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Search Results: 1 - 10 of 148656 matches for " Bárbara Wilkinson Brito "
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Tumores astrocíticos:: un acercamiento a una patología Astrocytic tumors:: a disease approach
Aliz Mathild Vega Rodríguez,Matilde Irene Rodríguez Vázquez,Bárbara Wilkinson Brito,Aymara Fernández Lorente
Revista M??dica Electr?3nica , 2012,
Abstract: El cáncer constituye un serio problema de salud para la humanidad. La mayoría de los tumores primarios del Sistema Nervioso Central son tumores astrocíticos. En esta revisión se provee información sobre algunos aspectos relacionados con los tumores astrocíticos, que incluyen la clasificación, factores pronóstico, tratamiento habitual, terapia biológica y factores angiogénicos. El glioblastoma multiforme se diagnostica en los pacientes con una mayor frecuencia. El tratamiento estándar en pacientes con tumores astrocíticos comprende la cirugía, seguida de radiación y quimioterapia. Sin embargo, cada vez son más importantes las investigaciones dirigidas a la inmunoterapia y terapia génica como parte de las opciones terapéuticas en estos pacientes. Cancer is a serious health problem around the world. The majority of primary tumors of the Central Nervous System are of astrocytic lineage. In this review we provide an overview of several aspects related to this type of tumor, that includes classification, prognostic factors, therapy, and angiogenic factors. Glioblastoma Multiforme is diagnosed in patients at a much higher frequency. Standard treatment for patients with astrocytic tumors is surgery followed by radiotherapy and chemotherapy. However, immunotherapy and gene therapy studies are increasing to become other therapeutic options in these patients.
Stratified Cox Regression Analysis of Survival under CIMAvax®EGF Vaccine  [PDF]
Carmen Viada Gonzalez, Jean-Fran?ois Dupuy, Martha Fors López, Patricia Lorenzo Luaces, Camilo Rodríguez Rodríguez, Gisela González Marinello, Elia Neninger Vinagera, Beatriz García Verdecia, Bárbara Wilkinson Brito, Liana Martínez Pérez, Mayelin Troche de la Concepción, Tania Crombet-Ramos
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.48A002
Abstract:

Background: The Center of Molecular Immunology (CIM) is a center in Cuba devoted to the research, development and manufacturing of biotechnological products. CIMAvax?EGF is a vaccine for the treatment of non-small cell lung cancer patients (NSCL). Purpose: The aim of this work is to evaluate the effects of some potential prognostic factors on the overall survival of patients treated with CIMAvax?EGF vaccine, based on data collected in a phase II and a phase III clinical trials. Methods: The stratified Cox regression model is used to evaluate the effects of these prognostic factors, based on separate analysis for each trial, and on the combined data from both trials. Results: Patients with Performance status 0 or 1, with IV stage of tumor and male under 60 years obtain more benefit in terms of overall survival if they receive CIMAvax?EGF. Conclusions: Vaccinated group has a better performance if patients have a performance status 0 or 1, stage IV and age under 60 years. These prognostic factors influence overall survival in a positive way for those patients that received CIMAvax?EGF.

Aula virtual de Estadística en soporte multimedia
Viada González,Carmen; Lorenzo Luaces,Patricia; Fors López,Martha; Robaina García,Mayteé; Santiesteban González,Yanela; Santiesteban González,Yuliannis; Frías Blanco,Aliuska; álvarez Cardona,Mabel; Wilkinson Brito,Bárbara; Troche Concepción,Mayelin; Martínez Pérez,Liana; Fernández Lorente,Aymara; Duran Soto,Yunier; Pascau Illas,Julio;
Revista Cubana de Inform??tica M??dica , 2011,
Abstract: the process of teaching and learning quality in the area of statistics is determined largely by the good clinical practices. sometimes university courses that include subjects related to statistics are not viewed in its practical curriculum statistical system, and in others, these are not sufficient to develop the practical skills required for this discipline. in general, the material constraints condition the total or partial absence of practical activities. the increasing development of information technology and communication (ict) has provided the possibility of filling these gaps, with the development of interactive multimedia and virtual classrooms. this project includes a set of practice of statistics in multimedia, which aim to prepare the student to obtain maximum performance in statistical systems. this product can be used as a substitute for real classroom in those cases where for reasons of time, space, actual practice is not possible.
