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Search Results: 1 - 10 of 452332 matches for " Benedita Maria do R. D.;Sim?es "
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Desvelando o cotidiano do adolescente hospitalizado
Almeida, Inez Silva de;Rodrigues, Benedita Maria do R. D.;Simes, S?nia Mara Faria;
Revista Brasileira de Enfermagem , 2005, DOI: 10.1590/S0034-71672005000200003
Abstract: my experience in the adolescence was marked by the hospitalization process. currently, as a nursing professional that take care of hospitalized young, there arose inquietudes that originated this study. the investigation object was the significance of the hospitalization in the adolescence, having as objective to understand this significance for the hospitalized adolescent. it was used the qualitative approach in the light of the martin heidegger′s existential phenomenology. the setting was a specific internment unit for adolescents and the deponents were hospitalized young. this study made possible to understand that the adolescent unveiled himself as a being-with and understand of himself as a being in the world thrown to the death. the research pointed to the need of a real implementation of the public policies addressed to the hospitalized adolescent.
Alzheimer’s Disease: Characterization, Evolution and Implications of the Neuroinflammatory Process [Doen a de Alzheimer: Caracteriza o, Evolu o e Implica es do Processo Neuroinflamatório]
Flávia P. D. Viegas,Maria Cecília R. Simes,Miguel D. da Rocha,Maísa R. Castelli
Revista Virtual de Química , 2011,
Abstract: Alzheimer’s Disease (AD) is a neurodegenerative disease characterized by a progressive memory loss and severe cognition decline, associated to degradation of cholinergic neurons in many areas of central nervous system (CNS), with a dramatic reduction in neurotransmitters, specially acetylcholine. The illness progression is also accompanied by behavior changes, leading to individual incapacity and depression, and evolving to dementia and death. AD is related to cerebral aging and located loss of neurons, mainly at hippocampus and basal pro-encephalic tissue. Pathohystologically, AD is characterized by extracellular deposits of senile plaques formed by insoluble fragments of amyloid protein precursor (A ) and intracellular neurofibrillary tangles in the brain, constituted by fragments of hyperphosphorylated TAU protein, with a massive loss in neurons. Despite typical behavior aspects of AD installation, recent studies, especially from the last decade, have evidenced the occurrence of a complex inflammatory process in the neuronal tissue. The relevancy of neuroinflammation in the installation, progression and severity of AD, as well as the mechanisms of immune system activation and key cells in the initial shot of inflammatory cascade in CNS, as microglia and astrocytes, have been demonstrated by important reviews in the literature. Activation of microglia can lead to recruitment of astrocytes that increase the inflammatory response to the extracellular A deposits. This neuroinflammatory component of AD is additionally characterized by a local acute phase response mediated by cytokines, complement cascade activation and induction of an enzymatic inflammatory system, as induced NO synthase (iNOS) and generation of cyclooxygenase 2 (COX-2). Then, astrocytes participate of the degradation and remotion of A , acting as a protective barrier between A deposits and neurons. The multifactorial character of the inflammatory response is characterized by the occurrence of a wide diversity of pro- and anti-inflammatory mediators, some of them being responsible for promotion of neurodegenerative mechanisms, while others could limit the advance of inflammation or exert benefit neurotrophic effects. Therefore, it includes not only a single mediator, but a set of inflammatory agents that would determine the prevalence of benefic or deletery effects during AD progression.
Individual factors related to chronic condition in Portuguese adolescents: Highlights from the HBSC/WHO study  [PDF]
Teresa Santos, Margarida Gaspar de Matos, Maria Celeste Simes, Helena Fonseca, Maria do Céu Machado
Health (Health) , 2013, DOI: 10.4236/health.2013.511A2005

Background: Adolescence includes a period (10 to 19 years) of profound biopsychosocial changes, constituting potentially difficult challenges, which may become more pronounced in the presence of a chronic condition and its limitations. Responses are not homogeneous and can be quite variable, depending on various specific individual factors. Research comparing adolescents with or without chronic illness, or comparing across different conditions, has been contradictory, not confirming a direct relationship between the degree of suffering and the chronic condition. Objective: To characterize and assess the impact of 1) having a chronic condition (CC) and 2) how CC affects school participation; and its association with life satisfaction and perception of wellness, controlling for demographic factors: age, gender and family socioeconomic status (SES). Methods: 5050 Portuguese adolescents with an average age of 14 years participated in the Health Behaviour in School-aged Children/WHO (HBSC). Results: The majority of the adolescents with CC reported that their conditions did not affect school participation. Adolescents with CC who indicated that CC affected school participation felt more frequently unwell and presented lower life satisfaction. Being a boy, younger and having high family socio economic status (SES) were identified as predictors of higher life satisfaction; on the other hand, being a girl, older, having lower SES, living with CC and feeling that CC affects school participation are predictors for feeling more frequently unwell. Conclusions: These

