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Search Results: 1 - 10 of 138996 matches for " Betina Heinsb?k Thuesen "
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Vitamin D Status and Cause-Specific Mortality: A General Population Study
Tea Skaaby, Lise Lotte Nystrup Husemoen, Charlotta Pisinger, Torben J?rgensen, Betina Heinsbk Thuesen, Mogens Fenger, Allan Linneberg
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0052423
Abstract: Background Vitamin D deficiency is associated with an increased risk of all-cause mortality in observational studies. The specific causes of death underlying this association lack clarity. We investigated the association between vitamin D status and cause-specific mortality. Methods We included a total of 9,146 individuals from the two population-based studies, Monica10 and Inter99, conducted in 1993–94 and 1999–2001, respectively. Vitamin D status was assessed as serum 25-hydroxyvitamin D. Information on causes of death was obtained from The Danish Register of Causes of Death until 31 December 2009. There were a total of 832 deaths (median follow-up 10.3 years). Results Multivariable Cox regression analyses with age as underlying time axis and vitamin D quartiles showed significant associations between vitamin D status and death caused by diseases of the respiratory system, the digestive system, and endocrine, nutritional and metabolic diseases with hazard ratios (HRs) 0.26 (ptrend = 0.0042), 0.28 (ptrend = 0.0040), and 0.21 (ptrend = 0.035), respectively, for the fourth vitamin D quartile compared to the first. We found non-significantly lower HRs for death caused by mental and behavioural diseases and diseases of the nervous system, but no association between vitamin D status and death caused by neoplasms or diseases of the circulatory system. Conclusion The associations of vitamin D status and cause-specific mortality suggest that we also look elsewhere (than to cardiovascular disease and cancer) to explain the inverse association between vitamin D status and mortality.
Vitamin D Status and Chronic Obstructive Pulmonary Disease: A Prospective General Population Study
Tea Skaaby, Lise Lotte Nystrup Husemoen, Betina Heinsbk Thuesen, Charlotta Pisinger, Torben J?rgensen, Runa Vavia Fenger, Allan Linneberg
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0090654
Abstract: Objectives Vitamin D deficiency is common among persons with chronic obstructive pulmonary disease (COPD). Whether vitamin D affects the development and deterioration of COPD or is a consequence of the disease lacks clarity. We investigated the association between vitamin D status and prevalent and incident COPD in the general population. Methods We included a total of 12,041 individuals from three general population studies conducted in 1993–94, 1999–2001, and 2006–2008, respectively, with vitamin D measurements. Information on COPD was obtained from the Danish National Patient Register and The Danish Registry of Causes of Death. Results There were 85 prevalent and 463 incident cases of COPD (median follow-up 9.7 years). We found a statistically significant inverse association between vitamin D status and prevalent COPD with odds ratio = 0.89 (95% confidence interval, CI: 0.79, 1.0), but no statistically significant association with incident COPD with a hazard ratio = 0.98 (95% CI: 0.94, 1.0), respectively, per 10 nmol/l higher vitamin D status, when adjusted for possible confounders. Conclusions We found a statistically significant inverse cross-sectional association between vitamin D status and COPD, but no association between vitamin D status and incident COPD.
Cause-Specific Mortality According to Urine Albumin Creatinine Ratio in the General Population
Tea Skaaby, Lise Lotte Nystrup Husemoen, Tarunveer Singh Ahluwalia, Peter Rossing, Torben J?rgensen, Betina Heinsbk Thuesen, Charlotta Pisinger, Knud Rasmussen, Allan Linneberg
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0093212
Abstract: Background Urine albumin creatinine ratio, UACR, is positively associated with all-cause mortality, cardiovascular disease and diabetes in observational studies. Whether a high UACR is also associated with other causes of death is unclear. We investigated the association between UACR and cause-specific mortality. Methods We included a total of 9,125 individuals from two population-based studies, Monica10 and Inter99, conducted in 1993–94 and 1999–2001, respectively. Urine albumin creatinine ratio was measured from spot urine samples by standard methods. Information on causes of death was obtained from The Danish Register of Causes of Death until 31 December 2010. There were a total of 920 deaths, and the median follow-up was 11.3 years. Results Multivariable Cox regression analyses with age as underlying time axis showed statistically significant positive associations between UACR status and risk of all-cause mortality, endocrine nutritional and metabolic diseases, mental and behavioural disorders, diseases of the circulatory system, and diseases of the respiratory system with hazard ratios 1.56, 6.98, 2.34, 2.03, and 1.91, for the fourth UACR compared with the first, respectively. Using UACR as a continuous variable, we also found a statistically significant positive association with risk of death caused by diseases of the digestive system with a hazard ratio of 1.02 per 10 mg/g higher UACR. Conclusion We found statistically significant positive associations between baseline UACR and death from all-cause mortality, endocrine nutritional and metabolic diseases, and diseases of the circulatory system and possibly mental and behavioural disorders, and diseases of the respiratory and digestive system.
