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Search Results: 1 - 10 of 6499 matches for " Beatriz;Pracchia "
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Linfoma primário do sistema nervoso central
Bellesso, Marcelo;Bizzetto, Renata;Pereira, Juliana;Beitler, Beatriz;Pracchia, Luis Fernando;Chamone, Dalton A. S.;
Revista Brasileira de Hematologia e Hemoterapia , 2008, DOI: 10.1590/S1516-84842008000100013
Abstract: primary central nervous system lymphoma (pcnsl) is an extranodal non-hodgkin lymphoma in the brain, leptomeninges, spinal cord or eyes. the incidence of pcnsl increased approximately three-fold in the last decades. nowadays, it represents 0.4 case per 100,000 people and accounts for 4% of all primary brain tumors. although individuals infected with hiv have a 3,600-fold increased risk of developing pcnsl compared with the general population, the incidence has not increased only in aids group. recent data suggest that the incidence of pcnsl declined in the aids group after the introduction of anti-retroviral drugs. around 90% of pcnsl cases are classified as diffuse large b-cell lymphoma, 10% involve the eyes and 10% of patients are hiv positive. the clinical presentation depends on the location of the tumor with neurological rather than systemic symptoms. computed tomography (ct) and magnetic resonance imaging (rmi) are essential in diagnosis, however the gold standard is tumor biopsy. staging should be made with imaging and bilateral biopsy of bone marrow. the main poor prognosic parameters are performance status greater than 1, age older than 60 years, elevated dhl, high liquor protein concentration and tumor located within the deep regions of the brain. bcl-6 expression identified in the tumor confers a better prognosis. currently, a combined therapy with high doses of methotrexate and whole-brain radiotherapy is the therapy of choice. nowever, whole-brain radiotherapy should be carefully analyzed because neurotoxity is a frequent problem in the elderly and in relapsed and refractory patients.
é necessária a realiza??o de biópsia de medula óssea bilateral para o estadiamento do linfoma difuso de grandes células B?
Bellesso, Marcelo;Velasques, Rodrigo Dolphini;Pracchia, Luis Fernando;Beitler, Beatriz;Aldred, Vera Lúcia;Chamone, Dalton Alencar Fisher;Pereira, Juliana;
Jornal Brasileiro de Patologia e Medicina Laboratorial , 2009, DOI: 10.1590/S1676-24442009000200004
Abstract: this retrospective study aims to analyze the usefulness of bilateral bone marrow biopsy in bone marrow infiltration by diffuse large b-cell lymphoma (dlbcl). our objectives were to assess the incidence of unilateral bm involvement by dlbcl and compare fragment length obtained from positive and negative samples for infiltration. furthermore, we compared the differences between unilateral and bilateral infiltration correlating with lactic dehydrogenase (ldh) and computerized tomography (ct) staging. we evaluated 268 cases of dlbcl and observed medullary infiltration in 34 cases (13%). it was not possible to evaluate 6 out of 34 cases. 70 bm fragments were reviewed as to the presence or absence of infiltration and length. the mean number of fragments per case was 2.5; the mean bm fragment length was 11.01 mm (± 5.12 mm) and the mean bm fragment length per case was 27.53 mm. there was unilateral bm infiltration in six cases (21.4%). there were no differences in the mean fragment length as to the presence/absence of infiltration 10.95 mm (± 5.2 mm) versus 11.57 mm, p > 0.05, respectively. there were no differences in 23 cases between the comparison of unilateral medullary infiltration versus bilateral with lactic dehydrogenase and ct staging. we concluded that bilateral bone marrow biopsy was superior to unilateral because it may increase by 21.4% the detection of bm involvement by dlbcl.
Quimioterapia associada à terapia anti-retroviral de alta eficácia no tratamento dos linfomas n?o-Hodgkin agressivos relacionados à Síndrome da Imunodeficiência Adquirida
Pereira, Juliana;Hallack Neto, Abrah?o E;Pracchia, Luís F.;Alcantara, Andréa;Maurino, Beatriz B.;Dorliac-Llacer, Pedro E.;Chamone, Dalton A. F.;
Revista Brasileira de Hematologia e Hemoterapia , 2004, DOI: 10.1590/S1516-84842004000300006
Abstract: non-hodgkin lymphoma is one of the most frequent oncological complications in patients with the acquired immune-deficiency syndrome (aids). in other countries, after the introduction of the highly active antiretroviral therapy (haart), the drop in the incidence of systemic aggressive lymphomas was below expectations, although the survival of these patients rose. in brazil, little is known about the clinical behavior and survival of the patients with lymphoma and aids in the post-haart era. the aim of this study was to retrospectively evaluate 25 patients with lymphomas and aids, treated with the combination of chemotherapy and haart. in agreement with the literature most of the patients were male (20 patients - 80%) with a median age of 39 years. we observed a predominance of the diffuse large b cell lymphoma subtype (13 patients - 52%), advanced stage (15 patients - 60%), with extra-nodal disease (22 patients - 88%) and b symptoms (18 patients - 72%). previous aids diagnosis was present in 14 patients (56%), higher than that reported in other series. fifty-two percent achieved cr, the estimated probability of overall survival and disease-free survival at 3 years were 54% e 42%, respectively. the median overall survival time was 15 months. hematological toxicity and infections were frequently observed, but no toxicity-related deaths were seen. therefore we conclude that the combined chemotherapy-haart treatment is feasible in brazilian patients and can provide similar overall survival than that described for some international groups, with an acceptable toxicity profile.
