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Search Results: 1 - 10 of 3057 matches for " Arthur Dondonis;Sanvitto "
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Efeito anti-inflamatório dos macrolídeos em doen?as pulmonares da infancia
Luisi, Fernanda;Gandolfi, Thays Dornelles;Daudt, Arthur Dondonis;Sanvitto, Jo?o Pedro Zelmanowicz;Pitrez, Paulo Márcio;Pinto, Leonardo Araujo;
Jornal Brasileiro de Pneumologia , 2012, DOI: 10.1590/S1806-37132012000600016
Abstract: macrolides are drugs that have antimicrobial effects, especially against intracellular pathogens. various studies have shown that macrolides might also have anti-inflammatory effects. macrolides inhibit the production of interleukins and can reduce pulmonary neutrophilic inflammation. clinical trials have demonstrated beneficial effects of macrolides in various chronic lung diseases. the objective of this study was to review recent data in the medical literature on the anti-inflammatory effects of macrolides in childhood lung diseases by searching the medline (pubmed) database. we used the following search terms: "macrolide and cystic fibrosis"; "macrolide and asthma"; "macrolide and bronchiolitis obliterans"; and "macrolide and acute bronchiolitis". we selected articles published in international scientific journals between 2001 and 2012. clinical studies and in vitro evidence have confirmed the anti-inflammatory effect of macrolides in respiratory diseases. some clinical trials have shown the benefits of the administration of macrolides in patients with cystic fibrosis, although the risk of bacterial resistance should be considered in the analysis of those benefits. such benefits are controversial in other respiratory diseases, and the routine use of macrolides is not recommended. further controlled clinical trials are required in order to assess the efficacy of macrolides as anti-inflammatory drugs, so that the benefits in the treatment of each specific clinical condition can be better established.
A nova gradua??o da unisinos: compartilhando a experiência de um ato pedagógico
Mallmann, Marly Terezinha;Daudt, S?nia Isabel Dondonis;
Revista Brasileira de Enfermagem , 2003, DOI: 10.1590/S0034-71672003000400007
Abstract: in this article we present the process of creation of an innovative proposal for undergraduate teaching, developed by an interdisciplinary group at "universidade do vale do rio dos sinos - unisinos". besides pointing out the theoretical-epistemological referential supporting this proposal, we will also be discussing the implications some paradigm ruptures have brought to the educational process presently being used at this university. we would like to introduce the reader to the process behind this way of understanding and living the educational practice, as well as to follow the account of an experience a group of teachers has had, when confronted with the task of pondering a new undergraduate program.
Optimal Recovery of Holomorphic Functions from Inaccurate Information about Radial Integration  [PDF]
Arthur DeGraw
American Journal of Computational Mathematics (AJCM) , 2012, DOI: 10.4236/ajcm.2012.24035
Abstract: This paper addresses the optimal recovery of functions from Hilbert spaces of functions on the unit disc. The estimation, or recovery, is performed from inaccurate information given by integration along radial paths. For a holomorphic function expressed as a series, three distinct situations are considered: where the information error in L2 norm is bound by δ>0 or for a finite number of terms the error in l2N norm is bound by δ>0 or lastly the error in the jth coefficient is bound by δj>0. The results are applied to the Hardy-Sobolev and Bergman-Sobolev spaces.
Collective dynamics of excitons and polaritons in semiconductor nanostructures
A. Amo,D. Sanvitto,L. Vina
Physics , 2009, DOI: 10.1088/0268-1242/25/4/043001
Abstract: Time resolved photoluminescence is a powerful technique to study the collective dynamics of excitons and polaritons in semiconductor nanostructures. We present a two excitation pulses technique to induce the ultrafast and controlled quenching of the exciton emission in a quantum well. The depth of the dip is given by the magnitude of the warming of the carriers induced by the arrival of a laser pulse when an exciton population is already present in the sample. We use this technique to study the relaxation mechanisms of polaritons in semiconductor microcavities, which are of great importance to enhance the conditions for their condensation under non-resonant excitation. We also explore the dynamics of polariton fluids resonantly created in the lower polariton branch in a triggered optical parametric oscillator configuration, showing evidence of polariton superfluidity, and opening up the way to the real-time study of quantum fluids.
The rationale for pre-race aspirin to protect susceptible runners from sudden cardiac death during marathons: Deconstructing the Pheidippides conundrum  [PDF]
Arthur J. Siegel
World Journal of Cardiovascular Diseases (WJCD) , 2013, DOI: 10.4236/wjcd.2013.35A003
Abstract: Objectives: While endurance exercise such as training for marathons is cardioprotective, cardiac arrests and sudden death occur in previously healthy runners during races predominantly in middle-aged males due to atherosclerotic heart disease. Recent evidence related to this problem is reviewed herein including epidemiologic studies and findings related to acute cardiac risk in asymptomatic middle-aged male runners during races. Method: Literature review related to the above. Findings: The risks of cardiac arrest and sudden death were 1 in 57,002 and 1 in 171,005 respectively in runners with a mean age of 49.7 years among 1,710,052 participants in marathons in the United States since 1980. Atherosclerotic heart disease was the cause of death in over 90% of cases in two retrospective studies and a greater than two-fold increase in cardiac arrests was observed in middle-aged men in the latter half of a 10-year prospective registry beginning in the year 2000. Asymptomatic middle-aged male runners showed elevated biomarkers of inflammation such as interleukin-6, C-reactive protein together with procoagulant effects including in vivo platelet activation, indicating susceptibility to atherothrombosis. Conclusions: Antithrombotic prophylaxis is evidence-based by validated clinical paradigms to prevent cardiac arrest and sudden death in susceptibile marathon runners at high risk for atherothrombosis during races.