Vitamin D Status, Filaggrin Genotype, and Cardiovascular Risk Factors: A Mendelian Randomization Approach
Tea Skaaby, Lise Lotte Nystrup Husemoen, Torben Martinussen, Jacob P. Thyssen, Michael Melgaard, Betina Heinsbk Thuesen, Charlotta Pisinger, Torben J?rgensen, Jeanne D. Johansen, Torkil Menné, Berit Carlsen, Pal B. Szecsi, Steen Stender, Runa Vavia Fenger, Mogens Fenger, Allan Linneberg
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0057647
Abstract: Background Vitamin D deficiency is associated with increased cardiovascular disease risk in observational studies. Whether these associations are causal is not clear. Loss-of-function mutations in the filaggrin gene result in up to 10% higher serum vitamin D concentrations, supposedly due to a decreased UV-protection of the keratinocytes. We used a Mendelian randomization approach to estimate the causal effect of vitamin D status on serum lipids, blood pressure, body mass index, waist circumference, and the metabolic syndrome. Methods Three population based studies were included, Monica10 (2,656 individuals aged 40–71 years), Inter99 (6,784 individuals aged 30–60 years), and Health2006 (3,471 individuals aged 18–69 years) conducted in 1993–94, 1999–2001, and 2006–2008, respectively. Participants were genotyped for the two most common filaggrin gene mutations in European descendants R501X and 2282del4, in all three studies and further for the R2447X mutation in the Inter99 and Health2006 studies. Filaggrin genotype was used as instrumental variable for vitamin D status. Baseline measurements of serum 25-hydroxyvitamin D were performed in all three studies. Results Instrumental variable analyses showed a 23.8% (95% confidence interval, CI 3.0, 48.6) higher HDL cholesterol level and a 30.5% (95% CI: 0.8, 51.3) lower serum level of triglycerides per doubling of vitamin D. These associations were, however, not statistically significant when applying the Bonferroni adjusted significance level. The remaining lipids showed non-significant changes in a favorable direction. Doubling of vitamin D gave a non-significantly lower odds ratio = 0.26 (95% CI: 0.06, 1.17) of the metabolic syndrome. There were no statistically significant causal effects of vitamin D status on blood pressure, body mass index, or waist circumference. Conclusion Our results support a causal effect of higher vitamin D status on a more favorable lipid profile, although more studies in other populations are needed to confirm our results.
Indices d'un operateur differentiel matriciel et applications
K. Betina
Mathematics , 2005,
Abstract: In this paper, one determines the formal index and the polynomial index of a matrix linear differential operator P with coefficients in Mn(C[x]) and detAm(x) not identically zero. Then, one applies these results to give a new proof of a Bezivin-Robba theorem equivalent to the Lindemann-Wierstrass theorem, as to find sufficient conditions on the Riccati matrix differential equation Y' = A(x)+B(x)Y +Y C(x)Y with coefficients in Mn(C[x]) so that any meromorphic solution is rational and other sufficient conditions so that the general solution is algebraic.
Worsening Clinical Outcome with Increasing Number of So-Called Off-Label or Unapproved Indications for Use of Drug Eluting Stents  [PDF]
Anders M. Gall?e, Ulrik Abildgaard, Henning Kelb?k, Niels Bligaard, J?rgen L. Jeppesen, Leif Thuesen, Peter R. Hansen
World Journal of Cardiovascular Diseases (WJCD) , 2016, DOI: 10.4236/wjcd.2016.67025
Abstract: Objective: We explored the impact of increasing number of off-label patient and lesion character-istics on 5-year clinical outcome following implantation of first generation drug eluting stents. Furthermore we tried to assess if stent performance might be improved if the off-label character-istics present were taken into account to guide the stent brand selection. Design: A total of 2888 coronary lesions treated with first generation drug eluting stents were classified for eventual presence of 18 different off-label characteristics and correlated to the 5-year clinical outcome by multiple stepwise Cox regression analysis. Results: The composite of cardiac death, myocardial infarction and target vessel revascularization (major adverse cardiac event, MACE) was 16.7% in cases with zero off-label characteristics and showed a stepwise increased rate up to 32.7% in cases with 5 off-label characteristics. The MACE rate for the sirolimus eluting stent appears to be 10% lower than the paclitaxel stent group and it may be further reduced by 10% - 18% if the off-label characteristics present in each case were taken into account to guide the stent brand selection. Conclusion: With increasing number of concomitantly appearing off-label characteristics there is a stepwise increase in MACE rate. The MACE rate may be reduced if the off-label characteristics were used to guide the stent brand selection.
Biópsia de pele e seu estudo histológico: por quê? para quê? como? parte II
Werner, Betina;
Anais Brasileiros de Dermatologia , 2009, DOI: 10.1590/S0365-05962009000500010
Abstract: skin biopsy is a common procedure in dermatology practice. the cost-benefit ratio, though, can be unfavorable if attention is not paid to specific details in performing a skin biopsy. for example, proper selection of anatomical site and best lesion to perform a biopsy are very important. the present article discusses those and other variables that directly influence the satisfaction level of the dermatologist who undertakes it, the pathologist who analysis it and the patient of whom the biopsy is taken.
