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Search Results: 1 - 10 of 13532 matches for " Beatriz Sanchez-Correa "
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CMV Latent Infection Improves CD8+ T Response to SEB Due to Expansion of Polyfunctional CD57+ Cells in Young Individuals
Alejandra Pera, Carmen Campos, Alonso Corona, Beatriz Sanchez-Correa, Raquel Tarazona, Anis Larbi, Rafael Solana
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0088538
Abstract: Cytomegalovirus (CMV) latent infection has a deleterious effect on the efficacy of influenza vaccination in the elderly, suggesting that CMV restricts immunological diversity impairing the immune system functionality in old age. Polyfunctional T cells produce multiple cytokines and higher amounts than mono-functional T cells. High number of polyfunctional T cells correlates with better prognosis during infection. Thus, the efficiency of T cell response associates with quality (polyfunctionality) rather than with quantity (percentage of T cells). We analyze the effect of CMV infection on CD8+ T cells polyfunctionality ―degranulation (CD107a), IFN-gamma and TNF-alpha production―, from young CMV-seropositive and CMV-seronegative individuals and in middle age CMV-seropositive donors, in response to Staphylococcal Enterotoxin B (SEB). Our results show a higher percentage of polyfunctional CD8+ T cells in young CMV-seropositive individuals compared to CMV-seronegative. Also, we find an expansion of CD8+CD57+ T cells in CMV-seropositive individuals, which are more polyfunctional than CD8+CD57? cells. In middle age individuals there is a higher frequency of SEB-responding CD8+ T cells, mainly TNF-alpha or TNF-alpha/IFN-gamma producers, whereas the percentage of polyfunctional cells (IFN-gamma/TNF-alpha/CD107a) is similar to the percentages found in young CMV-seropositive. Therefore, whereas it has been shown that CMV latent infection can be detrimental for immune response in old individuals, our results indicate that CMV-seropositivity is associated to higher levels of polyfunctional CD8+ T cells in young and middle age donors. This increase in polyfunctionality, which can provide an immunological advantage in the response to other pathogens, is due to a CD8+CD57+ T cell expansion in CMV-seropositive individuals and it is independent of age. Conversely, age could contribute to the inflammation found in old individuals by increasing the percentage of cells producing pro-inflammatory cytokines. These findings highlight the necessity of further studies on the benefits/detrimental effects of CMV infection in the response to vaccination and other infections.
El modelo de rasch en dirección de operaciones
Lidia Sanchez,Beatriz Blanco
WPOM : Working Papers on Operations Management , 2012, DOI: 10.4995/wpom.v3i2.1037
Abstract: Durante décadas, en el área de Dirección de Operaciones, se ha destacado la necesidad de un acercamiento entre el mundo académico y el profesional, reclamando la realización de estudios empíricos que aporten soluciones prácticas a los profesionales. De ahí que durante los últimos a os se hayan producido dos fenómenos clave: la convergencia entre los temas objeto de investigación y los temas de interés para las empresas; y un aumento en el número de estudios empíricos realizados. Ahora bien, otro factor importantísimo a la hora de aportar conocimientos prácticos a la disciplina es la herramienta o metodología aplicada. Por ello, el desarrollo de nuevas herramientas o la aplicación de otras ya existentes en otros campos es un tema interesante. Es en este punto donde adquiere importancia la Metodología de Rasch. Esta técnica ha sido tradicionalmente utilizada en disciplinas tales como la Psicología o la Medicina. Sin embargo, ya hace algunos a os, ha comenzado a utilizarse en otras áreas de conocimiento, entre ellas, el área de Administración y Dirección de Empresas. No obstante, su aplicación al área concreta de Operaciones es escasa y, por ello, las posibilidades de desarrollo e investigaciones futuras son numerosas. La Metodología de Rasch, útil para el dise o y la explotación de encuestas, se basa en tres principios, unidimensionalidad, aditividad e invarianza, y permite obtener medidas objetivas a partir del análisis de variables categóricas. Entre sus múltiples aplicaciones destacamos las siguientes: análisis de la viabilidad y fiabilidad globales, análisis de la unidimensionalidad del constructo, análisis de escalas del cuestionario, priorización (ordenación) de los ítems y/o de los sujetos, análisis DAFO… Es, por lo tanto, una metodología muy rica con multitud de posibilidades para su aplicación en la disciplina. Dado su incipiente desarrollo en esta área de conocimiento el objetivo de este trabajo es, por un lado, presentar la Metodología de Rasch y, por otro, realizar un análisis bibliométrico (con el software Sitkis) sobre el Modelo de Rasch aplicado al área de la gestión (Management). Este análisis permitirá: observar la evolución temporal de las publicaciones, conocer cuáles son las obras de obligada consulta, conocer los autores de referencia en el área así como las publicaciones (fuentes) más importantes. Consideramos que el presente trabajo es interesante dado que da a conocer una novedosa metodología para su aplicación en el área de Operaciones y, además, aporta información relevante para todos aquellos que, interesados en la misma, quier
