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Search Results: 1 - 10 of 14009 matches for " Balvinder Singh "
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Probiotics : An Innovative Globe
Vikash Kumar,Balvinder Singh
Pharmaceutical Reviews , 2008,
Abstract: Probiotics are live microorganisms (in most cases, bacteria) that are similar to beneficial microorganisms found in the human gut. They are also called “friendly bacteria” or “good bacteria”. Probiotics are available to consumers mainly in the form of dietary supplements and foods. They can be used as complementary and alternative medicine. History of Probiotics:Probiotics, which means "for life", have been used for centuries as natural components in health-promoting foods. The original observation of the positive role played by certain bacteria was first introduced by Russian scientist and Nobel laureate Eli Metchnikoff, who in the beginning of the 20th century suggested that it would be possible to modify the gut flora and to replace harmful microbes by useful microbes1.
Me-Too Drugs - A Tiny Revolutionize
Vikash Kumar,Balvinder Singh
Pharmaceutical Reviews , 2008,
Abstract: What are “Me-Too” Drugs? 1, 2 : The Process of new drug development is complicated, time-consuming and expensive. In modern chemotherapy, when drugs were discovered and developed through the process of screening thousands of molecules for a variety of disease conditions, using animal models, there has been a growing criticism that too many molecules were developed with similar chemical structure and the same pharmacological profile, with very little to distinguish them from each other in terms of their therapeutic utility. In other words, once the first breakthrough discovery is made of a new pharmacological activity for a new molecule, subsequent years saw the emergence of a host of new molecules or "me-too" drugs from the same chemical class and possessing the same pharmacological profile.
Preparation of 2-Aminobenzothiazole Derivatives : A Review
Vikash Kumar,Balvinder Singh
Pharmaceutical Reviews , 2008,
Abstract: The present review focus on synthesis of various 2-aminobenzothiazoles derivatives by cyclizing the arylthioureas, 2-aminothiophenol and substituted anilines with the help of different catalysts or agents. Chloroformamidinium Salts; latest and efficient reagent for preparation of 2-aminobenzothiazole derivatives. In bioorganic and medicinal chemistry 2-aminobenzothiazoles derivatives are broadly found with applications in drug discovery and development of the treatments of diabetes1, epilepsy2,3, inflammation4, amyotrophic lateral sclerosis5, analgesia6, tuberculosis7, and viral infection8. Riluzole9 (1) was chemically a 2-aminobenzothiazole derivative that is 6-(trifluoromethoxy)-2-benzothiazolamine and was found to interfere with glutamate neurotransmission in biochemical, electrophysiological and behavioral experiments. In 1887,Hoffmann10 first reported the cyclizations of 2- aminothiophenol to 2-aminobenzothiazoles. Hofmann noted only formation of 2- anilinobenzothiazole from the reaction of 2-aminothiophenol and phenyl isothiocyanate
Development of a Risk Model for Abdominal Wound Dehiscence  [PDF]
Mujahid Ahmad Mir, Farzana Manzoor, Balvinder Singh, Imtiyaz Ahmad Sofi, Abu Zaved Rameez, Sheikh Imran Farooq
Surgical Science (SS) , 2016, DOI: 10.4236/ss.2016.710063
Abstract: Objectives: To identify independent risk factors for abdominal wound dehiscence and develop a risk model to recognize high risk patients. Methods: The samples studied were patients who underwent midline laparotomy in the department of surgery, SMHS Hospital Srinagar from March 2009 to April 2015. For each case of abdominal wound dehiscence, three controls were selected from a group of patients who had undergone open abdominal surgery as close as possible in time. Preoperative, perioperative, and postoperative variables and in-hospital mortality were studied for all patients. Cases were compared with controls using the chi-square test or the Mann-Whitney U-test for categorical or continuous data, respectively. Subsequently, multivariate stepwise logistic regression with backwards elimination test used to identify main independent risk factors of abdominal wound dehiscence. The resulting regression coefficients for the major risk factors were used as weights for these variables to calculate a risk score for abdominal wound dehiscence. Results: 140 cases of abdominal wound dehiscence were reported and compared with 420 selected controls. All variables that were significant in univariate analyses were entered in a multivariate stepwise logistic regression to determine which variables were significant independent risk factors. Major independent risk factors were male gender, chronic pulmonary disease, corticosteroid use, smoking, obesity, anemia, jaundice, ascites, and sepsis, type of surgery, postoperative coughing, and wound infection. Based on these findings, a risk model was developed. Conclusions: The model can give an estimate of the risk of abdominal wound dehiscence for individual patients. High-risk patients may be planned preventive wound closing with reinforcements as mesh.
