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Search Results: 1 - 10 of 406 matches for " Arianna Paci "
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Inflammatory Bowel Diseases: What Do We Still Need to Investigate?  [PDF]
Marina Taus, Debora Busni, Daniele Fumelli, Arianna Paci, Giulia Nicolai, Albano Nicolai
Open Journal of Gastroenterology (OJGas) , 2015, DOI: 10.4236/ojgas.2015.510024
Abstract: Inflammatory bowel disease (IBD) including Crohn (CD) and ulcerative colitis (UC), is intestinal disorders with an unknown specific etiology. Many factors are involved in the pathogenesis: genetic, environment, nutrition, immunity and intestinal dysbiosis. In the present work, we review the most important trigger mechanisms involved in IBD, with a particular regard to the role of microbiota and fecal mass transplantation as a new therapeutic approach, that even if it can be considered safe and effective, data are necessary regarding all procedures not yet standardized and timing of treatment.
Mammography and beyond: developing technologies for the early detection of breast cancer
Eugenio Paci
Breast Cancer Research , 2002, DOI: 10.1186/bcr429
Abstract: Following a short presentation of the history of mammography, the theory of efficacy evaluation through randomized clinical trials (all referenced) and the more recent evaluations of screening programmes that are ongoing in several countries are critically re-examined. The second chapter discusses new developments in breast imaging and in related technologies; a table presents the current status of imaging technologies for a large number of devices, few of which are currently of interest with regard to early detection. Most of the technologies discussed pertain to clinical diagnosis, and are unlikely to surpass mammography in the field of early detection in the near future.A chapter entitled Technologies in development: genetic and tumor markers reports on the progress that has been made in this important field, but it states that "... the ability to predict who will develop breast cancer is modest at best." We are still in the realm of basic research, and application of these technologies in screening is far from reaching routine daily practice. However, the authors emphasize the opportunity to improve predictive oncology in the early stages of breast cancer. Furthermore, with private companies developing genetic tests, and the fact that "The tests are not subject to FDA [Food and Drug Administration] regulation and thus clinical validity and utility did not have to be documented before entry into the market", there is a need for a new policy and for genetic counselling for women who request testing.The following chapter on the development and regulation of new technologies (which is referred to only within the context of the USA) is original to the best of my knowledge, at least for a European audience. The narrative of the initiatives and collaborations that have been active between government agencies, private industries and associations, and the examples of funding mechanisms for medical technology development confirm the massive investment into breast cancer c
Current problems of close-to-nature silviculture in Italy
Paci M
Forest@ , 2004,
Abstract: The main problems of Italian forests are critically reviewed, considering the ecological as well the socio-economic factors that have been responsable of the main evolutionary processes, i.e., the secondary succession under artificial conifer stands, the ageing of the coppice forest, the post-cultivation evolution on abandoned fields and the increase of wild ungulates, which currently represents one of the most dramatic problems to be faced in forest management. Concepts as biodiversity, multifunctionality and sustainable management are the foundations, nowadays, of forest management. The main elements traditionally characterizing the close-to-nature silviculture are discussed and critically examined, warning against ideology and rigidity. Two concepts are more carefully discussed: natural vegetation dynamics and mixed uneven aged forest. An analysis of the priorities of silviculture in Italy concludes the paper, namely: the importance to take advantage of the “natural opportunities” in the cheapest way (the cost of the thinnings is a first rate problem, nowadays); to consider forests ecosystems in the context of surrounding natural and cultural landscape; to define proper management strategies for secondary successions on abandoned fields and pastures; to aim at re-naturalizing artificial conifer stands and increasing/maintaining forest biodiversity; to tackle effectively the wild ungulates problem.
The importance of forest ecology in forestry faculties in Italy
Paci M
Forest@ , 2007, DOI: -
Abstract: A comment is made on recent changes in the teaching organization of Forestry faculties in Italy, which in some cases seems to constrain the role of ecological disciplines.
Perspectives for the Italian Universities
Paci M
Forest@ , 2008,
Abstract: Appropriate procedures for appointing professors, efficient evaluation and control procedures, the respect of the responsibility principle and the competitive selection of students are key points to which the Italian Universities should pay great attention and prompt action to avoid decline.
Roberto Del Favero completes the description of Italian forests
Paci M
Forest@ , 2010,
Abstract: The description of Italian woods by Roberto Del Favero is now completed: after the book dedicated to the “woods of the Alpine regions” and the one concerning the “woods of the southern Italy and Italian islands”, a third book completes the arrangement, aimed to the forest management, of the Italian woods. In the treatise, the strict connection between ecology and silviculture must be underlined: the silvicultural choices are proposed in accordance with ecological requirements of the tree species, as well as to the natural dynamic of stands.
I confini di Urania. La geografia come limes perdurante
Deborah Paci
Diacronie : Studi di Storia Contemporanea , 2009,
Abstract: The notion of “inner boundary” is the key point in understanding the internal dynamics of independence and autonomy movements that have made their appearance in Corsica and Sicily during the nineteenth and twentieth centuries. The comparative-historical dimension allows to dispel the stereotype of the insular particularism and the cultural specificity.
