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Search Results: 1 - 10 of 6505 matches for " Beatriz;Aldred "
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é necessária a realiza??o de biópsia de medula óssea bilateral para o estadiamento do linfoma difuso de grandes células B?
Bellesso, Marcelo;Velasques, Rodrigo Dolphini;Pracchia, Luis Fernando;Beitler, Beatriz;Aldred, Vera Lúcia;Chamone, Dalton Alencar Fisher;Pereira, Juliana;
Jornal Brasileiro de Patologia e Medicina Laboratorial , 2009, DOI: 10.1590/S1676-24442009000200004
Abstract: this retrospective study aims to analyze the usefulness of bilateral bone marrow biopsy in bone marrow infiltration by diffuse large b-cell lymphoma (dlbcl). our objectives were to assess the incidence of unilateral bm involvement by dlbcl and compare fragment length obtained from positive and negative samples for infiltration. furthermore, we compared the differences between unilateral and bilateral infiltration correlating with lactic dehydrogenase (ldh) and computerized tomography (ct) staging. we evaluated 268 cases of dlbcl and observed medullary infiltration in 34 cases (13%). it was not possible to evaluate 6 out of 34 cases. 70 bm fragments were reviewed as to the presence or absence of infiltration and length. the mean number of fragments per case was 2.5; the mean bm fragment length was 11.01 mm (± 5.12 mm) and the mean bm fragment length per case was 27.53 mm. there was unilateral bm infiltration in six cases (21.4%). there were no differences in the mean fragment length as to the presence/absence of infiltration 10.95 mm (± 5.2 mm) versus 11.57 mm, p > 0.05, respectively. there were no differences in 23 cases between the comparison of unilateral medullary infiltration versus bilateral with lactic dehydrogenase and ct staging. we concluded that bilateral bone marrow biopsy was superior to unilateral because it may increase by 21.4% the detection of bm involvement by dlbcl.
Cars, corporations, and commodities: Consequences for the social determinants of health
James Woodcock, Rachel Aldred
Emerging Themes in Epidemiology , 2008, DOI: 10.1186/1742-7622-5-4
Abstract: In this paper, we explain how thinking about social forms and social processes can develop epidemiological theory about the social determinants of health. We present the case of the car, the related social forms of the commodity and corporation, and the social processes of motorisation and capital accumulation. These concepts help to elucidate the car's role in production and consumption, and how this impacts on health. Our focus on these social forms and social processes introduces an area missing from social epidemiological work with implications for theoretical and empirical work. We discuss these implications for debates on psychosocial versus material pathways and the impact of place on health, before offering suggestions on how to progress the research agenda and identify major anti-health forces.Health inequalities and the social determinants of health have become part of mainstream health discourse. In March 2005, the World Health Organization (WHO) set up a Commission on Social Determinants of Health [1] involving some leading global social epidemiologists.Social epidemiologists have drawn attention to health inequalities as avoidable, unfair and inequitable, challenging the individual risk factor approach and medical solutions dominating much of 20th century research. Developments include using the concept of embodiment to understand health outcomes as the manifestation of social inequalities [2] and the re-emergence of life course approaches investigating long-term and cumulative health effects of exposures [3]. Theoretical schemas combine ecological and social perspectives, including the eco-social model of Krieger [2], the eco-epidemiological model of Susser [4], and the social-ecologic systems perspective of McMichael [5]. The earlier social production perspective, which in Doyal with Pennell's [6] classic text interrogated relationships between commodity production, profit, and health, is explicitly included in Krieger's models. We intend this article
‘Quaker Sweat’ as Intangible Heritage
Benjamin Gratham Aldred
International Journal of Intangible Heritage , 2011,
Abstract: In 2004, a small ritual to be held at a Quaker conference in Massachusetts stirred up a big controversy. The ‘Quaker Sweat’, a syncretic ritual drawing on Lakota, Cherokee and Religious Society of Friends sources, drew protests from a local Native American group. The controversy that emerged within the Friends General Conference, a national Quaker group, highlights the complex dynamics of the cultural property debate. Does the ritual belong to George Price, who developed it? Does the ritual belong to the Lakota, who taught him and gave him permission? Does the ritual belong to the Wampanoag on whose land it was to take place? In the ensuing debate, questions of syncretism and property are examined, taking into account the complex issues of personal versus cultural value, the role of history and experience in cultural property and the complexities of different cultural models of agency related to shared cultural forms. How does a cultural property debate develop between interested actors without the intervention of governments or inter-governmental bodies?