Biópsia de pele e seu estudo histológico: Por quê? Para quê? Como? Parte I
Werner, Betina;
Anais Brasileiros de Dermatologia , 2009, DOI: 10.1590/S0365-05962009000400010
Abstract: histopathologic study is considered gold-standard for diagnosis of skin lesions, either neoplastic or inflammatory, most of the times. to take the most out of a skin biopsy, physicians should be aware of the reasons for performing the procedure followed by microscopic examination, the objectives to be achieved and the best manner to do the biopsy, including the best technique and best anatomical site for a particular disease.
Arbeitsidentit t und widersprüchliche Erfahrungen in der Lebensgeschichte von Sozialarbeiter/innen und Krankenschwestern Work Identity and Contradictory Experiences of Welfare Workers in a Life-history Perspective Identidad de trabajo y experiencias contradictorias de trabajadores del bienestar en una perspectiva de historia de vida
Betina Dybbroe
Forum : Qualitative Social Research , 2012,
Abstract: Ver nderungen im Gesundheitswesen und der sozialen Wohlfahrt fordern die Berufsidentit ten von Krankenschwestern und Sozialarbeiter/innen in Skandinavien heraus. Diejenigen, die von solchen Ver nderungen betroffen sind, werden durch das neue psychosoziale Setting an ihren Arbeitspl tzen auch pers nlich tangiert. In diesem Aufsatz wird ein Forschungsprojekt mit d nischen Krankenschwestern und Sozialarbeiter/innen vorgestellt. Der Fokus liegt auf der sich ver ndernden Arbeitsidentit t, und dieser subjektive Entwicklungsprozess macht einen besonderen theoretischen und methodologischen Forschungsansatz notwendig: Das Verstehen von lebensgeschichtlicher und beruflich bedingter Erfahrung wird in der Perspektive von Alfred LORENZER's Kulturtheorie untersucht. Es geht darum, den gesellschaftlichen Wandel zu verstehen, der den Arbeitsplatz, die Berufsausübung und die jeweilige Lebensgeschichte in besonderer Weise betrifft. Zwei Konzepte von LORENZER, ein theoretisches und ein methodisches, n mlich die "Interaktionsform" und das "szenische Verstehen", wurden in der Untersuchung angewendet, weil man mit ihnen eine optimale methodische Perspektive zur Analyse der Arbeitserfahrung entwickeln kann. Eine ethnografische und lebensgeschichtlich orientierte Untersuchung von jungen Krankenschwestern in Krankenh usern wird vorgestellt, in welchen die Arbeit geschlechtsspezifisch organisiert ist und nur geringe M glichkeiten zu einer Identifikation mit der Arbeit bestehen. Es werden soziale und pers nliche Dynamiken untersucht, in denen habituelle und kreative Orientierungen und Praktiken in der Gesundheitsversorgung sichtbar gemacht werden. In gleicher Weise werden die widersprüchlichen Ver nderungen der Arbeit – ihre Vermarktung und ihre Demokratisierung – analysiert. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs1203214 Transformation of the welfare sectors challenge professional identities of care and welfare workers in Scandinavia. At the same time welfare and care workers take part in these changes and are changed in the psycho-social setting of the workplace. This article presents research about care work in Denmark with a focus on subjective processing of work identity, applying a psycho-societal theoretical and methodical approach. A life historical and experiential understanding of Alfred LORENZER's cultural theory is applied to understand societal transformations, here in the work place and of professionals in relation to their present scene of work and in relation to their life history. Two concepts are applied, interaction form and scenic understanding, becaus
Wenn Sie auch schon aus dem Weg geraümet würde, es bliebe doch dergleichen“ “If she would also already be done away with, it would still remain the same”
Betina Aumair
querelles-net , 2005,
Abstract: Akribisch hat die Literaturwissenschaftlerin Angela Steidele dem nur fragmentarisch überlieferten Leben der vermutlich letzten Frau, die wegen der so genannten Unzucht mit einer anderen Frau“ (S. 1) in Deutschland hingerichtet worden ist, nachgespürt. Die Geschichte der Liebe zwischen Frauen ist eine noch weitgehend ungeschriebene“, insbesondere gilt das, wie Steidele im Nachwort schreibt, für die Zeit von 1500 bis 1850. Steidele gelingt mit dieser Einzelstudie ein Stück deutscher Sozial- und Geschlechterforschung, in der, wie sie selbst meint, die Abenteuerin Catharina Margaretha Linck alias Anastasius Lagrantinus Rosenstengel ihren würdigen Platz“ (S. 152) findet. The literary scholar Angela Steidele meticulously traces the sole fragmentarily documented life of the assumedly last woman in Germany to be executed “because of so-called sodomy with another woman” (1). The history of love between women is “still to a great extent unwritten,” this particularly true, as Steidele in the afterward writes, for the time period between 1500 and 1850. With this monograph, Steidele succeeds in constructing a piece of German social and gender research in which, as she herself suggests, “the adventurer Catharina Margaretha Linck alias Anastasius Lagrantinus Rosenstengel” finds “her honorable place” (152).
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