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Search Results: 1 - 10 of 14183 matches for " Beibei Jia "
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Research on the Relationship of Commercial Bank’s Loan Loss Provision and Earning Management and Capital Management  [PDF]
Xianlei Dong, Jia Liu, Beibei Hu
Journal of Service Science and Management (JSSM) , 2012, DOI: 10.4236/jssm.2012.52021
Abstract: This paper reviewed and analyzed the development of our nation’s loan loss provision system, then studied the relations of commercial bank loan loss provision and earnings management and capital management through empirical study. This paper selected 14 domestic commercial banks of year 2001-2009 as data sample, using Kanagaretnam et al.’s (2003) research method, dividing the loan loss provision into two parts that is discretionary and nondiscretionary part, and empirically studied the relationship of discretionary part of loan loss provision and earnings before taxes and provisions (EBTP) and capital adequacy ratio (CAR). Empirical results show that: there is significant positive correlation between the discretionary loan loss provisions and earnings before taxes and provisions (EBTP), and there is significant negative correlation between the discretionary loan loss provisions and capital adequacy ratio (CAR). That provides evidence for the relation of bank loan loss provision and earnings management and capital management. In the last, combining with empirical research findings and the status of the loan loss provision system of China’s commercial banks, this paper made several suggestions to improve the system of loan loss provision.
Aqua(dimethylformamide){tris[(1-methyl-1H-benzimidazol-2-yl)methyl]amine}nickel(II) dipicrate
Ke Li,Tao Sun,Yang Yang,Beibei Jia
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536810029181
Abstract: In the title complex, [Ni(C27H27N7)(C3H7NO)(H2O)](C6H2N3O7)2, the NiII ion is coordinated in a slightly distorted octahedral coordination evironment by an NiN4O2 ligand set. The tris(N-methylbenzimidazol-2-ylmethyl)amine ligand is in a tetradentate mode while a coordinated water molecule and a dimethylformamide ligand complete the coordination. In the crystal structure, intermolecular O—H...O hydrogen bonds link the cation and one of the pictrate anions into four-component centrosymmetric clusters.
System Model of Underground UWB Based on MB-OFDM  [PDF]
Yanjing Sun, Beibei Zhang
Int'l J. of Communications, Network and System Sciences (IJCNS) , 2011, DOI: 10.4236/ijcns.2011.41007
Abstract: To overcome the frequency-selective fading of ultra wide band (UWB) caused by the multi-path propagation in complicated environment of coal mines, an underground wireless communication system of UWB based on multi-band orthogonal frequency division multiplexing (MB-OFDM) for coal mine is presented. Inde-pendent angle impulse response is used to build up revised channel model for underground tunnels based on the traditional S-V model. With the revised channel model, we construct the underground UWB system based on MB-OFDM and give the band division scheme and the correction approach for channel. The model of the system was simulated in the complex environment of coal mine. Simulation results and analysis show that the underground wireless communication system of UWB based on MB-OFDM can effectively with-stand multipath fading and has the advantages of high anti-noise ability, low bit-error rate, and wide cover-age.
Dimensional Measurement of Complete-connective Network under the Condition of Particle’s Fission and Growth at a Constant Rate  [PDF]
JinSong Wang, BeiBei Hu
Journal of Software Engineering and Applications (JSEA) , 2012, DOI: 10.4236/jsea.2012.512B009
Abstract: We construct a complete-connective regular network based on Self-replication Space and the structural principles of cantor set and Koch curve. A new definition of dimension is proposed in the paper, and we also investigate a simplified method to calculate the dimension of two regular networks. By the study results, we can get a extension: the formation of Euclidean space may be built by the process of the Big Bang's continuously growing at a constant rate of three times.
Live Poultry Trade in Southern China Provinces and HPAIV H5N1 Infection in Humans and Poultry: The Role of Chinese New Year Festivities
Ricardo J. Soares Magalh?es, Xiaoyan Zhou, Beibei Jia, Fusheng Guo, Dirk U. Pfeiffer, Vincent Martin
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0049712
Abstract: Background The number of outbreaks of highly pathogenic avian influenza virus of the H5N1 subtype (HPAIV H5N1) over the past 5 years has been drastically reduced in China but sporadic infections in poultry and humans are still occurring. In this study, we aimed to investigate seasonal patterns in the association between the movement of live poultry originating from southern China and HPAIV H5N1 infection history in humans and poultry in China. Methodology/Principal Findings During January to April 2010, longitudinal questionnaire surveys were carried out monthly in four wholesale live bird markets (LBMs) in Hunan and Guangxi provinces of South China. Using social network analysis, we found an increase in the number of observed links and degree centrality between LBMs and poultry sources in February and March compared to the months of January and April. The association of some live poultry traders (LPT’s) with a limited set of counties (within the catchment area of LBMs) in the months of February and March may support HPAIV H5N1 transmission and contribute to perpetuating HPAIV H5N1 virus circulation among certain groups of counties. The connectivity among counties experiencing human infection was significantly higher compared to counties without human infection for the months of January, March and April. Conversely, counties with poultry infections were found to be significantly less connected than counties without poultry infection for the month of February. Conclusions/Significance Our results show that temporal variation in live poultry trade in Southern China around the Chinese New Year festivities is associated with higher HPAIV H5N1 infection risk in humans and poultry. This study has shown that capturing the dynamic nature of poultry trade networks in Southern China improves our ability to explain the spatiotemporal dissemination in avian influenza viruses in China.
