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Search Results: 1 - 10 of 473 matches for " Beniamino Caputo "
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The Theory of the Revenue Maximizing Firm  [PDF]
Beniamino Moro
Journal of Service Science and Management (JSSM) , 2008, DOI: 10.4236/jssm.2008.12019
Abstract: An endogenous growth model of the revenue maximizing firm is here presented. It is demonstrated that, in a static analysis, a revenue maximizing firm in equilibrium equates the average product of labor to the wage rate. In a dynamic analysis, the maximization rule becomes the balance between the rate of marginal substitution - between labor and capital - and the ratio of the wage rate over the discount rate. When the firm satisfies this rule, it grows endogenously at the rate of return on capital. The firm may also have multiple stationary equilibria, which are very similar to the static equilibrium. JEL classification: D21, O41.
The “Auto-Dissemination” Approach: A Novel Concept to Fight Aedes albopictus in Urban Areas
Beniamino Caputo,Annamaria Ienco,Daniela Cianci,Marco Pombi,Vincenzo Petrarca,Alberto Baseggio,Gregor J. Devine,Alessandra della Torre
PLOS Neglected Tropical Diseases , 2012, DOI: 10.1371/journal.pntd.0001793
Abstract: Background The main constraint to the fight against container-breeding mosquito vectors of human arboviruses is the difficulty in targeting the multiplicity of larval sources, mostly represented by small man-made water containers. The aim of this work is to assess the feasibility of the “auto-dissemination” approach, already tested for Aedes aegypti, as a possible alternative to traditional, inefficient control tools, against Ae. albopictus in urban areas. The approach is based on the possibility that wild adult females, exposed to artificial resting sites contaminated with pyriproxyfen, can disseminate this juvenile hormone analogue to larval habitats, thus interfering with adult emergence. Methodology We carried out four field experiments in two areas of Rome that are typically highly infested with Ae. albopictus, i.e. the main cemetery and a small green area within a highly urbanised neighbourhood. In each area we used 10 pyriproxyfen “dissemination” stations, 10 “sentinel” sites and 10 covered, control sites. The sentinel and control sites each contained 25 Ae. albopictus larvae. These were monitored for development and adult emergence. Principal Findings When a 5% pyriproxyfen powder was used to contaminate the dissemination sites, we observed significantly higher mortality at the pupal stage in the sentinel sites (50–70%) than in the controls (<2%), showing that pyriproxyfen was transferred by mosquitoes into sentinel sites and that it had a lethal effect. Conclusions The results support the potential feasibility of the auto-dissemination approach to control Ae. albopictus in urban areas. Further studies will be carried out to optimize the method and provide an effective tool to reduce the biting nuisance caused by this aggressive species and the transmission risk of diseases such as Dengue and Chikungunya. These arboviruses pose an increasing threat in Europe as Ae. albopictus expands its range.
