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Evaluation of Physiochemical Screening and Standardization on the Root of Rotula aquatica Lour.
Abhishek B*, Avinash Saini
Indian Journal of Pharmaceutical and Biological Research , 2013,
Abstract: The root of Rotula aquatica is also called as pashanbed, belonging to the family Borogenaceae. It is widely distributed in India from kumaun to Assam and western to southern India.The medicinal values of plant lie in their component phytochemicals such as alkaloids, flavonoids, phenolic compounds and other nutrients like as amino acid, proteins, which produce a definite physiological action on the human body. The proximate values such as moisture content, ash value, extractive value, were carried out. The dried roots powder was subjected to successive extraction with different solvents like petroleum ether, benzene, chloroform, methanol, ethanol and water. Macroscopic as well as microscopic studies of any crude drug are the primary steps to establish its botanical quality control before going to other studies. Hence Standardization of crude drug plays a very important role in identifying the purity and quality of crude drugs. The present investigation reveals Standardization which include Moisture Content, Total ash, Acid insoluble ash, Water soluble ash, Water soluble Extractive value, Alcohol soluble Extractive value, Phytochemical screening, and further isolation and identification of Phytoconstituents.
Genetic diversity among Indian phytopathogenic isolates of Fusarium semitectum Berkeley and Ravenel  [PDF]
Avinash Ingle, Mahendra Rai
Advances in Bioscience and Biotechnology (ABB) , 2011, DOI: 10.4236/abb.2011.23023
Abstract: We report total ten isolates of F. semitectum recovered from different hosts. Identity of these isolates was determined by morphological and cultural characteristics and confirmed by RAPD-PCR analysis using forty random primers. Morphologically all the ten isolates showed similarity, but based on RAPD-PCR analysis, these isolates can be categorized in three groups depending upon similarity co-efficient. Genetic similarity coefficients between pair wise isolates varied from 0.00 to 1.95 based on an unweighted paired group method of arithmetic average (UPGMA) cluster analysis. RAPD-PCR technique can be used as an important tool for the genetic differentiation among isolates of F. semitectum.
Ab-Initio Structural Study of SrMoO3 Perovskite  [PDF]
Avinash Daga, Smita Sharma
Journal of Modern Physics (JMP) , 2012, DOI: 10.4236/jmp.2012.312238
Abstract: The equilibrium crystal structure parameter and bulk modulus of the SrMoO3 perovskite has been calculated with ab-initio method based on density functional theory (DFT) using both local density approximation (LDA) and generalized gradient approximation (GGA). The corresponding total free energy along with its various components for SrMoO3 was obtained. The lattice parameter and bulk modulus calculated for SrMoO3 within LDA are 3.99 A and 143.025 GPa respectively whereas within GGA are 4.04 A and 146.14 GPa respectively, both agree well with the available experimental data. The total energy calculated within LDA and GGA is almost the same however lower results are obtained for GGA. All calculations have been carried out using ABINIT computer code.
Insights on the structural characteristics of NDM-1: The journey so far  [PDF]
Avneet Saini, Rohit Bansal
Advances in Biological Chemistry (ABC) , 2012, DOI: 10.4236/abc.2012.24040
Abstract: New Delhi metallo-β-lactamase (NDM-1) has created a medical storm ever since it was first reported; as it is active on virtually all clinically used β-lactam antibiotics. NDM-1 rampancy worldwide is now considered a nightmare scenario, particularly due to its rapid dissemination. An underlying theme in the majority of recent studies is structural characterization as knowledge of the three-dimensional structure of NDM-1 shall help find connections between its structure and function. Moreover, structural details are even critical in order to reveal the resistance mecha- nism to β-lactam antibiotics. In this perspective, we review structural characteristics of NDM-1 that have been delineated since its first report. We anticipate that these structure-function connections made by its characterization shall further serve as future guidelines for elucidating pathways towards de novo design of functional inhibitors.
Controlled Growth of CdS Nanocrystals: Core/Shell viz Matrix  [PDF]
Prinsa. verma, Avinash C Pandey
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2011, DOI: 10.4236/jbnb.2011.24050
Abstract: The ability to precisely control the size of semiconductor nanocrystals can create an opportunity for producing functional materials with new properties, which are of importance to applications such as Light emitting diodes, biomedical diagnosis, solar cells, and spintronics. And size of nanoparticle can be controlled with efficient capping agent. For the same purpose we reported, two types of capping, one will lead to nanomatrix and other to Shelled nanostructures. Enhancement in emission intensity observed with Shell nanostructures compare to matrix. PVP is used to control the particle size, to prevent agglomeration and making thin films. A blue shift in energy level at the nanoscale is demonstrated by optical absorption. Electron microscopy studies with an SEM and TEM show a particle size of 10 nm and 15 nm. We also investigated the particle size distribution of nanoparticles by small angle scattering (SAXS) study.
Peptoids with aliphatic sidechains as helical structures without hydrogen bonds and collagen/ inverse-collagen type structures  [PDF]
Fateh S. Nandel, Avneet Saini
Journal of Biophysical Chemistry (JBPC) , 2011, DOI: 10.4236/jbpc.2011.21006
Abstract: Aliphatic homo-polypeptoids of NAla, NVal, NIle and NLeu both in the presence and absence of protecting groups adopt helical structures without hydrogen bonds with Φ, Ψ values of ~ 0, ± 90° with trans amide bonds. These structures are stabilized by carbonyl-carbonyl interactions and characterized by ~ 3.16 residues per turn with a pitch of ~ 6.13 Å. It has been shown that like polyvaline and polyleucine peptides, poly-peptoids can also be exploited for the construction of potential surfactant like molecules by incorporating charged amino acid residues at the N terminal. A single-handed template with Φ, Ψ values of ~ 0, 90° can be attained by incorporating L-leu or L-val at the C-terminal of poly-NIle. Analysis of the simulation results in water as a function of time reveals that the opening of helical structures without hydrogen bonds takes place at sub-picosecond time scale starting from the N-terminal. This leads to the formation of collagen or inverse-collagen type structures (Φ, Ψ ~ -60, 145° and 60, -145° respectively) stabilized by interactions of water molecules with the backbone carbonyl groups.
Molecularly Imprinted Polymers for the Detection of Food Toxins: A Minireview  [PDF]
Shivender Singh Saini, Anupreet Kaur
Advances in Nanoparticles (ANP) , 2013, DOI: 10.4236/anp.2013.21011
Abstract:

Food contamination from natural or anthropogenic sources poses severe risks to human health. It is now largely accepted that continuous exposure to low doses of food Toxins such as mycotoxins, phycotoxins can be related to several chronic diseases, including some type of cancer and serious hormonal dysfunctions. Contemporary analytical methods have the sensitivity required for contamination detection and quantification, but direct application of these methods on real samples can be rarely performed because of matrix complexity. Thus, selective analytical methods, relying on intelligent functional materials are needed. Recent years have seen the increasing use of molecular imprinted polymers in contaminant analysis in food because these materials seem to be particularly suitable for applications where analyte selectivity is essential. It offers several advantages to the agrofood industry in areas such as analysis, sensoring, extraction, or preconcentration of components. It has the potential of becoming a tool for acquiring truly simple, rapid, and robust direct measurements.

Common Fixed Point Result of Multivalued and Singlevalued Mappings in Partially Ordered Metric Space  [PDF]
Rajesh Kumar Saini, Archana Sharma
Advances in Pure Mathematics (APM) , 2013, DOI: 10.4236/apm.2013.31019
Abstract:

In recent times the fixed point results in partially ordered metric spaces has greatly developed. In this paper we prove common fixed point results for multivalued and singlevalued mappings in partially ordered metric space. Our theorems generalized the theorem in [1] and extends the many more recent results in such spaces.

Numerical Solution of Singularly Perturbed Two-Point Boundary Value Problem via Liouville-Green Transform  [PDF]
Hradyesh Kumar Mishra, Sonali Saini
American Journal of Computational Mathematics (AJCM) , 2013, DOI: 10.4236/ajcm.2013.31001
Abstract:

In this paper, authors describe a Liouville-Green transform to solve a singularly perturbed two-point boundary value problem with right end boundary layer in the interval [0, 1]. They reply Liouville-Green transform into original given problem and finds the numerical solution. Then they implemented this method on two linear examples with right end boundary layer which nicely approximate the exact solution.

Periodontal diseases: A risk factor to cardiovascular disease
Saini Rajiv,Saini Santosh,Saini Sugandha
Annals of Cardiac Anaesthesia , 2010,
Abstract:
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