HIV-1-Infected and Immune-Activated Macrophages Induce Astrocytic Differentiation of Human Cortical Neural Progenitor Cells via the STAT3 Pathway
Hui Peng, Lijun Sun, Beibei Jia, Xiqian Lan, Bing Zhu, Yumei Wu, Jialin Zheng
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0019439
Abstract: Diminished adult neurogenesis is considered a potential mechanism in the pathogenesis of HIV-1-associated dementia (HAD). In HAD, HIV-1-infected and immune-activated brain mononuclear phagocytes (MP; perivascular macrophages and microglia) drive central nervous system (CNS) inflammation and may alter normal neurogenesis. We previously demonstrated HIV-1-infected and lipopolysaccharide (LPS) activated monocyte-derived macrophages (MDM) inhibit human neural progenitor cell (NPC) neurogenesis, while enhancing astrogliogenesis through the secretion of the inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), in vitro and in vivo. Here we further test the hypothesis that HIV-1-infected/activated MDM promote NPC astrogliogenesis via activation of the transcription factor signal transducer and activator of transcription 3 (STAT3), a critical factor for astrogliogenesis. Our results show that LPS-activated MDM-conditioned medium (LPS-MCM) and HIV-infected/LPS-activated MDM-conditioned medium (LPS+HIV-MCM) induced Janus kinase 1 (Jak1) and STAT3 activation. Induction of the Jak-STAT3 activation correlated with increased glia fibrillary acidic protein (GFAP) expression, demonstrating an induction of astrogliogenesis. Moreover, STAT3-targeting siRNA (siSTAT3) decreased MCM-induced STAT3 activation and NPC astrogliogenesis. Furthermore, inflammatory cytokines (including IL-6, IL-1β and TNF-α) produced by LPS-activated and/or HIV-1-infected MDM may contribute to MCM-induced STAT3 activation and astrocytic differentiation. These observations were confirmed in severe combined immunodeficient (SCID) mice with HIV-1 encephalitis (HIVE). In HIVE mice, siRNA control (without target sequence, sicon) pre-transfected NPCs injected with HIV-1-infected MDM showed more astrocytic differentiation and less neuronal differentiation of NPCs as compared to NPC injection alone. siSTAT3 abrogated HIV-1-infected MDM-induced astrogliogenesis of injected NPCs. Collectively, these observations demonstrate that HIV-1-infected/activated MDM induces NPC astrogliogenesis through the STAT3 pathway. This study generates important data elucidating the role of brain inflammation in neurogenesis and may provide insight into new therapeutic strategies for HAD.
TNF-α Affects Human Cortical Neural Progenitor Cell Differentiation through the Autocrine Secretion of Leukemia Inhibitory Factor
Xiqian Lan, Qiang Chen, Yongxiang Wang, Beibei Jia, Lijun Sun, Jialin Zheng, Hui Peng
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0050783
Abstract: Proinflammatory cytokine tumor necrosis factor-alpha (TNF-α) is a crucial effector of immune responses in the brain that participates in the pathogenesis of several acute and chronic neurodegenerative disorders. Accumulating evidence has suggested that TNF-α negatively regulates embryonic and adult neurogenesis. However, the effect of TNF-α on cell fate decision in human neural progenitor cells (NPCs) has rarely been studied. Our previous studies have shown that recombinant TNF-α enhances astrogliogenesis and inhibits neurogenesis of human NPCs through the STAT3 (signal transducer and activator of transcription 3) pathway. In the current study, we further elucidated the specific mechanism involved in TNF-α-induced astrogliogenesis. We found that TNF-α activated STAT3 at delayed time points (6 h and 24 h), whereas conditioned medium collected from TNF-α-treated NPCs induced an immediate STAT3 activation. These data suggest TNF-α plays an indirect role on STAT3 activation and the subsequent NPC differentiation. Further, we showed that TNF-α induced abundant amounts of the IL-6 family cytokines, including Leukemia inhibitory factor (LIF) and Interleukin 6 (IL-6), in human NPCs. TNF-α-induced STAT3 phosphorylation and astrogliogenesis were abrogated by the addition of neutralizing antibody for LIF, but not for IL-6, revealing a critical role of autocrine secretion of LIF in TNF-α-induced STAT3 activation and astrogliogenesis. This study generates important data elucidating the role of TNF-α in neurogenesis and may provide insight into new therapeutic strategies for brain inflammation.
