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Search Results: 1 - 10 of 10901 matches for " Beatriz Perez-Nevot "
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Genetic polymorphisms in folate pathway enzymes, DRD4 and GSTM1 are related to temporomandibular disorder
Angel Aneiros-Guerrero, Ana M Lendinez, Arturo R Palomares, Beatriz Perez-Nevot, Lidia Aguado, Alvaro Mayor-Olea, Maximiliano Ruiz-Galdon, Armando Reyes-Engel
BMC Medical Genetics , 2011, DOI: 10.1186/1471-2350-12-75
Abstract: A case-control study was designed to evaluate the impact of genetic polymorphisms above described on TMD. A total of 229 individuals (69% women) were included at the study; 86 were patients with TMD and 143 were healthy control subjects. Subjects underwent to a clinical examination following the guidelines by the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD). Genotyping of 20 Single Nucleotide Polymorphisms (SNPs), divided in two groups, was performed by multiplex minisequencing preceded by multiplex PCR. Other seven genetic polymorphisms different from SNPs (deletions, insertions, tandem repeat, null genotype) were achieved by a multiplex-PCR. A chi-square test was performed to determine the differences in genotype and allelic frequencies between TMD patients and healthy subjects. To estimate TMD risk, in those polymorphisms that shown significant differences, odds ratio (OR) with a 95% of confidence interval were calculated.Six of the polymorphisms showed statistical associations with TMD. Four of them are related to enzymes of folates metabolism: Allele G of Serine Hydoxymethyltransferase 1 (SHMT1) rs1979277 (OR = 3.99; 95%CI 1.72, 9.25; p = 0.002), allele G of SHMT1 rs638416 (OR = 2.80; 95%CI 1.51, 5.21; p = 0.013), allele T of Methylentetrahydrofolate Dehydrogenase (MTHFD) rs2236225 (OR = 3.09; 95%CI 1.27, 7.50; p = 0.016) and allele A of Methionine Synthase Reductase (MTRR) rs1801394 (OR = 2.35; 95CI 1.10, 5.00; p = 0.037). An inflammatory oxidative stress enzyme, Gluthatione S-Tranferase Mu-1(GSTM1), null allele (OR = 2.21; 95%CI 1.24, 4.36; p = 0.030) and a neurotransmission receptor, Dopamine Receptor D4 (DRD4), long allele of 48 bp-repeat (OR = 3.62; 95%CI 0.76, 17.26; p = 0.161).Some genetic polymorphisms related to folates metabolism, inflammatory oxidative stress, and neurotransmission responses to pain, has been significantly associated to TMD syndromeTemporomandibular joint disorder (TMD) is characterized by a set of symptoms
5-Aminolevulinic Acid (5-ALA): Analysis of Preclinical and Safety Literature  [PDF]
Michael H. Perez, Beatriz L. Rodriguez, Terry T. Shintani, Keitaro Watanabe, Setsuko Miyanari, Rosanne C. Harrigan
Food and Nutrition Sciences (FNS) , 2013, DOI: 10.4236/fns.2013.410131
Abstract:

Problem: 5-ALA has been used for many years at relatively high dose amounts in single doses for photodynamic therapy and immunofluorescence of tumors. An analysis of compiled data relating to safety and any side-effects about the use of 5-ALA at low doses has not yet been published. Purpose: This report analyzes data about the safety of the use of 5-Aminolevulinic Acid (5-ALA) in low doses as a supplement over an extended period of time. Methods: This investigation is a systematic analysis of the current literature ((Medline, and SBI) and snowballing techniques) related to the safety and efficacy of 5-ALA in animals and humans. Clinical trials in progress using 5-ALA were also analyzed. Constant comparative analyses were used to synthesize the findings. Results: The safety of low-dose 5-ALA as a supplement has been demonstrated by animal and human studies. The results suggest that none of the investigations document the presence of symptoms or abnormal laboratory results of clinical significance. The minor laboratory changes documented were judged not clinically significant.

The Role of 5-Aminolevulinic Acid (5-ALA) and Sleep  [PDF]
Michael H. Perez, Terry T. Shintani, Beatriz L. Rodriguez, James Davis, Rosanne C. Harrigan
International Journal of Clinical Medicine (IJCM) , 2013, DOI: 10.4236/ijcm.2013.410A001
Abstract: Objective: To determine if there is a relationship between the administration of the dietary supplement containing 5-Aminolevulinic Acid (5-ALA) and sleep. Methods: A double-blind, randomized parallel-group study was conducted. It was a 4-month study of 40 participants between the ages of 40 and 70. Males and females were recruited equally. There were 20 in each group who had existing sleep disorders. The tool used to measure participant sleep improvement included the Pittsburgh Insomnia Rating Scale-20 Question (PIRS-20). Improved sleep is reflected when the total PIRS-20 score is lower. Results: Improvement in sleep in the group taking 50 mg 5-ALA, compared to controls, was significant. The mean change, from baseline through week 6, was -5.67 units less on the sleep scale than the control group with a p value of 0.001. The mean change from week 6 to week 10 when the participant was no longer taking the supplement was 4.55 units higher than the control group with a p value of 0.062, which is of borderline significance. Conclusions: There is a relationship between the administration of dietary supplements containing 5-ALA and sleep. The results of this study suggest that 5-ALA is associated with improved sleep. The mechanism for sleep improvement needs to be explored. Further research is warranted.
