oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Search Results: 1 - 10 of 12 matches for " Biancamaria Gliozzo "
All listed articles are free for downloading (OA Articles)
Page 1 /12
Display every page Item
Additive value of blood neutrophil gelatinase-associated lipocalin to clinical judgement in acute kidney injury diagnosis and mortality prediction in patients hospitalized from the emergency department
Salvatore Di Somma, Laura Magrini, Benedetta De Berardinis, Rossella Marino, Enrico Ferri, Paolo Moscatelli, Paola Ballarino, Giuseppe Carpenteri, Paola Noto, Biancamaria Gliozzo, Lorenzo Palladino, Enrico Di Stasio
Critical Care , 2013, DOI: 10.1186/cc12510
Abstract: This is a multicenter Italian prospective emergency department (ED) cohort study in which we enrolled 665 patients admitted to hospital from the ED.Blood NGAL and serum creatinine (sCr) where determined at ED presentation (T0), and at: 6 (T6), 12 (T12), 24 (T24) and 72 (T72) hours after hospitalization. A preliminary assessment of AKI by the treating ED physician occurred in 218 of 665 patients (33%), while RIFLE AKI by expert nephrologists was confirmed in 49 of 665 patients (7%). ED physician's initial judgement lacked sensitivity and specificity, over predicting the diagnosis of AKI in 27% of the cohort, while missing 20% of those with AKI final diagnosis. The area under the receiver operating characteristic curve (AUC), obtained at T0, for blood NGAL alone in the AKI group was 0.80. When NGAL at T0 was added to the ED physician's initial clinical judgment the AUC was increased to 0.90, significantly greater when compared to the AUC of the T0 estimated glomerular filtration rate (eGFR) obtained either by modification of diet in renal disease (MDRD) equation (0.78) or Cockroft-Gault (0.78) formula (p=0.022 and p=0.020 respectively). The model obtained by combining NGAL with ED physician's initial clinical judgement compared to the model combining sCr with the ED physician's initial clinical judgement, resulted in a net reclassification index of 32.4 percentage points. Serial assessment of T0 and T6 hours NGAL provided a high negative predictive value (NPV) (98%) in ruling out the diagnosis of AKI within 6 hours of patients' ED arrival. NGAL (T0) showed the strongest predictive value for in-hospital patient's mortality at a cut-off of 400 ng/ml.Our study demonstrated that assessment of a patient's initial blood NGAL when admitted to hospital from the ED improved the initial clinical diagnosis of AKI and predicted in-hospital mortality. Blood NGAL assessment coupled with ED physician's clinical judgment may provide utility in deciding the appropriate strategies for
I paesaggi identitari: riferimento comune per il Piano paesistico e il Piano di sviluppo rurale 2006-2013. Il caso dell'Umbria
Biancamaria Torquati
Aestimum , 2006,
Abstract:
About the effects of combining Latent Semantic Analysis with natural language processing techniques for free-text assessment Sobre los efectos de combinar Análisis Semántico Latente con otras técnicas de procesamiento de lenguaje natural para la evaluación de preguntas abiertas
Diana Pérez,Enrique Alfonseca,Pilar Rodríguez,Alfio Gliozzo
Revista Signos , 2005,
Abstract: This article presents the combination of Latent Semantic Analysis (LSA) with other natural language processing techniques (stemming, removal of closed-class words and word sense disambiguation) to improve the automatic assessment of students' free-text answers. The combinational schema has been tested in the experimental framework provided by the free-text Computer Assisted Assessment (CAA) system called Atenea (Alfonseca & Pérez, 2004). This system is able to ask randomly or according to the students' profile an open-ended question to the student and then, assign a score to it. The results prove that for all datasets, when the NLP techniques are combined with LSA, the Pearson correlation between the scores given by Atenea and the scores given by the teachers for the same dataset of questions improves. We believe that this is due to the complementarity between LSA, which works more at a shallow semantic level, and the rest of the NLP techniques used in Atenea, which are more focused on the lexical and syntactical levels. Este artículo presenta la combinación de Análisis Semántico Latente (LSA) con otras técnicas de procesamiento del lenguaje natural (lematización, eliminación de palabras funcionales y desambiguación de sentidos) para mejorar la evaluación automática de respuestas en texto libre. El sistema de evaluación de respuestas en texto libre llamado Atenea (Alfonseca & Pérez, 2004) ha servido de marco experimental para probar el esquema combinacional. Atenea es un sistema capaz de realizar preguntas, escogidas aleatoriamente o bien conforme al perfil del estudiante, y asignarles una calificación numérica. Los resultados de los experimentos demuestran que para todos los conjuntos de datos en los que las técnicas de PLN se han combinado con LSA la correlación de Pearson entre las notas dadas por Atenea y las notas dadas por los profesores para el mismo conjunto de preguntas mejora. La causa puede encontrarse en la complementariedad entre LSA, que trabaja a un nivel semántico superficial, y el resto de las técnicas NLP usadas en Atenea, que están más centradas en los niveles léxico y sintáctico.
