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Search Results: 1 - 10 of 936 matches for " Ayu Ogawa "
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Suppression of Adiponectin by Aberrantly Glycosylated IgA1 in Glomerular Mesangial Cells In Vitro and In Vivo
Tatsuyuki Inoue, Hitoshi Sugiyama, Masashi Kitagawa, Keiichi Takiue, Hiroshi Morinaga, Ayu Ogawa, Yoko Kikumoto, Shinji Kitamura, Yohei Maeshima, Hirofumi Makino
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0033965
Abstract: The pathogenesis of IgA nephropathy (IgAN) may be associated with the mesangial deposition of aberrantly glycosylated IgA1. To identify mediators affected by aberrantly glycosylated IgA1 in cultured human mesangial cells (HMCs), we generated enzymatically modified desialylated and degalactosylated (deSial/deGal) IgA1. The state of deglycosylated IgA1 was confirmed by lectin binding to Helix aspersa (HAA) and Sambucus nigra (SNA). In the cytokine array analysis, 52 proteins were upregulated and 34 were downregulated in HMCs after stimulation with deSial/deGal IgA1. Among them, the secretion of adiponectin was suppressed in HMCs after stimulation with deSial/deGal IgA1. HMCs expressed mRNAs for adiponectin and its type 1 receptor, but not the type 2 receptor. Moreover, we revealed a downregulation of adiponectin expression in the glomeruli of renal biopsy specimens from patients with IgAN compared to those with lupus nephritis. We also demonstrated that aberrantly glycosylated IgA1 was deposited in the mesangium of patients with IgAN by dual staining of HAA and IgA. Moreover, the urinary HAA/SNA ratio of lectin binding was significantly higher in IgAN compared to other kidney diseases. Since adiponectin has anti-inflammatory effects, including the inhibition of adhesion molecules and cytokines, these data suggest that the local suppression of this adipokine by aberrantly glycosylated IgA1 could be involved in the regulation of glomerular inflammation and sclerosis in IgAN.
The induction of T-and B-cells of immune memory during the vaccination with different types of vaccines
Volyansky AYu.
Annals of Mechnikov's Institute , 2012,
Abstract: The dynamics of the generation of T-and B-cell of immunological memory under the influence of vaccination with different types of vaccines have been investigated. It was found that the creation of resistant strained immunity (The adsorbed diphtheria-tetanus toxin with a reduced amount of antigens, measles vaccine) is associated with a twofold increase during the first months after inoculation of the amount of TCM (CCR7 + CD45RA-) - and BM (CD22 + CD72 +) - memory cells in the peripheral blood. The induction of only memory T-cells (TCM), which is not accompanied by the formation of memory B cells, does not lead to the prolonged preservation of immunity.
Carbon Dioxide Capture and Utilization for Gas Engine  [PDF]
Takashi Ogawa
Energy and Power Engineering (EPE) , 2013, DOI: 10.4236/epe.2013.510064

Sodium glycinate absorption and ethylene carbonate synthesis from a mixture gas of ethylene oxide and carbon dioxide are evaluated as carbon dioxide capture and utilization system for gas engine flue gas. The energy requirement for CO2 capture is estimated at 3.3 GJ/tonne CO2. The ethylene carbonate synthesis utilizes more than 90% of the captured CO2 and supply 2.5 GJ/tonne CO2 of thermal energy, which is 76% of the energy requirement for CO2 capture. The thermal integration of the sodium glycinate absorption and the ethylene carbonate synthesis reduces the energy requirement for CO2 capture from 3.3 GJ/tonne CO2 to 0.8 GJ/tonne CO2. The energy requirement for the CO2 capture is supplied using the steam saturated at 0.78 MPa from the gas engine without its electric power reduction.

