oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

2019 ( 5 )

2018 ( 16 )

2017 ( 20 )

2016 ( 18 )

Custom range...

Search Results: 1 - 10 of 4315 matches for " Asha Jacob "
All listed articles are free for downloading (OA Articles)
Page 1 /4315
Display every page Item
MAGNITUDE OF THYMINE IN DIFFERENT FRAMES OF MESSENGER RNAs
Rajasekaran E.,Asha Jacob,Klaus Heese
International Journal of Bioinformatics Research , 2012,
Abstract: Thymine is the one and only base transcribed into uracil during production of proteins. Thymine in DNA and uracil in mRNA plays a major role in producing proteins with appropriate carbon content for stability and activity. Thymine distribution is different frames of coding nucleic acids are investigated statistically. The results confirm that frame 1 supposed to have definite thymine content. Frame 3 prefers to have least thymine content. Frames 4 & 5 maintain some degree of thymine while 2 & 6 have a variable fraction of thymine
Mechanism of the Anti-inflammatory Effect of Curcumin: PPAR- Activation
Asha Jacob,Rongqian Wu,Mian Zhou,Ping Wang
PPAR Research , 2007, DOI: 10.1155/2007/89369
Abstract: Curcumin, the phytochemical component in turmeric, is used as a dietary spice and a topical ointment for the treatment of inflammation in India for centuries. Curcumin (diferuloylmethane) is relatively insoluble in water, but dissolves in acetone, dimethylsulphoxide, and ethanol. Commercial grade curcumin contains 10–20% curcuminoids, desmethoxycurcumin, and bisdesmethoxycurcumin and they are as effective as pure curcumin. Based on a number of clinical studies in carcinogenesis, a daily oral dose of 3.6 g curcumin has been efficacious for colorectal cancer and advocates its advancement into Phase II clinical studies. In addition to the anticancer effects, curcumin has been effective against a variety of disease conditions in both in vitro and in vivo preclinical studies. The present review highlights the importance of curcumin as an anti-inflammatory agent and suggests that the beneficial effect of curcumin is mediated by the upregulation of peroxisome proliferator-activated receptor-γ (PPAR-γ) activation.
Mechanism of the inhibitory effect of ghrelin in sepsis
Asha Jacob, Rongqian Wu, Mian Zhou, et al
Hepatic Medicine: Evidence and Research , 2010, DOI: http://dx.doi.org/10.2147/HMER.S7187
Abstract: hanism of the inhibitory effect of ghrelin in sepsis Review (3988) Total Article Views Authors: Asha Jacob, Rongqian Wu, Mian Zhou, et al Published Date February 2010 Volume 2010:2 Pages 33 - 38 DOI: http://dx.doi.org/10.2147/HMER.S7187 Asha Jacob, Rongqian Wu, Mian Zhou, Gene F Coppa, Ping Wang Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, and The Feinstein Institute for Medical Research, Manhasset, NY, USA Abstract: Sepsis and septic shock are the leading causes of death in intensive care units. Approximately 40%–70% of the mortality is associated with severe sepsis and septic shock. Systemic antibiotic usage, surgical intervention, aggressive fluid resuscitation and careful monitoring are common measures currently used to treat sepsis. Despite the advances in the understanding of the pathophysiology of sepsis, very little progress has been made towards therapeutic interventions. Recently we have shown that ghrelin, a stomach-derived peptide which is an endogenous ligand for the growth hormone secretagogue receptor (GHSR-1a), is beneficial in attenuating the inflammatory response, organ injury and mortality in an experimental model of polymicrobial sepsis induced by cecal ligation and puncture (CLP). In this review, we describe the mechanism of action of ghrelin in sepsis, highlight the role ghrelin plays in attenuating the hepatic dysfunction induced by sepsis and septic shock and suggest in developing ghrelin as a potential therapy for sepsis.
Mechanism of the inhibitory effect of ghrelin in sepsis
Asha Jacob,Rongqian Wu,Mian Zhou,et al
Hepatic Medicine: Evidence and Research , 2010,
Abstract: Asha Jacob, Rongqian Wu, Mian Zhou, Gene F Coppa, Ping WangDepartment of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, and The Feinstein Institute for Medical Research, Manhasset, NY, USAAbstract: Sepsis and septic shock are the leading causes of death in intensive care units. Approximately 40%–70% of the mortality is associated with severe sepsis and septic shock. Systemic antibiotic usage, surgical intervention, aggressive fluid resuscitation and careful monitoring are common measures currently used to treat sepsis. Despite the advances in the understanding of the pathophysiology of sepsis, very little progress has been made towards therapeutic interventions. Recently we have shown that ghrelin, a stomach-derived peptide which is an endogenous ligand for the growth hormone secretagogue receptor (GHSR-1a), is beneficial in attenuating the inflammatory response, organ injury and mortality in an experimental model of polymicrobial sepsis induced by cecal ligation and puncture (CLP). In this review, we describe the mechanism of action of ghrelin in sepsis, highlight the role ghrelin plays in attenuating the hepatic dysfunction induced by sepsis and septic shock and suggest in developing ghrelin as a potential therapy for sepsis.Keywords: ghrelin, sepsis, inhibition septic shock, GHSR-1a, cecal ligation
