it therefore catered for different conditions. Of the four evaluation methods, the SE method was the most convenient way to determine the pre-dispersion state prior to the preparation of CFRC composites. This method was helpful for predicting the subsequent dispersion state of carbon fibers in the cement matrix because it economized a large quantity of raw materials and time.
Indirect Radiative Forcing and Climatic Effect of the Anthropogenic Nitrate Aerosol on Regional Climate of China

LI Shu,WANG Tijian,ZHUANG Bingliang,HAN Yong,

大气科学进展 , 2009,
Abstract: The regional climate model (RegCM3) and a tropospheric atmosphere chemistry model (TACM) were couplcd, thus a regional climate chemistry modeling system (RegCCMS) was constructed, which was applied to investigate the spatial distribution of anthropogenic nitrate aerosols, indirect radiative forcing, as well as its climatic effect over China. TACM includes the thermodynamic equilibrium model ISORROPIA and a condensed gas-phase chemistry model. Investigations show that the concentration of nitrate aerosols is relatively high over North and East China with a maximum of 29μg m-3 in January and 8 μg m-3 in July.Due to the influence of air temperature on thermodynamic equilibrium, wet scavenging of precipitation and the monsoon climate, there are obvious seasonal differences in nitrate concentrations. The average indirect radiative forcing at the tropopause due to nitrate aerosols is -1.63 W m-2 in January and -2.65 W m-2 in July, respectively. In some areas, indirect radiative forcing reaches -10 W m-2. Sensitivity tests show that nitrate aerosols make the surface air temperature drop and the precipitation reduce on the national level. The mean changes in surface air temperature and precipitation are -0.13 K and -0.01 mm d-1 in January and -0.09 K and -0.11 mm d-1 in July, respectively, showing significant differences in different regions.
Eddy Covariance Tilt Corrections over a Coastal Mountain Area in South-east China: Significance for Near-Surface Turbulence Characteristics