La movilidad social en Tucumán, Argentina, 1869-1895 Social Mobility in Tucumán, Argentina, 1869-1895
Beatriz álvarez,María Florencia Correa Deza
América Latina en la historia económica , 2013,
Abstract: Este trabajo analiza la movilidad social en Tucumán durante el periodo 1869-1895, utilizando una metodología que permite comparar niveles de vida de individuos en dos etapas diferentes del ciclo de vida. Los resultados sugieren la presencia de movilidad pero de una magnitud considerablemente menor a la que retratan las visiones impresionistas de estadistas y viajeros de la época y a la sugerida por la historiografía para el caso del Litoral. Creemos que a pesar del gran crecimiento económico experimentado por la provincia a fines del siglo XIX, la mayor presencia de rasgos tradicionales en relación con los modernos, en el espacio provincial, podría haber moderado los beneficios de este proceso. Tanto la singular distribución de las variables educativas como las particularidades de la migración recibida por la provincia constituyen algunos elementos de este rezago. In this paper we try to analyze social mobility in Tucumán during the 18691895 period by using a methodology that enables us to compare living standards from individuals in different life cycle stages. Our results suggest the existence of mobility but in a considerably lower magnitude than the views provided by travelers and statesmen notes and than the image for other regions in the country posed by the researchers. We believe that in spite of the significant economic growth experienced during this period, the stronger presence of traditional features, relative to the modern aspects, could have lessened benefits from this process. The peculiar distribution of educational variables and the fact of receiving mostly native immigration were some elements of this lag.
Plantas que causam altera??es mecanicas ou traumáticas em ruminantes e equinos, com ênfase em Stipa spp. (Gramineae)
Riet-Correa, Beatriz;Riet-Correa, Gabriela;Riet-Correa, Franklin;
Pesquisa Veterinária Brasileira , 2011, DOI: 10.1590/S0100-736X2011000600010
Abstract: many plants cause mechanical injury in horses and ruminants, as those that cause traumatism on skin and mucosa, and those that cause lesions in the digestive system, including esophagus obstruction, rumen overload, and intestinal obstruction. in this paper, plants causing mechanical injury to ruminants and horses in brazil are reviewed, and an outbreak in sheep of mechanical injury of the skin by stipa sp. in uruguay is reported. the sheep, mainly lambs, showed large number of fruits of stipa sp. in the wool, some of them penetrating the skin, panniculus adiposus, and cutaneous trunci muscle, causing multifocal dermatitis and panniculitis.
Chuva de sementes em uma floresta de galeria no Parque do Bacaba, em Nova Xavantina, Mato Grosso, Brasil
Lagos, Maria do Carmo Correa;Marimon, Beatriz Schwantes;
Revista árvore , 2012, DOI: 10.1590/S0100-67622012000200012
Abstract: the study was carried out in the gallery forest of the bacaba stream, municipal bacaba park (14o43'12.2s e 52o21'36.7"w) in nova xavantina, mato grosso state, brazil. seed rain was studied and compared among three forest sections (upper, middle and lower), 200 m away from each other, running downstream and differing in slope. twenty circular seed-traps (0.3 m2) were randomically distributed at each forest section and monitored from june 2007 to may 2008. seeds were dried until constant weight, and classified in two categories, based on the presence of flight structures (v) and the absence of these structures (nv). number of morpho-species, seeds and biomass were compared at the forest sections through the dry and rainy periods. it was collected 20,965 seeds over 24 fortnights, being 777 seeds type v and 20,188 seeds type nv. in the upper section, 52 morpho-species of seeds were recorded in the middle 55 and in the lower 49. the morpho-species diversity of seeds was lower than the diversity of the woody species in the same area. regarding the seasonal pattern for seed rain, for v (number, morpho-species and biomass) and for nv seeds (biomass) as well, the control of visitors in the bacaba park especially in the dispersion peak of seeds at the end of dry period and the beginning of the rains (september-december) is recommended. tour of minimum impact may benefit the establishment of seeds and seedlings and ensure sustainability of the forest.
