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Search Results: 1 - 10 of 13250 matches for " Benjamin CH Kwan "
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Outcomes and Cost Effectiveness of a Respiratory Coordinated Care Program in Patients with Severe or Very Severe COPD  [PDF]
Shahila Aslam, Johnathan Man, Jason Behary, John Riskallah, Saidul Ansary, Benjamin CH Kwan
Open Journal of Respiratory Diseases (OJRD) , 2016, DOI: 10.4236/ojrd.2016.63008
Abstract: Multidisciplinary community coordinated care programs are widely adopted to optimise care of chronic disease patients, but there is a need for further evaluation in the setting of COPD. This observational study evaluated 147 patients with severe or very severe COPD who were enrolled in a multidisciplinary community respiratory coordinated care program (RCCP) from 2007 to 2012. Comparison was made of hospitalisation rates and length of stay for 12 months prior to joining the program, and the first 12 months after joining the program. This data was used to inform a cost analysis. Enrolment into RCCP halved the annual hospital admission rate from 1.18 to 0.57 admissions per year (relative risk reduction 51.4%, p < 0.001), and annual total length of stay was reduced from 8.06 to 3.59 days per patient per year (p < 0.001). Hospital admissions were reduced from 5.05 days to 2.00 days (p < 0.001). Accounting for the program’s costs, these changes resulted in a $US 906.94 ($AUD 972.80) cost saving per patient per year. A RCCP program can reduce patient hospitalisation and overall costs in the COPD setting.
A Retrospective Study of Radiographic Anatomy of Wrist in Chinese Population  [PDF]
Chris Yuk Kwan Tang, Fung Kwok Keung Boris, Fok Margaret Woon Man, Lee Juliana Tsz Yan, Aslam Muhammad Zeeshan, Fang Benjamin, Wong Joyce, Yeung Kelvin
E-Health Telecommunication Systems and Networks (ETSN) , 2018, DOI: 10.4236/etsn.2018.73003
Abstract: In wrist pathology, there is a need to establish the normal range of radiographic measurement parameters. Previous study showed that the contralateral wrist might not be valid as a reference for all parameters. There is a lack of literature describing the normal range of wrist radiographic parameters in literature. As a result, a retrospective study was carried out. Patients who underwent standard wrist x-rays during the period February 2012 to February 2013 (one single year) were retrospectively reviewed. 71 patients were included. Scapholunate angle was 54.7° (±6.5°). Scapholunate interval was 2.0 mm (±0.4 mm). Ulnar variance was +1.0 mm (±1.8 mm). Carpal height was 31.8 mm (±3.0 mm). Radial inclination was 25.1° (±2.1°). All 71 patients had 1 sesamoid bone at first metacarpal. 16.9% (12 out of 71) patients had positive cortical ring signs. All these parameters are valuable clinically, especially in monitoring of the wrist disease progression, in the design of wrist implants and for future clinical research.
Fluctuation-enhanced sensing
L. B. Kish,G. Schmera,Ch. Kwan,J. Smulko,P. Heszler,C. -G. Granqvist
Physics , 2007, DOI: 10.1117/12.726838
Abstract: We present a short survey on fluctuation-enhanced gas sensing. We compare some of its main characteristics with those of classical sensing. We address the problem of linear response, information channel capacity, missed alarms and false alarms.
In Vivo Mapping of Vascular Inflammation Using Multimodal Imaging
Benjamin R. Jarrett,Carlos Correa,Kwan Liu Ma,Angelique Y. Louie
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0013254
Abstract: Plaque vulnerability to rupture has emerged as a critical correlate to risk of adverse coronary events but there is as yet no clinical method to assess plaque stability in vivo. In the search to identify biomarkers of vulnerable plaques an association has been found between macrophages and plaque stability—the density and pattern of macrophage localization in lesions is indicative of probability to rupture. In very unstable plaques, macrophages are found in high densities and concentrated in the plaque shoulders. Therefore, the ability to map macrophages in plaques could allow noninvasive assessment of plaque stability. We use a multimodality imaging approach to noninvasively map the distribution of macrophages in vivo. The use of multiple modalities allows us to combine the complementary strengths of each modality to better visualize features of interest. Our combined use of Positron Emission Tomography and Magnetic Resonance Imaging (PET/MRI) allows high sensitivity PET screening to identify putative lesions in a whole body view, and high resolution MRI for detailed mapping of biomarker expression in the lesions.
