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Search Results: 1 - 10 of 210471 matches for " Barry L Sharaf "
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Adrenergic gene polymorphisms and cardiovascular risk in the NHLBI-sponsored Women's Ischemia Syndrome Evaluation
Michael A Pacanowski, Issam Zineh, Haihong Li, B Delia Johnson, Rhonda M Cooper-DeHoff, Vera Bittner, Dennis M McNamara, Barry L Sharaf, C Noel Merz, Carl J Pepine, Julie A Johnson
Journal of Translational Medicine , 2008, DOI: 10.1186/1479-5876-6-11
Abstract: We genotyped 628 women referred for coronary angiography for eight polymorphisms in the α1A-, β1-, β2- and β3-adrenergic receptors (ADRA1A, ADRB1, ADRB2, ADRB3, respectively), and their signaling proteins, G-protein β 3 subunit (GNB3) and G-protein α subunit (GNAS). We compared the incidence of death, myocardial infarction, stroke, or heart failure between genotype groups in all women and women without obstructive coronary stenoses.After a median of 5.8 years of follow-up, 115 women had an event. Patients with the ADRB1 Gly389 polymorphism were at higher risk for the composite outcome due to higher rates of myocardial infarction (adjusted hazard ratio [HR] 3.63, 95% confidence interval [95%CI] 1.17–11.28; Gly/Gly vs. Arg/Arg HR 4.14, 95%CI 0.88–19.6). The risk associated with ADRB1 Gly389 was limited to those without obstructive CAD (n = 400, Pinteraction = 0.03), albeit marginally significant in this subset (HR 1.71, 95%CI 0.91–3.19). Additionally, women without obstructive CAD carrying the ADRB3 Arg64 variant were at higher risk for the composite endpoint (HR 2.10, 95%CI 1.05–4.24) due to subtle increases in risk for all of the individual endpoints. No genetic associations were present in women with obstructive CAD.In this exploratory analysis, common coding polymorphisms in the β1- and β3-adrenergic receptors increased cardiovascular risk in women referred for diagnostic angiography, and could improve risk assessment, particularly for women without evidence of obstructive CAD.ClinicalTrials.gov NCT00000554.Coronary artery disease (CAD) is the leading cause of morbidity and mortality among women in the United States [1]. More than half of women presenting with chest pain or suspected myocardial ischemia do not have angiographic evidence of stenosis [2]. Despite the absence of obstructive lesions, many of these women have been shown to have myocardial ischemia due to microvascular disease [3,4] and are at high risk for cardiovascular events [5,6]. Diagnosing CAD an
The inheritance of susceptibility to lichen planus
Hafez M,Sharaf L,Seafan F
Indian Journal of Dermatology , 2006,
Abstract: The role of inheritance of susceptibility in lichen planus was studied by genetic analysis of data from 71 families of probands with lichen planus. 12 families were multiplex and the other 59 were simplex. The incidence of the disease among relatives of probands was significantly higher than that in the general population and the frequency diminished with the descend in the degree of relationship between relatives and probands. Pedigrees of the families of probands did not consist of any single-gene inheritance. The results shown by the curve of liability of the relatives, the frequency in the first degree relatives and the relative frequency points to a polygenic-environmental interaction. The heritability of liability for lichen planus which measures the relative contribution of genetic factors in etiology was found to be 56 percent for first-degree relatives. The etiology of lichen planus is still not properly known. Several pathogenetic theories have been proposed despite limited supportive evidences. The main theories are: infective, autoimmune, psychogenic and genetic. The aim of this work is to throw a beam of light on the genetic role in the pathogenesis of lichen planus.
A Patient Bill of Rights for Psychotropic Prescription: A Call for a Higher Standard of Care  [PDF]
Barry L. Duncan, David O. Antonuccio
International Journal of Clinical Medicine (IJCM) , 2011, DOI: 10.4236/ijcm.2011.24061
Abstract: The pharmaceutical industry has made it very difficult to know what the clinical trial evidence actually is regarding psychotropics. Consequently, primary care physicians and other front-line practitioners are at a disadvantage when attempting to adhere to the ethical and scientific mandates of evidence based prescriptive practice. This article calls for a higher standard of prescriptive care derived from a risk/benefit analysis of clinical trial evidence. The authors assert that current prescribing practices are often empirically unsound and unduly influenced by pharmaceutical company interests, resulting in unnecessary risks to patients. In the spirit of evidenced based medicine’s inclusion of patient values as well as the movement toward health home and integrated care, we present a patient bill of rights for psychotropic prescription. We then offer guidelines to raise the bar of care equal to the available science for all prescribers of psychiatric medications.
