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Search Results: 1 - 10 of 304 matches for " Atoumane Faye "
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Renal Disease among HIV Positive Patients in Senegal  [PDF]
Khodia Fall, Mouhamadou Moustapha Cissé, Ahmed Tall Lemrabott, Maria Faye, Mouhamed Cherif Dial, Atoumane Faye, Seynabou Fall, Moustapha Faye, Alex Keita, Mansour Mbengue, Seynabou Diagne, Niakhaleen Keita, Bacary Ba, Abdou Niang, Boucar Diouf, El Hadji Fary Ka
Open Journal of Nephrology (OJNeph) , 2017, DOI: 10.4236/ojneph.2017.74012
Abstract: Introduction: Renal disease (RD) in human immunodeficiency virus (HIV) infection is a decisive turning point in the development and prognosis of this disease. In Africa, the prevalence varies between 2.5% and 48.6%. In Senegal, little data are available in the literature. The objective of our study was to describe the epidemiological, clinical, paraclinical, therapeutic and progressional aspects in patients living with HIV (PLWHIV). Patients and methods: This was a retrospective, descriptive and analytical study carried out over a 10-year period in the Department of Internal Medicine and Nephrology at the Aristide Le Dantec Hospital in Dakar, Senegal. We included all 15-year old and above PLHIV with available CD4 count and viral load. Results: Out of 248 PLHIV, 32 had kidney disease (KD), which means a hospital prevalence of 12.9%. The mean age was 51.22 ± 10 years (extremes of 36 and 77 years) with a sex ratio (male/female) of 1.28. Renal signs were dominated by glomerular nephropathy syndrome. It was present at 80%. Tubulo-interstitial nephropathy syndrome and chronic uremic syndrome accounted for 6.25% and 3.1% of cases, respectively. Renal function Impairment was present in 21 patients with 18 cases of acute kidney injury (85.7%) and 3 cases of chronic renal failure (14.3%), including 2 in stage 5 of chronic kidney disease. Renal biopsy (RB) was indicated and performed in 20 (62.5%) patients with glomerular signs in 12 patients (60%). Glomerular lesions were dominated by focal and segmental glomerulosclerosis (FSGS) in 6 cases, membraneous nephropathy (MN) in 4 cases and minimal change disease (MCD) in 2 cases. Tubulo-interstitial and vascular lesions were present in 45% and 12.5% of cases, respectively. In highly active antiretroviral therapy (HAART), 12 (37.5%) patients had total remission, 9 (28.12%) had partial remission. One (3.12%) death from severe metabolic acidosis on chronic renal failure was deplored. Conclusion: This study illustrates the high prevalence of RD in PLHIV in our exercise context.
Pernicious Anemia Associated Autoimmune Diseases in a Sub Saharian African Internal Medicine Service  [PDF]
Abdoulaye Pouye, Seynabou Fall Dieng, Daher Abdoukarim Oumar, Fatou Samba Diago N’Diaye, Nafissatou Diagne Sakho, Atoumane Faye, Souhaibou N’Dongo
Open Journal of Internal Medicine (OJIM) , 2014, DOI: 10.4236/ojim.2014.43009
Abstract: Introduction: Pernicious anemia is an autoimmune disease. It is characterized by the presence of an autoimmune atrophic gastritis and various autoantibodies that lead to a vitamin B12 deficiency responsible for a macrocytic anemia. It is frequently associated with other specific or non-organ- specific autoimmune diseases. We report six patients with pernicious anemia associated with other autoimmune diseases. Patients and Results: There were six patients (4 females/2 males), mean age of 39.67 years. In all cases it was found macrocytic anemia. The average Hb was 6.08 g/dl and the average MGV: 110.67 fl. Bone marrow aspiration was performed in all patients. Megaloblastosis compatible with a lack of vitamin B12 or folic acid was constant. Determination of serum vitamin B12 was low in all cases while folic acid levels were within standards. Immuno- logically it was found in all patients, a positivity of anti-intrinsic factor antibody and/or anti- parietal cells antibody at rates up to 67 times over normal ranges. Pernicious anemia was associated with autoimmune thyroid dysfunction in 4 patients. It was two cases of Hashimoto thyroiditis at hypothyroidic phase (high TSHus, thyréoperoxydase anti-antibody positive (over 10 N) in both cases and Graves’ disease in the two other cases. Pernicious anemia was associated with a syndrome of primary antiphospholipid antibody in a case. Furthermore pernicious anemia was found in a patient autoimmune type 1 diabetes with strongly positive anti -GAD antibodies and rheumatoid arthritis by retaining it in the diagnosis of multiple autoimmune syndrome. Conclusion: These cases illustrate the existence of the association of pernicious anemia with other autoimmune diseases in our context. This should encourage practitioners to seek hided autoimmune diseases when they consider the diagnosis of pernicious anemia.