Estratifica??o de risco em linfoma difuso de grandes células B
Hallack Neto, Abrah?o E.;Pereira, Juliana;Saboya, Rosaura;Beitler, Beatriz;Pracchia, Luis Fernando;Dulley, Frederico L.;Chamone, Dalton A. F.;
Revista Brasileira de Hematologia e Hemoterapia , 2006, DOI: 10.1590/S1516-84842006000400016
Abstract: diffuse large b-cell lymphoma is a heterogeneous clinical pathological entity which accounts for about 30% to 35% of all non-hodgkin's lymphoma cases. it is considered to be aggressive due to the patient's short survival time when incorrect treatment is provided. since 1993, treatment has been carried out according to ipi, which has been validated in several studies. however, since there are different responses from patients with the same ipi submitted to similar therapies, new prognostic markers are needed for these patients. as the biological nature of such lymphomas is becoming better known, other variables are starting to be used in order to stratify risk. in this review we will approach the key biological markers used as prognostic factors to treat diffuse large b-cell lymphoma patients.
Gemcitabina e ifosfamida no tratamento do linfoma de Hodgkin refratário ou recidivado após múltiplas terapias
Pracchia, Luís Fernando;Linardi, Camila C.G.;Buccheri, Valeria;
Revista Brasileira de Hematologia e Hemoterapia , 2007, DOI: 10.1590/S1516-84842007000400021
Abstract: patients with hodgkin's lymphoma relapsed after or refractory to multiple therapies (rhl) have a dismal prognosis. monotherapy with gemcitabine can promote an overall response rate of about 40% in these patients and its association with alkylating agents can provide better results. we retrospectively evaluated 17 rhl cases. all were treated with the combination of gemcitabine (1.0 g/m2; d1 and d8) and ifosfamide (1.0 g/m2; d1 to d5) in a 21-day cycle. treatment response was evaluated according to the cotswolds criteria. toxicity was evaluated according to who criteria. the median age of all patients was 34 years (18-53). nine of them (53%) were men and eight (47%) had stage iii/iv. the median number of previous treatments was 2 (2-3); two patients had already been treated with autologous stem cell transplant. overall response rate to the combined regimen was 62.5% (95% ci = 38.8% - 86.2%) and the median progression-free survival was 15 months (95% ci = 4 - 24 months). fifty-six cycles were evaluated for toxicity. the most frequent toxicities observed by cycle were: hepatic grade i/ii in 48.2% of the cycles and grade iii/iv in 1.8%; anemia grade i/ii in 45%; neutropenia grade i/ii in 36% and grade iii/iv 16%. grade iii/iv renal toxicity on any degree of haematuria were not observed. combined therapy with gemcitabine and ifosfamide promoted responses in more than half of the evaluated patients with an acceptable toxicity profile.
Tratamento do linfoma de Hodgkin após falha do transplante autólogo
Santos, Fernanda M.;Pracchia, Luís F.;Linardi, Camila G. C.;Buccheri, Valeria;
Revista Brasileira de Hematologia e Hemoterapia , 2008, DOI: 10.1590/S1516-84842008000400007
Abstract: hodgkin's lymphoma (hl) is a lymphoid malignancy with excellent prognosis, however nearly 15% of the patients in early stages and 35% in advanced stages have progressive disease after initial treatment. autologous bone marrow or hematopoietic stem cell transplantation (abmt) are the treatments of choice in these cases. this report presents the therapeutic approach and the outcome of hl patients who experience relapse after or are refractory to abmt. of 38 patients with lh who underwent abmt between april 1996 and november 2005, 17 presented with relapsed/refractory disease and were included in this analysis. in these cases, the choice of rescue therapy varied upon the clinical conditions of each patient and was based on previously unused chemotherapy agents. after abmt, 10 (59%) of the 17 patients were in complete remission, one (6%) in partial remission and six (35%) were refractory. fourteen of the 17 patients received different schemes of rescue therapy at the time of abmt failure, one patient was treated exclusively with radiotherapy and two died before any treatment. we observed an overall response rate of 57.4% (95% ci: 23.2 - 90.7%). the median progression-free survival was 19 months and the median overall survival was 32 months. despite abtm, relapsed/refractory lh can not be cured with currently available chemotherapeutic agents, the patients had long survival times with frequent exacerbations of the diseas.