Restricted Three-Body Problem in Cylindrical Coordinates System  [PDF]
Mohammed Sharaf, Aisha Alshaery
Applied Mathematics (AM) , 2012, DOI: 10.4236/am.2012.38134
Abstract: In this paper, the equations of motion for spatial restricted circular three body problem will be established using the cylindrical coordinates. Initial value procedure that can be used to compute both the cylindrical and Cartesian coordinates and velocities is also developed.
Acute ST-Segment Elevation Myocardial Infarction: Combined Intracoronary Low Dose Eptifibatide and Thrombus Aspiration  [PDF]
Sharaf Eldeen Mahmoud
World Journal of Cardiovascular Diseases (WJCD) , 2014, DOI: 10.4236/wjcd.2014.412069
Abstract: Aim of the work: To evaluate the efficacy and safety of bolus only intra coronary platelet glyco-protein GP IIb/IIIa receptor antagonists combined with thrombus-aspiration during percutaneous coronary intervention (PCI) in ST-segment elevation myocardial infarction (STEMI). Patient and Methods: 25 consecutive STEMI patients treated by primary PCI including thrombus aspiration were prospectively enrolled, from a total of 180 PCIs performed at our institution between January 2013 and January 2014. All patients received aspirin (250 mg i.v.) and clopidogrel (600 or 300 mg if already on clopidogrel) plus standard heparin. Glycoprotein IIb/IIIa antagonists were administered at physicians’ discretion before thrombus aspiration. Eptifibatide was used as a slandered Glycoprotein IIb/IIIa antagonists as a dose of the 180-μg/kg eptifibatide bolus only. The bolus was administered for 2 minutes via the thrombus aspiration catheter (STEMI cath of min-vasys) just before thrombus aspiration. Twelve-lead ECGs were recorded at baseline and 60 min (45 - 75 min) after completion of PCI. The primary endpoint was the TIMI 3 patency of the infarct-related coronary artery before PCI. Secondary endpoints were TIMI patency following PCI, ST resolution 60 min after PCI, all-cause death, reinfarction, urgent revascularization, stroke (haemorrhagic, non-haemorrhagic), and severe bleeding complications. Results: The angiography was performed in all 25 patients. The incidence of a TIMI flow grade 3 of the infarct-related coronary artery before PCI was 16% while TIMI grade 2 and I was 24% and 36% respectively. The incidence of a TIMI flow grade 0 (no reflow) of the infarct-related coronary artery before PCI was 24%. Visible thrombus in 52% of patients and 40% of patients have more than one critically disease vessel. Primary PCI was performed in 25 patients. Eptifibatide intracoronary was given through thrombus aspiration catheter before thrombus aspiration. Drug eluting stents were implanted in 60% of patients. Only two patients with acute stent thrombosis did not receive any stents at PCI. One patient died 24 h after the procedure due to severe heart failure and cardiogenic shock. No reinfarction was noted within 30 days after the procedure. Generally heart failure improved significantly after the procedure and at the end of 30 day post operative. Only 3 patients had persistent heart failure class III (12%). 84% of patients had TIMI flow III at the end of procedure with over all significant improvement. Significant TIMI flow improvement after procedure was noticed with P value, 001.
Reduced Differential Transform Method for Solving Linear and Nonlinear Goursat Problem  [PDF]
Sharaf Mohmoud, Mohamed Gubara
Applied Mathematics (AM) , 2016, DOI: 10.4236/am.2016.710092
Abstract: In this paper a new method for solving Goursat problem is introduced using Reduced Differential Transform Method (RDTM). The approximate analytical solution of the problem is calculated in the form of series with easily computable components. The comparison of the methodology presented in this paper with some other well known techniques demonstrates the effectiveness and power of the newly proposed methodology.