Assessing Attitudes of Chronic Patients towards Disease Self-management in Singapore
Kwong Si Zheng, Kwan Yu Heng, Benjamin Seng, Helena Hor Mei Ling, Joanne Yeh Chang
Archives of Pharmacy Practice , 2011,
Abstract: Objective: The aim of this study was to assess the attitudes ofpatients in Singapore suffering from chronic disorders towardsself-management of their disease.Materials and Methods: A cross-sectional study wasconducted using a questionnaire administered by 2nd yearPharmacy students. Patients with at least one of theseconditions (hypertension, diabetes and/orhypercholesterolemia) in the outpatient pharmacy of a tertiaryhospital were interviewed. Data collected was analysed usingnon-parametric statistics (Chi-square and Spearman’s rho) toassess the association between demographic variables andpatient self-management habits.Results: A total of 211 surveys were collected. More than 50%of patients did not seek further knowledge of their medicalcondition (52.1%). Most of them also could not remembernames of the medications (55.5%). This was largely due to acombination of English illiteracy (26%) and difficultmedication names (25%). Only 18% of patients possessedcompetent self-management habits. An association wasdemonstrated between competent self-management habits andincome (p<0.001), educational attainment (p<0.001) and race(p=0.020).Conclusion: Only a minority of patients currently possesscompetent self-management habits, which may pose a barrierto patient-centred care. Income, educational attainment andrace are important predictors of patient propensity towardsdisease self-management.
Global analysis of patterns of gene expression during Drosophila embryogenesis
Pavel Tomancak, Benjamin P Berman, Amy Beaton, Richard Weiszmann, Elaine Kwan, Volker Hartenstein, Susan E Celniker, Gerald M Rubin
Genome Biology , 2007, DOI: 10.1186/gb-2007-8-7-r145
Abstract: We determined and documented embryonic expression patterns for 6,003 (44%) of the 13,659 protein-coding genes identified in the Drosophila melanogaster genome with over 70,000 images and controlled vocabulary annotations. Individual expression patterns are extraordinarily diverse, but by supplementing qualitative in situ hybridization data with quantitative microarray time-course data using a hybrid clustering strategy, we identify groups of genes with similar expression. Of 4,496 genes with detectable expression in the embryo, 2,549 (57%) fall into 10 clusters representing broad expression patterns. The remaining 1,947 (43%) genes fall into 29 clusters representing restricted expression, 20% patterned as early as blastoderm, with the majority restricted to differentiated cell types, such as epithelia, nervous system, or muscle. We investigate the relationship between expression clusters and known molecular and cellular-physiological functions.Nearly 60% of the genes with detectable expression exhibit broad patterns reflecting quantitative rather than qualitative differences between tissues. The other 40% show tissue-restricted expression; the expression patterns of over 1,500 of these genes are documented here for the first time. Within each of these categories, we identified clusters of genes associated with particular cellular and developmental functions.A defining feature of multi-cellular organisms is their ability to differentially utilize the information contained in their genomes to generate morphologically and functionally specialized cell types during development. Regulation of gene expression in time and space is a major driving force of this process.A gene's expression pattern can be defined as a series of differential accumulations of its products in subsets of cells as development progresses. Patterns of mRNA expression are studied by two principal methods - microarray analysis [1] and in situ hybridization [2,3]. Microarray analysis provides both a qu
Intensive Diabetes Treatment and Cardiovascular Disease in Patients with Type 1 Diabetes
Janice Kwan
University of Toronto Medical Journal , 2006, DOI: 10.5015/utmj.v83i2.311
From Cherry Picking to Convergence – Migrating E-Learning Delivery to an LMS (Learning Management System) – the COLeLIO Experience
Angela Kwan
International Journal of Advanced Corporate Learning (iJAC) , 2012, DOI: 10.3991/ijac.v5i3.2174
