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Search Results: 1 - 10 of 2086 matches for " Atsushi Kittaka "
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Chiral Peptide Nucleic Acids with a Substituent in the N-(2-Aminoethy)glycine Backbone
Toru Sugiyama,Atsushi Kittaka
Molecules , 2013, DOI: 10.3390/molecules18010287
Abstract: A peptide nucleic acid (PNA) is a synthetic nucleic acid mimic in which the sugar-phosphate backbone is replaced by a peptide backbone. PNAs hybridize to complementary DNA and RNA with higher affinity and superior sequence selectivity compared to DNA. PNAs are resistant to nucleases and proteases and have a low affinity for proteins. These properties make PNAs an attractive agent for biological and medical applications. To improve the antisense and antigene properties of PNAs, many backbone modifications of PNAs have been explored under the concept of preorganization. This review focuses on chiral PNAs bearing a substituent in the N-(2-aminoethyl)glycine backbone. Syntheses, properties, and applications of chiral PNAs are described.
A Peptide Nucleic Acid to Reduce Type I Collagen Production by Fibroblast Cells  [PDF]
Yasutada Imamura, Suzuka Tsuboi, Toru Sugiyama, Atsushi Kittaka, Yonchol Shin
Open Journal of Medicinal Chemistry (OJMC) , 2015, DOI: 10.4236/ojmc.2015.51001
Abstract: In this study, we prepared a peptide nucleic acid (PNA) against the gene coding for the human alpha 1 chain of type I collagen. This PNA was incorporated into normal human fibroblast cells by electroporation, leading to a decrease in the mRNA level of the gene. Furthermore, mRNA for the alpha 2 chain of type I collagen was also reduced. The production of collagen protein exhibited a similar profile to the changes in mRNA. These results indicate that PNA targeting COL1A1 is effective as an antigene reagent, and opens the possibility of future clinical applications in fibroproliferative disorders.
Novel Vitamin D Analogs for Prostate Cancer Therapy
Tai C. Chen,Atsushi Kittaka
ISRN Urology , 2011, DOI: 10.5402/2011/301490
Clinical Analysis of Pulmonary Nontuberculous Mycobacterial Disease Complicated by Lung Cancer during the Follow-Up Periods  [PDF]
Yoshihiro Kobashi, Makoto Kittaka, Keiji Mouri, Shigeki Kato, Mikio Oka
Open Journal of Respiratory Diseases (OJRD) , 2016, DOI: 10.4236/ojrd.2016.64009
Abstract: Introduction: The objective of this study was the estimation of the clinical characteristics of patients with pulmonary nontuberculous mycobacterial (NTM) disease complicated by lung cancer during the follow-up periods. Methods: We analyzed the clinical findings of four patients (2.0%) complicated by lung cancer during the follow-up periods of over six months at least after the definite diagnosis of pulmonary NTM disease of 202 patients with pulmonary NTM disease experienced in our hospital in the last decade. Results: There were four patients with pulmonary NTM disease complicated by lung cancer and all of them were caused by Mycobacterium avium complex (MAC). They were all elderly male patients and had underlying diseases. Three patients were diagnosed with primary lung cancer and one diagnosed with metastatic lung cancer from colon cancer within 3 years after the diagnosis of pulmonary NTM disease. The treatments for lung cancer were surgical resection for all patients with localized lesions. One patient died due to the worsening of underlying disease and the remaining three survived except for the recurrence of one patient. Conclusion: Although the complication rate of pulmonary NTM disease and lung cancer was a lower percentage (2.0%) than in previous reports, the careful follow-up for patients with pulmonary NTM disease without forgetting the possible complication of lung cancer is necessary.
Economic Growth with Asset Bubbles in a Small Open Economy  [PDF]
Atsushi Motohashi
Theoretical Economics Letters (TEL) , 2016, DOI: 10.4236/tel.2016.65097
Abstract: This paper analyzes the characteristics of asset bubbles in a small open economy. First, we show that financial globalization relaxes the existence conditions for asset bubbles. This result implies that more countries may experience asset bubbles in a global economy. Second, we show that the effect of asset bubbles in a global economy is larger than in a closed economy. In particular, countries with high financial friction experience a high economic growth rate before a foreign bubble bursts and they are subjected to more negative influence after that. This conclusion implies that financial globalization may cause large economic movements before and after a bubble bursts.