Doen?as do sistema nervoso de bovinos no semiárido nordestino
Galiza, Glauco J.N.;Silva, Maria L.C.R.;Dantas, Ant?nio F.M.;Simes, Sara V.D.;Riet-Correa, Franklin;
Pesquisa Veterinária Brasileira , 2010, DOI: 10.1590/S0100-736X2010000300014
Abstract: diseases of the nervous system of cattle in the semiarid region of northeastern brazil were evaluated by a retrospective study of 411 cattle necropsies performed in the veterinary hospital of the federal university of campina grande, patos, paraíba, from january 2000 to december 2008. of the 411 cases analyzed, 139 (33.81%) were from cattle that presented nervous signs and the records were reviewed to determine the epidemiological, clinical, and macroscopic and histologic main features. diagnosis was inconclusive in 28 cases (20.14%). in cases with diagnosis the main diseases were rabies (48.7% of the cases with nervous signs), brain abscesses (7.2%) including three cases of pituitary abscesses, malignant catarrhal fever (6.3%), botulism (6.3%), congenital malformations (4.5%), trauma (4.5%), tuberculosis (2.7%), tetanus (2.7%), infection by bovine hervesvirus-5 (2.7%), non-suppurative encephalomyelitis (2.7%), intoxication by prosopis juliflora (2.7%), congenital status spongiosus of unknown etiology (1.8%), and polioencephalomalacia (1.8%). other diseases diagnosed only once (0.9%) were cryptococcosis, listeriosis, thromboembolic encephalitis, lymphosarcoma, trypanosso-miasis, and babesiosis by babesia bovis.
Hitchhiking Trypanosoma cruzi minicircle DNA affects gene expression in human host cells via LINE-1 retrotransposon
Simes-Barbosa, Augusto;Arga?araz, Enrique R;Barros, Ana Maria;Rosa, Ana de Cássia;Alves, Nivaldo P;Louvandini, Patrícia;D'Souza-Ault, Marian R;Nitz, Nadjar;Sturm, Nancy R;Nascimento, Rubens J;Teixeira, Antonio RL;
Memórias do Instituto Oswaldo Cruz , 2006, DOI: 10.1590/S0074-02762006000800003
Abstract: the horizontal transfer of trypanosoma cruzi mitochondrial minicircle dna to the genomes of naturally infected humans may play an important role in the pathogenesis of chagas disease. minicircle integrations within line-1 elements create the potential for foreign dna mobility within the host genome via the machinery associated with this retrotransposon. here we document integration of minicircle dna fragments in clonal human macrophage cell lines and their mobilization over time. the movement of an integration event in a clonal transfected cell line was tracked at three months and three years post-infection. the minicircle sequence integrated into a line-1 retrotransposon; one such foreign fragment subsequently relocated to another genomic location in association with associated line-1 elements. the p15 locus was altered at three years as a direct effect of minicircle/line-1 acquisition, resulting in elimination of p15 mrna. here we show for the first time a molecular pathology stemming from mobilization of a kdna/line-1 mutation. these genomic changes and detected transcript variations are consistent with our hypothesis that minicircle integration is a causal component of parasite-independent, autoimmune-driven lesions seen in the heart and other target tissues associated with chagas disease.
Estudo comparativo dos meios de contraste baritado e iodado-i?nico e n?o-i?nico no trato respiratório de ratos
Biondo-Simes, Maria de Lourdes Pessole;Greca, Fernando Hintz;Pedrazzani, Maurizzio;Mello Jr, Heraldo O.;Ioshii, Sérgio Ossamu;Cavalcanti, Maria Francisca Kaizu;Souza, Débora R. Voltarelli de;Kimura, Letícia Yurie;
Acta Cirurgica Brasileira , 2003, DOI: 10.1590/S0102-86502003000500009
Abstract: purpose: during roadiologic studies, passage of the contrast medium to the tracheobronchial tree may occur, causibng adverse or even fatal reactions. the objective of the present study was to determine the changes in the respiratory tract triggered by the presence of contrast medium. methods: ninety-one rats were divided at random into 5 groups, i.e., an intact control group of 7 animals and 4 groups of 21 rats each. the manipulated control group received physiological saline and the experimental groups respectively received barium, ionic iodine and non-ionic iodine. under anesthesia and direct visualization of the trachea, 0.75 ml/kg (0.25 ml) of the contrast medium was injected into the animals of each group. the effects of the procedure were determined after 1 hour, 1 day and 1 week, with the animals being sacrificed at each time point by drawing lots. radiographic documentation was obtained, followed by resection and histopathologic examination of the lungs. results: after 1 hour, the middle fields and the right upper field were involved in the group injected with barium. in the groups injected with ionic iodine and non-ionic iodine, the entire right lung was found to be opacified. after 1 day and 1 week, the groups injected with iodine were normal, whereas the group injected with barium showed involvement of the middle fields. after 1 week, histopathologic examination revealed that the group injected with barium exhibited large amounts of intra-alveolar, perivascular and peribronchial macrophages conclusion: the ionic and non-ionic iodine contrast media led to temporary changes, whereas barium promoted a chronic inflammatory reaction with maintenance of radiographic translation.