Abstract: The Commonwealth of Learning e-learning for International Organizations (COLeLIO) (www.col.org/colelio) Initiative engages appropriate technology to custom design and deliver just-in-time (JIT) workplace e-learning for adult learners based in field offices and headquarters of international organizations spread all over the world. To ensure reliable and easy access to learning, COLeLIO chooses appropriate technologies to underpin course design, development and delivery taking into consideration bandwidth and access issues. Responding to constantly changing learning environments and learners' needs, eLIO learning materials have evolved from print to digital over the last decade. In recent years, eLIO saw the need to streamline the delivery operation for their 1,000 learners annually, involving 40 tutors and teams of course administrators. Recognizing that the conduits supporting online learning have mushroomed in recent years and that more affordable and robust open source learning management platforms are available to support and sustain online learning for transparency, accountability and quality results, COLeLIO spent 12 months searching for and adapting a technology solution to create a one-stop access to resources, support, discussions, and records for learners, tutors and administrators. This paper captures the story of change management by eLIO and shares some key lessons learned.
Sarcopenia, a Neurogenic Syndrome?
Ping Kwan
Journal of Aging Research , 2013, DOI: 10.1155/2013/791679
Sarcopenia, a Neurogenic Syndrome?
Ping Kwan
Journal of Aging Research , 2013, DOI: 10.1155/2013/791679
Abstract: Sarcopenia is an aging-associated condition, which is currently characterized by the loss of muscle mass and muscle strength. However, there is no consensus regarding its characterization hitherto. As the world older adult population is on the rise, the impact of sarcopenia becomes greater. Due to the lack of effective treatments, sarcopenia is still a persisting problem among the global older adults and should not be overlooked. As a result, it is vital to investigate deeper into the mechanism underlying the pathogenesis of sarcopenia in order to develop more effective therapeutic interventions and to inscribe a more uniform characterization. The etiology of sarcopenia is currently found to be multifactorial, and most of the pharmacological researches are focused on the muscular factors in aging. Although the complete mechanism underlying the development of sarcopenia is still waiting to be elucidated, we propose in this article that the primary trigger of sarcopenia may be neurogenic in origin based on the intimate relationship between the nervous and muscular system, namely, the motor neuron and its underlying muscle fibers. Both of them are affected by the cellular environment and their physiological activity. 1. Introduction Sarcopenia (Greek: sarx means “flesh,” penia means “loss”) is an age-related geriatric syndrome first described on a meeting in 1988 by Dr. Rosenberg as a phenomenon whereby the age-related decline in lean body mass affects ambulation, mobility, energy intake, overall nutrient intake and status, independence, and breathing [1]. More recently, sarcopenia is characterized by the gradual loss of muscle mass, muscle strength, and muscle function/quality in aging [2, 3]. However, there are studies indicating that sarcopenia should be referred only as the age-related loss in muscle mass whilst the age-related loss in muscle strength should be isolated as a new condition called “dynapenia” based on the evidences indicating that the loss of muscle mass and strength are two distinct processes with different pathophysiology [4]. Hitherto, there is no consistent data among a variety of prevalence studies probably due to the difference in study sample, definition of sarcopenia, and the assessment tool used [3]. For example, for the population of over 80 years old, American study of New Mexico Elder Health Survey has found that there were >40% of women and 50% of men who were sarcopenic whilst the NHANES III database study reveals that 11% of women and 7% of men were sarcopenic. Also, the Italian study of InCHIANTI cohort reveals that 15%
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