LIU Li,WANG Tijian,SUN Zhenhai,WANG Qingeng,ZHUANG Bingliang,HAN Yong,LI Shu,

大气科学进展 , 2012,
Abstract: Turbulence characteristics of an atmospheric surface layer over a coastal mountain area were investigated under different coordinate frames. Performances of three methods of coordinate rotation: double rotation (DR), triple rotation (TR), and classic planar-fit rotation (PF) were examined in terms of correction of eddy covariance flux. Using the commonly used DR and TR methods, unreasonable rotation angles are encountered at low wind speeds and cause significant run-to-run errors of some turbulence characteristics. The PF method rotates the coordinate system to an ensemble-averaged plane, and shows large tilt error due to an inaccurate fit plane over variable terrain slopes. In this paper, we propose another coordinate rotation scheme. The observational data were separated into two groups according to wind direction. The PF method was adapted to find an ensemble-averaged streamline plane for each group of hourly runs with wind speed exceeding 1.0 m s-1. Then, the coordinate systems were rotated to their respective best-fit planes for all available hourly observations. We call this the PF10 method. The implications of tilt corrections for the turbulence characteristics are discussed with a focus on integral turbulence characteristics, the spectra of wind-velocity components, and sensible heat and momentum fluxes under various atmospheric stabilities. Our results show that the adapted application of PF provides greatly improved estimates of integral turbulence characteristics in complex terrain and maintains data quality. The comparisons of the sensible heat fluxes for four coordinate rotation methods to fluxes before correction indicate that the PF10 scheme is the best to preserve consistency between fluxes.
Oxidative stress in NSC-741909-induced apoptosis of cancer cells
Xiaoli Wei, Wei Guo, Shuhong Wu, Li Wang, Peng Huang, Jinsong Liu, Bingliang Fang
Journal of Translational Medicine , 2010, DOI: 10.1186/1479-5876-8-37
Abstract: The generation of ROS was measured by using the cell-permeable nonfluorescent compound H2DCF-DA and flow cytometry analysis. Cell viability was determined by sulforhodamine B assay. Western blot analysis, immunofluorescent staining and flow cytometry assays were used to determine apoptosis and molecular changes induced by NSC-741909.Treatment with NSC-741909 induced robust ROS generation and marked MAPK phosphatase-1 and -7 clustering in NSC-741909-sensitive, but not resistant cell lines, in a dose- and time-dependent manner. The generation of ROS was detectable as early as 30 min and ROS levels were as high as 6- to 8-fold above basal levels after treatment. Moreover, the NSC-741909-induced ROS generation could be blocked by pretreatment with antioxidants, such as nordihydroguaiaretic acid, aesculetin, baicalein, and caffeic acid, which in turn, inhibited the NSC-741909-induced JNK activation and apoptosis.Our results demonstrate that the increased ROS production was associated with NSC-741909-induced antitumor activity and that ROS generation and subsequent JNK activation is one of the primary mechanisms of NSC-741909-mediated antitumor cell activity.We recently identified a small molecule (oncrasin-1) through cell-based synthetic lethality screening that can effectively kill several lung cancer cell lines harboring mutant K-Ras genes [1]. Subsequent analyses of oncrasin-1 analogues led us to identify several active compounds with similar chemical structures. NSC-741909 is one of the oncrasin-1 analogues that was highly active against several cell lines derived from lung, colon, breast, ovarian, and kidney cancers when tested in NCI-60 cancer cell lines by the Developmental Therapeutics Program at the National Cancer Institute. Using a reverse-phase protein microarray assay, we determined molecular changes in 77 protein biomarkers in an oncrasin-sensitive lung cancer cell line after treatment with NSC-741909 [2]. These results showed that treatment with NSC-741909
Pathophysiological Significance of Hepatic Apoptosis
Kewei Wang,Bingliang Lin
ISRN Hepatology , 2013, DOI: 10.1155/2013/740149
Abstract: Apoptosis is a classical pathological feature in liver diseases caused by various etiological factors such as drugs, viruses, alcohol, and cholestasis. Hepatic apoptosis and its deleterious effects exacerbate liver function as well as involvement in fibrosis/cirrhosis and carcinogenesis. An imbalance between apoptotic and antiapoptotic capabilities is a prominent characteristic of liver injury. The regulation of apoptosis and antiapoptosis can be a pivotal step in the treatment of liver diseases. 