Mejoras en el acceso a la información de los ensayos clínicos
Acosta Martínez,Maylén; Rodríguez Valdés,Daylis; Viada González,Carmen; Ramos Suzarte,Mayra; Corrales Reyna,Eduardo; Frías Blanco,Aliuska; Santiesteban González,Yanela; Wilkinson Brito,Bárbara; Martínez Pérez,Liana; Troche Concepción,Mayelin; Valencia Jarvis,Natacha; Valencia Jarvis,María Esther; Torres Gemeil,Olga;
Revista Cubana de Salud Pública , 2010, DOI: 10.1590/S0864-34662010000300019
Abstract: the molecular immunology center has been developing biomolecules for cancer treatment. as the development of such products continues, phases i, ii, iii and iv of clinical assays also advance, which leads to an increase of the number of patients to be treated and the number of involved hospitals. there are ten different products involved in over 50 national and multinational clinical assays in which 2 500 patients are predicted to be included every year. approximately 30 hospitals from 13 provinces are included in this process. for the purpose of improving the access of committed researchers to the clinical assay information, a new website with four sections was devised. those sections are related to products and their indications, good clinical practice, remote data entry and clinical assay management. all the above-mentioned improves the quality of the information given to involved clinical researchers and results in better organization of the complex activity of clinical assays in cuba.
Terapia combinada con magneto, láser y ejercicios en la tendinitis de hombro: Servicio de Rehabilitación Integral José Jacinto Milanés. Junio 2007-junio 2008
Solís de la Paz,Dayma; Pe?ate Brito,Jayne Bárbara;
Revista M??dica Electr?3nica , 2011,
Abstract: magnetotherapy, although it has been used for different orthopaedic diseases, has not been used in tendinitis associated to the laser and therapeutic exercises; therefore we made an explicative, experimental study, type therapeutic clinical trial, to state the efficacy of this therapy in patients with tendinitis at the integral rehabilitation service jose jacinto milanes. two groups of 42 patients were formed, an experimental one with local application of pulsated magnetic fields, punctual laser in the pain zone and in the ig4, ig11 and ig15 acupunctural points, besides an exercises program and mechanic therapy during three weeks, and another one with conventional treatment and exercises. the studied groups were characterized from the socio-demographic and clinical point of view. we used the functional assessment scale of the shoulder, exploring four aspects: pain, join mobility, muscular strength and global function before, during and after treatment in both groups, and at the end we made a final evaluation to determine the treatment efficacy. there was a predominance of the male genre patients, aged more than 40 years, mainly 50-60 years. the most frequent diagnosis was supraspinous tendinitis, followed by bicipital tendinitis. we made a percentual comparison at the beginning and at the end in both groups. all the parameters evaluated in the functional assessment scale of the shoulder showed improvement with the indicated treatment, and the achieved results showed the efficacy of the applied treatment.
Challenges for the implementation of the Family Planning Program in a low-income community in aracaju, Sergipe, Brazil Desafios para a implementa o do Programa de Planejamento Familiar em uma comunidade de baixa renda em Aracaju (Sergipe), Brasil
Bárbara de Alcantara Brito Maia,Jo?o Batista Cavalcante Filho,Valeska Holst Antunes
Revista Brasileira de Medicina de Família e Comunidade , 2010, DOI: 10.5712/rbmfc2(8)66
Abstract: A study on the reproductive characteristics and the meaning of family planning for childbearing age women and for the health team providing care to them was conducted in a low-income community in Aracaju - SE. In the descriptive stage of the study structured questionnaires were applied to 90 users of a Primary Care Unit random-selected from the family files containing personal data and information about the reproductive life of the women. This stage was followed by a qualitative approach in focal groups with six users and the health team applying semi-structured questionnaires for assessing the practice of family planning. The study showed that knowledge and offer of contraceptive methods are no guarantee of proper family planning. More than 97% of the participants related knowing about the condom, the pill and the contraceptive injection. 73,6% of the sexually active women practiced contraception but 76% of those who already had had a pregnancy referred to one or more unintended gestations. The focal groups revealed the need for other approaches to family planning such as preconception care, access to the partners and education in health to be developed by the team in order to help the users to better plan their offspring. Um estudo das características reprodutivas e do significado do planejamento familiar para mulheres em idade fértil e para a equipe de saúde que as assiste foi realizado em uma comunidade de baixa renda em Aracaju (SE). Na etapa descritiva, foram aplicados questionários estruturados a 90 usuárias de uma Unidade Básica de Saúde, por sorteio aleatório das pastas-família, contendo dados pessoais e da vida reprodutiva. Esta etapa foi seguida de uma abordagem qualitativa, na qual foram realizados grupos focais com seis usuárias e com a equipe de saúde, utilizando questionários semi-estruturados para avaliar a prática de planejamento familiar. As mulheres mostraram que conhecimento e oferta de métodos anticoncepcionais n o garantem um planejamento familiar adequado. Mais de 97% das participantes referiram conhecer a camisinha, a pílula e o injetável, e 73,6% das sexualmente ativas praticam anticoncep o, mas 76% daquelas que já engravidaram referiram uma ou mais gesta es n o-planejadas. Nos grupos focais, outras abordagens do planejamento familiar, como assistência à pré-concep o, acesso ao homem e educa o em saúde, mostraram que precisam ser trabalhadas pela equipe para que as usuárias programem melhor sua prole.