Review of literature: Role of 5-aminolevulinic acid and sleep  [PDF]
Michael H. Perez, Beatriz L. Rodriguez, Terry T. Shintani, Terry T. Shintani, Rosanne C. Harrigan
World Journal of Neuroscience (WJNS) , 2013, DOI: 10.4236/wjns.2013.34042
Abstract:

Objective: To determine if current peer-reviewed literature supports the existence of a relationship between the administration of dietary supplements containing 5-Aminolevulinic Acid (5-ALA) and sleep. Methods: Conceptual analysis of a systematically defined group of data is based on publications in referred journals. Constant comparative analyses were used to analyze the data. Detailed analyses were used to identify trends that led to qualifying relationships between the use of 5-ALA and heme. In addition, the relationship among heme, melatonin, and sleep were explored. Since there were no published data related to 5-ALA and sleep, an analysis of what is known about 5-ALA and heme was undertaken. Results: Currently, within the scope of this review, no literature available directly connecting 5-ALA and sleep was found. Research indicates that 5-ALA has an indirect relationship with intra-cellular energy production, which could result in a wide range of effects fromcellular to endocrine to neurologic to behavioral. In addition, there is evidence that 5-ALA may influence tryptophan and serotonin levels. Conclusion: While there are no studies on 5-ALA and sleep were found, current research suggests several potential mechanisms by which 5-ALA could influence sleep. The mechanisms suggest the potential for 5-ALA to assist in the adjustment of a person’s circadian cycle, endocrine function, or neurologic function in order to allow for better sleep in a natural way. In doing so, it may provide for a safer alternative to currently available sleep medication. Further research is needed to explore this possibility.

Cuestión se?orial y arbitrismo en la Espa?a del trienio liberal: Observaciones sobre un proyecto de ley de Manuel María Cambronero (1765 - 1834)
López Nevot,José Antonio;
Revista de estudios histórico-jurídicos , 2005, DOI: 10.4067/S0716-54552005000100007
Abstract: this article discusses the problem posed by the noble domain in the spain of the liberal triennial through an interpretive bill of the abolitionist law of the cadiz courts as of august 6th, 1811, published in 1821by an anonymous jurist, although apparently it was manuel maría cambronero (1765-1834) who did. in said bill, although cambronero proposes, on the one hand, the abolition of all personal services and assistance, whether their origin is found in the domain jurisdiction or in any other, even if it were the contract, it declares, on the other, that ancestral and territorial domains be protected, thus favoring the interests of the ancient lords.
Cuestión se orial y arbitrismo en la Espa a del trienio liberal: Observaciones sobre un proyecto de ley de Manuel María Cambronero (1765 - 1834)
José Antonio López Nevot
Revista de estudios histórico-jurídicos , 2005,
Abstract: En el artículo se estudia la problemática del régimen se orial en la Espa a del Trienio Liberal, a través de un proyecto de ley interpretativa del Decreto abolicionista de las Cortes de Cádiz de 6 de agosto de 1811, publicado en 1821 por un jurista anónimo, aunque todo parece indicar que se trata de Manuel María Cambronero (1765 - 1834). En el citado proyecto de ley, si bien Cambronero propone la abolición de todos los servicios y prestaciones personales, ya tuvieran por origen la jurisdicción se orial, ya cualquier otro, aunque fuese el contrato, por otra parte declara protegidos los se oríos solariegos y territoriales, favoreciendo así los intereses de los antiguos se ores. This article discusses the problem posed by the noble domain in the Spain of the Liberal Triennial through an interpretive bill of the abolitionist Law of the Cadiz Courts as of August 6th, 1811, published in 1821by an anonymous jurist, although apparently it was Manuel María Cambronero (1765-1834) who did. In said bill, although Cambronero proposes, on the one hand, the abolition of all personal services and assistance, whether their origin is found in the domain jurisdiction or in any other, even if it were the contract, it declares, on the other, that ancestral and territorial domains be protected, thus favoring the interests of the ancient lords.