Comparative analyses reveal discrepancies among results of commonly used methods for Anopheles gambiaemolecular form identification
Federica Santolamazza, Beniamino Caputo, Maria Calzetta, José L Vicente, Emiliano Mancini, Vincenzo Petrarca, Jo?o Pinto, Alessandra della Torre
Malaria Journal , 2011, DOI: 10.1186/1475-2875-10-215
Abstract: The genotyping of more than 400 A. gambiae specimens from nine African countries, and the sequencing of the IGS-amplicon of 115 of them, highlighted discrepancies among results obtained by the different approaches due to different kinds of biases, which may result in an overestimation of MS putative hybrids, as follows: i) incorrect match of M and S specific primers used in the allele specific-PCR approach; ii) presence of polymorphisms in the recognition sequence of restriction enzymes used in the PCR-RFLP approaches; iii) incomplete cleavage during the restriction reactions; iv) presence of different copy numbers of M and S-specific IGS-arrays in single individuals in areas of secondary contact between the two forms.The results reveal that the PCR and PCR-RFLP approaches most commonly utilized to identify A. gambiae M and S forms are not fully interchangeable as usually assumed, and highlight limits of the actual definition of the two molecular forms, which might not fully correspond to the two A. gambiae incipient species in their entire geographical range. These limits are discussed and operational suggestions on the choice of the most convenient method for large-scale M- and S-form identification are provided, also taking into consideration technical aspects related to the epidemiological characteristics of different study areas.The mosquito vector species responsible for most Plasmodium falciparum-malaria transmission in sub-Saharan Africa, Anopheles gambiae sensu stricto (hereafter A. gambiae), is ongoing a process of ecological diversification and adaptive lineage splitting which is changing patterns of malaria transmission and affecting vector control strategies in West Africa [1-4]. Two morphologically indistinguishable incipient species (provisionally named M and S molecular forms) have been described within A. gambiae, based on form-specific single nucleotide polymorphisms (SNPs) on the intergenic spacer (IGS) and internal transcribed spacer (ITS) region
Anopheles gambiae complex along The Gambia river, with particular reference to the molecular forms of An. gambiae s.s
Beniamino Caputo, Davis Nwakanma, Musa Jawara, Majidah Adiamoh, Ibrahima Dia, Lassana Konate, Vincenzo Petrarca, David J Conway, Alessandra della Torre
Malaria Journal , 2008, DOI: 10.1186/1475-2875-7-182
Abstract: Collections of indoor-resting An. gambiae s.l. females were carried out along a ca. 400 km west to east transect following the River Gambia from the western coastal region of The Gambia to south-eastern Senegal during 2005 end of rainy season/early dry season and the 2006 rainy season. Specimens were identified to species and molecular forms by PCR-RFLP and the origin of blood-meal of fed females was determined by ELISA test.Over 4,000 An. gambiae s.l. adult females were collected and identified, 1,041 and 3,038 in 2005 and 2006, respectively. M-form was mainly found in sympatry with Anopheles melas and S-form in the western part of the transect, and with Anopheles arabiensis in the central part. S-form was found to prevail in rural Sudan-Guinean savannah areas of Eastern Senegal, in sympatry with An. arabiensis. Anopheles melas and An. arabiensis relative frequencies were generally lower in the rainy season samples, when An. gambiae s.s. was prevailing. No large seasonal fluctuations were observed for M and S-forms. In areas where both M and S were recorded, the frequency of hybrids between them ranged from to 0.6% to 7%.The observed pattern of taxa distribution supports the hypothesis of a better adaptation of M-form to areas characterized by water-retaining alluvial deposits along the Gambia River, characterized by marshy vegetation, mangrove woods and rice cultivations. In contrast, the S-form seems to be better adapted to free-draining soil, covered with open woodland savannah or farmland, rich in temporary larval breeding sites characterizing mainly the eastern part of the transect, where the environmental impact of the Gambia River is much less profound and agricultural activities are mainly rain-dependent. Very interestingly, the observed frequency of hybridization between the molecular forms along the whole transect was much higher than has been reported so far for other areas.The results support a bionomic divergence between the M and S-forms, and suggest
Supercritical Fluid Adsorption of Domperidone on Silica Aerogel  [PDF]
Giuseppe Caputo
Advances in Chemical Engineering and Science (ACES) , 2013, DOI: 10.4236/aces.2013.33024

Silica aerogel (SA) was loaded with domperidone to demonstrate the potentiality of adsorption processes based on the usage of supercritical carbon dioxide to treat poorly water-soluble drugs, forming new kinds of drug delivery systems. The effects of pressure, temperature and solution concentration on loaded SA were studied. Adsorption isotherms were measured at 35and 45 and fitted with Langmuir model. Release kinetics of the adsorbed drug were also evaluated by in vitro dissolution tests. Results showed that domperidone can be uniformly dispersed into the aerogel and that the release rate of domperidone from the composite, constituted by drug and silica aerogel, is much faster than that of the crystalline drug. The proposed adsorption method is suitable for the production of domperidone fast release tablets.

