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Assessment of Hematological Toxicity in Children with Acute Lymphoblastic Leukemia, Receiving Treatment with ALL IC-BFM 2009 Protocol  [PDF]
Zeynep Canan Ozdemir, Yeter Düzenli Kar, Ayse Bozkurt Turhan, Ozcan Bor
Open Access Library Journal (OALib Journal) , 2017, DOI: 10.4236/oalib.1103807
Abstract:
The most common childhood cancer is acute lymphoblastic leukemia (ALL). Chemotherapy-associated hematological toxicity is well-known; however, there are few studies on hematologic toxicity incidence in children with ALL. We investigated the severity and incidence of hematologic toxicity during intense chemotherapy processes in children treated with ALL IC-BFM 2009 protocol. The study included 41 leukemic children in standard (SR) and intermediate risk (IR) groups treated between 2011 and 2015. During the induction period, the incidence of grade 4 toxicity in neutrophil count was 60%; the incidence of grade ≥ 3 toxicity in hemoglobin level was 34%; and the incidence of grade ≥ 3 toxicity in the platelet count was 51%. Deep neutropenia duration was 36.6 ± 12.7 (18-68) days during the induction. 53% of the febrile neutropenic (FEN) episodes developed during the induction period. There were no statistical differences between SR and IR risk groups with respect to hemogram values deep neutropenia duration and the number of FEN episodes (p > 0.05, all). There was a positive correlation between the number of FEN episodes and duration of neutropenia. During the induction, the mean neutrophil count remained between 0.5-1 × 109/L. FEN episodes most commonly developed during the induction phase.
Achilles tendon rupture: physiotherapy and endoscopy-assisted surgical treatment of a common sports injury
Mahmut Nedim Doral, Murat Bozkurt, Egemen Turhan, et al
Open Access Journal of Sports Medicine , 2010, DOI: http://dx.doi.org/10.2147/OAJSM.S10670
Abstract: chilles tendon rupture: physiotherapy and endoscopy-assisted surgical treatment of a common sports injury Review (5185) Total Article Views Authors: Mahmut Nedim Doral, Murat Bozkurt, Egemen Turhan, et al Published Date December 2010 Volume 2010:1 Pages 233 - 240 DOI: http://dx.doi.org/10.2147/OAJSM.S10670 Mahmut Nedim Doral1,2, Murat Bozkurt3, Egemen Turhan4, Gürhan D nmez2, Murat Demirel5, Defne Kaya2, Kivan Atesok7, zgür Ahmet Atay1, Nicola Maffulli6 1Department of Orthopedics and Traumatology, 2Department of Sports Medicine, Hacettepe University School of Medicine, Sihhiye, Ankara, Turkey; 3Department of Orthopedics and Traumatology, Ankara Etlik Ihtisas Training and Research Hospital, Ankara, Turkey; 4Department of Orthopedics and Traumatology, Zonguldak Karaelmas University School of Medicine, Zonguldak, Turkey; 5Department of Orthopedics and Traumatology, Ankara Bayindir Medical Center, Ankara, Turkey; 6Centre for Sports and Exercise Medicine, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK; 7St. Michael's Hospital Division of Orthopaedics Musculoskeletal Research Lab, Toronto, Ontario, Canada Abstract: Although the Achilles tendon (AT) is the strongest tendon in the human body, rupture of this tendon is one of the most common sports injuries in the athletic population. Despite numerous nonoperative and operative methods that have been described, there is no universal agreement about the optimal management strategy of acute total AT ruptures. The management of AT ruptures should aim to minimize the morbidity of the injury, optimize rapid return to full function, and prevent complications. Since endoscopy-assisted percutaneous AT repair allows direct visualization of the synovia and protects the paratenon that is important in biological healing of the AT, this technique becomes a reasonable treatment option in AT ruptures. Furthermore, Achilles tendoscopy technique may decrease the complications about the sural nerve. Also, early functional postoperative physiotherapy following surgery may improve the surgical outcomes.