1. Apoptosis Apoptosis is a process of programmed cell death. Apoptotic cells are characterized by energy-dependent biochemical mechanisms and obvious morphological changes [1, 2]. These features include membrane blebbing, cell shrinkage, nuclear chromatin condensation, and chromosomal DNA fragmentation. The apoptotic process deletes single cell or small clusters of cells without inflammatory response [3]. Apoptotic cells die in a controlled and regulated fashion. This makes apoptosis distinct from other uncontrolled modes of cell death such as necrosis, necroptosis, autophagy, and cornification [4]. Uncontrolled cell death leads to cell lysis, inflammatory response, and serious health problems [5]. Apoptosis is associated with multiple pathophysiological functions. During the embryological stage of mammals, apoptosis is important for the normal development of organs [6]. In adults, apoptosis regulates physiological processes (e.g., removing aged cells) and maintains tissue homeostasis [7]. Dysfunction or dysregulation of the apoptotic program is implicated in a variety of congenital anomalies and pathological conditions such as tumorigenesis, autoimmune diseases, neurodegenerative disorders, and others [8]. 2. Hepatic Apoptosis Hepatic apoptosis, as name indicated, means cell suicide in liver. The hepatic apoptosis is different from hepatocyte apoptosis. The hepatocyte apoptosis describes the apoptotic cell death in only hepatocytes (one type of liver cells), but the hepatic apoptosis reflects the interaction of manifold cells in liver and represents a comprehensive outcome of multiple effects. The liver is an organ consisting of several phenotypically distinct cell types, for example, hepatocytes, cholangiocytes, stellate cells, sinusoidal endothelial cells, Kupffer cells, oval cells, and so forth [9]. Predominant hepatocytes make up 70–80% of the liver cells [10]. Hepatocytes manufacture critical circulating proteins, generate bile acid-dependent bile flow, detoxify endo- and xenobiotics, and regulate intermediary metabolism [11]. Hepatocyte injury results
Antitumor Activity of a Novel Oncrasin Analogue Is Mediated by JNK Activation and STAT3 Inhibition
Wei Guo,Shuhong Wu,Li Wang,Xiaoli Wei,Xiaoying Liu,Ji Wang,Zhimin Lu,Melinda Hollingshead,Bingliang Fang
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0028487
Abstract: To optimize the antitumor activity of oncrasin-1, a small molecule identified through synthetic lethality screening on isogenic K-Ras mutant tumor cells, we developed several analogues and determined their antitumor activities. Here we investigated in vitro and in vivo antitumor activity of NSC-743380 (1-[(3-chlorophenyl) methyl]-1H-indole-3-methanol, oncrasin-72), one of most potent analogues of oncrasin-1.
Targeting different types of human meningioma and glioma cells using a novel adenoviral vector expressing GFP-TRAIL fusion protein from hTERT promoter
Jessica T Li, Ka Bian, Alan L Zhang, Dong H Kim, William W Ashley, Rahul Nath, Ian McCutcheon, Bingliang Fang, Ferid Murad
Cancer Cell International , 2011, DOI: 10.1186/1475-2867-11-35
Abstract: Gliomas and meningiomas are the two most common types of human brain tumors. Currently there is no effective cure for recurrent malignant meningiomas or for gliomas. Ad/gTRAIL has been shown to be effective in killing selected lung, colon and breast cancer cells, but there have been no studies reporting its antitumor effects on malignant meningiomas. Therefore, we tested the antitumor effect of Ad/gTRAIL for the first time in human malignant meningioma and glioma cell lines, and in intracranial M6 and U87 xenografts.Materials and Methods: Human malignant meningioma and glioma cells were infected with adenoviruses, Ad/gTRAIL and Ad/CMV-GFP. Cell viability was determined by proliferation assay. FACS analysis and quantification of TRAIL were used to measure apoptosis in these cells. We injected Ad/gTRAIL viruses in intracranial M6 and U87 xenografts, and measured the brain tumor volume, quantified apoptosis by TUNEL assay in the brain tumor tissue.Our studies demonstrate that in vitro/in vivo treatment with Ad/gTRAIL virus resulted in significant increase of TRAIL activity, and elicited a greater tumor cell apoptosis in malignant brain tumor cells as compared to treatment with the control, Ad/CMV-GFP virus without TRAIL activity.We showed for the first time that adenovirus Ad/gTRAIL had significant antitumor effects against high grade malignant meningiomas as well as gliomas. Although more work needs to be done, our data suggests that Ad/gTRAIL has the potential to be useful as a tool against malignant brain tumors.Gliomas and meningiomas are the two most common types of human brain tumors. Malignant gliomas are the most aggressive and deadliest type of brain tumor[1]. Meningiomas, on the other hand, are usually benign but often recur after surgical removal. They can undergo malignant transformation, and depending on their location can be serious and even potentially lethal to patients [2]. It has been reported that there has been a steady increase in the incidence of
Characteristics of neighborhood interaction in urban land-use changes: A comparative study between three metropolitan areas of Japan