Quality of Melon 'UFERSA-05 var. ACIDULUS and Pele de Sapo “Mabel” Minimally Processed, Kept in Different Packages  [PDF]
Maria Luiza Pereira de Araújo, Fanquiele Ribeiro de Oliveira, Marianne Lima Barboza, Glauber Enrique Souza Nunes, Pahlevi Augusto de Souza, Adriano do Nascimento Simes
Food and Nutrition Sciences (FNS) , 2014, DOI: 10.4236/fns.2014.58079

This study aimed at evaluating the quality of melon Pele de Sapo “Mabel” and Yellow melon “UFERSA-05” minimally processed preserved in different packages. The fruits were harvested at Mossoró-RN and transported to Serra Talhada-PE. In the first study, melon fruit Piel de Sapo “Mabel” was selected, washed, weighed, cooled, peeled, cut into cube shape, sanitized in chlorine solution, drained, packaged in rigid polypropylene tray, sealed with polypropylene film or polypropylene rigid cap and kept for 8 days at 8. In the second study, fruits of yellow melon “UFERSA-05” and Pele de Sapo “Mabel” were minimally processed and kept in rigid polypropylene tray, sealed with polypropylene film and stored for 8 days at 8. There was no significant interaction between packaging (sealed with film and polypropylene cover) and period of conservation, for pH, total titratable acidity (TTA), total soluble solids (TSS) and Loss of fresh mass (LFM) for Melon “Mabel”. While there was significant interaction between types of melon (“UFERSA-05” and “Mabel”) and storage period (0, 2, 4, 6, and 8 days) for pH, TTA and TSS. In sensory evaluation were noticeable changes in appearance, flavor, aroma and flesh firmness, characterized by translucency, alcoholic aroma and softening in “Mabel” melon kept in tray with lid. Melon “UFERSA-05” showed lower pH, total soluble solids, total soluble sugars, PME activity, lack of translucency high flesh firmness compared to “Mabel” melon during storage. The high levels of sugars in melon “Mabel” may be related to the incidence of translucency, which was not observed in “UFERSA-05” melon, with a strong potential to minimal processing.

Borges de Meneses,Ramiro Délio; Simes,Maria Clara;
Eidos , 2009,
Abstract: this paper focuses on max schelers idea of person and its meaning in terms of values organized according categories. the work of scheler on ethics expands the solidarity of the person as cordis ordo by the construction of a hierarchical system of values. therefore, the recognition of the realm of universal values, a sector of which forms the ethos of a given age, has to be supplemented by that of the order of the time with its individual values and claims. there are many lectures of values in axiological philosophy, as we explain in this paper according to material-values ethics, and they are very important in the revelation of the other.
A Pessoa e os valores para as solidariedades: significados axiológicos
Ramiro Délio null,Maria Clara Simes
Eidos , 2009,
Abstract: Según Max Scheler, el descubrimiento de la persona designa, por supuesto, la entrada axiológica al mundo de los valores, que se organiza según categorías. Siendo la persona una actividad, M. Scheler la considera de acuerdo a su aspecto relacional. El progreso del valor interpersonal se encuentra en la comunidad, al ser una persona total y valiosa. Luego, el valor del amor se considera como intrínseco, siendo el amor de la persona un valor per se como persona en totalidad. Pero, la solidaridad representa un momento valioso de la persona, como cordis ordo, dado que manifiesta su participación activa en la promoción del Otro.
A escolariza o e as práticas sociais de leitura e escrita: a análise dos educandos adultos da Escola Básica
Maria da Concei??o R. Fonseca,Fernanda M. Simes
Revista Portuguesa de Educa??o , 2011,
Abstract: This article brings about reflections of a research carried out in the Project for the Youth and Adults in Elementary School from Federal University of Minas Gerais (Brazil). These reflections are on how adults, in the process of basic schooling, analyze their practices of reading and writing, understand their literacy experiences in school and evaluate the potential impacts on those practices. The analysis of four semi-structured interviews with students from Youth and Adults Education suggests that they consider the diversity of their reading and writing practice and recognize, although in a relativistic way, the role of schools in the promotion of literate practices of social use. The interviewees identify the expansion and the refining of their practices in reading and writing, triggered by demands and opportunities of the school experience. They point, however, to a certain independence from their everyday practices of literacy in relation to the school practices, independence which is a result of school experience or which is, in spite of it, preserved.
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