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Search Results: 1 - 10 of 218066 matches for " Beatriz L. Rodriguez "
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5-Aminolevulinic Acid (5-ALA): Analysis of Preclinical and Safety Literature  [PDF]
Michael H. Perez, Beatriz L. Rodriguez, Terry T. Shintani, Keitaro Watanabe, Setsuko Miyanari, Rosanne C. Harrigan
Food and Nutrition Sciences (FNS) , 2013, DOI: 10.4236/fns.2013.410131

Problem: 5-ALA has been used for many years at relatively high dose amounts in single doses for photodynamic therapy and immunofluorescence of tumors. An analysis of compiled data relating to safety and any side-effects about the use of 5-ALA at low doses has not yet been published. Purpose: This report analyzes data about the safety of the use of 5-Aminolevulinic Acid (5-ALA) in low doses as a supplement over an extended period of time. Methods: This investigation is a systematic analysis of the current literature ((Medline, and SBI) and snowballing techniques) related to the safety and efficacy of 5-ALA in animals and humans. Clinical trials in progress using 5-ALA were also analyzed. Constant comparative analyses were used to synthesize the findings. Results: The safety of low-dose 5-ALA as a supplement has been demonstrated by animal and human studies. The results suggest that none of the investigations document the presence of symptoms or abnormal laboratory results of clinical significance. The minor laboratory changes documented were judged not clinically significant.

The Role of 5-Aminolevulinic Acid (5-ALA) and Sleep  [PDF]
Michael H. Perez, Terry T. Shintani, Beatriz L. Rodriguez, James Davis, Rosanne C. Harrigan
International Journal of Clinical Medicine (IJCM) , 2013, DOI: 10.4236/ijcm.2013.410A001
Abstract: Objective: To determine if there is a relationship between the administration of the dietary supplement containing 5-Aminolevulinic Acid (5-ALA) and sleep. Methods: A double-blind, randomized parallel-group study was conducted. It was a 4-month study of 40 participants between the ages of 40 and 70. Males and females were recruited equally. There were 20 in each group who had existing sleep disorders. The tool used to measure participant sleep improvement included the Pittsburgh Insomnia Rating Scale-20 Question (PIRS-20). Improved sleep is reflected when the total PIRS-20 score is lower. Results: Improvement in sleep in the group taking 50 mg 5-ALA, compared to controls, was significant. The mean change, from baseline through week 6, was -5.67 units less on the sleep scale than the control group with a p value of 0.001. The mean change from week 6 to week 10 when the participant was no longer taking the supplement was 4.55 units higher than the control group with a p value of 0.062, which is of borderline significance. Conclusions: There is a relationship between the administration of dietary supplements containing 5-ALA and sleep. The results of this study suggest that 5-ALA is associated with improved sleep. The mechanism for sleep improvement needs to be explored. Further research is warranted.
Review of literature: Role of 5-aminolevulinic acid and sleep  [PDF]
Michael H. Perez, Beatriz L. Rodriguez, Terry T. Shintani, Terry T. Shintani, Rosanne C. Harrigan
World Journal of Neuroscience (WJNS) , 2013, DOI: 10.4236/wjns.2013.34042

Objective: To determine if current peer-reviewed literature supports the existence of a relationship between the administration of dietary supplements containing 5-Aminolevulinic Acid (5-ALA) and sleep. Methods: Conceptual analysis of a systematically defined group of data is based on publications in referred journals. Constant comparative analyses were used to analyze the data. Detailed analyses were used to identify trends that led to qualifying relationships between the use of 5-ALA and heme. In addition, the relationship among heme, melatonin, and sleep were explored. Since there were no published data related to 5-ALA and sleep, an analysis of what is known about 5-ALA and heme was undertaken. Results: Currently, within the scope of this review, no literature available directly connecting 5-ALA and sleep was found. Research indicates that 5-ALA has an indirect relationship with intra-cellular energy production, which could result in a wide range of effects fromcellular to endocrine to neurologic to behavioral. In addition, there is evidence that 5-ALA may influence tryptophan and serotonin levels. Conclusion: While there are no studies on 5-ALA and sleep were found, current research suggests several potential mechanisms by which 5-ALA could influence sleep. The mechanisms suggest the potential for 5-ALA to assist in the adjustment of a person’s circadian cycle, endocrine function, or neurologic function in order to allow for better sleep in a natural way. In doing so, it may provide for a safer alternative to currently available sleep medication. Further research is needed to explore this possibility.