Association between insertion/deletion polymorphism in angiotensin-converting enzyme gene and acute lung injury/acute respiratory distress syndrome: a meta-analysis
Matsuda Akihisa,Kishi Taro,Jacob Asha,Aziz Monowar
BMC Medical Genetics , 2012, DOI: 10.1186/1471-2350-13-76
Abstract: Background A previous meta-analysis reported a positive association between an insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme gene (ACE) and the risk of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). Here, we updated this meta-analysis and additionally assessed the association of this polymorphism with ALI/ARDS mortality. Methods We searched electronic databases through October 2011 for the terms “angiotensin-converting enzyme gene”, “acute lung injury”, and “acute respiratory distress syndrome,” and reviewed all studies that reported the relationship of the I/D polymorphism in ACE with ALI/ARDS in humans. Seven studies met the inclusion criteria, comprising 532 ALI/ARDS patients, 3032 healthy controls, and 1432 patients without ALI/ARDS. We used three genetic models: the allele, dominant, and recessive models. Results The ACE I/D polymorphism was not associated with susceptibility to ALI/ARDS for any genetic model. However, the ACE I/D polymorphism was associated with the mortality risk of ALI/ARDS in Asian subjects ( Pallele < 0.0001, Pdominant = 0.001, Precessive = 0.002). This finding remained significant after correction for multiple comparisons. Conclusions There is a possible association between the ACE I/D polymorphism genotype and the mortality risk of ALI/ARDS in Asians.
A Study on a Conductor System for Investigation of Proximity Effect  [PDF]
Asha Shendge
Journal of Electromagnetic Analysis and Applications (JEMAA) , 2012, DOI: 10.4236/jemaa.2012.411061
Abstract: The proximity effect is very significant to investigate transient peak voltages and EMC related problems of a conductor system. In this paper, effect of energized single conductor in close proximity of an Al plate when an Al plate is used as return path is investigated to find out proximity effect. The analysis involves simulation by the Finite Time Domain Method (FDTD) in comparison with field measurements. It is observed that the current distribution is uneven in pipe conductor due to the proximity effect of varying heights from ground.
Cyclic arginine-glycine-aspartate attenuates acute lung injury in mice after intestinal ischemia/reperfusion
Shingo Matsuo, Weng-Lang Yang, Monowar Aziz, Asha Jacob, Ping Wang
Critical Care , 2013, DOI: 10.1186/cc12493
Abstract: Ischemia in adult male C57BL/6 mice was induced by fastening the superior mesenteric artery with 4-0 suture. At 45 min later, the vascular suture was released to allow reperfusion. cRGD (5 mg/kg BW) or normal saline (vehicle) was administered by intra-peritoneal injection 1 h prior to ischemia. Blood, gut, and lung tissues were collected at 4 h after reperfusion for various measurements.Intestinal I/R caused severe widespread injury to the gut and lungs. Treatment with cRGD improved the integrity of microscopic structures in the gut and lungs, as judged by histological examination. Intestinal I/R induced the expression of 1, 2 and 3 integrins, ICAM-1, and fibronectin. cRGD significantly inhibited myeloperoxidase activity in the gut and lungs, as well as neutrophils and macrophages infiltrating the lungs. cRGD reduced the levels of TNF- and IL-6 in serum, in addition to IL-6 and MIP-2 in the gut and lungs. Furthermore, the number of TUNEL-staining cells and levels of cleaved caspase-3 in the lungs were significantly lowered in the cRGD-treated mice in comparison to the vehicle mice.Treatment with cRGD effectively protected ALI and gut injury, lowered neutrophil infiltration, suppressed inflammation, and inhibited lung apoptosis after intestinal I/R. Thus, there is a potential of developing cRGD as a treatment for patients suffering from ALI caused by intestinal I/R.
Downregulation of protein disulfide isomerase in sepsis and its role in tumor necrosis factor-alpha release
Mian Zhou, Asha Jacob, Natalie Ho, Michael Miksa, Rongqian Wu, Subir R Maitra, Ping Wang
Critical Care , 2008, DOI: 10.1186/cc6977