The interplay of StyR and IHF regulates substrate-dependent induction and carbon catabolite repression of styrene catabolism genes in Pseudomonas fluorescens ST
Giordano Rampioni, Livia Leoni, Biancamaria Pietrangeli, Elisabetta Zennaro
BMC Microbiology , 2008, DOI: 10.1186/1471-2180-8-92
Abstract: StyR-P and IHF compete for binding to the URE region. PstyA full activity in inducing conditions is achieved when StyR-P and IHF bind to site STY2 and to the URE, respectively. Under catabolite repression conditions, StyR-P binds the STY1 site, replacing IHF at the URE region. StyR-P bound to both STY1 and STY2 sites oligomerizes, likely promoting the formation of a DNA loop that closes the promoter in a repressed conformation. We found that StyR and IHF protein levels did not change in catabolite repression conditions, implying that PstyA repression is achieved through an increase in the StyR-P/StyR ratio.We propose a model according to which the activity of the PstyA promoter is determined by conformational changes. An open conformation is operative in inducing conditions when StyR-P is bound to STY2 site and IHF to the URE. Under catabolite repression conditions StyR-P cellular levels would increase, displacing IHF from the URE and closing the promoter in a repressed conformation. The balance between the open and the closed promoter conformation would determine a fine modulation of the promoter activity. Since StyR and IHF protein levels do not vary in the different conditions, the key-factor regulating PstyA catabolite repression is likely the kinase activity of the StyR-cognate sensor protein StyS.Styrene is a basic building block for the manufacture of a broad range of products containing molecules such as polystyrene, butadiene-styrene latex, styrene copolymers and unsaturated polyester resins. These products range from packaging materials to food service items to a myriad of consumer electronics, construction, transportation and medical applications. Styrene exposure may cause contact-based skin inflammation, irritation of eyes, nose and respiratory tract, while neurological effects, such as alterations in vision, hearing loss and longer reaction times, have been associated with styrene exposure in the workplace [1]. Microbial biodegradation and polluted air
Models of collaboration between general practice and mental health services in Italy
Berardi,Domenico; Bortolotti,Biancamaria; Menchetti,Marco; Bombi,Annarosa; Tarricone,Ilaria;
The European Journal of Psychiatry , 2007, DOI: 10.4321/S0213-61632007000100010
Abstract: background and objectives: anxiety and depressive disorders represent an important public health problem, which involves not only the mental health services, but the general practice as well. this paper examines models of collaboration between general practice and community mental health services developed in italy. methods: different consultation -liaison activities are presented. for every collaboration model advantages and disadvantage are discussed. results: the structured consultation liaison service is based on supplying diagnostic consultation and therapeutic interventions in support of general practitioners (gps). the service could be based in either a community mental health centre (cmhc) or externally. diagnostic evaluation can be followed by brief and focal therapeutic interventions, in support of the gp's therapeutic plan. the spontaneous collaboration in small centres are frequent in rural areas where the contained dimensions of the services and the direct acquaintance between psychiatrists and gps encourage the personalization of the collaboration. the model of liaison and group-training focuses on direct contact between consultant and gps. in the course of regular meetings, the consultant gives the gps supervision and education, and they can discuss the therapeutic plans for patients requiring specialist intervention. conclusion: the empiric classification presented should be considered an attempt to represent a complex reality. every service, in fact, carries out activities that are necessarily wider than abstract typologies and that overlap with other models' activities.
Lettura paesaggistica degli interventi strutturali nel settore vitivinicolo: una proposta metodologica
Biancamaria Torquati,Giulia Giacchè,Mara Bodesmo,Leonardo Gioffrè
Aestimum , 2012,
Abstract: -
Models of collaboration between general practice and mental health services in Italy
Domenico Berardi,Biancamaria Bortolotti,Marco Menchetti,Annarosa Bombi
The European Journal of Psychiatry , 2007,
Abstract: Background and objectives: Anxiety and Depressive disorders represent an important public health problem, which involves not only the mental health services, but the General Practice as well. This paper examines models of Collaboration between General Practice and Community Mental Health Services developed in Italy. Methods: Different Consultation -Liaison activities are presented. For every Collaboration model advantages and disadvantage are discussed. Results: The structured Consultation Liaison Service is based on supplying diagnostic consultation and therapeutic interventions in support of General Practitioners (GPs). The service could be based in either a Community Mental Health Centre (CMHC) or externally. Diagnostic evaluation can be followed by brief and focal therapeutic interventions, in support of the GP's therapeutic plan. The spontaneous collaboration in small centres are frequent in rural areas where the contained dimensions of the services and the direct acquaintance between psychiatrists and GPs encourage the personalization of the collaboration. The model of Liaison and Group-Training focuses on direct contact between consultant and GPs. In the course of regular meetings, the consultant gives the GPs supervision and education, and they can discuss the therapeutic plans for patients requiring specialist intervention. Conclusion: The empiric classification presented should be considered an attempt to represent a complex reality. Every service, in fact, carries out activities that are necessarily wider than abstract typologies and that overlap with other models' activities.