Rosai-Dorfman Disease: Two Cases Report and Literature Review  [PDF]
Atoumane Faye, Nafissatou Diagne Sakho, Fatou Samba D. Ndiaye, Seynabou Fall, Awa Cheikh Ndao Mbengue, Boundia Djiba, Baidy Sy Kane, Souhaibou Ndongo, Abdoulaye Pouye
Open Journal of Internal Medicine (OJIM) , 2015, DOI: 10.4236/ojim.2015.52004
Abstract: The lymph node is the revelation mode of several pathology. In tropical area, their etiology are dominated by tuberculosis and hemopathy. Some etiology such as histiocytosis are rarely mentioned. We report two cases of Rosai-Dorfman-Destombes disease. The first observation concerned a patient of 45 years without pathological antecedent, who had a inguinal and cervical tumoral lymph nodes. This evolved in a feverish poor general condition. Infection research was negative. Morphological explorations found deep lymph nodes. The excision biopsy examination concluded to Rosai-Dorfman-Destombes disease. The second observation concerned a patient of 40 years without pathological antecedent, who had a chronic non-inflammatory left supra-collarbone lymph node, associated with poor general condition and fever. X-ray showed mediastinal lymph nodes and ultra-sonography showed mesenteric lymph nodes, and latero-aortic lymph nodes. The examination of the excision biopsy was for Rosai Dorfman Destombes disease. The difficulty of diagnosis in our regions based on technical tray lack and our patients financial limits. Also this disease is rarely mentioned first. This is often the source of considerable diagnostic delay noted in our two patients and therefore the initiation of an untimely anti-tuberculosis treatment.
Kimura’s Disease: A Case Report and Literature Review  [PDF]
Atoumane Faye, Nafissatou Diagne Sakho, Awa Cheikh Ndao Mbengue, Fatou Samba D. Ndiaye, Seynabou Fall, Boundia Djiba, Baidy Sy Kane, Souhaibou Ndongo, Abdoulaye Pouye
Open Journal of Internal Medicine (OJIM) , 2015, DOI: 10.4236/ojim.2015.52003
Abstract: Kimura’s disease, common pathology in the East, responsible of chronic neck swelling is rarely reported in sub-Saharan Africa. We reported a case which was observed in the internal medicine department of Aristide Le Dantec hospital in Dakar. This was a young 15-year-old, with no particular disease history, who had recurrent non-inflammatory swelling next to the left zygomatic bone associated with itching. Biology revealed an inflammatory syndrom, eosinophilia and increased serum IgE. The histological examination of the mass biopsy concluded to Kimura disease. The corticosteroid has reduced the size of the mass within a few weeks of treatment. Kimura’s disease is unknown in our regions. His painless character and chronic evolution delay the time of diagnosis. This case proves the reality of this disease, which must find a place in the diagnosis approach of cervical swelling.
