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Search Results: 1 - 10 of 3010 matches for " Bhikku Angoth and Narsimha Reddy Yellu* "
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INFLUENCE OF VERAPAMIL ON PHARMACOKINETICS OF PIOGLITAZONE IN NORMAL AND DIABETIC RATS
Ravikanth Chintala , Chaitanya Gadiko , Bhikku Angoth and Narsimha Reddy Yellu*
International Journal of Pharmaceutical Sciences and Research , 2013,
Abstract: ABSTRACT: The study was undertaken to find out the pharmacokinetic drug interaction of verapamil on pioglitazone in normal and alloxan induced diabetic rats following single and multiple dose treatment. Human oral therapeutic doses of pioglitazone and verapamil were extrapolated to rats based on their body surface area. The serum pioglitazone concentrations were estimated by a sensitive reverse phase – high performance liquid chromatography (RP-HPLC) method. In single and multiple dose study, verapamil significantly increased the pioglitazone exposure (AUC, Cmax) and decreased its elimination by prolongation of t1/2 and mean residence time (MRT) with a relative decrease in clearance (CL). The effect is more significant in diabetic rats. In the present study a pharmacokinetic interaction between verapamil and pioglitazone was observed. The possible interaction may involve both P-glycoprotein and CYP enzymes. Investigating this type of interactions pre-clinically is helpful to avoid drug-drug interactions in actual clinical situation.
Antioxidant, analgesic and anti-inflammatory activities of Leucas cephalotes (Roxb.ex Roth) Spreng
Baburao, Bhukya;Reddy, Anreddy Rama Narsimha;Kiran, Gangarapu;Reddy, Yellu Narsimha;Mohan, Gottumukkala Krishna;
Brazilian Journal of Pharmaceutical Sciences , 2010, DOI: 10.1590/S1984-82502010000300016
Abstract: the whole plant of the methanolic extract from leucas cephalotes was screened for invitro antioxidant (using the dpph method), invivo analgesic (using hot plate test in mice) and anti-inflammatory (using rat paw edema test) activities. the methanolic extract of leucas cephalotes (melc) scavenged the dpph radicals in a dose-dependent manner. the ic50 value to scavenge dpph radicals was found to be 421.3μg/ml. a significant (p<0.0005) analgesic activity was observed at 60 min with 200 mg/kg, and 400 mg/kg exhibited maximum activity. the maximum anti-inflammatory response was produced at 3 hr and 2 hr with doses of 200 and 400 mg/kg, respectively. these results suggest that the methanolic extract from leucas cephalotes exerts significant analgesic and anti-inflammatory effects, which were comparable with standard drugs.
Protective Effects of Methanolic Fruit Extract of Solena amplexicaulis in Carbon Tetrachloride Induced Hepatotoxicity on Rat
Parameshwar Hanwathe,Ravi Kumar Bobbala,Krishna Mohan Gottumukhala,Narsimha Reddy Yellu
Stamford Journal of Pharmaceutical Sciences , 2010,
Abstract: Herbal medicines derived from plant extracts are being increasingly utilized to treat a wide variety of clinical diseases. In the present study, the hepatoprotective activity of methanolic extract of the fruits of Solena amplexicaulis (Family, Cucurbitaceae) at doses of 250 mg/kg and 500 mg/kg body weight per oral were evaluated by carbon tetrachloride intoxication in rats. The toxic group which received Carbon tetrachloride (1ml/kg body weight per oral.) dissolved in 1:1 ratio in olive oil alone exhibited significant increase in serum alanine amino transferase, aspartate amino transferase, alkaline phosphatase and total bilirubin levels compared to the groups received pretreatment of Solena amplexicaulis per oral. The extract treated group remarkably controlled the aspartate amino transferase, serum alanine amino transferase, alkaline phosphatase and total bilirubin levels in serum and the effects were comparable with standard drug (silymarin 100 mg/kg body weight per oral). The histological examinations of the liver showed propound steatosis degeneration and nodule formation in the hepatic architecture of carbon tetrachloride treated rats. But the animals received pretreatment of the extract shown decreased necrotic zone and hepatocellular degeneration when compared to the liver exposed to carbon tetrachloride intoxication alone. This study suggests that methanolic extract of the fruit of Solena amplexicaulis has a liver protective effect against carbon tetrachloride-induced hepatotoxicity.
An Asymptotic-Fitted Method for Solving Singularly Perturbed Delay Differential Equations  [PDF]
Awoke Andargie, Yanala Narsimha Reddy
Applied Mathematics (AM) , 2012, DOI: 10.4236/am.2012.38132
Abstract: In this paper, we presented an asymptotic fitted approach to solve singularly perturbed delay differential equations of second order with left and right boundary. In this approach, the singularly perturbed delay differential equations is modified by approximating the term containing negative shift using Taylor series expansion. After approximating the coefficient of the second derivative of the new equation, we introduced a fitting parameter and determined its value using the theory of singular Perturbation; O’Malley [1]. The three term recurrence relation obtained is solved using Thomas algorithm. The applicability of the method is tested by considering five linear problems (two problems on left layer and one problem on right layer) and two nonlinear problems.