About the effects of combining Latent Semantic Analysis with natural language processing techniques for free-text assessment
Pérez,Diana; Alfonseca,Enrique; Rodríguez,Pilar; Gliozzo,Alfio; Strapparava,Carlo; Magnini,Bernardo;
Revista signos , 2005, DOI: 10.4067/S0718-09342005000300004
Abstract: this article presents the combination of latent semantic analysis (lsa) with other natural language processing techniques (stemming, removal of closed-class words and word sense disambiguation) to improve the automatic assessment of students' free-text answers. the combinational schema has been tested in the experimental framework provided by the free-text computer assisted assessment (caa) system called atenea (alfonseca & pérez, 2004). this system is able to ask randomly or according to the students' profile an open-ended question to the student and then, assign a score to it. the results prove that for all datasets, when the nlp techniques are combined with lsa, the pearson correlation between the scores given by atenea and the scores given by the teachers for the same dataset of questions improves. we believe that this is due to the complementarity between lsa, which works more at a shallow semantic level, and the rest of the nlp techniques used in atenea, which are more focused on the lexical and syntactical levels.
The role of different methanogen groups evaluated by Real-Time qPCR as high-efficiency bioindicators of wet anaerobic co-digestion of organic waste
Deborah Traversi, Silvia Villa, Marco Acri, Biancamaria Pietrangeli, Raffaella Degan, Giorgio Gilli
AMB Express , 2011, DOI: 10.1186/2191-0855-1-28
Abstract: Methanogenesis is a characteristic unique to the Archaea (Woese 2007). Biological methane production involves 25 genes and numerous specific proteins and coenzymes. However, the gene number involved in the different aspects of methane production is much higher (Galagan et al. 2002). Methane can be produced through different pathways, each of which has a different substrate. Among the precursor organic molecules, we find CO2, formate, acetate and methyl groups. The CO2, with H2 as an electron donor, is reduced to methane via the hydrogenotrophic mechanism. Acetate is involved in the aceticlastic pathway, and the methyl group acts as the starting point of the methylotrophic pathway (Ferry 2010a, b). Anaerobic digestors are one typical habitat, especially for the following genera: Methanobacterium, Methanothermobacter, Methanomicrobium, Methanoculleus, Methanofollis, Methanospirillum, Methanocorpusculum, Methanosarcina and Methanosaeta (Liu and Whitman 2008). Two genera of Archaea, Methanosarcina and Methanosaeta, are methane producing from acetate, and this acetoclastic mechanism produces higher proportions of biogenic methane. These two genera are also the most studied in recent years with the advent of the complete genome sequencing of some strains (Barber et al. 2011). Methanogenesis is the final step of the anaerobic digestion process in the reactor. Other microorganisms, such as hydrolytic acidogens and acetogens, are involved in the previous steps. These microorganisms prepare the substrates for methanogenesis, which is considered to be the rate-limiting step (Rozzi and Remigi 2004). Anaerobic digestion technologies vary throughout Europe. For example, Germany has more than 4000 digesters (Dolan et al. 2011) and there are numerous examples of integrated management of waste and biomethane fuel production to provide public transport in Sweden and France (Lantz et al. 2007; Dolan et al. 2011). Recently, other countries have begun promotional projects to encourage a
Depression in Primary care: Interpersonal Counseling vs Selective serotonin reuptake inhibitors. The DEPICS Study. A multicenter randomized controlled trial. Rationale and design
Marco Menchetti, Biancamaria Bortolotti, Paola Rucci, Paolo Scocco, Annarosa Bombi, Domenico Berardi, DEPICS Study Group
BMC Psychiatry , 2010, DOI: 10.1186/1471-244x-10-97
Abstract: This multi-center randomized controlled trial was conducted in 9 Italian centres with the aim to compare the efficacy of Inter-Personal Counseling, a brief structured psychological intervention, to that of Selective Serotonin Reuptake Inhibitors. Patients with depressive symptoms referred by Primary Care Physicians to psychiatric consultation-liaison services were eligible for the study if they met the DSM-IV criteria for major depression, had a score ≥13 on the 21-item Hamilton Depression Rating Scale, and were at their first or second depressive episode. The primary outcome was remission of depressive symptoms at 2-months, defined as a HDRS score ≤ 7. Secondary outcome measures were improvement in global functioning and recurrence of depressive symptoms at 12-months. Patients who did not respond to Inter-Personal Counseling or Selective Serotonin Reuptake Inhibitors at 2-months received augmentation with the other treatment.This trial addresses some of the shortcomings of existing trials targeting major depression in primary care by evaluating the comparative efficacy of a brief psychological intervention that could be easily disseminated, by including a sample of patients with mild/moderate depression and by using different outcome measures.Australian New Zealand Clinical Trials Registry ACTRN12608000479303Major Depression (MD) is an important public health problem, associated with high levels of disability, impairment in quality of life, and increased mortality rates [1,2], similarly to severe medical conditions like congestive heart failure and diabetes [3]. Moreover, depression is associated with high health services utilization, work absenteeism, and decreased performances at work [4,5] with elevated direct and indirect social costs. Epidemiological studies showed that MD has a high prevalence in primary care ranging from 2.6% to 29.5% [6-8].Many patients with depression seek help in primary care and an increasing proportion has been treated in this setting,
Page 1 /12
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.