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OALib Journal期刊

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Endothelial Nitric Oxyde Synthase Gene Polymorphisms in a Tunisian Deep Vein Thrombosis Group  [PDF]
Nedra Grira, Nadia Ben Abdelhafidh, Manel Ayoub, Rihab Sendesni, Bochra Adib, Najla Stambouli, Salah Othmani, Zied Aouni, Chakib Mazigh
Journal of Biosciences and Medicines (JBM) , 2016, DOI: 10.4236/jbm.2016.49004
Abstract: Deep vein thrombosis (DVT) is a multi-factorial disease involving both genetic and acquired risk factors. The objective of this study was to determine the frequencies of endothelial nitric oxide synthase (eNOS) gene polymorphisms G894T (rs1799983) and T-786C (rs2070744) to assess the role of these polymorphisms as a potential risk factor in the development of DVT. Methods: In this case-control study, we included 32 patients with deep vein thrombosis (DVT) and 31 healthy control subjects. Clinical characteristics were collected. Lipids plasma concentrations were determined by the colorimetric method. Genotyping for the polymorphisms was performed by restriction fragment length polymorphism (PCR-RFLP) method. Results: We had found that the eNos G894T genotype G/T was significantly increasing the risk of DTV (P = 0.042, OR = 3.9; 95% CI = 1.09 to 13.92). But no association of the eNOS T-786C variant and DVT was found. For the eNOs T-786C polymorphism, the frequency of the T/T genotype was 87.5% in patients (with an allelic frequency of T Allele equal to 91%). No significant difference was noted between the two groups (P > 0.05). Conclusion: The eNOs G894T polymorphism seems to be in association with DVT and may be considered as a risk factor, but this is not the case for the T-786C polymorphism.
Endothelial Nitric Oxide Synthase (eNOS) Glu298Asp Gene Polymorphism (G894T) as a Risk Factor for Type 2 Diabetes Mellitus in the Tunisian Population  [PDF]
Rihab Sendesni, Nedra Grira, Oussama Lamine, Sana Aboulkassem, Manel Ayoub, Nejla Stambouli, Ouertani Haroun, Chakib Mazigh, Zied Aouni
Open Access Library Journal (OALib Journal) , 2018, DOI: 10.4236/oalib.1104171
Abstract:
Introduction: Diabetes mellitus is a chronic disease whose global expansion gives it the characteristics of a pandemic. Diabetes risk factors are well known. In this work we proposed to study the role of genetic polymorphism of the eNOS G894T gene in the development of diabetes on the one hand and of these degenerative complications other. Methods: We conducted a prospective case-control study in which we included 200 subjects divided into 100 patients with type 2 diabetes and 100 controls in apparent good health. For each patient and control we measured lipid parameters, CRP-us and sought the G894T polymorphism of eNOS gene by PCR-RFLP. Results: The analysis of our results shows a statistically significant elevated TG values (p < 10﹣3), Lp (a) (p < 10﹣3), and CRP-us (p < 10﹣3) in type 2 diabetes compared with controls. The mutated genotypes of GT eNOS gene was significantly more frequent in diabetic patients. In our series, we did not notice any significant difference in genotype or allele frequency between diabetics with and without degenerative complications. Conclusion: The G894T polymorphism of eNOS gene appears to be a risk factor of T2DM. His role in the development of degenerative complications remains proved.
On Slide Mode Control of Chaotic Rikitake Two-Disk Dynamo—Chaotic Simulations of the Reversals of the Earth’s Magnetic Field  [PDF]
Ahmad Harb, Nabil Ayoub
International Journal of Modern Nonlinear Theory and Application (IJMNTA) , 2014, DOI: 10.4236/ijmnta.2014.33015
Abstract:

The modern nonlinear theory, bifurcation and chaos theory are used in this paper to analyze the dynamics of the Rikitake two-disk dynamo system. The mathematical model of the Rikitake system consists of three nonlinear differential equations, which found to be the same as the mathematical model of the well-known Lorenz system. The study showed that under certain value of control parameter, the system experiences a chaotic behaviour. The experienced chaotic oscillation may simulate the reversal of the Earth’s magnetic field. The main objective of this paper is to control the chaotic behaviour in Rikitake system. So, a nonlinear controller based on the slide mode control theory is designed. The study showed that the designed controller was so effective in controlling the unstable chaotic oscillations.