Achilles tendon rupture: physiotherapy and endoscopy-assisted surgical treatment of a common sports injury
Mahmut Nedim Doral,Murat Bozkurt,Egemen Turhan,et al
Open Access Journal of Sports Medicine , 2010,
Abstract: Mahmut Nedim Doral1,2, Murat Bozkurt3, Egemen Turhan4, Gürhan D nmez2, Murat Demirel5, Defne Kaya2, Kivan Atesok7, zgür Ahmet Atay1, Nicola Maffulli61Department of Orthopedics and Traumatology, 2Department of Sports Medicine, Hacettepe University School of Medicine, Sihhiye, Ankara, Turkey; 3Department of Orthopedics and Traumatology, Ankara Etlik Ihtisas Training and Research Hospital, Ankara, Turkey; 4Department of Orthopedics and Traumatology, Zonguldak Karaelmas University School of Medicine, Zonguldak, Turkey; 5Department of Orthopedics and Traumatology, Ankara Bayindir Medical Center, Ankara, Turkey; 6Centre for Sports and Exercise Medicine, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK; 7St. Michael's Hospital Division of Orthopaedics Musculoskeletal Research Lab, Toronto, Ontario, CanadaAbstract: Although the Achilles tendon (AT) is the strongest tendon in the human body, rupture of this tendon is one of the most common sports injuries in the athletic population. Despite numerous nonoperative and operative methods that have been described, there is no universal agreement about the optimal management strategy of acute total AT ruptures. The management of AT ruptures should aim to minimize the morbidity of the injury, optimize rapid return to full function, and prevent complications. Since endoscopy-assisted percutaneous AT repair allows direct visualization of the synovia and protects the paratenon that is important in biological healing of the AT, this technique becomes a reasonable treatment option in AT ruptures. Furthermore, Achilles tendoscopy technique may decrease the complications about the sural nerve. Also, early functional postoperative physiotherapy following surgery may improve the surgical outcomes.Keywords: Achilles tendon rupture, percutaneous repair, endoscopic control, growth factors
Anterior sacral Meningocele Associated with Tethered Cord Syndrome Presenting with Constipation: US, CT, MRI and X-Ray Findings  [PDF]
Gokhan Soker, Eda Soker, Bozkurt Gulek, Tugba Tumer, Omer Kaya, Muhammet Arslan, Ayse Yildirim Celikdemir, Cengiz Y?lmaz
Open Journal of Radiology (OJRad) , 2015, DOI: 10.4236/ojrad.2015.52017
Abstract: Anterior sacral meningocele is characterized by the herniation of the thecal sac into the retroperitoneal space. A 33-year-old man was referred to our hospital with the complaints of a longlasting constipation and nonspecific lower abdominal pain. At ultrasound, a cystic mass was detected at the presacral space. Computed Tomography revealed a defect at the anterior aspect of the sacrum, together with a presacral cystic mass which showed a connection with the dural sac. At Magnetic Resonance Imaging, it was demonstrated that the cystic mass made an impression on the rectum, and did not possess any solid components. An anteroposterior pelvis radiogram demonstrated a sacral deformity and the scimitar sign. Upon these imaging findings, the patient got the diagnosis of an anterior sacral meningocele. The possibility of an anterior sacral meningocele must always be kept in mind in the differential diagnosis of a pelvic cystic mass.