A Decreased Level of Serum Soluble Klotho Is an Independent Biomarker Associated with Arterial Stiffness in Patients with Chronic Kidney Disease
Masashi Kitagawa, Hitoshi Sugiyama, Hiroshi Morinaga, Tatsuyuki Inoue, Keiichi Takiue, Ayu Ogawa, Toshio Yamanari, Yoko Kikumoto, Haruhito Adam Uchida, Shinji Kitamura, Yohei Maeshima, Kazufumi Nakamura, Hiroshi Ito, Hirofumi Makino
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0056695
Abstract: Background Klotho was originally identified in a mutant mouse strain unable to express the gene that consequently showed shortened life spans. In humans, low serum Klotho levels are related to the prevalence of cardiovascular diseases in community-dwelling adults. However, it is unclear whether the serum Klotho levels are associated with signs of vascular dysfunction such as arterial stiffness, a major determinant of prognosis, in human subjects with chronic kidney disease (CKD). Methods We determined the levels of serum soluble Klotho in 114 patients with CKD using ELISA and investigated the relationship between the level of Klotho and markers of CKD-mineral and bone disorder (CKD-MBD) and various types of vascular dysfunction, including flow-mediated dilatation, a marker of endothelial dysfunction, ankle-brachial pulse wave velocity (baPWV), a marker of arterial stiffness, intima-media thickness (IMT), a marker of atherosclerosis, and the aortic calcification index (ACI), a marker of vascular calcification. Results The serum Klotho level significantly correlated with the 1,25-dihydroxyvitamin D level and inversely correlated with the parathyroid hormone level and the fractional excretion of phosphate. There were significant decreases in serum Klotho in patients with arterial stiffness defined as baPWV≥1400 cm/sec, atherosclerosis defined as maximum IMT≥1.1 mm and vascular calcification scores of ACI>0%. The serum Klotho level was a significant determinant of arterial stiffness, but not endothelial dysfunction, atherosclerosis or vascular calcification, in the multivariate analysis in either metabolic model, the CKD model or the CKD-MBD model. The adjusted odds ratio of serum Klotho for the baPWV was 0.60 (p = 0.0075). Conclusions Decreases in the serum soluble Klotho levels are independently associated with signs of vascular dysfunction such as arterial stiffness in patients with CKD. Further research exploring whether therapeutic approaches to maintain or elevate the Klotho level could improve arterial stiffness in CKD patients is warranted.
Influencing of Deep Frying in Forming of Trans Fatty Acid.
Ratu Ayu Dewi Sartika
Makara Seri Sains , 2009,
Abstract: Frying process is one of the cooking's techniques usingvegetable oil. This process is commonly used in food industry, restaurants, food services, food retail and householdscale. This is a laboratory experimental study which performed in laboratory of Public Health Nutrition FKM-UI andIntegrated Laboratory IPB, Bogor from December 2005 until March 2006. It was conducted by two (2) type oftreatment (used cooking oil ex cassava and meat) with 4 (four) times for each treatment. The objective of this study is toknow the influence of frying by using deep frying (frying in high temperature and in a long time) and repeating to transfatty acid formation in cooking oil. From the result revealed that fatty acid type mostly contained in a fresh cooking oilis oleic acid. Trans fatty acid was formed after second repeating of deep frying and increased in line with the frequent ofrepeating. Correlation test result had shown that negative association between elaidic acid (trans) and oleic acid (cis)(r = - 0,8; p value = 0.016). In accordance with the beginning of trans fatty acid formation, it would be better to use thecooking oil not more than twice.
Ayu Fitriani,Nurul Hidayah
Abstract: This study aimed to identify the relationship between sense of humors and depression in adolescents in terms of gender. The subjects of this study were students of SMA Negeri 1 Sewon, Bantul, Yogyakarta class X and XI. The data collection tools of this study used the Beck Depression Inventory (BDI) and the Sense of Humor Scale Version-B, and used the analysis covariance method to analyze the data. The results of this study showed significant differences in depression among female subjects and male subjects with a value of F = 6.905 and p = 0.010 (p <0.05) by controlling the sense of humor variable. The average level of female depression (7.284) was higher than male subjects (6.196). This result will be discussed further in this paper.