Diagnosis and treatment of polycythemia vera: Brazilian experience from a single institution
Linardi, Camila da Cruz Gouveia;Pracchia, Luís Fernando;Buccheri, Valeria;
Sao Paulo Medical Journal , 2008, DOI: 10.1590/S1516-31802008000100010
Abstract: context and objective: polycythemia vera (pv) is a chronic myeloproliferative disorder characterized by predominant proliferation of erythroid precursors. few data are available concerning brazilian patients with this condition. the aim of this study was to describe clinical and demographic characteristics of pv patients at diagnosis and analyze their long-term outcomes. design and setting: retrospective study at the division of hematology, faculdade de medicina da universidade de s?o paulo (fmusp), s?o paulo. methods: all consecutive patients with pv diagnosed according to world health organization criteria were eligible for this study. clinical and demographic characteristics, thrombotic events, transformation to acute leukemia, myelofibrosis and survival were evaluated. results: sixty-six patients were evaluated. thirty-six (54.5%) were females, with a median age at diagnosis of 61 years. at diagnosis, the median hemoglobin concentration was 18.8 mg/dl and the median platelet count was 593,000/mm3. fifty-eight patients (88.0%) were treated with hydroxyurea with or without phlebotomy. during a median follow-up of 77 months, 22 patients (33.3%) had new thrombotic events, mainly of arterial type. the overall incidence of leukemia and myelofibrosis was 0.42% per patient-year and 1.06% per patient-year, respectively. median overall survival was not reached and the seven-year survival rate was 77.8%. conclusion: the pv patients described here had long survival and arterial thrombotic events were the most important and common complication among this population.
The Role of Courage in Intellectual Work  [PDF]
Liliana Beatriz Irizar
Psychology (PSYCH) , 2014, DOI: 10.4236/psych.2014.59114

Intellectual life is not a thing apart from the humanizing and moralizing influences that moral virtues provide. Saint Thomas’s teachings about moral virtues suggest how essential he considers them for a flourishing speculative life. He makes all this very clear in the Second Part of the Summa Theologiae. The potential parts of fortitude which have a crucial role in intellectual work are patience, perseverance and magnanimity. In this article I show how these potential virtues act in speculative life.

Linear Partial Differential Equations of First Order as Bi-Dimensional Inverse Moments Problem  [PDF]
Maria Beatriz Pintarelli
Applied Mathematics (AM) , 2015, DOI: 10.4236/am.2015.66090
Abstract: We consider linear partial differential equations of first order
\"\" on a region \"\". We will see that we can write the equation in partial derivatives as an Fredholm integral equation of the first kind and will solve this latter with the techniques of inverse problem moments. We will find an approximated solution and bounds for the error of the estimated solution using the techniques on problem of moments.
Significado prognóstico dos graus histológicos do linfoma de Hodgkin do tipo esclerose nodular
Pracchia, Luís Fernando;Buccheri, Valeria;Menezes, Yara de;Siqueira, Sheila A. C.;Mori, Nair Sumie;Chamone, Dalton Alencar Fisher;
Jornal Brasileiro de Patologia e Medicina Laboratorial , 2005, DOI: 10.1590/S1676-24442005000500012
Abstract: background: nodular sclerosis (ns), a frequent histological subtype of hodgkin?s lymphoma (hl), presents great variability in its cellular composition. in the 80's, researchers of the british national lymphoma investigation (bnli) proposed a histological-based subclassification for ns hl. they identified two histological grades - ns hl grade i (ns hl i) and ns hl grade ii (ns hl ii) - and reported that ns ii patients had a lower survival rate in comparison with ns i patients. others studies, however, did not reproduce these findings. objective: evaluate the prognostic significance of the bnli grading system. material and method: we retrospectively studied 69 ns hl patients. more than 90% of the included cases were treated with combined modality therapy or exclusive chemotherapy, the treatment type was not different for ns i and ns ii patients. results: thirty-five cases (51%) were classified as ns i and 34 (49%) as ns ii. we did not observe significant differences in the distribution of other prognostic factors between the two ns grades. the complete remission rate after initial therapy was 85.7% in the ns i group and 82.4% in the ns ii group (p = 0.75). the predicted 5-year overall survival rate was 67% in the ns i patients and 83.5% in the ns ii patients (p = 0.13). the predicted 5-year disease free survival rate for nsi and nsii patients was 85.2% and 87%, respectively (p = 0.72). conclusion: the histological bnli grading system was not associated with the prognosis of this uniformly treated ns lh population.
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