Correlation between Inflammatory Markers and Lipid Parameters in a Tunisian Coronary Artery Disease Group  [PDF]
Rihab Sendesni, Dhaker Lahidheb, Manel Ayoub, Nedra Grira, Dhekra Lafi, Nejla Stambouli, Mabrouka El Oudi, Ezzedine Ghazouani, Habib Haouala, Zied Aouni, Chakib Mazigh
Open Access Library Journal (OALib Journal) , 2016, DOI: 10.4236/oalib.1102635
Abstract:
Aims: To evaluate the relationship between inflammatory biomarkers and lipid parameters in a Tunisian coronary artery disease group. Material and Methods: In the study, we have included 122 subjects with acute coronary syndrome (ACS) confirmed by coronary angiography, selected among patients admitted to the cardiology department and 162 subjects free of any cardiovascular disease, recruited from medical and paramedical volunteers. Lipid parameters, high sensitivity CRP (hsCRP) and proinflammatory cytokines (IL6, IL8 and TNFα) were determined for all patients and controls. Results: A highly significant difference (P < 103) was noted between the mean of the hsCRP in coronary patients (14.65 ± 9.81 mg/L) compared to controls (1.63 ± 1.75 mg/L). We note also a significant difference between the means of IL6 in the diseased population (11.56 ± 8.23 pg/mL) compared to controls (2.5 ± 0.84 pg/mL) with a value of P < 103. The hsCRP values are inversely correlated with the HDLc values. No association was found between IL 8 and the various lipid parameters. Patients having high IL6 values had higher levels of CT and CT/HDLc ratio. This correlation is statistically significant. Regarding TNFα, there is a positive and significant correlation with CT and LDLc. Conclusion: Significant correlation was found between inflammatory markers and lipids profile. This may explain the role of inflammation in the development of cardiovascular disease.
Evaluation of Cardiovascular Risk Factors in Tunisian Coronary Patients  [PDF]
Grira Nadra, Sandesni Rihab, Lamine Ossama, Aboulkassem Sana, Ayoub Manel, El Oudi Mabrouka, Stambouli Najla, Lahidheb Thaker, Haouala Habib, Mazigh Chakib, Aouni Zied
Open Access Library Journal (OALib Journal) , 2018, DOI: 10.4236/oalib.1104214
Abstract:
Introduction: Ischemic heart disease ranked among the leading causes of death worldwide. Several biological and genetic risk factors associated with acute coronary syndrome. By addressing the risk factors, it is possible to prevent most of the cardiovascular diseases and contribute to the reduction of complications of acute coronary syndrome. Material and Methods: Our study is a prospective study that was conducted to the main military hospital of instruction of Tunis. Recruitment involved 122 coronary (n = 122) and 705 controls (n = 705) totaling a population of 827 subjects. Data collection concerned socio-demographic characteristics, anthropometric measurements, habits and lifestyle, health status and biological assessment. Results: Our study reported a high prevalence of cardiovascular classic risk factor particularly overweight (62.3%), diabetes (63.1%) and hypertension (50%). In 55% of coronary patients, moderate to intermediate hyperhomocysteinemia was found, but it appears to be an independent risk factor. The results of our study show a significant difference in the genotypic frequencies of the C677T mutation in the MTHFR gene between the two populations, cases and controls. Conclusion: Acute coronary syndromes are the leading cause of sudden death in adults. The evaluation of risk factors after acute coronary syndrome episode is essential for a better management according to the recommendations of learned societies and standards of good practice.
Role of Radiology in Infectious Diseases, HIV/AIDS Overview.
A Ayoub
Dar Es Salaam Medical Students' Journal , 2011,
Abstract: INTRODUCTION: Since the first case of HIV/AIDS appeared in USA and Africa more than two decades ago, the incidence of HIV/AIDS has continuously been increasing worldwide. It is estimated that 42 million people lived with HIV/AIDS in 2009 among whom 29.4 million (70%) were in Sub-Saharan Africa. Since there is no cure or vaccine presently available or in sight in near future, the current treatment strategy is to treat the opportunistic infections and HIV associated conditions. Developing countries account for about 60% of prevalence and 90% of new infections arise in the poor countries.2 In Africa the “worst case” scenario projections in the next 20 years are that: One quarter of the workforce will die, life expectancy will decrease from average of 63 to 47 years and 14 million children will be orphaned. OBJECTIVES: Emphasis on Diagnostic Imaging as the mainstay of management of patients with HIV/AIDS and related diseases. Demonstration of the role of radiology in the evaluation of patients, as guidance in interventional procedures such as drainages and biopsies as well as in the follow up of patients. Establishment of correct diagnosis of HIV associated conditions as they are very important so that patients can get appropriate treatment and less expenses are incurred during management. METHODOLOGY: This paper is a product of reviewing manuscripts and data available in journals,books and internet as stipulated in the reference section. The role of radiology in diagnosing and treating HIV/AIDS manifestations in each body system: HIV/AIDS spares no organ or system hence all radiological modalities have a role to play in the diagnosis and follow up of HIV/AIDS patients as is demonstrated in this imaging summary.
