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Search Results: 1 - 10 of 2171 matches for " Atsushi Fukumoto "
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Piericidins, Novel Quorum-Sensing Inhibitors against Chromobacterium violaceum CV026, from Streptomyces sp. TOHO-Y209 and TOHO-O348  [PDF]
Kazuhiro Ooka, Atsushi Fukumoto, Tomoe Yamanaka, Kanako Shimada, Ryo Ishihara, Yojiro Anzai, Fumio Kato
Open Journal of Medicinal Chemistry (OJMC) , 2013, DOI: 10.4236/ojmc.2013.34012
Abstract: Piericidin A1, 3’-rhamnopiericidin A1, and a novel compound piericidin E, a new quorum-sensing (QS) inhibitor
against Chromobacterium violaceum CV026, were isolated from the culture broth of Streptomyces sp. QS is well
known as a microbial signaling system and controls certain types of gene expression resulting in bioluminescence,
biofilm formation, swarming motility, antibiotic biosynthesis, and virulence factor production. C. violaceum CV026 is
commonly used to determine qualitative and quantitative QS activity. The structures of piericidin derivatives were characterized,
and their QS activities were determined.
Relationship between Perceived Health Status and Health Practices in the General Adult Population in Japan  [PDF]
Yukari Noguchi, Kimiyo Ueda, Kumiko Fukumoto, Koichi Harada, Atsushi Ueda, Chang-Nian Wei
Open Journal of Preventive Medicine (OJPM) , 2015, DOI: 10.4236/ojpm.2015.56031
Abstract: The objective of this study was to explore the relationship of perceived health status and Breslow’s seven health Practices(7 - 8 hours of sleep per night, maintaining a healthy weight, moderate or no alcohol intake, regular physical activity, no eating between meals, eating breakfast, and having never smoked cigarettes) in adult residents in Kumamoto Prefecture Japan. We used 2011 data from the “Health Japan 21” program in Kumamoto Prefecture, a study consisting of 2519 adults aged from 20 - 74 years. Data for the study were gathered by questionnaire. The questionnaire was divided into following sections: perceived health status, seven health practices, life satisfaction, depression, social network, and demographic variables. We found that those groups engaged in more than four health practices had higher scores for perceived health status than those groups with less than four. Using Pearson’s correlation coefficient, positive correlations were found between perceived health status and health practices (r = 0.229, p < 0.001), life satisfaction (r = 0.279, p < 0.001), and social network (r = 0.089, p < 0.001); negative correlations were found with age (r = 0.058, p < 0.01), body mass index (BMI) (r = 0.093, p< 0.001), and depression (r = 0.109, p < 0.001). Furthermore, we clarified the differences in perceived health status by age and gender. The data from multiple regression analysis show an association between level of perceived health status and life satisfaction, the seven health practices, employment, age, depression, and social network. Our findings demonstrate a relationship between perceived health status and the seven health practices, and can be used to encourage healthier practices to enhance perceived health status and life satisfaction in community health care work.
Sensitization Potential of Dental Resins: 2-Hydroxyethyl Methacrylate and Its Water-Soluble Oligomers Have Immunostimulatory Effects
Izumi Fukumoto, Atsushi Tamura, Mitsuaki Matsumura, Hiroyuki Miura, Nobuhiko Yui
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0082540
Abstract: The immunostimulatory effects of the representative dental resin monomer 2-hydroxyethyl methacrylate (HEMA), a HEMA derivative that does not contain a double bond (2-hydroxyethyl isobutyrate, HEIB), and polymerized water-soluble oligomers of HEMA (PHEMA) were investigated. It is known that expression levels of either or both of CD54 and CD86 in THP-1 cells are increased by exposure to sensitizing substances. In this study, the expression levels of CD54 and CD86, the production of reactive oxygen species (ROS), and the viability of the cells were measured after 24 h of incubation with these materials at different concentrations. The concentrations of the materials that induced the expression of both CD54 and CD86 were low in the following order: NiSO4, HEMA, and methyl methacrylate (MMA). These results indicate that these dental resin monomers have lower sensitizing potentials than NiSO4. Although HEIB, which lacks a double bond, resulted in negligible ROS production and reduced cytotoxicity than HEMA, it induced the expression of CD54 and CD86. Comparison of the results for HEMA and HEIB indicates that dental resin monomer-induced sensitization may be related not only to the oxidative stress related to the methacryloyl group but also to the structures of these compounds. Of particular interest is the result that a water-soluble PHEMA oligomer with a relatively high-molecular weight also exhibited negligible cytotoxicity, whereas the expression level of CD54 increased after exposure to PHEMA at a high concentration. This result serves as a warning that polymerized substances also have the potential to induce sensitization. This study provides insight into the nature of allergic responses to dental resin materials in clinical use and may facilitate the development of more biocompatible restorative materials in the future.