Abstract: Adult male rats were subjected to sepsis by cecal ligation and puncture (CLP) or endotoxemia (continuous infusion of 1 μg/kg body weight LPS by an osmotic pump) for 20 hours. Hepatic tissues were collected and PDI gene expression was determined. In additional experiments, cells from a macrophage-like cell line, RAW 264.7, were treated with 100 ng/mL LPS for 4 hours and protein expressions were measured. RAW 264.7 cells were also treated with bacitracin, a specific PDI inhibitor, for 24 hours, and tumor necrosis factor-alpha (TNF-α) gene and protein expression as well as its release in the cell supernatant were determined. To further confirm the beneficial effect of PDI in sepsis, RAW 264.7 cells were transfected with PDI short interfering RNA (siRNA) and PDI gene expression and TNF-α release were measured by quantitative polymerase chain reaction and enzyme-linked immunosorbent assay, respectively.PDI gene expression was significantly decreased by 28% and 69% at 20 hours after CLP or LPS infusion, respectively. LPS also decreased PDI protein expression by 33% in RAW 264.7 cells. Incubation of RAW 264.7 cells with bacitracin significantly increased TNF-α gene expression and TNF-α release as well as its cellular levels in a dose-dependent manner. Transfection of RAW 264.7 cells with PDI siRNA produced an average 36.8% inhibition of the PDI gene expression. This downregulation was correlated with a 3.19-fold increase in TNF-α release into the cell supernatant.Taken together, these results suggest that downregulation of PDI by sepsis significantly increases proinflammatory cytokine production. Thus, prevention of PDI downregulation in sepsis may be a novel approach to attenuate hyperinflammation and to reduce tissue injury under such conditions.Infection and sepsis continue to be the most common causes of death in noncardiac intensive care units [1-4]. Evidence indicates that, in the US alone, more than 750,000 patients develop sepsis and septic shock each year with an
Cold-Inducible RNA-Binding Protein Is an Important Mediator of Alcohol-Induced Brain Inflammation
Salil R. Rajayer, Asha Jacob, Weng-Lang Yang, Mian Zhou, Wayne Chaung, Ping Wang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0079430
Abstract: Binge drinking has been associated with cerebral dysfunction. Ethanol induced microglial activation initiates an inflammatory process that causes upregulation of proinflammatory cytokines which in turn creates neuronal inflammation and damage. However, the molecular mechanism is not fully understood. We postulate that cold-inducible RNA-binding protein (CIRP), a novel proinflammatory molecule, can contribute to alcohol-induced neuroinflammation. To test this theory male wild-type (WT) mice were exposed to alcohol at concentrations consistent to binge drinking and blood and brain tissues were collected. At 5 h after alcohol, a significant increase of 53% in the brain of CIRP mRNA was observed and its expression remained elevated at 10 h and 15 h. Brain CIRP protein levels were increased by 184% at 10 h and remained high at 15 h. We then exposed male WT and CIRP knockout (CIRP?/?) mice to alcohol, and blood and brain tissues were collected at 15 h post-alcohol infusion. Serum levels of tissue injury markers (AST, ALT and LDH) were significantly elevated in alcohol-exposed WT mice while they were less increased in the CIRP?/? mice. Brain TNF-α mRNA and protein expressions along with IL-1β protein levels were significantly increased in WT mice, which was not seen in the CIRP?/? mice. In cultured BV2 cells (mouse microglia), ethanol at 100 mM showed an increase of CIRP mRNA by 274% and 408% at 24 h and 48 h respectively. Corresponding increases in TNF-α and IL-1β were also observed. CIRP protein levels were markedly increased in the medium, suggesting that CIRP was secreted by the BV2 cells. From this we conclude that alcohol exposure activates microglia to produce and secrete CIRP and possibly induce pro-inflammatory response and thereby causing neuroinflammation. CIRP could be a novel mediator of alcohol-induced brain inflammation.
Some Common Fixed Point Theorems in Menger Space  [PDF]
Sanjay Kumar, Asha Rani
Applied Mathematics (AM) , 2012, DOI: 10.4236/am.2012.33038
Abstract: This paper consists four sections. First section is central to the text. In second section, we generalize the results of Kohli and Vashistha [1] for pairs of mappings using weakly compatible maps. Third section deals the results for pair of weakly compatible maps along with property (E.A.) using different types of control functions, which generalize the results of Kohli and Vashistha [1] and Kubiaczyk and Sharma [2]. Fourth section is concerned with results for occasionally weakly compatible maps and generalizes, extends and unifies several well known comparable results in literature.
Page 1 /4315
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.