Hot Events Detection of Stock Market Based on Time Series Data of Stock and Text Data of Network Public Opinion  [PDF]
Beibei Cao
Journal of Data Analysis and Information Processing (JDAIP) , 2019, DOI: 10.4236/jdaip.2019.74011
Abstract: With the highly integration of the Internet world and the real world, Internet information not only provides real-time and effective data for financial investors, but also helps them understand market dynamics, and enables investors to quickly identify relevant financial events that may lead to stock market volatility. However, in the research of event detection in the financial field, many studies are focused on micro-blog, news and other network text information. Few scholars have studied the characteristics of financial time series data. Considering that in the financial field, the occurrence of an event often affects both the online public opinion space and the real transaction space, so this paper proposes a multi-source heterogeneous information detection method based on stock transaction time series data and online public opinion text data to detect hot events in the stock market. This method uses outlier detection algorithm to extract the time of hot events in stock market based on multi-member fusion. And according to the weight calculation formula of the feature item proposed in this paper, this method calculates the keyword weight of network public opinion information to obtain the core content of hot events in the stock market. Finally, accurate detection of stock market hot events is achieved.
Ubiquitin B in Cervical Cancer: Critical for the Maintenance of Cancer Stem-Like Cell Characters
Yuan Tian, Wencheng Ding, Yingying Wang, Teng Ji, Shujuan Sun, Qingqing Mo, Pingbo Chen, Yong Fang, Jia Liu, Beibei Wang, Jianfeng Zhou, Ding Ma, Peng Wu
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0084457
Abstract: Cervical cancer cells exhibit an increased requirement for ubiquitin-dependent protein degradation associated with an elevated metabolic turnover rate. Ubiquitin, which is a small, highly conserved protein expressed in all eukaryotic cells, can be covalently linked to certain target proteins to mark them for degradation by the ubiquitin-proteasome system. Previous studies highlight the essential role of Ubiquitin B (UbB) and UbB-dependent proteasomal protein degradation in histone deacetylase inhibitor (HDACi) -induced tumor selectivity. We hypothesized that UbB plays a critical role in the function of cervical cancer stem cells. We measured endogenous UbB levels in mammospheres in vitro by real-time PCR and Western blotting. The function of UbB in cancer stem-like cells was assessed after knockdown of UbB expression in prolonged Trichostatin A-selected HeLa cells (HeLa/TSA) by measuring in vitro cell proliferation, cell apoptosis, invasion, and chemotherapy resistance as well as by measuring in vivo growth in an orthotopic model of cervical cancer. We also assessed the cancer stem cell frequency, tumorsphere formation, and in vivo growth of human cervical cancer xenografts after UbB silencing. We found that HeLa/TSA were resistant to chemotherapy, highly expressed the UbB gene and the stem cell markers Sox2, Oct4 and Nanog. These cells also displayed induced differentiation abilities, including enhanced migration/invasion/malignancy capabilities in vitro and in vivo. Furthermore, an elevated expression of UbB was shown in the tumor samples of chemotherapy patients. Silencing of UbB inhibited tumorsphere formation, lowered the expression of stem cell markers and decreased cervical xenograft growth. Our results demonstrate that UbB was significantly increased in prolonged Trichostatin A-selected HeLa cells and it played a key role in the maintenance of cervical cancer stem-like cells.
Sedimentary characteristics and controlling factors of the Early Ordovician platform-slope-basin in the northern margin of the Qaidam Basin.

MA Shuai
,CHEN Shiyue,JIA Beibei,SUN Jiaopeng,WANG Feng,ZENG Hanyu

- , 2018, DOI: 10.13745/j.esf.yx.2017-5-1
Abstract: 通过对柴北缘地区的野外地质调查及室内实验分析,根据地质剖面中发育的岩石组合类型、沉积构造等特征,对研究区早奥陶世台地斜坡盆地相沉积体系进行了详细研究。认为研究区早古生代持续的海平面上升、柴北缘洋陆俯冲及陆弧碰撞是控制该时期盆山格局及沉积充填演化的重要因素。柴北缘早奥陶世台地边缘颗粒滩相发育在多泉山组中下部,岩性以生物碎屑灰岩、鲕粒灰岩以及泥晶灰岩为特征。而研究区斜坡相深水物质主要是由重力流搬运的碳酸盐岩再沉积物组成,共识别出包括细粒沉降微晶泥、滑塌角砾岩、颗粒流、瘤状灰岩、碎屑流以及浊积岩等不同类型的斜坡异地沉积物。研究区盆地相处于碳酸盐岩沉积体系岛弧碎屑岩沉积体系两大沉积体系的转换位置。受到柴北缘洋陆俯冲及陆弧碰撞等影响,隆升的陆壳基底及大陆岛弧物质向盆地提供大量碎屑物质,因此在靠近岛弧边缘地区发育了砂质碎屑流、浊流等重力流沉积体系下的弧后盆地沉积产物。
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