Exploring Proteins in Anopheles gambiae Male and Female Antennae through MALDI Mass Spectrometry Profiling
Francesca R. Dani, Simona Francese, Guido Mastrobuoni, Antonio Felicioli, Beniamino Caputo, Frederic Simard, Giuseppe Pieraccini, Gloriano Moneti, Mario Coluzzi, Alessandra della Torre, Stefano Turillazzi
PLOS ONE , 2008, DOI: 10.1371/journal.pone.0002822
Abstract: MALDI profiling and imaging mass spectrometry (IMS) are novel techniques for direct analysis of peptides and small proteins in biological tissues. In this work we applied them to the study of Anopheles gambiae antennae, with the aim of analysing expression of soluble proteins involved in olfaction perireceptor events. MALDI spectra obtained by direct profiling on single antennae and by the analysis of extracts, showed similar profiles, although spectra obtained through profiling had a richer ion population and higher signal to noise ratio. Male and female antennae showed distinct protein profiles. MALDI imaging experiments were also performed and differences were observed in the localization of some proteins. Two proteins were identified through high resolution measurement and top-down MS/MS experiments. A 8 kDa protein only present in the male antennae matched with an unannotated sequence of the An. gambiae genome, while the presence of odorant binding protein 9 (OBP-9) was confirmed through experiments of 2-DE, followed by MS and MS/MS analysis of digested spots. This work shows that MALDI MS profiling is a technique suitable for the analysis of proteins of small and medium MW in insect appendices, and allows obtaining data for several specimens which can be investigated for differences between groups. Proteins of interest can be identified through other complementary MS approaches.
Chromosomal plasticity and evolutionary potential in the malaria vector Anopheles gambiae sensu stricto: insights from three decades of rare paracentric inversions
Marco Pombi, Beniamino Caputo, Frederic Simard, Maria A Di Deco, Mario Coluzzi, Alessandra Torre, Carlo Costantini, Nora J Besansky, Vincenzo Petrarca
BMC Evolutionary Biology , 2008, DOI: 10.1186/1471-2148-8-309
Abstract: Here, we present data on 82 previously undescribed rare chromosomal inversions (RCIs) recorded during extensive field sampling in 16 African countries over a 30 year period, which may shed light on the dynamics of chromosomal plasticity in An. gambiae. We analyzed breakpoint distribution, length, and geographic distribution of RCIs, and compared these measures to those of the common inversions. We found that RCIs, like common inversions, are disproportionately clustered on 2R, which may indicate that this arm is especially prone to breakages. However, contrasting patterns were observed between the geographic distribution of common inversions and RCIs. RCIs were equally frequent across biomes and on both sides of the Great Rift Valley (GRV), whereas common inversions predominated in arid ecological settings and west of the GRV. Moreover, the distribution of RCI lengths followed a random pattern while common inversions were significantly less frequent at shorter lengths.Because 17/82 (21%) RCIs were found repeatedly at very low frequencies – at the same sampling location in different years and/or in different sampling locations – we suggest that RCIs are subject mainly to drift under unperturbed ecological conditions. Nevertheless, RCIs may represent an important reservoir of genetic variation for An. gambiae in response to environmental changes, further testifying to the considerable evolutionary potential hidden within this pan-African malaria vector.Chromosomal paracentric inversions are mutations where part of a chromosome, not including the centromere, has been reversed with respect to a standard orientation of reference. These inversions have now been described from a diversity of species, including humans [1], but historically were most readily observed in dipteran groups such as midges, blackflies, fruitflies and anopheline mosquitoes, where the presence of giant (polytene) chromosomes facilitates detection and analysis of inversions [2,3].Theoretical and empi
Le città del Jabal Nafusah Libico: strutture insediative e spazi abitativi. The Cities of the Libyan Nafusah Mountain: Type of Dwellings and Urban Settlements.