Integrating Citizens in Adaptive Management: A Propositional Analysis
Bruce Shindler,Kristin Aldred Cheek
Ecology and Society , 1999,
Abstract: Lee has advocated for the use of civic science in the implementation of adaptive management experiments, noting that people and political processes are central features of adaptive approaches to land management. This paper explores the growing relationship between the public and forest management agencies, and uses a propositional analysis to guide methods for integrating citizens into adaptive management situations. Important characteristics are organized and discussed in six thematic areas. Citizen-agency interactions are more effective when (1) they are open and inclusive, (2) they are built on skilled leadership and interactive forums, (3) they include innovative and flexible methods, (4) involvement is early and continuous, (5) efforts result in action, and (6) they seek to build trust among participants. Particular attention to the situational context of actions and decisions helps to determine the relevance of adaptive management for individuals in these settings.
Varieties of Capitalism, Varieties of Innovation? A Comparison of Old and New EU Member States
Matthew M. C. Allen,Maria L. Aldred
Journal of Contemporary European Research , 2009,
Abstract: This article seeks, firstly, to shed light on the main claim of the Varieties of Capitalism (VoC) framework that socio-economic institutions can help to shape comparative advantage, and, secondly, to complement existing assessments that have relied predominantly on qualitative data and that have tended to focus on a few economic sectors. It examines the distribution of export success in a number of economic sectors, in which competitiveness is said to be characterised by either radical or incremental innovation, as well as exports in knowledge-intensive service sectors. Unlike previous studies it applies the framework to some of the new member states of the European Union in Central and Eastern Europe. This is an important area to examine the contentions of the VoC framework, because, if those arguments are correct, they should be applicable to the new member states. Moreover, it draws on the latest available data; for indicators measuring export success this is done at the lowest level of aggregation. In contrast to previous studies, a more appropriate measure of trade specialisation, revealed symmetric comparative advantage, is used. Whilst some of the evidence supports the VoC framework, much of it does not. This raises important conceptual and methodological issues that should be addressed by future research.
Environmental Factors and Interactions with Mycobiota of Grain and Grapes: Effects on Growth, Deoxynivalenol and Ochratoxin Production by Fusarium culmorum and Aspergillus carbonarius
Naresh Magan,David Aldred,Russell Hope,David Mitchell
Toxins , 2010, DOI: 10.3390/toxins2030353
Abstract: Mycotoxigenic fungi colonizing food matrices are inevitably competing with a wide range of other resident fungi. The outcomes of these interactions are influenced by the prevailing environmental conditions and the competing species. We have evaluated the competitiveness of F. culmorum and A. carbonarius in the grain and grape food chain for their in vitro and in situ dominance in the presence of other fungi, and the effect that such interactions have on colony interactions, growth and deoxynivalenol (DON) and ochratoxin A (OTA) production. The Index of Dominance shows that changes in water activity (aw) and temperature affect the competitiveness of F. culmorum and A. carbonarius against up to nine different fungi. Growth of both mycotoxigenic species was sometimes inhibited by the presence of other competing fungi. For example, A. niger uniseriate and biseriate species decreased growth of A. carbonarius, while Aureobasidium pullulans and Cladosporium species stimulated growth. Similar changes were observed when F. graminearum was interacting with other grain fungi such as Alternaria alternata, Cladopsorium herbarum and Epicoccum nigrum. The impact on DON and OTA production was very different. For F. culmorum, the presence of other species often inhibited DON production over a range of environmental conditions. For A.carbonarius, on a grape–based medium, the presence of certain species resulted in a significant stimulation of OTA production. However, this was influenced by both temperature and aw level. This suggests that the final mycotoxin concentrations observed in food matrices may be due to complex interactions between species and the environmental history of the samples analyzed.