Motivating Generation Y and Virtual Teams  [PDF]
Arthur M. Baldonado
Open Journal of Business and Management (OJBM) , 2013, DOI: 10.4236/ojbm.2013.12006
Abstract: How can team members remain effective if members cannot engage in face-to-face interactions? Although the concept of global virtual teams has been a relatively new phenomenon, their use by organizations is a growing trend. The growth of globalization and the explosion of new technology have led to a new paradigm—a workplace that has no walls or boundaries. The purpose of the qualitative, descriptive study was to explore the motivational needs of Gen Y virtual team members and their impact in the workplace based on Herzberg’s two-factor theory of motivation. The participants consisted of Gen Y members at the Lakeland,Florida. The author used a researcher-developed, written survey as research methodology. The findings of the study revealed that Gen Y cohort placed great importance to both hygiene and motivator factors in their motivational needs. Advancement and personal life were both important to Gen Y participants. Managers must be flexible in their managerial approach to Gen Y workers.
A Hypothesis Concerning the Effect of Schedule on the Pattern of 5-Fluorouracil Toxicity  [PDF]
Arthur J. Weiss
Journal of Cancer Therapy (JCT) , 2015, DOI: 10.4236/jct.2015.63028
Abstract:

The significant effect that scheduling has upon the severity and types of drug toxicity has been known for many years. Evidence is available demonstrating that the schedule chosen will substantially effect the relative distribution of drug to various target organs. It has been shown that a likely cause for this with doxorubicin is that the efficiency of the various enzyme complexes responsible for disposing of the drug can be affected by scheduling. We believe a similar process can explain the marked effect that scheduling has on the pattern of 5-fluorouracil toxicity and present both clinical and computer data to illustrate this.

“How We Die” in New Mexico: A Judicial Prescription without Relief  [PDF]
Arthur G. Svenson
Beijing Law Review (BLR) , 2015, DOI: 10.4236/blr.2015.62012
Abstract: By some accounts, New Mexico Judge Nan Nash fashioned a landmark ruling in a civil dispute pitting two doctors and a cancer patient against the state. At issue, a statute making it unlawful to “deliberately aid[] another in the taking of his own life.” Plaintiffs in Morris v. King (2014) contended that for a “mentally-competent, terminally-ill individual” who sought a peaceful death over a painful life, a doctor prescribing lethal drugs for this purpose could not be prosecuted since physician aid in dying was not assisted suicide. While plaintiffs’ statutory claim was rejected, Judge Nash did hold that the statute as applied to physician aid in dying violated state constitutional guarantees safeguarding inalienable rights to “liberty, safety and happiness.” I argue that the interpretive path Judge Nash designed to justify her ruling is littered at critical junctures with strangely settled issues. For this reason, her judicial prescription legalizing this end-of-life choice wants the persuasive foundation that such a landmark holding deserves.
Preventing Sudden Cardiac Death during Marathons with Pre-Race Aspirin  [PDF]
Arthur J. Siegel
World Journal of Cardiovascular Diseases (WJCD) , 2015, DOI: 10.4236/wjcd.2015.58024
Abstract: Objectives: Prevention of sudden cardiac death is the number one clinical priority in sports cardiology. While the overall cardiovascular risk of long distance running is acknowledged as low, the frequency of cardiac arrests and sudden death has increased in middle-aged males during marathons since the year 2000. An evidence-based strategy for protecting susceptible runners from these acute cardiac events during races is considered based on identification of the underlying cause. Method: Review of articles in Pub Med on adverse cardiac events during marathons. Findings: Recent epidemiological studies have identified an increasing frequency of cardiac arrest in middle-aged males during marathons since the year 2000 with atherosclerotic heart disease as the main cause of sudden cardiac death. Same-aged asymptomatic middle-aged male physician-runners showed a post-race polymorphonuclear leukocytosis with sequential increases in interleukin-6 and C-reactive protein as a likely consequence of rhabdomyolysis after “hitting the wall”. Increased fibrinogen, von Willebrand factor and D-dimer with in vivo platelet activation indicated a concurrent hemostatic imbalance with pro-coagulant effects. Cardiac troponins I and T and NT-pro-B-type natriuretic peptide were elevated after races as additionally predictive of acute cardiac events in asymptomatic persons. Conclusions: High short-term risk for acute cardiac events in asymptomatic middle-aged male runners is shown by stratification of validated biomarkers, which may render non-obstructive coronary atherosclerotic plaques vulnerable to rupture during marathons. Pre-race aspirin usage is prudent to reduce these events mediated by atherothrombosis based on conclusive evidence for prevention of first acute myocardial infarctions in same-aged healthy male physicians. Prospective studies are needed to determine the efficacy of pre-race low-dose aspirin for curtailing the increasing frequency of race-related cardiac arrest and sudden death in susceptible runners.
Communication, Gender and Formality: A Study of Request Forms Used by Undergraduate Students in Ghana  [PDF]
Philip Arthur Gborsong
Advances in Journalism and Communication (AJC) , 2016, DOI: 10.4236/ajc.2016.41003
Abstract: The question of sex difference in communication has been a growth industry as scholars have attempted to claim and to counter claim that there are or are not important differences in the ways in which males and females communicate. In this work, an attempt is made to find out if male and female students make requests differently. The study considered the sentence types used by males and females, the levels of formality in request making, the variety of English used, and the politeness of the requests made. Using the Speech Act Theory of Austin and Searle, and the Convergence theory in Gender as a theoretical base, an argument is made that females and males make requests differently. A major finding was that the interrogative was the most commonly used sentence type in making requests especially by females; the males used imperatives more often than the females. In instances where declaratives were used, it was observed that males used simple declarative sentences whereas the females used complex declarative sentences.
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