Two Initial Value Problems Approach for Solving Singular Perturbations Problems  [PDF]
Awoke Andargie, Yanala Narsimha Reddy
American Journal of Computational Mathematics (AJCM) , 2012, DOI: 10.4236/ajcm.2012.23027
Abstract: In this paper, we presented an initial value approach for solving singularly perturbed two point boundary value problems with the boundary layer at one end (left or right). By employing asymptotic power series expansion, the given singularly perturbed two-point boundary value problem is replaced by two first order initial value problems. To demonstrate the applicability of the present method three linear and two nonlinear problems with left end boundary layer are considered. It is observed that the present method approximates the exact solution very well.
rac-5-Bromo-N-benzylisatincreatinine ethanol monosolvate
Narsimha Reddy Penthala,Peter A. Crooks
Acta Crystallographica Section E , 2013, DOI: 10.1107/s160053681300038x
Abstract: In the title compound [systematic name: rac-1-benzyl-5-bromo-3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)-2,3-dihydro-1H-indol-2-one ethanol monosolvate], C19H17BrN4O3·C2H5OH, which crystallized as a racemate (RR and SS), the isatin ring is almost planar, with an r.m.s. deviations from the mean plane of 0.0276 (14) . The phenyl ring of the benzyl group makes a dihedral angle with the mean plane of the isatin ring of 87.40 (5)° and the dihedral angle between the imidazole and isatin rings is 58.56 (7)°. In the crystal, molecules are linked into two-dimensional pleated-sheet networks in the ac plane formed by O—H...O, N—H...O and O—H...N hydrogen bonds; within these sheets there are R44(10) rings that involve three molecules of the title compound and a single ethanol solvent molecule. In addition, there are π–π interactions between inversion-related benzyl groups, with an interplanar spacing of 3.444 (3) .
rac-N-Benzylisatincreatinine (unknown solvate)
Narsimha Reddy Penthala,Peter A. Crooks
Acta Crystallographica Section E , 2013, DOI: 10.1107/s1600536813000378
Abstract: The title compound, C19H18N4O3 [systematic name: (RS)-1-benzyl-3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)-2,3-dihydro-1H-indol-2-one], was prepared as a racemate (RR and SS) by the aldol condensation of N-benzylisatin with creatinine in the presence of sodium acetate in acetic acid. The r.m.s. deviation of the isatin ring system is 0.033 . The benzyl group is disordered over two orientations, with refined occupancies of 0.847 (7) and 0.153 (7). The dihedral angles between the isatin ring system and the benzene ring (major disorder component) and the imidazole ring are 82.82 (7) and 51.31 (3)°, respectively, In the crystal, molecules are linked into (001) sheets by N—H...O and O—H...N hydrogen bonds, which incorporate R22(9) ring motifs. The crystal was grown from mixed solvents (ethanol, methanol and possibly also ethyl acetate). These solvents are disordered in the crystal and the resulting electron density was found to be uninterpretable. The solvent contribution to the scattering was removed with the SQUEEZE routine in PLATON [Spek (2009). Acta Cryst. D65, 148–155]. The formula mass and density do not take account of the solvent.
(Z)-2-Amino-5-[2,4-dimethoxy-6-(4-methoxystyryl)benzylidene]-1,3-thiazol-4(5H)-one methanol solvate
Nikhil Reddy Madadi,Thirupathi Reddy Yerram Reddy,Narsimha Reddy Penthala,Sean Parkin
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536810018520
Abstract: In the crystal structure of the title compound, C21H20N2O4S·CH3OH, molecules are linked into chains by a series of intermolecular N—H...O, N—H...N and O—H...O hydrogen bonds. The molecular structure shows a double bond with Z geometry, connecting the thiazolone and resveratrol units. The dihedral angle between the thiazolone ring and the nearest dimethoxybenzene ring is 53.02 (7)°.
(Z)-3-(1-Benzofuran-2-yl)-2-(3,4,5-trimethoxyphenyl)acrylonitrile
Narsimha Reddy Penthala,Sean Parkin,Peter A. Crooks
Acta Crystallographica Section E , 2012, DOI: 10.1107/s1600536812005831
Abstract: In the title compound, C20H17NO4, the double bond of the acrylonitrile group separating the 1-benzofuran moiety from the 3,4,5-trimethoxyphenyl ring has Z geometry. The 1-benzofuran groups are π–π stacked with inversion-related counterparts such that the furan ring centroid–centroid distance is 3.804 (5) . The dihedral angle between the planes of the trimethoxyphenyl ring and the acrylonitrile group is 24.2 (2)°.
(Z)-3-(1H-Indol-3-yl)-2-(3,4,5-trimethoxyphenyl)acrylonitrile
Narsimha Reddy Penthala,Sean Parkin,Peter A. Crooks
Acta Crystallographica Section E , 2012, DOI: 10.1107/s1600536812005855
Abstract: In the title compound, C20H18N2O3, the C=C bond of the acrylonitrile group that links the indole and the 3,4,5-trimethoxyphenyl rings has Z geometry, with dihedral angles between the plane of the acrylonitrile unit and the planes of the benzene and indole ring systems of 21.96 (5) and 38.94 (7)°, respectively. The acrylonitrile group is planar (r.m.s. deviation from planarity = 0.037 ). Molecules are linked into head-to-tail chains that propagate along the b-axis direction by bifurcated N—H...O intermolecular hydrogen bonds, which form an R12(5) motif between the indole NH group and the two methoxy O atoms furthest from the nitrile group.
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