The effects of kefir and enteral feeding products on colonic anastomosis: Experimental study
Hakan Yigitbas,Mustafa U Kalayci,Mehmet Abdussamet Bozkurt,Ahmet N Turhan
Medical Journal of Bakirk?y , 2011,
Abstract: Objective: Kefir is rich and affective probiotic feeding material with evidence based medical effects. There are many studies about antimicrobial, scatrizant, anticancer effects of Kefir but there is not any study on anastomotic burst pressure and healing effects on intestinal wall around anastomosis in the postoperative period (8). In this study the efficacy of Kefir (Alt nk l ) and Ensure (Abbott) as enteral feeding products as colonic anastomotic healing has been investigated. Material and Methods: In this study 40 Wistar-albino female rats were used. Rats were divided into 4groups as sham group (Group A), anastomosis group (Group B), kefir after anastomosis group (Group C), and ensure after anastomosis group (Group D). Results: There was no significant difference between the hemoglobin, hematocrit, leukocyte and thrombocyte levels of the groups (p>0.05) whereas there was statistically significant difference between the total protein levels of the groups (p<0.05). In the Kefir group bursting pressure was measured higher than in sham (p:0.003, p<0.01) and anastomosis group (p:0.001, p<0.01). In the Ensure group bursting pressure was measured statistically higher than in sham (p:0.035, p<0.05) and anastomosis (p:0.035, p<0.05) groups. In the sham group hydroxyproline levels were statistically higher than in anastomosis (p:0.001, p<0.01), Kefir (p:0.004, p<0.01) and Ensure (p:0.002, p< 0.01) groups. Conclusion: Kefir is currently being used for academically purposes as further clinical studies are needed. With more clinical studies preoperative use of Kefir would reduce postoperative mortality and morbidity rates.
A new integrable generalization of the Korteweg - de Vries equation
Ayse Karasu-Kalkanli,Atalay Karasu,Anton Sakovich,Sergei Sakovich,Refik Turhan
Physics , 2007, DOI: 10.1063/1.2953474
Abstract: A new integrable sixth-order nonlinear wave equation is discovered by means of the Painleve analysis, which is equivalent to the Korteweg - de Vries equation with a source. A Lax representation and a Backlund self-transformation are found of the new equation, and its travelling wave solutions and generalized symmetries are studied.
Clinical Approach for the Pneumomediastinum after Blunt Chest Trauma  [PDF]
Onder Kavurmaci, Tevfik Ilker Akcam, Ali Ozdil, Ayse Gul Ergonul, Kutsal Turhan, Alpaslan Cakan, Ufuk Cagirici
Open Journal of Thoracic Surgery (OJTS) , 2017, DOI: 10.4236/ojts.2017.71002
Abstract: Objective: Pneumomediastinum (PM) can be observed after blunt and penetrating chest trauma. Most of the patients with PM due to trauma can be managed conservatively. This study aimed to evaluate the cases with PM on thorax computed tomography (CT) after blunt chest trauma (BCT). Methods: Medical records of patients with PM due to BCT between January 2000 and December 2014 were reviewed retrospectively. Thorax CT was used to verify pneumomediastinum in all patients. Twenty-four patients which had different causes of PM (penetrating trauma, iatrogenic, spontaneous) were excluded from the study. Data of sixty-nine patients with the diagnosis of PM secondary to BCT and who were observed without any further procedure for the cause of PM, were evaluated retrospectively. Results: There were 59 male and 10 female patients with the mean age of 47.60 ± 17.47 years (range, 16 to 80 years). The most common cause of PM etiology was traffic accident with a rate of 38 (55.06%) patients, followed by fall from height in 25 (36.24%), compression in 3 (4.35%) and drubbing in 3 (4.35%) patients. There was a 12.46 ± 6.42 days (range, 6 to 28 days) mean duration of chest tube drainage which was performed for accompanying pathologies like pneumothorax and hemothorax. No complication was determined for short and long term follow-up of patients when all hospital records were analyzed in terms of complication. Conclusions: PM after BCT may be a marker of esophageal and tracheobronchial injury and invasive procedures like bronchoscopy and endoscopy can be needed for differential diagnosis. We evaluated 69 patients in good general status and no need for intensive care management with PM in this study and observed them without any further procedure. As a result of these findings we concluded that for the PM patients after BCT with uneventful clinical course, conservative treatment without any further procedure is a safe and sufficient method.