Simplicial Descent Categories
Beatriz Rodriguez Gonzalez
Mathematics , 2008,
Abstract: Much of the homotopical and homological structure of the categories of chain complexes and topological spaces can be deduced from the existence and properties of the 'simple' functors Tot : {double chain complexes} -> {chain complexes} and geometric realization : {sSets} -> {Top}, or similarly, Tot : {simplicial chain complexes} -> {chain complexes} and | | : {sTop} -> {Top}. The purpose of this thesis is to abstract this situation, and to this end we introduce the notion of '(co)simplicial descent category'. It is inspired by Guillen-Navarros's '(cubical) descent categories'. The key ingredients in a (co)simplicial descent category D are a class E of morphisms in D, called equivalences, and a 'simple' functor s : {(co)simplicial objects in D} -> D. They must satisfy axioms like 'Eilenberg-Zilber', 'exactness' and 'acyclicity'. This notion covers a wide class of examples, as chain complexes, sSets, topological spaces, filtered cochain complexes (where E = filtered quasi-isomorphisms or E = E_2-isomorphisms), commutative differential graded algebras (with s = Navarro's Thom-Whitney simple), DG-modules over a DG-category and mixed Hodge complexes, where s = Deligne's simple. From the simplicial descent structure we obtain homotopical structure on D, as cone and cylinder objects. We use them to i) explicitly describe the morphisms of HoD=D[E^{-1}] similarly to the case of calculus of fractions; ii) endow HoD with a non-additive pre-triangulated structure, that becomes triangulated in the stable additive case. These results use the properties of a 'total functor', which associates to any biaugmented bisimplicial object a simplicial object. It is the simplicial analogue of the total chain complex of a double complex, and it is left adjoint to Illusie's 'decalage' functor.
(Co)Simplicial Descent Categories
Beatriz Rodriguez Gonzalez
Mathematics , 2008, DOI: 10.1016/j.jpaa.2011.10.003
Abstract: In this paper we study the question of how to transfer homotopic structure from the category sD of simplicial objects in a fixed category D to D. To this end we use a sort of homotopy colimit s : sD --> D, which we call simple functor. For instance, the Bousfield-Kan homotopy colimit in a Quillen simplicial model category is an example of simple functor. As a remarkable example outside the setting of Quillen models we include Deligne simple of mixed Hodge complexes. We prove here that the simple functor induces an equivalence on the corresponding localized categories. We also describe a natural structure of Brown category of cofibrant objects on sD. We use these facts to produce cofiber sequences on the localized category of D by E, which give rise to a natural Verdier triangulated structure in the stable case.
Triangulated structures induced by simplicial descent categories
Beatriz Rodriguez Gonzalez
Mathematics , 2008,
Abstract: The present paper is devoted to study the homotopy category associated with a simplicial descent category (D,s,E) (arXiv:0808.3684v2). We prove that the class E of equivalences has a calculus of left fractions over a quotient category of D modulo homotopy. We study the fiber/cofiber sequences induced by a (co)simplicial descent structure. Examples of such fiber/cofiber sequences are deduced for (commutative) differential graded algebras, simplicial sets or topological spaces. We prove that the homotopy category of a stable simplicial descent category is triangulated. In addition, these triangulated structures may be extended to the homotopy categories of diagram categories of D. As a corollary, we obtain the triangulated structures on: (filtered) derived categories of abelian categories, the derived category of DG-modules over a DG-category, the stable derived category of fibrant spectra and the localized category of mixed Hodge complexes.
A derivability criterion based on the existence of adjunctions
Beatriz Rodriguez Gonzalez
Mathematics , 2012,
Abstract: In this paper we introduce a derivability criterion of functors based on the existence of adjunctions rather than on the existence of resolutions. It constitutes a converse of Quillen-Maltsiniotis Derived Adjunction Theorem. We present two consequences of our derivability criterion. On the one hand, we prove that the two notions for homotopy colimits corresponding to Grothendieck derivators and Quillen model categories are equivalent. On the other hand, we deduce that the internal hom for derived Morita theory constructed by B. Toen is indeed the right derived functor of the internal hom of dg-categories.
Realizable homotopy colimits
Beatriz Rodriguez Gonzalez
Mathematics , 2011,
Abstract: In this paper we prove that for any model category, the Bousfield-Kan construction of the homotopy colimit is the absolute left derived functor of the colimit. This is achieved by showing that the Bousfield-Kan homotopy colimit is moreover a realizable homotopy colimit, defined by means of a suitable 2-category of relative categories. In addition, in the case of exact coproducts, we characterize the realizable homotopy colimits that satisfy a cofinality property as those given by a formula following the pattern of Bousfield-Kan construction: they are the composition of a "geometric realization" with the simplicial replacement.
A Case of Endometriosis in Episiotomy Scar with Anal Sphincter Involvement  [PDF]
Beatriz Ruiz de Gauna, David Rodriguez, Sergi Cabré, Justo Callejo
International Journal of Clinical Medicine (IJCM) , 2011, DOI: 10.4236/ijcm.2011.25104
Abstract: Endometriosis is defined as the presence of endometrial tissue apart from its usual location (endometrium). It is the second most prevalent benign gynecologic disease after the presence of fibroids in women of childbearing age (incidence of 10% - 25%). Endometriosis predominantly locates on peritoneal surfaces, but it also affects the vagina, vulva, recto-vaginal septum and perineum, usually secondary to surgical or obstetric trauma. We present a case of a patient with perineal endometriosis (single nodule) in the scar of episiotomy and involvement of external anal sphincter with local and catamenial pain but with continence maintained. The endometric nodule was removed, and wide dissection and sphincteroplasty were performed. Afterwards, treatment with GnRh analogues was prescribed for a four-month period. Surgical outcome was successful and the patient was asymptomatic during subsequent menstruations.
Godement resolutions and sheaf homotopy theory
Beatriz Rodriguez Gonzalez,Agusti Roig
Mathematics , 2013, DOI: 10.1007/s13348-014-0123-x
Abstract: The Godement cosimplicial resolution is available for a wide range of categories of sheaves. In this paper we investigate under which conditions of the Grothendieck site and the category of coefficients it can be used to obtain fibrant models and hence to do sheaf homotopy theory. For instance, for which Grothendieck sites and coefficients we can define sheaf cohomology and derived functors through it.
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