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OALib Journal期刊

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Prevalence of Nail Biting Among Preschool Children in Bitola
Domnika Rajchanovska , Beti Ivanovska Zafirova
Journal of Special Education and Rehabilitation , 2011, DOI: 10.2478/v10215-011-0005-7
Abstract: Nail biting may have a significant role in the development of some anomalies and harmful effects upon the oral-facial system. Objective: The objective of the study was to determine the prevalence of nail biting among preschool children in Bitola. Methods: Through an observational, intersection (cross-sectional) study, 890 children who came to medical checkups during the period from January to December 2009 were included. The following methods were applied: psychological testing (Test of Chuturikj), pediatric examination, interview with parents and the questionnaire: Child Behaviour Checklist-Achenbach, 1981. Results: The study included 890 children, 401 of which were at the age of three, 489 were at the age of five, 51.6% of them were males and 48.4% females. The level of prevalence of nail biting was 22.02%. The statistical analysis showed that the habit is more insignificant (p>0.05) in children at the age of 5 and among the male gender. The tested difference in the frequency of nail biting among children from the cities or villages was not statistically significant (p>0.05). Children who do not have their own room more often manifest this habit statistically insignificantly (p>0.05). Depending on the number of members and children in the family, the tested differences were statistically significant (p<0.05). However, in terms of the order of the child's birth they were statistically insignificant (p>0.05). Children whose parents have a high education level significantly less bite their nails (p<0.01). Increased presence of this habit is found among respondents in families with average incomes, with p=0.004. Conclusion: Dentists and pediatricians should work together on prevention, early diagnosis and treatment of this habit, in order to achieve an impact over dental development.
Concurrent radiochemotherapy in locally-regionally advanced oropharyngeal squamous cell carcinoma: analysis of treatment results and prognostic factors
Valentina Krstevska, Igor Stojkovski, Beti Zafirova-Ivanovska
Radiation Oncology , 2012, DOI: 10.1186/1748-717x-7-78
Abstract: Sixty-five patients with stage III or IV squamous cell carcinoma of the oropharynx who underwent concurrent radiochemotherapy between January 2005 and December 2010 were retrospectively analyzed. All patients received radiotherapy to 70 Gy/35 fractions/2 Gy per fraction/5 fractions per week. Concurrent chemotherapy consisted of weekly cisplatin (30 mg/m2) started at the first day of radiotherapy.Median age was 57 years (range, 36 to 69 years) and 59 (90.8%) patients were male. Complete composite response was achieved in 47 patients (72.3%). Local and/or regional recurrence was the most frequent treatment failure present in 19 out of 25 patients (76.0%). At a median follow-up of 14 months (range, 5 to 72 months), 2-year local relapse-free, regional relapse-free, locoregional relapse-free, disease-free, and overall survival rates were 48.8%, 57.8%, 41.7%, 33.2% and 49.7%, respectively.On multivariate analysis the only significant factor for inferior regional relapse-free survival was the advanced N stage (p?=?0.048). Higher overall stage was independent prognostic factor for poorer local relapse-free survival, locoregional relapse-free survival and disease-free survival (p?=?0.022, p?=?0.003 and p?=?0.003, respectively). Pre-treatment haemoglobin concentration was an independent prognostic factor for local relapse-free survival, regional relapse-free survival, locoregional relapse-free survival, disease-free survival, and overall survival (p?=?0.002, p?=?0.021, p?=?0.001, p?=?0.002 and p?=?0.002, respectively).Poor treatments results of this study suggested that introduction of intensity-modulated radiotherapy, use of induction chemotherapy followed by concurrent radiochemotherapy, accelerated radiotherapy regimens, and molecular targeted therapies could positively influence treatment outcomes. The incorporation of reversal of anaemia should be also expected to provide further improvement in locoregional control and survival in patients with advanced squamous cell car
PREVALENCE OF NAIL BITINGAMONG PRESCHOOL CHILDREN IN BITOLA
Dominika RAJCHANOVSKA,Beti ZAFIROVA
Journal of Special Education and Rehabilitation , 2011,