Toward accurate high-throughput SNP genotyping in the presence of inherited copy number variation
Laura E MacConaill, Micheala A Aldred, Xincheng Lu, Thomas LaFramboise
BMC Genomics , 2007, DOI: 10.1186/1471-2164-8-211
Abstract: To address this issue, we have developed a method to infer a "generalized genotype" from raw SNP microarray data. Here we apply our approach to data from 48 individuals and uncover thousands of aberrant SNPs, most in regions that were previously unreported as copy number variants. We show that our allele-specific copy numbers follow Mendelian inheritance patterns that would be obscured in the absence of SNP allele information. The interplay between duplication and point mutation in our data shed light on the relative frequencies of these events in human history, showing that at least some of the duplication events were recurrent.This new multi-allelic view of SNPs has a complicated role in disease association studies, and further work will be necessary in order to accurately assess its importance. Software to perform generalized genotyping from SNP array data is freely available online [1].A copy number variant (CNV) is defined as a chromosomal segment, at least 1 kb in length, whose (germline) copy number varies across individuals in the human population [2]. As the importance of these duplications and deletions in the study of a variety of diseases [3-6] is being realized, cataloging them and assessing their frequencies has become an important goal. Toward this end, two recent studies [7,8] have exploited erroneous SNP genotype calls, inferring germline deletions at clusters of calls that violate Mendelian inheritance or other conditions. The violations occur, however, as a result of the (diallelic) assumption of three possible genotypes (e.g. GG, GT, or TT) at each SNP site. If this assumption of two copies at each locus were relaxed, one could consider a generalized genotype whereby the SNP is multi-allelic when considering both base residue and copy number. An individual could carry, for example, a GGT (duplication), G – (hemizygous deletion), or – (homozygous deletion) genotype at a SNP locus. As most recent estimates put the proportion of the genome harboring
Amelogenesis imperfecta
Peter JM Crawford, Michael Aldred, Agnes Bloch-Zupan
Orphanet Journal of Rare Diseases , 2007, DOI: 10.1186/1750-1172-2-17
Abstract: Amelogenesis imperfecta (AI) is a term for a clinically and genetically heterogeneous group of conditions that affect the dental enamel, occasionally in conjunction with other dental, oral and extraoral tissues.AI represents a group of conditions, genomic in origin, which affect the structure and clinical appearance of the enamel of all or nearly all the teeth in a more or less equal manner, and which may be associated with morphologic or biochemical changes elsewhere in the body [1]. AI is a developmental condition of the dental enamel (characterised by hypoplasia and/or hypomineralisation) that shows autosomal dominant, autosomal recessive, sex-linked and sporadic inheritance patterns, as well as sporadic cases.Diagnosis involves exclusion of extrinsic environmental or other factors, establishment of a likely inheritance pattern, recognition of phenotype and correlation with the dates of tooth formation to exclude a chronological developmental disturbance.Reports vary widely depending upon the gene pool. Values of 1:14,000 in the USA [2] to 1:700 [3] have been reported.Many classifications of AI have evolved since the original division into hypoplastic and hypocalcified types in 1945 (See Table 1) [1,2,4-13]. Some have been exclusively based on the phenotype (appearance), others have used the phenotype as the primary discriminant and the mode of inheritance as a secondary factor in diagnosis.The multiplicity of classification systems based primarily or exclusively on phenotype can be confusing and it is not always possible to cross-reference between the various subtypes used, or to know which classification system might have been applied to a particular case. It would be ultimately useful to classify conditions by genome and by subsequent biochemistry [12,13]. More recently, it has been proposed that the mode of inheritance should be the primary mode of classification, with the phenotype as the secondary discriminant [1]. Although there are problems which arise fr
The 5q- syndrome
Elvira Deolinda Rodrigues Pereira Velloso,Vera Lucia Aldred
Einstein (S?o Paulo) , 2007,
Functional Profiling Reveals Critical Role for miRNA in Differentiation of Human Mesenchymal Stem Cells
Angela Schoolmeesters, Teresa Eklund, Devin Leake, Annaleen Vermeulen, Queta Smith, Shelley Force Aldred, Yuriy Fedorov
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0005605
Abstract: Background Mesenchymal stem (MS) cells are excellent candidates for cell-based therapeutic strategies to regenerate injured tissue. Although human MS cells can be isolated from bone marrow and directed to differentiate by means of an osteogenic pathway, the regulation of cell-fate determination is not well understood. Recent reports identify critical roles for microRNAs (miRNAs), regulators of gene expression either by inhibiting the translation or by stimulating the degradation of target mRNAs. Methodology/Principal Findings In this study, we employed a library of miRNA inhibitors to evaluate the role of miRNAs in early osteogenic differentiation of human MS cells. We discovered that miR-148b, -27a and -489 are essential for the regulation of osteogenesis: miR-27a and miR-489 down-regulate while miR-148b up-regulates differentiation. Modulation of these miRNAs induced osteogenesis in the absence of other external differentiation cues and restored osteogenic potential in high passage number human MS cells. Conclusions/Significance Overall, we have demonstrated the utility of the functional profiling strategy for unraveling complex miRNA pathways. Our findings indicate that miRNAs regulate early osteogenic differentiation in human MS cells: miR-148b, -27a, and -489 were found to play a critical role in osteogenesis.
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