Utilization of Coal Fly Ash as CO Gas Adsorbent
Dyah Sawitri,Ayu Lasryza
International Journal of Waste Resources , 2012, DOI: 10.12777/ijwr.v2i2.30
Abstract: This research focused on coal fly ash fabricated as CO adsorbent. Coal fly ash having grain size of 325 mesh was characterized by XRF, XRD and SEM-EDX. Physical activation was done at temperatures of 5000C, 5200C, 5400C, 5600C, 5800C and 6000C. Chemical activation was undertaken by mixing between fly ash and NaOH with mass ratio of 1: 1.2 with subsequent heating at 7500C for 1 h and followed by washing the specimens until pH=7. The samples were dried at 1000C for 1 h. The major constituents of unactivated coal fly ash are Fe, Ca, K, Si and Al in the form of quatz and anorthite. The chemical activation led to reduce the amount of quartz or increase the amount of anorthite. Physical activation does not affect the amount of minerals. Surface area of coal fly ash with physical activation at temperature 5400C and chemical activation is 32.444 m2/g (BET). doi: http://dx.doi.org/10.12777/ijwr.2.2.2012.13-15 [ How to cite this article: Sawitri, D., & Lasryza, A. (2012). Utilization of Coal Fly Ash as CO Gas Adsorbent. International Journal of Waste Resources (IJWR), 2(2), 13-15. doi: http://dx.doi.org/10.12777/ijwr.2.2.2012.13-15 ]
Do the Indonesians Receive the Dental Care Treatment They Need? A Secondary Analysis on Self-Perceived Dental Care Need
Diah Ayu Maharani
ISRN Dentistry , 2012, DOI: 10.5402/2012/769809
Gusti Ayu Made Suartika
Bumi Lestari , 2010,
Abstract: This article attempts to relate two important issues of regulating building height limit and sustainability of the natural environment. It is part of publications that document findings resulted from the so called fundamental research study, that was consecutively funded by the Indonesian Department of Education in 2008 and 2009. This study used hermeneutical research approach, which was observed through selective case studies. Within the last two decades, sustainability of our nature and life on earth have attracted a serious attention, not only from environmentalists, but also from economists, politicians, academics, as well as those who concern about socio-cultural development as a whole. In line with the intense environmental destruction's taking place in a speed which has never been anticipated, this aforementioned condition continues to require intensive actions. Architecture and regional planning, two disciplines that dedicate their focus of interests on building design and the management of spatial development, cannot turn their eyes away from such a world-widely spread phenomenon. Both disciplines utilize space a€“ nature a€“, which consequently bring about impacts on the surrounding environment. In relation to local development, planning discipline especially, orients its activities toward developing various mechanisms in guiding and controlling development, as well as sanctioning violations of planning laws. Ideally, these attributes aim at balancing spatial need of numerous interests, mitigating potential negative impacts on the environments, and offering solutions in overcoming problems and conflicts. Contextualizing its discussions within the above circumstances, this article investigates three prominent topics of discussion. First, it examines the idea of development and sustainability. Second, it studies the implementation of sustainability to the context of spatial development. Third, it bridges the first and second sections with the issue of building height limit regulation at a global level. Before embarking on discussion over these three elements, this article draws an emphasis on the inextricable correlations between sustainable development, spatial development, and building height. Overall, this article critically summaries considerations and efforts in sustaining our life on earth by appropriately addressing considerations of either limiting or relaxing building height limit in a particular planned area.
Milk Yield and Quality of Etawah Cross Bred Goat Fed Legume based Diet with Urea Molasses Block and or Rice Bran Supplement at Early Lactation
Ida Ayu Made Sukarini
Journal of Animal Production , 2006,
Abstract: The current experiment aimed to determine milk yield and its quality of the Etawah cross bred goat fed with diet supplemented with urea molasses block (UMB) and or rice bran, were conducted for 8 weeks of early lactation period. Four lactating goats with average body weight of 44 kg were used and allocated into 4 dietary treatment groups in a Cross Over Design. Group A: basal diet (50% Gliricidia sepium leaves (GS) + 50% Hibiscus tilliacius leaves (HT)) as control; B: diet A + 75 g (2.58%) UMB; C: diet A + 500 g (14.44%) rice bran; and D: diet A+75 g (2.31%) UMB + 500g (14.33%) rice bran. Each doe was subjected to all 4 treatments diet and every 2 weeks of rotation period of the treatment were given 4 days of rest. The goats were hand milked twice daily following injection of oxytocin (0.5 I.U). Daily milk yield was measured and aliquots of milk were taken for milk quality (chemical and physical) analysis. Results showed that supplementation of urea molasses block and or rice bran on legume-based diet in early lactation significantly improved both milk yield and its quality (P<0.01). The highest increament of milk yield was achieved by goat D, which was of 0.551 vs. 0.408 l/d compared to the control goat (A). Milk protein and milk dry matter were also highest in goat D which was 4.97 vs. 4.17% and 17.83 vs. 16.18% respectively. However, the highest milk fat content was obtained from goat C (5.46 vs. 5.05%) and the lowest was obtained from goat B (4.64 vs. 5.05%) compared to the control goat (A). (Animal Production 8(3): 196-205 (2006) Key Words : Etawah goat, urea molasses block, rice bran, milk quality
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