ZHAO Yaolong,CUI Bingliang,MURAYAMA Yuji,

地理学报 , 2011,
Abstract: Local spatial interaction between neighborhood land-use categories (i.e. neighborhood interaction) is an important factor which affects urban land-use change patterns. Therefore, it is a key component in cellular automata (CA)-based urban geosimulation models towards the simulation and forecast of urban land-use changes. Purpose of this paper is to interpret the similarities and differences of the characteristics of neighborhood interaction in urban land-use changes of different metropolitan areas in Japan for providing empirical materials to understand the mechanism of urban land-use changes and construct urban geosimulation models. Characteristics of neighborhood interaction in urban land-use changes of three metropolitan areas in Japan, i.e. Tokyo, Osaka, and Nagoya, were compared using such aids as the neighborhood interaction model and similarity measure function. As a result, urban land-use in the three metropolitan areas was found to have had similar structure and patterns during the study period. Characteristics of neighborhood interaction in urban land-use changes are quite different from land-use categories, meaning that the mechanism of urban land-use changes comparatively differs among land-use categories. Characteristics of neighborhood interaction reveal the effect of spatial autocorrelation in the spatial process of urban land-use changes in the three metropolitan areas, which correspond with the characteristics of agglomeration of urban land-use allocation in Japan. Neighborhood interaction amidst urban land-use changes between the three metropolitan areas generally showed similar characteristics. The regressed neighborhood interaction coefficients in the models may represent the general characteristics of neighborhood effect on urban land-use changes in the cities of Japan. The results provide very significant materials for exploring the mechanism of urban land-use changes and the construction of universal urban geosimulation models which may be applied to any city in Japan.
The Association between Expression of NK Cells and Prognosis of Patients with HBV Acute-on-Chronic Liver Failure in Advanced Phase  [PDF]
Weizhen Weng, Yiming Shi, Xiaohua Peng, Jing Xiong, Huijuan Cao, Bingliang Lin
Advances in Infectious Diseases (AID) , 2017, DOI: 10.4236/aid.2017.74012
Abstract: Acute-on-chronic liver failure (Acute-on-chronic liver failure, ACLF) is acute liver function decompensation on the basis of chronic liver disease. The progression of ACLF develops from advanced phase, plateau phase to remission phase. The pathophysiological basis of ACLF in different phases is various. In advanced phase, immune imbalance and systemic inflammatory reaction plays key roles. In this study, we try to assess the association between expression of NK cells and its receptors and prognosis of patients with ACLF in advanced phase. A total of 35 inpatients with HBV acute-on-chronic liver failure in advanced phase were recruited. They were divided into case group (n = 18) and control group (n = 17) according to whether the patients was dead in the 12 weeks. PBMC were detected for the frequency and expression of NK cell receptors by flow cytometric analysis. Our results demonstrated that patients who died had lower expression of NK cells and inhibitory receptor KIR3DL1, higher levels of FASL. During 12-week follow-up in those case alive, we found that NK cells increased, while expression of FASL decreased. High short-term mortality of ALCF was associated with NK cell, especially related to KIR3DL1 and FASL (PNK = 0.036, PKIR3DL1 = 0.0265, PFasL = 0.0008).
The method of regional air resource assessment and its application in the west coast of Taiwan Strait

LIU Li,WANG Tijian,LI Zongkai,ZHUANG Bingliang,XIE Min,WANG Qingeng,SUN Zhenhai,

环境科学学报 , 2011,
Abstract: To meet the requirements of regional atmosphere environment management, the concept of air resource was put forward. Then estimation and assessment methods were presented. A case study was conducted for the domain of the west of Taiwan Strait. Based on the analysis of climate characteristics and various weather systems associated with high levels of air pollution occurring in this area, both the regional and local meteorological fields were simulated with the Weather Research and Forecasting (WRF) model. The key factors that affected air resource significantly were selected from the meteorological fields and turbulence parameters. They acted as evaluating indicators of regional air resource. Each of the factors was classified and then graded to determine the weighted coefficient. The total scores of air resource in west Strait were estimated from the weighted sum of the respective factor scores. The levels of air resource were determined subsequently. Finally, spatial distribution of the overall scores and the levels of air resource were obtained. It showed that the air resource over the Strait was of the top grade (5) with the score 18. The grades in the rest were of 2 to 4 with the scores 14 to 18. In general, the air resource in coastal area was most abundant, in inland flat less and in mountainous area the least, showing an inhomogeneous pattern. The results indicated that the method proposed in this paper was a reasonable solution to assess regional air resource. There will be a great application prospect for regulation and management of atmosphere environment.
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