Extremophiles: A Novel Source of Industrially Important Enzymes
Lokendra Kumar,Gyanendra Awasthi,Balvinder Singh
Biotechnology , 2011,
Abstract: Microbial life does not seem to be limited to specific environments. During the past few decades it has become clear that microbial communities can be found in the most diverse conditions, including extremes of temperature, pressure, salinity and pH. These microorganisms, called extremophiles, produce biocatalysts that are functional under extreme conditions. Consequently, the unique properties of these biocatalysts have resulted in several novel applications of enzymes in industrial processes. From recent study, major approaches to extending the range of applications of extremozymes have emerged. Both the discovery of new extremophilic species and the determination of genome sequences provide a route to new enzymes, with the possibility that these will lead to novel applications. Only a minor fraction of the microorganisms on earth have been exploited. Novel developments in the cultivation and production of extremophiles but also developments related to the cloning and expression of their genes in heterologous hosts, will increase the number of enzyme-driven transformations in chemical, food, pharmaceutical and other industrial applications. Of equal importance directed evolutions provide approaches to improve enzyme stability and modify specificity in ways that may not exist in the natural world.
Yadav Dinesh Prasad,Chhipa Ram Chandra,Kumar Lokendra,Singh Balvinder
International Research Journal of Pharmacy , 2012,
Abstract: Protein glycation takes place when elevated levels of reduced sugars react with amino groups in proteins, reaction known as Maillard reaction. If this process continues, it will lead to the formation of complex, often unstable, irreversible and reactive compounds Advanced Glycation End- Products (AGEs) a process that may take weeks or even months to accomplish. Plant extracts have their own importance and now being studied extensively due to having little or no side effects. In present study salep was selected and used to check the glycation inhibitory activity. Various combinations of glucose, protein and salep extracts were made under in vitro conditions and their activity was monitored with Trichloro acetic acid treatment method at 350 nm. Glycated products/ AGEs were more with high glucose and high protein concentration and these were decreased by highest concentration of salep extract i.e. 25 mg/mL or 250 μL. Lower concentrations of plant extract produced either no or least response against Maillard reaction.
U turn to venous air embolism
Singh Harsimran,Tewari Anurag,Kaur Balvinder,Garg Suchita
Indian Journal of Critical Care Medicine , 2009,
Abstract: There is a definitive risk of venous air embolism when the fluid infusion is complete and the drip set is still open in a glass bottle.We have devised a novel way of preventing the chances of air embolism when the fluid in the glass bottle finishes. It really gives a "U" turn to the chances of venous air embolism.
Authors′ reply
Singh Harsimran,Tewari Anurag,Kaur Balvinder,Garg Suchita
Indian Journal of Critical Care Medicine , 2009,
Laryngoscope based lighted stylet for intubation: An innovation
Singh Harsimran,Tewari Anurag,Bansal Abishek,Kaur Balvinder
Saudi Journal of Anaesthesia , 2010,
Health Outcome Measures in Atopic Dermatitis: A Systematic Review of Trends in Disease Severity and Quality-of-Life Instruments 1985–2010
Balvinder Rehal,April Armstrong
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0017520
Abstract: A number of disease-severity and quality-of-life (QoL) instruments have emerged in atopic dermatitis (AD) in the last decade.
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