Polymorphisms of CD16A and CD32 Fcγ receptors and circulating immune complexes in Ménière's disease: a case-control study
José A Lopez-Escamez, Pablo Saenz-Lopez, Irene Gazquez, Antonia Moreno, Carlos Gonzalez-Oller, Andrés Soto-Varela, Sofía Santos, Ismael Aran, Herminio Perez-Garrigues, águeda Iba?ez, Miguel A Lopez-Nevot
BMC Medical Genetics , 2011, DOI: 10.1186/1471-2350-12-2
Abstract: The functional CD16A (FcγRIIIa*559A > C, rs396991) and CD32A (FcγRIIa*519A > G, rs1801274) SNPs were analyzed using PCR-based TaqMan Genotyping Assay in two cohorts of 156 mediterranean and 112 Galicia patients in a case-control study. Data were analyzed by χ2 with Fisher's exact test and Cochran-Armitage trend test (CATT). CIC were measured by ELISA for C1q-binding CIC.Elevated CIC were found in 7% of patients with MD during the intercrisis period. No differences were found in the allelic frequency for rs396991 or rs1801274 in controls subjects when they were compared with patients with MD from the same geographic area. However, the frequency of AA and AC genotypes of CD16A (rs396991) differed among mediterranean and Galicia controls (Fisher's test, corrected p = 6.9 × 10-4 for AA; corrected p = 0.02 for AC). Although genotype AC of the CD16A receptor was significantly more frequent in mediterranean controls than in patients, [Fisher's test corrected p = 0.02; OR = 0.63 (0.44-0.91)], a genetic additive effect for the allele C was not observed (CATT, p = 0.23). Moreover, no differences were found in genotype frequencies for rs396991 between patients with MD and controls from Galicia (CATT, p = 0.14). The allelic frequency of CD32 (rs1801274) was not different between patients and controls either in mediterranean (p = 0.51) or Galicia population (p = 0.11).Elevated CIC are not found in most of patients with MD. Functional polymorphisms of CD16A and CD32 genes are not associated with onset of MD.Ménière's disease (MD) is a chronic disease defined by recurrent spells of vertigo associated with sensorineural hearing loss and tinnitus or aural fullness. Different autoimmune diseases share susceptibility loci, but consistent associations with multiple autoimmune disorders have been restricted to three genes: the human leukocyte antigen (HLA) DRB1 gene, the PTPN22 gene encoding lymphoid tyrosine phosphatase LYP and the gene encoding cytotoxic T lymphocyte-associated 4 (CTL
Anomalias oculares e características genéticas na síndrome de Marfan
Sallum, Juliana Maria Ferraz;Chen, Jane;Perez, Ana Beatriz Alvarez;
Arquivos Brasileiros de Oftalmologia , 2002, DOI: 10.1590/S0004-27492002000600005
Abstract: purpose: to identify the ocular abnormalities in marfan′s syndrome patients. methods: prospective study of 46 marfan patients with complete ophthalmologic evaluation. seventeen patients also underwent a clinical genetic and molecular analysis. results: among the 46 patients included in this study, the following ocular abnormalities were found more frequently: ectopia lentis (67.3%), hypoplastic irides (67.3%), retinal detachment (7.6%), flattened cornea (2.2%), megalocornea (2.2%) and myopia (34.8%). five patients (10.9%) presented normal ocular evaluation in both eyes. a pathogenic mutation different from those published in other studies was found in one patient. conclusions: ocular abnormalities in marfan′s syndrome are frequent. the better understanding of the fbn-1 gene and its expression in the eye are very helpful tools for the diagnosis and treatment of the abnormalitites.
Estresse hídrico e reguladores de crescimento na germina??o de sementes de canafístula
Botelho, Beatriz Amoroso;Perez, Sonia Cristina Juliano Gualtieri de Andrade;
Scientia Agricola , 2001, DOI: 10.1590/S0103-90162001000100008
Abstract: scarified selected seeds of the wood tree species 'canafístula' were submitted to water stress at 27oc, with and without addition of putrescine and spermidine at concentrations of 5 and 10mm and gibberellin 0.1mm. the values of rate and germination percentage of all the experiments indicated that the seeds are resistant to water stress. when putrescine and spermidine were added to the germination media the performance under stress increased significantly. gibberellin extended the maximal tolerance limit to water stress.
Anomalias oculares e características genéticas na síndrome de Marfan
Sallum Juliana Maria Ferraz,Chen Jane,Perez Ana Beatriz Alvarez
Arquivos Brasileiros de Oftalmologia , 2002,
Abstract: Objetivo: Para se identificar as altera es oculares presentes na síndrome de Marfan, este trabalho apresenta a avalia o oftalmológica de 46 indivíduos portadores desta doen a. Métodos: Estudo prospectivo com avalia o clínica de 46 pacientes portadores de síndrome de Marfan com avalia o oftalmológica completa. Dezessete pacientes também foram submetidos a exame genético clínico e estudo molecular. Resultados: Dos quarenta e seis pacientes incluídos neste estudo, as seguintes altera es oculares foram encontradas com maior freqüência: subluxa o do cristalino (67,3%), hipoplasia de íris (23,9%), descolamento de retina (7,6%), córnea plana (2,2%), megalocórnea (2,2%) e miopia ou astigmatismo miópico (34,8%). Cinco pacientes (10,9%) apresentaram exame ocular normal em ambos os olhos. Detectou-se uma muta o patogênica distinta das relatadas na literatura em uma paciente, uma muta o de sentido trocado que ocorreu no éxon 28 levando à mudan a de aminoácido C1166Y. Conclus es: As altera es oculares da síndrome de Marfan s o freqüentes e o conhecimento do gene responsável FBN-1 e de sua express o no olho auxiliam para o diagnóstico e tratamento destas anomalias.
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