Seronegative Myasthenia Gravis and a Biermer’s Anemia: A Rare Association  [PDF]
Boundia Djiba, Ba?dy Sy Kane, Awa Cheikh Ndao, Michel Assane Ndour, Nafissatou Diagne, Atoumane Faye, Mohamed Dieng, Ma?mouna Sow, Abdoulaye Pouye
Open Journal of Internal Medicine (OJIM) , 2017, DOI: 10.4236/ojim.2017.74017
Abstract: We report a rare association of seronegative myasthenia gravis and a Biermer’s anemia (or pernicious anemia). A Senegalese patient of 31 years has been followed for a vitamin B12 deficiency anemia, 12 months before his hospitalization in our department. She has been admitted for an intense and invalidating fatigability in spite of the correction of anemia, associated to a right ptosis. This clinical picture has electively been improved to the prostigmine test. The electromyography had revealed a compatible decrement with a diagnosis of myasthenia. The positivity of the antibodies anti gastric parietal cells and the twice negativity of the antibody against acetylcholine receptor (AChR) and muscle-specific kinase (MuSK) had permitted to deduct a diagnosis of seronegative myasthenia and Biermer’s anemia. The evolution was favorable under substitutive B12 vitamin therapy associated to corticotherapy and azathioprine. We insist on the research and the early treatment of a myasthenia, in a context of Biermer’s anemia, before suggestive clinical signs in spite of the negativity of the anti-Rach antibodies and anti-Musk.
Adenopathies in Internal Medicine Etiological Profile and Diagnostic Limits  [PDF]
Michel Assane Ndour, Atoumane Faye, Abdoulaye Leye, Boundia Djiba, Maimouna Sow, Sy Baydi Kane, Ngoné Diaba Diack, Fall Codou Biram, Yakham Mohamed Leye, Mouhamed Dieng, Nafy Ndiaye, Léa Marie Kabou, Abdoulaye Pouye
Open Journal of Internal Medicine (OJIM) , 2017, DOI: 10.4236/ojim.2017.73009
Abstract: INTRODUCTION: An adenopathy is a pathological hypertrophy of a lymph node of various etiologies requiring a rigorous approach. Thus we proposed in this work to study the etiological particularities of patients admitted for adenopathy in order to identify their specificities. METHODS: This was an observational study of a transverse and descriptive type, which took place from 1 July 2015 to 30 June 2016 in the internal medicine department of the Aristide Le Dantec national hospital in Dakar. RESULTS: We identified 84 patients, consisted of 46 male and 38 female. The sex ratio was 1.2. The mean age was 37.5 years. The consultation period was on average 2 months with extremes of 1 month and 1 year. The mean hospital stay was 29. 2 days with extremes of 1 week and 2 months. The etiologies found were classified into 6 groups. Hemopathies (30.9%) were dominated by acute leukemia in 8 patients (9.52%), non-Hodgkin’s lymphoma in 9 patients (9.5%), Hodgkin’s disease in 5 patients (5.9%). Chronic lymphocytic leukemia was retained in 3 patients (3.5%) and Castleman disease in 1 patient. Systemic diseases (11.9%) were divided into lupus disease in 4 patients and rheumatoid arthritis in 4 patients, one case of Sj?gren’s syndrome and one case of sarcoidosis. Infections were very frequent in our study, found in 34 patients (40.4%). Tuberculosis was more frequent (27.3%). The association with HIV was noted in 4 patients. The other infections were pyogenic in 3 patients (3.5%), HIV in 6 patients (7.1%), Borrelia and toxoplasma in 1 patient respectively. Cancers (8.3%) were metastatic of primary tumors including the esophagus, lung, prostate, cavum, stomach, pancreas and breast, one case each. One patient presented lymphadenopathy with inguinal localization, the etiology of which was found to be thrombophlebitis of the right lower limb. The hystiocytic pathologies (3.5%) were all related to lymphohystiocytic activation syndrome (LHAS) secondary to tuberculosis in 2 patients and pyomyositis in 1 patient. The difficulties encountered were mainly the inaccessibility of certain complementary examinations and the delay in obtaining the results. CONCLUSION: Adenopathies are a very common reason for consultation in internal medicine. This study allowed us to draw up the etiological profile of adenopathies in our practice but also to identify the main difficulties which are among other things the inaccessibility of certain complementary examinations.