Beniamino Polimeni
Abstract: L’interesse verso la zona del Jabal Nafusah, nella Libia nord occidentale, nasce dalla volontà di studiare un sistema di insediamenti e di trasformazioni del paesaggio che per caratteristiche ed esiti formali rappresentano un unicum all’interno del Maghreb. Il lavoro presentato, diviso in quattro sezioni, si propone come un possibile metodo di lettura delle forme urbane e delle architetture che le hanno generate, attraverso lo studio delle tre città berbere di Nalut, Cabao, Ulad Mahmud. Tre casi di studio significativi analizzati mediante gli strumenti del disegno e dell’analisi grafica con lo scopo di comprenderne l’organizzazione logica delle configurazioni e verificarne la continuità territoriale. L’obiettivo è quello di creare una sequenza storico/analitica che partendo dagli oggetti architettonici più minuti, i più vicini alla scala umana per struttura e dimensione, proceda fino all’estensione urbana e territoriale. Un metodo di analisi induttivo che seppur limitato ad una porzione circoscritta dà vita ad un valido processo di interpretazione formale. Interest in the Jabal Nafusah Mountain, in the north-eastern part of Libya, arises from the desire to study a system of settlements and landscape transformations which are unique to the Maghreb territory characteristics. The goal of this research is to propose a reading method for the urban structure and architectural forms, by the analysis of three models of settlement: Nalut, Cabao, Ulad Mahamud. These three significant study cases are analyzed by graphic and historical instruments with the purpose of under standing and verifying configuration and territorial continuity. The aim is to create an analytic sequence which starts from the territory with minimal architectural objects and extends to those nearest to the human scale of structure and dimensions, allowing us to understand the relations among the landscape, the history and the city formation.
Il “Manifesto” contro la disoccupazione nell’UE sette anni dopo: quali suggerimenti sono sempre attuali?
Beniamino Moro
Moneta e Credito , 2005,
Abstract: L’articolo analizza retrospettivamente dopo sette anni l’impatto che la pubblicazione del “Manifesto contro la disoccupazione nell’UE” ha avuto sulle politiche economiche attivate nei vari paesi europei. Dal lato dell’offerta, si prende atto che molti suggerimenti del“Manifesto” sono stati messi in pratica, tra cui risultano particolarmente significative le riforme del mercato del lavoro approvate di recente in Italia, Germania e Francia. Taliriforme hanno introdotto più flessibilità nei contratti di lavoro, che ha favorito l’aumento dell’occupazione e la discesa del tasso di disoccupazione in tutti i paesi. Non altrettanto soddisfacenti, invece, sono stati i risultati conseguiti nelle politiche di gestione della domanda aggregata. Alle politiche fiscali restrittive imposte dal rispetto dei parametri di Maastricht, infatti, ha fatto riscontro una politica monetaria della BCE altrettanto restrittiva,che ha fatto apprezzare l’euro e fatto perdere competitività alle merci europee nel mercato internazionale. Altrettanto deludenti sono giudicate le politiche regionali di sviluppo, per lequali si suggerisce un uso più appropriato della politica d’incentivazione fiscale per attirare nuovi investimenti nelle aree sottosviluppate.
Incentivi fiscali e politiche di sviluppo economico regionale in Europa (Fiscal Incentives and Regional Economics Development Policies in Europe)
Beniamino Moro
Moneta e Credito , 2001,
Abstract: The paper shows that fiscal policy and tax incentives are more effective than monetary policy and monetary incentives in supporting a regional development policy among European regions. Anyway, only recently the EU Commission agreed that member countries can use tax incentives instead of monetary ones to support new investment in European less developed areas, but she still does not permit that a member state can apply a differentiated fiscal policy on a regional basis. In fact, according to the Commission, a reduced tax rate for growth purposes in European less developed areas has the same effect as a working aid for those firms located in these areas, which is forbidden by the Code of conduct that regulates fiscal competition among member states. The paper shows this interpretation is not correct and also demonstrates that a regional fiscal policy differentiated among areas inside the same member state can be supported without violate the sound principles of fiscal free competition incorporated in the Code of Conduct.
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