Changes in the Equilibrium of Standing on One Leg at Various Life Stages
Shu Morioka,Takahiko Fukumoto,Makoto Hiyamizu,Atsushi Matsuo,Hideaki Takebayashi,Kenzo Miyamoto
Current Gerontology and Geriatrics Research , 2012, DOI: 10.1155/2012/516283
Abstract: The ability to maintain a one-leg standing position and the relation between plantar two-point discrimination and standing time on one leg were assessed. Participants were 1,241 apparently healthy people aged 2–92 years. Participants were asked to stand on one leg with eyes open (EO group) or closed (EC group) for up to 120 seconds. Coefficients of determination (COD) between subjects’ ages and results for both groups were calculated by quadratic and cubic functions. The slope of the tangent line drawn against the resultant curve was calculated by a differential formula. COD for the quadratic function were 0.65 (EO) and 0.33 (EC); age at maximum values in both groups was 37 years. COD for the cubic function were 0.77 (EO) and 0.52 (EC); maximum values were at ages 30 (EO) and 28 (EC) and minimum values at ages 88 (EO) and 77 (EC). The ability to remain standing on one leg with eyes closed appears to begin deteriorating in the late 20s. Age and plantar two-point discrimination distance had a significant positive correlation, and the two-point discrimination distance and standing time on one leg had a significant negative correlation. Decreased plantar sensation appears to be related to the decline in duration of one-leg standing. 1. Introduction Children will gain upright postural control equivalent to adults’ when they are aged 7–10 years [1–4] or 9–12 years [5] according to various studies. The reason may be that children aged over 6 years can appropriately integrate the afferent sensory information required for posture control [6] and acquire the same upright postural control strategy as do adults’ [1]. Foudriat et al. [7] revealed that upright postural control in children up to 3 years of age is vision-dominant, but from that age onward, control will be gradually shifted to somatosensory-dominant control. Somatosensory-dominant postural control equivalent to that of adults will be achieved at ages over 6 years, which indicates that the development of standing balance may be nearly completed in the early school years. Morioka [8] has reported that the ability to maintain the one-leg standing position with eyes open will dramatically improve in children within the period from late preschool age to early school age, and the improvement will slow down during late school age. That study indicated that the development of standing balance is nonlinear and that it is accelerated beginning at a certain age. On the other hand, the involutional process of standing balance has been reported to be opposite to the process of developing postural control strategies
Treatment of an Extensive Maxillary Cyst Using Nasal Airway and Balloon Catheter Devices
Atsushi Kasamatsu,Chonji Fukumoto,Morihiro Higo,Yosuke Endo-Sakamoto,Katsunori Ogawara,Masashi Shiiba,Hideki Tanzawa,Katsuhiro Uzawa
Case Reports in Dentistry , 2014, DOI: 10.1155/2014/216828
Abstract: Introduction. Large maxillary cysts occasionally expand into the maxilla and erode the maxillary sinus and nasal cavity. The Caldwell-Luc procedure is the recommended treatment for large maxillary sinus cysts. However, it is hard to preserve the nasal space in the case of large maxillary sinus cysts that penetrate into the nasal cavity. Methods. A 22-year-old man who had large maxillary sinus cysts was referred to our department for a surgical treatment. After removing the cyst from the maxillary sinus using the Caldwell-Luc procedure, we used nasal airway and balloon catheter devices to preserve the space of the inferior nasal meatus and maxillary sinus. These devices were removed 10 days postoperatively. Insertion and removal of both devices were simple and painless. Findings. The nasal airway and balloon catheter devices were useful for performing maxillary sinus surgery to remove large cysts. Our method was satisfactorily safe and was an effective minimally invasive treatment that preserved the space of the inferior nasal meatus and maxillary sinus. 