Severity of the Rheumatoid Arthritis in Sub-Saharan Africa: Study of 403 Senegalese Observations  [PDF]
Moustapha Niasse, Ba?dy Sy Kane, Abdoul Aziz Ndiaye, Awa Cheikh Ndao, Boundia Djiba, Seynabou Fall, Ngoné Diaba Diack, Fatimata Bintou Sall, Michel Assane Ndour, Nafy Diagne, Atoumane Faye, Biram Codou Fall, Souha?bou Ndongo, Abdoulaye Pouye
Open Journal of Internal Medicine (OJIM) , 2017, DOI: 10.4236/ojim.2017.74016
Abstract: Introduction: We assess the severity of the rheumatoid arthritis in a Senegalese African black population. Patients and methods: It is a retrospective study achieved in the service of Internal Medicine of Aristide Le Dantec teaching hospital of Dakar between January 2005 and December 2016 in patients suffering from rheumatoid arthritis. We specified for every patient the predictive data of severity of the rheumatoid arthritis. Results: Four hundred and three patients have been gathered (39 men and 364 women), with the mean age of 45.8 years. An active tobacco addiction was noticed in 10 patients. The diagnostic delay was on average of 72 months. Characteristic articular deformations were noticed in 215 patients (53.3%). They were correlated to male (p = 0.038), to age (p = 0.001) and to the activity of the rheumatoid arthritis (p = 0.0445). Systemic manifestations have been observed in 213 cases (52.9%), particularly anemia (50.8%). They were correlated to the anti-CCP antibodies (p = 0.047). The ESR was increased at the first hour in 84.4% of cases (median: 43 mm; extreme: 1and 160). CRP was elevated in 63.71% of cases (median of 12 mg/l; extreme: 1 and 384). The rheumatoid factor was positive in 57.6% of the cases. The anti-CCP antibodies were present in 89.2% of the cases. Articular erosions were objectified in all cases. A DAS 28 superior to 5.1 was noticed in 71% of cases. Conclusion: The rheumatoid arthritis was severe in our study.
Antisynthetase Syndrome in Senegalese Patients: Report of Three Cases  [PDF]
Ba?dy Sy Kane, Moustapha Niasse, Michel Assane Ndour, Awa Cheikh Ndao, Boundia Djiba, Mohamed Dieng, Ma?mouna Sow, Nafissatou Diagne, Atoumane Faye, Souhaibou Ndongo, Abdoulaye Pouye
Open Journal of Internal Medicine (OJIM) , 2019, DOI: 10.4236/ojim.2019.94017
Abstract: Introduction: Antisynthetase syndrome is an original entity and rare autoimmune myositis and systemic disease, characterized clinically by a wide spectrum of clinical manifestations and the presence of autoantibodies directed against aminoacyl RNAt synthetases. We describe this disease in 03 Senegalese patients. Observations: The first patient was a 49-years-old black woman who was referred in our department after 06-months of follow-up for a misdiagnosis of tuberculosis. The clinical examination revealed polyarthritis, muscle weakness, chronic cough with crackling rales at the pulmonary bases, Raynaud phenomenon and dry syndrome. The second patient, a 21-years-old black woman, had polyarthritis and a progressive muscle weakness. The clinical examination showed also cutaneous signs including an erythema on the dorsal part of the fingers and the presence of the heliotrope erythema on the eyes. The last patient was a 52 years-old black woman. His clinical examination showed polyarthritis, muscle weakness and an appearance of mechanics’ hands. The creatinine phosphokinase was at 6.26 × N, 40.3 × N and 33.64 × N respectively in our patients. The chest computer tomography revealed an interstitial lung disease with a pattern of non-specific interstitial pneumonia in all three patients. The autoantibodies anti-Jo1 was also positive in all patients. The diagnosis of antisynthetase syndrome was retained with an overlap of antisynthetase and Sj?gren’s syndrome in the first observation. The evolution was favourable in our 03 observations with a therapeutic combination including Prednisone-Azathioprine and Kinesitherapy. Conclusion: Antisynthetase syndrome has been exceptionally reported in sub-Saharan Africa. It must be particularly mentioned in front of the triad: myositis, arthritis and interstitial lung disease. The identification of an auto-antibody directed against RNA t synthetases, particularly anti-Jo1, is essential for its diagnosis. Prognosis is related to interstitial lung involvement. The evolution has been favourable in our patients receiving Glucorticoid-Azathioprine combination therapy.