Heat Transfer Analysis of Different Types of Metal Hydrides in a Simple Geometric Storage Tank
Ayoub Kazim
Research Journal of Applied Sciences , 2012,
Abstract: In this study, a general 3-D steady state heat transfer analysis on a simple 1mX1mX1m hydrogen storage tank using different types of metal hydrides namely La0.95Nd0.05Ni5, LmNi(l) and Zr(Fe0.75Cr0.25)2 is carried out at hydrogen absorption rates of n=10-2 , n= 10-3 and n=10-4 mol/hr. The results demonstrated the significance of a higher absorption rate and reaction enthalpy of the metal hydride on the temperature distribution within the storage tank. Furthermore, a 12% and a negligible variation in the alloys temperature would occur if the changes in the thermal conductivity of hydrogen and convection coefficient are changed by 0.1 W/m C and 1 W m 2 C, respectively.
Determination of Combustion Parameters of a PEM Fuel Cell at Various Combustion Conditions
Ayoub Kazim
Journal of Engineering and Applied Sciences , 2012,
Abstract: This study evaluates the parameters that are associated with a combustion process of a Proton Exchange Membrane (PEM) fuel cell at various combustion conditions. Combustion parameters such as adiabatic flame temperature, air-fuel ratio, and fraction of water that condenses at 25 C and 1 atm, are considered in the analysis, which is performed at a theoretical air ratio ranging from 100 to 300% (from 0 to 200% excess air). Furthermore, exergy destruction associated with the combustion process was evaluated at each specified condition. The calculated results illustrated that the adiabatic flame temperature reached a maximum value of 2,526 K at 100% theoretical air and then reduced to 1,270 K at a theoretical air of 300%. Conversely, exergy destruction was evaluated to be 53,236 and 96,949 kJ kmol 1 at 100 and 300% of theoretical air, respectively.
Contes animaliers du Yémen
Houda Ayoub
Chroniques Yéménites , 2007,
Abstract: Patrimoine riche mais fragile, les contes yéménites sont l’objet d’un intérêt croissant de la part des chercheurs et des traducteurs, au Yémen comme en Europe. Fatima al-Baydan , qui a fondé en 2006 le centre M l Al-Dhahab (le Baton de Kohl ) pour la préservation du patrimoine oral de la mère et de l’enfant, a mené pendant une dizaine d’années un travail exceptionnel de collecte de contes, dans plusieurs gouvernorats du pays. L’atelier de traduction de l’école normale supérieure a rassemblé cinq contes brefs, issus de diverses régions, ayant tous pour personnages principaux des animaux. Animal Tales from YemenThe oral tales of Yemen are a very rich, but fragile heritage. They raise an increasing interest among the researchers and translators, in Yemen and abroad. Fatima al-Baydan , who created in 2006 the M l al-Dhahab ( the Kohl stick ) for the preservation of the oral litterature of the children and mothers, gathered an outstanding amount of tales in many governorates. The Ecole Normal Supérieure tranlation workshop (Paris) gathered five tales from various regions, which feature animals as main characters.
The Direct Extension Theorem
Ayoub Joseph
Mathematics , 2004,
Abstract: The problem of group extension can be divided into two sub-problems. The first is to find all the possible extensions of $H$ by $K$. The second is to find the different ways a group $G$ can arise as an extension of $H$ by $K$. Here we prove that the direct product $H\times K$ can arise as an extension of $H$ by $K$ in an essentially unique way: that is the direct extension. I would like to thank Yacine Dolivet for drawing my attention to the direct ``extension theorem'', and Anne-Marie Aubert as well as Charles-Antoine Louet for their support.
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