Molecular detection of cytomegalovirus, herpes simplex virus 2, human papillomavirus 16-18 in Turkish pregnants
Dinc, Bedia;Bozdayi, Gulendam;Biri, Aydan;Kalkanci, Ayse;Dogan, Bora;Bozkurt, Nuray;Rota, Seyyal;
Brazilian Journal of Infectious Diseases , 2010, DOI: 10.1590/S1413-86702010000600005
Abstract: objective: human cytomegalovirus (cmv) is the most common cause of viral intrauterine infections in the world. herpes simplex virus type 2 (hsv-2) and human papillomavirus (hpv) are the main agents of viral sexually transmitted diseases, which cause genital ulcers and genital warts, respectively. hpv infection has been linked to the majority of the anogenital malignancies. the aim of this study was to detect the existence of cmv, hsv-2 and hpv type 16-18 in turkish pregnants by using sensitive molecular assays. methods: one hundred thirty-four women (18-41 years old; mean age ± sd: 27 ± 8) applied to outpatient clinic of obstetrics and gynecology, in between 18th - 22nd weeks of their pregnancy and a control group of 99 healthy women (15-39 years old; mean age ± sd: 24 ± 8) were included in the study. cervical smear samples were used for dna extraction. cmv, hsv-2 and hpv 16-18 detections were carried out by real time pcr and in house pcr method, respectively. results: three patients (3/134; 2.2%) were found to be positive for each hpv and hsv-2. dual infection with hpv and hsv was found in just one patient. hpv 18 was detected in all positive samples. cmv was found to be positive in two patients (2/134; 1.4 %). conclusion: hpv, hsv and cmv must be screened due to high prevalence of these viruses in pregnants by using sensitive molecular methods.
Stability Analysis of a Nonlinear Difference Equation  [PDF]
Fatma Bozkurt
International Journal of Modern Nonlinear Theory and Application (IJMNTA) , 2013, DOI: 10.4236/ijmnta.2013.21001
Abstract:

The local and global behavior of the positive solutions of the difference equation

\"\"

was investigated, where the parametersα,βandγand the initial conditions are arbitrary positive numbers. Furthermore, the characterization of the stability was studied with a basin that depends on the conditions of the coefficients. The analysis about the semi-cycle of positive solutions has end the study of this work.

Case report: acute pancreatitis caused by postcholecystectomic hemobilia
Halil Alis, Mehmet A Bozkurt, Osman Z Oner, Kemal Dolay, Ahmet N Turhan, Adem U?ar, Ercan Inci, Ersan Aygun
BMC Gastroenterology , 2010, DOI: 10.1186/1471-230x-10-75
Abstract: We presented the case of a 32-year-old female, admitted to our emergency surgery clinic with hematemesis, jaundice and abdominal pain who had a history of laparoscopic cholecystectomy 4 months ago. Patient was diagnosed as acute pancreatitis and obstructive jaundice caused by postcholecystectomic hemobilia. Afterwards she is successfully treated by ERCP, angiographic identification and embolization of right hepatic artery pseudoaneurysm.We presented that postcholecystectomic hemobilia may cause acute pancreatitis and acute pancreatitis caused by postcholecystectomic hemobilia should also be included to the rare complications which may occur following cholecystectomy.Hemobilia is a rare cause of upper GI bleeding and the reasons for the majority of the cases are iatrogenic. It is also one of the rarest vascular complication following laparoscopic cholecystectomy but acute pancreatitis due to postcholecystectomic hemobilia as a late complication of cholecystectomy is not yet described.We report a case presented with acute pancreatitis caused by the hemobilia as a complication of cholecystectomy.A 32-year-old female presented with complaints of abdominal pain and hematemesis. History revealed that she has been suffering severe right upper quadrant pain for one year which resolved 4 months ago following elective laparoscopic cholecystectomy. Cystic artery and cystic duct was explored during operation and cholecystectomy was completed without any difficulty. Her physical examination revealed jaundice, abdominal tenderness, and melena. Her heart rate was 98/min., blood pressure 100/60 mm/hg and body temperature 36.7 C. Her abnormal blood analysis results were as following; hemoglobin: 6.4 g/dl, hematocrite: 21%, MCV: 70 fl, AST: 435 IU/L, ALT: 220 IU/L, GGT: 256 IU/L, LDH: 400 IU/L, amylase: 2046 IU/L, lipase: 7339 IU/L, total bilirubine: 8.0 mg/dl and direct bilirubine: 6.2 mg/dl.Nasogastric intubation and irrigation confirmed the presence of upper GI bleeding. Ten hours
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