1. Introduction Among large maxillary cysts that expand to the maxillary sinus, dentigerous cysts, and radicular cysts are two main odontogenic cysts [1]. In the oral and maxillofacial regions, cyst enucleation combined with the Caldwell-Luc procedure [2, 3], which has been the mainstay of maxillary sinus surgery over the past century, was adopted for their treatment [4]. In this report, we describe a new method to treat maxillary cysts that have expanded into the maxilla, the maxillary sinus, and the nasal cavity using nasal airway and balloon catheter devices after the Caldwell-Luc procedure. 2. Case Presentation A 22-year-old man suffering from complete nasal obstruction for the last 5 months was referred to our department. Computed tomography scan showed impacted teeth along with the radiopaque borders in bilateral maxillary sinuses (Figure 1). To remove the large maxillary sinus cysts and preserve the space of the inferior nasal meatus and maxillary sinus, surgical enucleation for the cysts was performed according to the Caldwell-Luc procedure [2–4]. After removing the cysts from the maxillary sinus, we created a nasoantral window in the lateral nasal wall as described previously [2, 3] and a hole at the same position as the nasoantral window in the nasal airway device (Figure 2(a) arrow). The maxillary sinus was packed with the balloon catheter, instead of a gauze tampon, through the lateral hole of the nasal airway (Figures 2(b), 2(c), and 3). These devices were removed 10 days postoperatively. A
Influencia asiática en las Américas: chinos y japoneses en América del Sur
Mary Fukumoto
Anthropologica , 1994,
Two-Triplet-Dimer Excitation Spectra in the Shastry-Sutherland Model for SrCu_2(BO_3)_2
Yoshiyuki Fukumoto
Physics , 2000, DOI: 10.1143/JPSJ.69.2755
Abstract: By using the perturbation expansion up to the fifth order, we study the two-triplet-dimer excitation spectra in the Shastry-Sutherland model, where the localized nature of a triplet-dimer, the propagation of a triplet-dimer pair by the correlated hopping and the long-range interactions between triplet-dimers play an essential role. It is found that the dispersion relations for first-neighbor triplet-dimer pair excitations with S=1 and p-type symmetry qualitatively explain the second-lowest branch observed in the neutron inelastic scattering experiment. It is also predicted that the second-lowest branch consists of two components, p_x- and p_y-states, with slightly different excitation energies. The origin of the singlet mode at 3.7meV observed in the Raman scattering experiment is also discussed.
Magnetization Plateaus in the Shastry-Sutherland Model for SrCu_2(BO_3)_2: Results of Fourth-Order Perturbation Expansion with a Low-Density Approximation
Yoshiyuki Fukumoto
Physics , 2000, DOI: 10.1143/JPSJ.70.1397
Abstract: Magnetization plateaus in the Shastry-Sutherland model for ${\rm SrCu_2(BO_3)_2}$ are studied by the perturbation expansion method. The fourth-order effective Hamiltonian which describes the dynamics of triplet dimers (TD's) with $S^{\rm tot}_z=1$ in the singlet sea is derived and then partially diagonalized for the space that consists of the TD configurations with the lowest second-order energy. The fourth-order terms are treated within a low-density approximation. Our procedure makes clear how TD interactions are responsible for the formation of magnetization plateaus. Particularly, the 1/4-plateau is obtained by the fourth-neighbor TD repulsion in the fourth-order perturbation, and a diagonal stripe arrangement of TD's appears at this plateau.
Cobordism category of plumbed 3-manifolds and intersection product structures
Yoshihiro Fukumoto
Mathematics , 2009,
Abstract: In this paper, we introduce a category of graded commutative rings with certain algebraic morphisms, to investigate the cobordism category of plumbed 3-manifolds. In particular, we define a non-associative distributive algebra that gives necessary conditions for an abstract morphism between the homologies of two plumbed 3-manifolds to be realized geometrically by a cobordism. Here we also consider the homology cobordism monoid, and give a necessary condition using w-invariants for the homology 3-spheres to belong to the inertia group associated to some homology 3-spheres.
Invariance of Finiteness of K-area under Surgery
Yoshiyasu Fukumoto
Mathematics , 2013,
Abstract: K-area is an invariant for Riemannian manifolds introduced by Gromov as an obstruction to the existence of positive scalar curvature. However in general it is difficult to determine whether K-area is finite or not. though the definition of K-area is quite natural. In this paper, we study how the invariant changes under surgery.
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