Frequency of Cardiovascular Risk Factors in Systemic Lupus Erythematosus: A Case-Control Study in a Department of Internal Medicine in Sub-Saharan Africa  [PDF]
Ma?mouna Sow, Ba?dy Sy Kane, Abdourahmane Samba, Awa Cheikh Ndao, Nafissatou Diagne, Boundia Djiba, Mouhamed Dieng, Atoumane Faye, Abdoulaye Pouye
Open Journal of Internal Medicine (OJIM) , 2020, DOI: 10.4236/ojim.2020.101001
Abstract: Background: The morbidity and mortality of systemic lupus erythematosus are largely due to accelerated atherosclerosis. This is partly related to the high prevalence of traditional cardiovascular risk factors. The aim of our study was to determine the frequency of these factors in lupus patients compared to a control population in a department of internal medicine. Methods: We realized a case-control study in patients with systemic lupus erythematosus according to ACR criteria in 1997. Patients were matched by age and gender with controls subjects without autoimmune disease. We studied the frequency of traditional cardiovascular risk factors in both populations. The study was done in the department of internal medicine of Aristide Le Dantec teaching Hospital, in Senegal, during the period from August 2017 to December 2018. The statistical analysis was performed with SPSS 23.0 software and the level of significance was retained for a p-value < 0.05. Results: We recruited 100 subjects including 50 patients and 50 controls. The mean age was 33.5 ± 11.3 years in cases and 33.3 ± 11.3 years in controls. Dyslipidemia was significantly associated with systemic lupus erythematosus (p = 0.009). Levels of triglycerides (p < 0.001) and uricemia (p < 0.001) were significantly higher in patients. The level of HDL cholesterol (p = 0.028) was lower in cases. Thus, low HDL cholesterolemia (p = 0.001), hypertriglyceridemia (p < 0.001), and hyperuricemia (p = 0.043) were more common in the cases. Renal failure was associated with systemic lupus erythematosus (p < 0.001). Difference in LDL-cholesterol (p = 0.103), hypertension (p = 1) and metabolic syndrome (p = 1) between cases and controls was not significant. Obesity and overweight were predominant in controls (p = 0.028). Conclusion: Traditional cardiovascular risk factors including dyslipidemia and hyperuricemia were more common in patients. Similarly, renal failure was associated with lupus.
Multivariate Geostatistical Model for Groundwater Constituents in Texas  [PDF]
Faye Anderson
International Journal of Geosciences (IJG) , 2014, DOI: 10.4236/ijg.2014.513132
Abstract: Although many studies have explored the quality of Texas groundwater, very few have investigated the concurrent distributions of more than one pollutant, which provides insight on the temporal and spatial behavior of constituents within and between aquifers. The purpose of this research is to study the multivariate spatial patterns of seven health-related Texas groundwater constituents, which are calcium (Ca), chloride (Cl), nitrate (NO3), sodium (Na), magnesium (Mg), sulfate (SO4), and potassium (K). Data is extracted from Texas Water Development Board’s database including nine years: 2000 through 2008. A multivariate geostatistical model was developed to examine the interactions between the constituents. The model had seven dependent variables—one for each of the constituents, and five independent variables: altitude, latitude, longitude, major aquifer and water level. Exploratory analyses show that the data has no temporal patterns, but hold spatial patterns as well as intrinsic correlation. The intrinsic correlation allowed for the use of a Kronecker form for the covariance matrix. The model was validated with a split-sample. Estimates of iteratively re-weighted generalized least squares converged after four iterations. Matern covariance function estimates are zero nugget, practical range is 44 miles, 0.8340 variance and kappa was fixed at 2. To show that our assumptions are reasonable and the choice of the model is appropriate, we perform residual validation and universal kriging. Moreover, prediction maps for the seven constituents are estimated from new locations data. The results point to an alarmingly increasing levels of these constituents’ concentrations, which calls for more intensive monitoring and groundwater management.
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