A moda, como meio de comunica o, gera símbolos diferenciados de tecnologia
Eliane Meire Soares Raslan,Beatriz Correa Pires Dornelles
Conex?o : Comunica??o e Cultura , 2010,
Abstract: Em cada esta o do ano, as grifes da moda mudam suas principais tendências no sentido das cores e estampas em diversos estilos. Este artigo busca mostrar o mercado promissor do mundo da moda e investimentos na produ o, na administra o e na profissionaliza o, o que dá início a mudan as no Brasil. Diversas variáveis orientam a imagem da moda, gerando símbolos e sentimentos múltiplos através do uso da comunica o. Valorizando o conhecimento sobre o assunto tratado, é possível utilizar a forma simbólica, que ajudará o mercado da moda a crescer e a desempenhar um papel muito importante na conserva o dos sistemas sociais e culturais. Com as novas op es de cursos rápidos e cursos universitários na área da moda, surgem uma configura o e uma reconfigura o do corpo humano na sua expans o. Por meio de análise teórica, será possível se aproximar do entendimento do uso do significado humano através de sua intera o, na forma de se comunicar, transmitindo uma mensagem ao indivíduo através da roupa. E saber se expressar de maneira correta para conseguir ser reconhecido e valorizado garantindo a confian a de um novo mercado da moda: o tecnológico. Quem n o o utiliza está fora do mercado.
Detection of ABCC1 expression in classical Hodgkin lymphoma is associated with increased risk of treatment failure using standard chemotherapy protocols
Greaves Wesley,Xiao Lianchun,Sanchez-Espiridion Beatriz,Kunkalla Kranthi
Journal of Hematology & Oncology , 2012, DOI: 10.1186/1756-8722-5-47
Abstract: Background The mechanisms responsible for chemoresistance in patients with refractory classical Hodgkin lymphoma (CHL) are unknown. ATP-binding cassette (ABC) transporters confer multidrug resistance in various cancers and ABCC1 overexpression has been shown to contribute to drug resistance in the CHL cell line, KMH2. Findings We analyzed for expression of five ABC transporters ABCB1, ABCC1, ABCC2, ABCC3 and ABCG2 using immunohistochemistry in 103 pre-treatment tumor specimens obtained from patients with CHL. All patients received first-line standard chemotherapy with doxorubicin (Adriamycin ), bleomycin, vinblastine, and dacarbazine (ABVD) or equivalent regimens. ABCC1 was expressed in Hodgkin and Reed-Sternberg (HRS) cells in 16 of 82 cases (19.5%) and ABCG2 was expressed by HRS cells in 25 of 77 cases (32.5%). All tumors were negative for ABCB1, ABCC2 and ABCC3. ABCC1 expression was associated with refractory disease (p = 0.01) and was marginally associated with poorer failure-free survival (p = 0.06). Multivariate analysis after adjusting for hemoglobin and albumin levels and age showed that patients with CHL with HRS cells positive for ABCC1 had a higher risk of not responding to treatment (HR = 2.84, 95%, CI: 1.12-7.19 p = 0.028). Conclusions Expression of ABCC1 by HRS cells in CHL patients predicts a higher risk of treatment failure and is marginally associated with poorer failure-free survival using standard frontline chemotherapy regimens.
The effect of tryptophan administration on the circadian rhythms of melatonin in plasma and the pineal gland of rats
Soledad Sanchez,Cristina Lucia Sanchez,Sergio Damian Paredes,Ana Beatriz Rodriguez
Journal of Applied Biomedicine , 2008,
Abstract: The most physiological processes that take place in the body have a circadian rhythm which is controlled by an internal biological clock located in the suprachiasmatic nucleus. The indole melatonin synthesized in the pineal gland, acts to synchronize these biological rhythms, and also it is synthesized and released following a circadian rhythm. The present study analyzed the levels of melatonin over a 24-hour period in Wistar rats in both basal and control conditions and after the oral administration of 125 mg/kg tryptophan, the amino acid that is the precursor of this indole, for 7 days. The levels of melatonin in the plasma and the pineal gland were measured by radioimmunoassay every hour during the night, and every 4 hours during the day. The results indicated that the tryptophan administration provoked raised levels of melatonin at all hours studied in both plasma and pineal. Of the chronobiological parameters studied, there were also increases in the values of the melatonin MESOR with respect to the values obtained in the basal and control groups (the respective increases being 45% and 52% in plasma, and 46% and 47% in the pineal), as well as an advanced acrophase with respect to the basal and control groups. In summary, our findings confirm that tryptophan intake one hour before lights-off increases melatonin levels in plasma and pineal over a 24-hour period, as well as advancing the peak of its synthesis.