A Case Report of Spontaneous Closure of a Posttraumatic Arterioportal Fistula
Hirotada Kittaka,Hiroshi Akimoto,Keitaro Tashiro
Case Reports in Emergency Medicine , 2013, DOI: 10.1155/2013/623704
Abstract: As the indications for the nonoperative management (NOM) of hepatic injury have expanded, the incidence of complications of NOM has increased. Among such complications, arterioportal fistula (APF) formation is rare, although dangerous, due to the potential for portal hypertension. Embolization is performed in APF patients with clinical signs suggestive of portal hypertension. Meanwhile, no indications for treatment have been established in APF patients without symptoms, as the natural history of posttraumatic APF is not well understood. We herein report the case of a 35-year-old female with severe hepatic injury (Grade IV on the Organ Injury Scale of the American Association for the Surgery of Trauma) due to a traffic accident. Her hemodynamic state remained stable, and an enhanced CT scan obtained on admission showed no extravasation of contrast medium, pseudoaneurysm formation, or APF; therefore, NOM was selected. Although the patient’s physical condition was stable, an enhanced CT scan obtained 13 days after the injury showed APF in segment 8 of the liver. Although embolization was considered, the APF was not accompanied by portal dilatation suggestive of portal hypertension; hence, strict observation was selected. Consequently, follow-up CT performed on day 58 after the injury revealed spontaneous closure of the APF. 1. Introduction The most common cause of arterioportal fistula (APF) has been reported to be hepatic trauma (28%), followed by iatrogenic procedures (16%), congenital vascular malformation (15%), malignancy (15%), and rupture of splanchnic artery aneurysms (14%) [1]. As the indications for the nonoperative management (NOM) of hepatic trauma injury have expanded, with high reported success rates ranging from 83% to 100% [2–4], the incidence of complications, including APF, posttraumatic pseudoaneurysms, bile leakage, and hepatic abscesses, has increased [3, 5, 6]. APF is rare; however, it is considered to be clinically dangerous due to the possibility of portal hypertension and ultimate rupture of esophageal varices. Therefore, transarterial embolization is usually performed in APF patients with clinical signs, such as splenomegaly or ascites, that are suggestive of portal hypertension [7–9]. On the other hand, no indications for treatment have been established in APF patients without symptoms, as the natural history of posttraumatic APF is not well understood. We encountered a rare case of spontaneous closure of posttraumatic APF detected on follow-up enhanced computed tomography (CT) for blunt liver trauma. 2. Case Report A 35-year-old
Large Enhancement of 3-K Phase Superconductivity in the Sr2RuO4-Ru Eutectic System by Uniaxial Pressure
Shunichiro Kittaka,Hiroshi Yaguchi,Yoshiteru Maeno
Physics , 2009, DOI: 10.1143/JPSJ.78.103705
Abstract: While the superconducting transition temperature Tc of Sr2RuO4 is 1.5 K, its onset Tc is enhanced as high as 3 K in the Sr2RuO4-Ru eutectic system, which is often referred to as the 3-K phase. We have investigated effects of uniaxial pressure on the non-bulk superconductivity in the 3-K phase. While Tc of pure Sr2RuO4 is known to be suppressed by hydrostatic pressure, a large enhancement of the superconducting volume fraction of the 3-K phase was observed for both out-of-plane and in-plane uniaxial pressures. Especially, under the in-plane pressure, the shielding fraction at 1.8 K of only less than 0.5% at 0 GPa exceeds 40% at 0.4 GPa. Such a large shielding fraction suggests that under the uniaxial pressure interfacial 3-K phase superconductivity penetrates deep into the bulk of Sr2RuO4. The present finding provides a significant implication to the unresolved origin of the enhancement of Tc to 3 K in the Sr2RuO4-Ru eutectic system.