Terapia combinada con magneto, láser y ejercicios en la tendinitis de hombro: Servicio de Rehabilitación Integral José Jacinto Milanés. Junio 2007-junio 2008 Combined therapy with magneto, laser and exercises in shoulder tendinitis: Integral Rehabilitation Service José Jacinto Milanes. June 2007-June 2008
Dayma Solís de la Paz,Jayne Bárbara Pe?ate Brito
Revista M??dica Electr?3nica , 2011,
Abstract: La magnetoterapia, aunque ha sido utilizada para diversas afecciones ortopédicas, no se ha empleado en la tendinitis asociada al láser y a los ejercicios terapéuticos, por lo que se realizó un estudio explicativo, experimental, tipo ensayo clínico terapéutico, para comprobar la eficacia de esta terapia en pacientes con tendinitis en el Servicio de Rehabilitación Integral José Jacinto Milanés. Se conformaron dos grupos con 42 pacientes, uno experimental con aplicación local de campos magnéticos pulsados, láser puntual en la zona dolorosa y en puntos de acupuntura Ig4, Ig11 e Ig15, además de un programa de ejercicios y mecanoterapia durante tres semanas, y otro control donde se empleó el tratamiento convencional y ejercicios. Se caracterizaron los grupos estudiados desde el punto de vista sociodemográfico y clínico. Se utilizó la e scala de valoración funcional del hombro, explorando cuatro aspectos: dolor, movilidad articular, fuerza muscular y función global antes, durante y después del tratamiento, en ambos grupos, y se realizó una evaluación final para determinar la eficacia del tratamiento. En la investigación predominó el sexo masculino, mayores de 40 a os y, sobre todo, de 50 a 60 a os. Los diagnósticos más frecuentes fueron las tendinitis del supraespinoso, seguido de la tendinitis bicipital. Se realizó contrastación porcentual al inicio y al final en ambos grupos. Todos los parámetros evaluados en escala de valoración funcional del hombro mostraron mejoría con el tratamiento indicado, y los resultados alcanzados demostraron la eficacia del tratamiento aplicado. Magnetotherapy, although it has been used for different orthopaedic diseases, has not been used in tendinitis associated to the laser and therapeutic exercises; therefore we made an explicative, experimental study, type therapeutic clinical trial, to state the efficacy of this therapy in patients with tendinitis at the Integral Rehabilitation Service Jose Jacinto Milanes. Two groups of 42 patients were formed, an experimental one with local application of pulsated magnetic fields, punctual laser in the pain zone and in the Ig4, Ig11 and Ig15 acupunctural points, besides an exercises program and mechanic therapy during three weeks, and another one with conventional treatment and exercises. The studied groups were characterized from the socio-demographic and clinical point of view. We used the functional assessment scale of the shoulder, exploring four aspects: pain, join mobility, muscular strength and global function before, during and after treatment in both groups, and at the end we made
Caustics in turbulent aerosols
M. Wilkinson,B. Mehlig
Physics , 2004, DOI: 10.1209/epl/i2004-10532-7
Abstract: Networks of caustics can occur in the distribution of particles suspended in a randomly moving gas. These can facilitate coagulation of particles by bringing them into close proximity, even in cases where the trajectories do not coalesce. We show that the long-time morphology of these caustic patterns is determined by the Lyapunov exponents lambda_1, lambda_2 of the suspended particles, as well as the rate J at which particles encounter caustics. We develop a theory determining the quantities J, lambda_1, lambda_2 from the statistical properties of the gas flow, in the limit of short correlation times.
Path Coalescence in Spatially Correlated Random Walks
M. Wilkinson,B. Mehlig
Physics , 2003,
Abstract: A particle subject to successive, random displacements is said to execute a random walk (in position or some other coordinate). The mathematical properties of random walks have been very thoroughly investigated, and the model is used in many areas of science and engineering as well as other fields such as finance and the life sciences. This letter describes a phenomenon occurring in a natural extension of this model: we consider the motion of a large number of particles subject to successive random displacements which are correlated in space, but not in time. If these random displacements are smaller than their correlation length, the trajectories coalesce onto a decreasing number of trails. This surprising effect is explained and quantitative results are obtained. Various possible realisations are discussed, ranging from coalescence of the tracks of water droplets blown off a windshield to migration patterns of animals.
Coagulation by Random Velocity Fields as a Kramers Problem
B. Mehlig,M. Wilkinson
Physics , 2003, DOI: 10.1103/PhysRevLett.92.250602
Abstract: We analyse the motion of a system of particles suspended in a fluid which has a random velocity field. There are coagulating and non-coagulating phases. We show that the phase transition is related to a Kramers problem, and use this to determine the phase diagram, as a function of the dimensionless inertia of the particles, epsilon, and a measure of the relative intensities of potential and solenoidal components of the velocity field, Gamma. We find that the phase line is described by a function which is non-analytic at epsilon=0, and which is related to escape over a barrier in the Kramers problem. We discuss the physical realisations of this phase transition.
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