LA IMAGEN Y LOS ECOS DEL LINGUISTA PROFESIONAL: LA CORRESPONDENCIA DE RODOLFO LENZ
VELLEMAN,BARRY L;
RLA. Revista de lingüística teórica y aplicada , 2008, DOI: 10.4067/S0718-48832008000100002
Abstract: this study proposes to document the wide range of interests found in the correspondence of the great german linguist in chile, rodolfo lenz (1863-1939), with special attention to three areas: 1) his correspondents with academic affiliations and scholarly organizations in the united states; 2) his participation in the international phonetic association; and 3) his dialogues with amado alonso and aurelio espinosa, two major figures in the field of spanish-american dialectology. at the end of the study is found the text of espinosa’s four letters to lenz. the study of lenz’ letters documents, not only the professionalization of the linguist of his time, but also the development of the field in a broader sense.
LA IMAGEN Y LOS ECOS DEL LINGUISTA PROFESIONAL: LA CORRESPONDENCIA DE RODOLFO LENZ THE IMAGE AND THE ECHOES OF THE PROFESSIONAL LINGUIST: THE CORRESPONDENCE OF RODOLFO LENZ
BARRY L VELLEMAN
RLA : Revista de Lingüística Teórica y Aplicada , 2008,
Abstract: Este estudio tiene el propósito de proporcionar una idea de la amplitud de intereses manifestados en la correspondencia del gran lingüista alemán en Chile, Rodolfo Lenz (1863-1938), prestando atención especial a tres áreas: 1) sus corresponsales de afiliación académica e institucional norteamericana; 2) su participación en la Asociación Fonética Internacional; y 3) sus diálogos con Amado Alonso y Aurelio Espinosa, dos figuras cumbres de la dialectología hispanoamericana. Al final del estudio se reproduce el texto de las cuatro cartas de Espinosa a Lenz. El estudio de las cartas de Lenz documenta tanto la profesionalización del lingüista durante el período como el desarrollo de ese campo en sentido más amplio. This study proposes to document the wide range of interests found in the correspondence of the great German linguist in Chile, Rodolfo Lenz (1863-1939), with special attention to three areas: 1) his correspondents with academic affiliations and scholarly organizations in the United States; 2) his participation in the International Phonetic Association; and 3) his dialogues with Amado Alonso and Aurelio Espinosa, two major figures in the field of Spanish-American dialectology. At the end of the study is found the text of Espinosa’s four letters to Lenz. The study of Lenz’ letters documents, not only the professionalization of the linguist of his time, but also the development of the field in a broader sense.
Introduction to the Special Feature: Adaptive Management - Scientifically Sound, Socially Challenged?
Barry L. Johnson
Ecology and Society , 1999,
Abstract:
The Role of Adaptive Management as an Operational Approach for Resource Management Agencies
Barry L. Johnson
Ecology and Society , 1999,
Abstract: In making resource management decisions, agencies use a variety of approaches that involve different levels of political concern, historical precedence, data analyses, and evaluation. Traditional decision-making approaches have often failed to achieve objectives for complex problems in large systems, such as the Everglades or the Colorado River. I contend that adaptive management is the best approach available to agencies for addressing this type of complex problem, although its success has been limited thus far. Traditional decision-making approaches have been fairly successful at addressing relatively straightforward problems in small, replicated systems, such as management of trout in small streams or pulp production in forests. However, this success may be jeopardized as more users place increasing demands on these systems. Adaptive management has received little attention from agencies for addressing problems in small-scale systems, but I suggest that it may be a useful approach for creating a holistic view of common problems and developing guidelines that can then be used in simpler, more traditional approaches to management. Although adaptive management may be more expensive to initiate than traditional approaches, it may be less expensive in the long run if it leads to more effective management. The overall goal of adaptive management is not to maintain an optimal condition of the resource, but to develop an optimal management capacity. This is accomplished by maintaining ecological resilience that allows the system to react to inevitable stresses, and generating flexibility in institutions and stakeholders that allows managers to react when conditions change. The result is that, rather than managing for a single, optimal state, we manage within a range of acceptable outcomes while avoiding catastrophes and irreversible negative effects.
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