MART-10, a New Generation of Vitamin D Analog, Is More Potent than 1α,25-Dihydroxyvitamin D3 in Inhibiting Cell Proliferation and Inducing Apoptosis in ER+ MCF-7 Breast Cancer Cells
Kun-Chun Chiang,Chun-Nan Yeh,Shin-Cheh Chen,Shih-Che Shen,Jun-Te Hsu,Ta-sen Yeh,Jong-Hwei S. Pang,Li-Jen Su,Masashi Takano,Atsushi Kittaka,Horng-Heng Juang,Tai C. Chen
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/310872
Abstract: Hormone antagonist therapy for estrogen receptor positive (ER+) breast cancer patients post radical surgery and radiation therapy has a poor prognosis and also causes bone loss. 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3] is a potent antitumor agent in pre-clinical studies, but caused hypercalcemia when its effective antitumor doses were used. Therefore, we investigated the effects of a less-calcemic 1α,25(OH)2D3 analog, 19-nor-2α-(3-hydroxypropyl)-1α,25-dihydroxyvitamin D3 (MART-10), on ER+MCF-7 cells. We demonstrate that MART-10 is 500- to 1000-fold more potent than 1α,25(OH)2D3 in inhibiting cell growth in a dose- and time-dependent manner. MART-10 is also much more potent in arresting MCF-7cell cycle progression at G0/G1 phase as compared to 1α,25(OH)2D3, possibly mediated by a greater induction of p21 and p27 expression. Moreover, MART-10 is more active than 1α,25(OH)2D3 in causing cell apoptosis, likely through a higher BAX/Bcl expression ratio and the subsequent cytochrome C release from mitochondria to cytosol. Based on our in vitro findings, MART-10 could be a promising vitamin D analog for the potential treatment of breast cancer, for example, ER+ patients, to decrease the tumor relapse rate and the side effect on bone caused by antihormone regimens. Thus, further in vivo animal study is warranted. 1. Introduction Breast cancer ranks first globally among the most commonly diagnosed and cancer-related deaths in women [1]. Over 1.38 million new breast cancer cases and 458,400 breast cancer-related deaths have been reported worldwide in 2008. Estrogen receptor (ER), which is present in nearly 70% of all breast cancer patients, plays a crucial role in the progression of breast cancer [2]. Thus, ER antagonists, tamoxifen and raloxifene, have been widely used to treat breast cancer and have contributed to a better prognosis for ER positive (ER+) breast cancer. However, only a 50% reduction in tumor relapse has been achieved by ER antagonist therapy [3]. Furthermore, the antagonists have serious side effects on bone [4], which highlights the necessity of seeking alternative treatments for ER+ breast cancer. Vitamin D is well known as a modulator of calcium and bone metabolism. For the past three decades, abundant evidence has been accumulated to indicate that the active form of vitamin D, 1α,25-dihydroxyvitamin D3, 1α,25(OH)2D3, or calcitriol, possesses many actions not associated with calcium and bone metabolism [5]. They include antiproliferation, antiangiogenesis, proapoptosis, prodifferentiation, and immune regulation in a cell- and tissue- specific
Eating disorders, body image, and dichotomous thinking among Japanese and Russian college women  [PDF]
Atsushi Oshio, Tatiana Meshkova
Health (Health) , 2012, DOI: 10.4236/health.2012.47062
Abstract: This study explored cross-cultural differences between Japan and Russia in terms of women’s body images, proneness to eating disorders, and the effects of dichotomous thinking. Participants included 419 Japanese and 187 Russian college women who completed the Dichotomous Thinking Inventory (DTI), the 26-item version of the Eating Attitudes Test, and responses regarding nine figures representing female body shapes. The mean age of the participants was 19.8 years, with no significant age differences between the countries. The results showed that Japanese women have leaner ideal body images than Russian women, whereas there were no cross-cultural differences in the participants’ real body images. DTI scores among Russian participants were higher than DTI scores among Japanese participants, which indicated that Russian women think more dichotomously than Japanese. Structural equation modeling indicated a significantly negative effect of dichotomous thinking only on real body image in Russia; the ideal body image had greater effects on eating disorder in Russia than in Japan.
Thermal Energy Collection Forecasting Based on Soft Computing Techniques for Solar Heat Energy Utilization System  [PDF]
Atsushi Yona, Tomonobu Senjyu
Smart Grid and Renewable Energy (SGRE) , 2012, DOI: 10.4236/sgre.2012.33030
Abstract: In recent years, introduction of alternative energy sources such as solar energy is expected. Solar heat energy utilization systems are rapidly gaining acceptance as one of the best solutions to be an alternative energy source. However, thermal energy collection is influenced by solar radiation and weather conditions. In order to control a solar heat energy utilization system as accurate as possible, it requires method of solar radiation estimation. This paper proposes the forecast technique of a thermal energy collection of solar heat energy utilization system based on solar radiation forecasting at one-day-ahead 24-hour thermal energy collection by using three different NN models. The proposed technique with application of NN is trained by weather data based on tree-based model, and tested according to forecast day. Since tree-based-model classifies a meteorological data exactly, NN will train a solar radiation with smoothly. The validity of the proposed technique is confirmed by computer simulations by use of actual meteorological data.
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