The Many Forms and Functions of Long Term Plasticity at GABAergic Synapses
Arianna Maffei
Neural Plasticity , 2011, DOI: 10.1155/2011/254724
Abstract: On February 12th 1973, Bliss and Lomo submitted their findings on activity-dependent plasticity of glutamatergic synapses. After this groundbreaking discovery, long-term potentiation (LTP) and depression (LTD) gained center stage in the study of learning, memory, and experience-dependent refinement of neural circuits. While LTP and LTD are extensively studied and their relevance to brain function is widely accepted, new experimental and theoretical work recently demonstrates that brain development and function relies on additional forms of plasticity, some of which occur at nonglutamatergic synapses. The strength of GABAergic synapses is modulated by activity, and new functions for inhibitory synaptic plasticity are emerging. Together with excitatory neurons, inhibitory neurons shape the excitability and dynamic range of neural circuits. Thus, the understanding of inhibitory synaptic plasticity is crucial to fully comprehend the physiology of brain circuits. Here, I will review recent findings about plasticity at GABAergic synapses and discuss how it may contribute to circuit function. 1. Heterosynaptic Inhibitory Plasticity 1.1. Long-Term Potentiation Plasticity of GABAergic synapses onto excitatory neurons, in the form of long-term potentiation (LTPi) and/or depression (LTDi) of inhibitory postsynaptic potentials (IPSPs), was initially reported in layer 5 of the rodent primary visual cortex [1]. Following these pioneering studies, bidirectional inhibitory plasticity was observed in many areas of the brain—neonatal hippocampus [2], deep cerebellar nuclei [3, 4], lateral superior olive [5], brain stem [6], and onto dopaminergic neurons in the ventral tegmental area (VTA) [7, 8]. Although there are significant differences in the induction and expression mechanisms of high-frequency long-term inhibitory plasticity (HF-LTPi and HF-LTDi, Figure 1), some common features have been identified across several brain circuits. Most forms of HF-LTPi involve Ca2+-mediated signaling. The source of Ca2+ is specific to the inhibitory synapse: voltage-gated calcium channels (VGCC) in neonatal hippocampus (Figure 1(b), left panel) [9]; astrocytes in juvenile hippocampus [10]; postsynaptic intracellular stores in cortex (Figure 1(a), left panel) [11, 12]; activation of postsynaptic NMDA receptors in the VTA (Figure 1(c), left panel) [8]. In several systems, the induction of HF-LTPi and HF-LTDi depends on high-frequency activation of glutamatergic and GABAergic axons. Postsynaptic activation of glutamatergic receptors is often required for the induction of HF-LTPi, while
Educational models and concept of childhood in the Gaza Strip Educare a Gaza
Arianna Taddei
Ricerche di Pedagogia e Didattica , 2010,
Abstract: In 2008, R.E.C. (Remedial Education Centre, Gaza, Palestine) was carrying out the project “Promotion of the democratic process and active participation among young population in the Gaza Strip”, approved by the Europe Initiative for democracy and Human Rights, and financed by the European Union. The project included a research activity, “Educational models and concept of childhood in the Gaza Strip”. The research is an idea coming from the long-term collaboration, started in 2002, between EducAid (Italian Ngo, Rimini, Italy) and R.E.C. in the educational work with the vulnerable children in the Gaza Strip.Teachers, educators and parents play a fundamental role in the education of children and adolescents; therefore families, associations and schools should be places where children become aware of their rights as human beings, in order to become, one day, active citizens of a society that themselves can improve. It’s of fundamental importance the policy that institutions carry out (supporting families, schools and associations), because it guarantees a functional education system. We interfaced with the different faces of formal and informal education, and it was impossible not to have the sensation of being inside a big prison, not too big, if we think its size compared to one and a half million inhabitants, between a closed tall and gray wall, a sea hardly accessible due to embargo, and Erez, the check point of transit for Israel. No gas, no fuel, no electricity, yet children continue to go to school, the roads are crowded by pedestrians who are waiting for a taxi for hours under the sun, wondering if they can go to work. The potential of education and schooling represent non-violent weapons to defend peace, promote change, make children aware of their rights, begin to live their citizenship at school, at home, in the associations. Through the testimonies we realized how much these valuable potentials are in danger in the Gaza Strip, as indeed in many other places in the world where people are slaves to someone or something, and lose confidence, tighten up their minds, are afraid to change, to fight for transforming what the political, social, local and international system make difficult and overwhelming. In 2008, R.E.C. (Remedial Education Centre, Gaza, Palestine) was carrying out the project “Promotion of the democratic process and active participation among young population in the Gaza Strip”, approved by the Europe Initiative for democracy and Human Rights, and financed by the European Union. The project included a research activity, “Educational m
Althea Gyles’ Symbolic (De)Codification of William Butler Yeats’ ‘Rose and Wind Poetry’
Arianna Antonielli
Studi Irlandesi : a Journal of Irish Studies , 2011,
Abstract: In 1897, Yeats’s The Secret Rose was published in London by Lawrence & Bullen, while two years later, in 1899, the London editor Elkin Mathews published The Wind Among the Reeds. Both volumes are extremely interesting, not only for their acknowledged poetical value but also for their material worth. This is due to their elaborate designs: gold stamps on the spine and cover 1897 edition of the Secret Rose and intertwining reeds on The Wind Among the Reeds cover. Both were done by the Irish artist Althea Gyles (1867-1949). Gyles was frequently described by Yeats as a “symbolic artist” producing a “symbolic art” (Memoirs: Autobiography – A First Draft, 1972). Her paintings deeply influenced Yeats’s symbolical and imaginary system, to such a degree that they formed its perfect iconic counterpart. Following this hypothesis, Antonielli concentrates on Yeats’s main esoteric topoi, symbols and images emerging from the poems in The Secret Rose and The Wind Among the Reeds, and on their ‘translation’ into Althea Gyles’s iconic visions and artistic output. She examines how Yeats’s poems were clarified or further complicated by Gyles’s corresponding designs and how Yeats and Gyles, through their own peculiar artistic expressions, exemplified a shared symbolic vision of phenomenal reality.
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