Uso da microalbuminúria em amostras urinárias aleatórias para o rastreamento de pré-eclampsia em grávidas diabéticas
Sanchez Victor Hugo Saucedo,Bertini Anna Maria,Taborda Wladimir Correa,Barros Rosy Ane Araujo
Revista Brasileira de Ginecologia e Obstetrícia , 2003,
Abstract: OBJETIVO: avaliar o desempenho da dosagem de microalbuminúria como método para rastreamento de pré-eclampsia MéTODOS: estudo prospectivo longitudinal no qual foram incluídas 45 grávidas diabéticas. Foi quantificada a microalbuminúria em três períodos distintos da gravidez: antes da 18a semana, entre a 18a e a 24a semana e entre a 32a e a 36a semana de gravidez. Todas as pacientes freqüentaram o pré-natal entre janeiro de 2000 e dezembro de 2001. O ensaio de microalbuminúria/creatinina é método quantitativo para medir baixas concentra es de albumina, creatinina e a rela o albumina/creatinina na urina. Como critério indicativo de dano renal incipiente e risco para pré-eclampsia foi empregada a rela o albumina/creatinina maior que 16 mg/g. A sensibilidade, especificidade, valor preditivo positivo e valor preditivo negativo da rela o albumina/creatinina foram calculados para predizer a ocorrência ou ausência de pré-eclampsia. RESULTADOS: do total de pacientes, 17% apresentaram pré-eclampsia. A sensibilidade da rela o albumina/creatinina foi crescente de 12,5% com 18 semanas para 25% entre 18 e 24 semanas e 87% após a 32a semana. Em contraste, a especificidade teve valor decrescente de 97 para 89 e 83%, respectivamente. O valor preditivo positivo foi relativamente baixo, com valores de 50, 33 e 53% nos três diferentes períodos de avalia o. De outro modo, o valor preditivo negativo foi elevado nas três faixas de idade gestacional, com valores de 83, 84 e 96%. CONCLUS ES: a quantifica o aleatória da microalbuminúria p de predizer corretamente a n o ocorrência de pré-eclampsia em grávidas diabéticas, sendo pouco eficiente para a identifica o correta das pacientes que evoluíram com pré-eclampsia.
Morpho-anatomy and criopreservation effects on phisiologycal quality of soapberry seeds Morfoanatomía y respuesta fisiológica de las semillas de chambimbe a condiciones de crioconservación
Bonilla Correa Carmen Rosa,Arce Kadaffi,Sanchez Manuel Salvador,Escobar Roosvelt
Acta Agronómica , 2007,
Abstract: The aims of this research were: to describe the seed morphoanatomy of soap berry, to evaluate drying conditions, physiology of the seeds in cryopreservation and mechanical scarification of seeds. The study was carried out in the laboratories of the National University of Colombia at Palmira branch and the Humboldt Institute of the International Center of Tropical Agriculture (CIAT) with seeds harvested in August of 2005, in Palmira. The study was made in two phases: first, to carried out the characterization, morphoanatomical description and pre-treatments of mechanical scarification. Second, to establish curves of drying with different relations from sílica gel. Storage of seeds in liquid nitrogen to test germination after a month of storage. The results showed that with a moisture content of 12%, the best treatment of scarification was with manual drill. The germination was of 96%. The drying and cryopreservation treatment did not affect germination of the seeds. This test demonstrated that seeds with 12% of moisture and 92% of germination can be stored En los laboratorios de la Universidad Nacional de Colombia Sede Palmira y del Instituto Humboldt del Centro Internacional de Agricultura Tropical (CIAT) se realizó el estudio de caracterización, descripción morfoanatómica y evaluación de tratamientos de escarificación mecánica de semillas de chambimbe cosechadas en agosto de 2005 en Palmira. La estructura de protección la constituye un tejido conformado por varias capas, la más externa lignificada y de color negro, que también regula el intercambio líquido y gaseoso a través del micrópilo; muchas veces el poro está sellado. El contenido de humedad de semillas cosechadas del suelo fue de 12% y el mejor tratamiento de escarificación fue la perforación cerca del micrópilo con taladro manual (96% de germinación). El secado (sílica gel) y la crioconservación (nitrógeno líquido) durante un mes afectaron la germinación, indicando el posible comportamiento no ortodoxo de estas semillas, las cuales se pueden almacenar con 12% de humedad y 92% de germinación.
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