Abstract: Nail biting may have a significant role in the development of some anomalies and harmful effects upon the oral-facial system.Objective: The objective of the study was to determine the prevalence of nail biting among preschool children in Bitola.Methods: Through an observational, intersection (cross-sectional) study, 890 children who came to medical checkups during the period from January to December 2009 were included. The following methods were applied: psychological testing (Test of Chuturikj), pediatric examination, interview with parents and the questionnaire: Child Behaviour Checklist-Achenbach, 1981.Results: The study included 890 children, 401 of which were at the age of three, 489 were at the age of five, 51.6% of them were males and 48.4% females. The level of prevalence of nail biting was 22.02%. The statistical analysis showed that the habit is more insignificant (p>0.05) in children at the age of 5 and among the male gender. The tested difference in the frequency of nail biting among children from the cities or villages was not statistically significant (p>0.05). Children who do not have their own room more often manifest this habit statistically insignificantly (p>0.05).Depending on the number of members and children in the family, the tested differences were statistically significant (p<0.05). However, in terms of the order of the child’s birth they were statistically insignificant (p>0.05). Children whose parents have a high education level significantly less bite their nails (p<0.01). Increased presence of this habit is found among respondents in families with average incomes, with p=0.004. Conclusion: Dentists and pediatricians should work together on prevention, early diagnosis and treatment of this habit, in order to achieve an impact over dental development.
Prognostic Value of the Expression of p53 in Patients with Non-small Cell Lung Cancer
Biljana Ilievska Poposka,Snezhana Smickova,Simonida Jovanovska Crvenkovska,Beti Zafirovska Ivanovska
Macedonian Journal of Medical Sciences , 2009,
Abstract: Background. The p53 gene is frequently mutated in non-small-cell lung cancer (NSCLC). However, the effect of p53 gene mutations on patient prognosis remains unclear. Aim. The aim of this study is to determine the association of p53 abnormalities with clinical data and prognosis in patients with NSCLC. Material and Methods. Tumor tissues from 80 patients with NSCLC were assessed by immunohistochemistry for expression of p53. The immunohistochemical study was performed on formalin-fixed, paraffin-embedded sections using LCAB immunoperoxidase method with mouse anti-p53 monoclonal antibody (clone DO-7; DAKO). Results. Forty-three (53.75%) of 80 patients revealed aberrant immunostaining for p53. Except to the histological type of tumors, there was no correlation of p53 expression with the clinicopathologic features. The Kaplan-Meier survival analysis demonstrated that patients with p53 positive status had poor survival rate (p=0.005 by the Log Rank test= 7.914). In Cox, regression analysis p53 and performance status emerged as independent prognostic factors (p<0.009 and p<0.000 respectively). Conclusion. The results from this study indicated that the aberrant expression of p53 is significant and independent predictable prognostic factor for patients with NSCLC.
Prognostic Value of the Expression of p53 in Patients with Non-small Cell Lung Cancer
Biljana Ilievska Poposka, Snezhana Smickova, Simonida Jovanovska Crvenkovska, Beti Zafirovska Ivanovska, Tome Stefanovski, Marija Metodieva, Gordana Petrusevska
Macedonian Journal of Medical Sciences , 2009, DOI: 10.3889/MJMS.1857-5773.2009.0074
Abstract: Background. The p53 gene is frequently mutated in non-small-cell lung cancer (NSCLC). However, the effect of p53 gene mutations on patient prognosis remains unclear. Aim. The aim of this study is to determine the association of p53 abnormalities with clinical data and prognosis in patients with NSCLC. Material and Methods. Tumor tissues from 80 patients with NSCLC were assessed by immunohistochemistry for expression of p53. The immunohistochemical study was performed on formalin-fixed, paraffin-embedded sections using LCAB immunoperoxidase method with mouse anti-p53 monoclonal antibody (clone DO-7; DAKO). Results. Forty-three (53,75%) of 80 patients revealed aberrant immunostaining for p53. Except to the histological type of tumors, there was no correlation of p53 expression with the clinicopathologic features. The Kaplan-Meier survival analysis demonstrated that patients with p53 positive status had poor survival rate (p=0,005 by the Log Rank test= 7,914). In Cox, regression analysis p53 and performance status emerged as independent prognostic factors (p<0,009 and p<0,000 respectively). Conclusion. The results from this study indicated that the aberrant expression of p53 is significant and independent predictable prognostic factor for patients with NSCLC.
Total design for textile products
Zafirova Koleta
Hemijska Industrija , 2004, DOI: 10.2298/hemind0404161z
Abstract: Product development is less than 20-30 years old and a relatively new area of research compared to the other classic academic disciplines. Integrated product development is a philosophy that systematically employs the teaming of functional disciplines to integrate and concurrently apple all the necessary processes to produce an effective and efficient product that satisfies customer needs. Product development might also be understood as a multidisciplinary field of research. The disciplines directly participating in product development include engineering design, innovation, manufacturing, marketing and management. A background contribution is also generated by disciplines such as psychology, social sciences and information technology. This article is an overview that introduces this philosophy to textile product development.
SECOND SERVICE PROVIDERS FORUM
Jasmina IVANOVSKA
Journal of Special Education and Rehabilitation , 2006,
Abstract:
SERVICE PROVIDERS FORUM
Jasmina IVANOVSKA
Journal of Special Education and Rehabilitation , 2006,
Abstract:
THE DISTURBANCE OF METABOLISM OF THE AMINO ACIDS AS A CAUSATIVE FOR THE MENTAL RETARDATION-PHENYLKETONURIA
Jasmina IVANOVSKA
Journal of Special Education and Rehabilitation , 2000,
Abstract: PKU is the rare single-gene disease belonging to disturbance of metabolism of the amino acids, which in its own basics halved the mutated gene, whose leaning at the 12-chromosome charge for the synthesis of phenylalanine hydroxylase, turning on phenylalanine into tyrosine. Enzyme block usually leads to the accumulation of a toxic substrate and/or the deficient synthesis of a product needed for normal body function. In PKU there is a toxic accumulation of phenylalanine behind the deficient enzyme, phenylalanine hydrоxylase. The symptoms are: lighten hare, blue eyes, lithe pigmented skin, convulsion, mental retardation, low level of adrenalin caused for the lack of tyrosine, the urine have a specific smell of rats or gab.Inheritance of disease become in autosomal recessive way which always become possibility to stay hidden in the family and to inherit from knee to knee without manifestation of its own phenotype.The only therapy that successfully avoids the causes of this disease is phenylalanine-restricted diet. Today we have some affords for improvement of gene therapy, which can help us for determination to these disease. The success of the therapy depends from timing of the right detection also diagnostics all trough equivalent therapy which can successfully interrupt the new forms of mental retardation and other symptoms.
Joint Damage Accelerating Properties of Neutrophils  [PDF]
Viktoriya Milanova, Nina Ivanovska, Petya Dimitrova
Open Journal of Rheumatology and Autoimmune Diseases (OJRA) , 2014, DOI: 10.4236/ojra.2014.42016
Abstract: Neutrophils are innate immune cells involved in the initial inflammatory response and in the pathogenesis of rheumatoid arthritis (RA), an inflammatory joint disease. They produce cytokines, chemokines, proinflammatory mediators and secrete enzymes causing a direct destruction of cartilage and bone. Herein we investigated the ability of neutrophils to express the receptor activator of nuclear factor kappa-B ligand (RANKL) and to interfere with maturation of late pre-osteoclasts. The distribution of bone marrow (BM) Ly6G+ cells expressing RANKL was evaluated after BM cell dye labelling and transfer into zymosan-injected SCID recipient mice. Specific tartrate-resistant acid phosphatase (TRAP) staining was used to determine the number of multinucleated mature osteoclasts in the co-cultures of purified blood neutrophils with preosteoclasts. Ly6 G+ BM cells migrated extensively in synovial fluid and spleen of recipient zymosan-injected SCID mice. Labelled neutrophils have higher RANKL expression in synovial fluid unlike in spleen indicating that they obtained specific phenotype during their migration to the synovial fluid. Blood neutrophils increased the number of multinucleated mature osteoclasts in vitro. This effect was elicited by the pretreatment of neutrophils with interleukin (IL)-17. In summary, our study showed neutrophils’s properties to accelerate joint damage via RANKL and interactions with osteoclasts.
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