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Search Results: 1 - 10 of 1101 matches for " Araluen Freeman "
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Anti-Inflammatory and Anti-Remodelling Effects of ISU201, a Modified Form of the Extracellular Domain of Human BST2, in Experimental Models of Asthma: Association with Inhibition of Histone Acetylation
Cristan Herbert, Alexander M. Shadie, Melissa M. Bunting, Nicodemus Tedla, Linda Garthwaite, Araluen Freeman, Hyouna Yoo, Sang-Ho Park, Rakesh K. Kumar
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0090436
Abstract: There are few alternatives to glucocorticosteroids for treatment of asthma. We assessed the activity of a novel protein drug designated ISU201, the extracellular domain of the human cell surface protein BST2, stabilised by fusion with the Fc region of IgG, in mouse models of mild chronic asthma and an acute exacerbation of asthma. The ability of ISU201 to suppress airway inflammation and remodelling was compared with that of dexamethasone. Female BALB/c mice were systemically sensitised with ovalbumin, then received controlled low-level challenge with aerosolised ovalbumin for 6 weeks, which induced lesions of mild chronic asthma, and were treated with drugs during the final 2 weeks. Alternatively, sensitised mice received 4 weeks of chronic low-level challenge and were treated 24 and 2 hours before a final single moderate-level challenge, which triggered acute airway inflammation simulating an asthmatic exacerbation. Inflammation and remodelling were quantified, as was the expression of pro-inflammatory cytokines in bronchoalveolar lavage fluid and tissues. To identify cellular targets of ISU201, we assessed the effects of the drug on activated lymphocytes, macrophages and airway epithelial cells. In the model of mild chronic asthma, ISU201 was as effective as dexamethasone in suppressing airway inflammation and most changes of remodelling. In the model of an allergen-induced acute exacerbation of chronic asthma, ISU201 was also an effective anti-inflammatory agent, although it was less active than dexamethasone. The drug acted on multiple cellular targets, suppressing production of pro-inflammatory cytokines by lymphocytes and macrophages. ISU201 significantly reduced acetylation of histone H4 in airway epithelial cells, suggesting at least one potential mechanism of action. We conclude that in these models of asthma, ISU201 is a broad-spectrum inhibitor of both airway inflammation and remodelling. Thus, unlike drugs which target specific mediators, it could potentially be an alternative or an adjunct to glucocorticoids for the treatment of asthma.
Management traits in dairy cattle: dystocia, udder characteristics related to production, and a review of other traits
AE Freeman
Genetics Selection Evolution , 1976, DOI: 10.1186/1297-9686-8-2-288b
Teaching animal breeding in the united states
AE Freeman
Genetics Selection Evolution , 1977, DOI: 10.1186/1297-9686-9-1-132b
Genetic differences in feed utilization by dairy cattle
AE Freeman
Genetics Selection Evolution , 1980, DOI: 10.1186/1297-9686-12-1-123c
Health promotion and the randomised controlled trial: a square peg in a round hole?
Ruth Freeman
BMC Oral Health , 2009, DOI: 10.1186/1472-6831-9-1
Abstract: In their paper published in BMC Oral Health in March 2008, entitled 'An ethnographic study of Latino preschool children's oral health in rural California: intersections among family, community, provider and regulatory sectors', Barker and Horton [1] examined the barriers experienced by immigrant parents when accessing dental care for their pre-school children. The authors set out the main parental difficulties or concerns encountered. These included fears of official bodies and a lack of awareness of health care entitlements, where to find health care amenities and public transport routes. At a more personal level parents' concerns included; language differences and literacy problems; health professionals' lack of cultural sensitivity and how their children's dental fears would be managed. This cocktail of concerns, worries and anxieties resulted in parents delaying treatment visits and consequently increasing oral health disparities in this ethnic minority group. Why should Barker and Horton's [1] work be of importance: why should an in-depth examination or assessment of community concerns be of relevance? What is the relevance of participants' narratives, as an expression of their internal world, for the radical discourse of health promotion and its evaluation?In the debate surrounding the radical discourse of health promotion [2,3] it is acknowledged that 'community empowerment and advocacy are pivotal in the promotion and maintenance of health' [4] and that an appreciation of people's main concerns paves the way for empowerment. Thus people's narratives or their main concerns are central in the radical discourse of health promotion, together with the assurance that if health promotion interventions are to be successful then they must not exacerbate social isolation, increase self-deprecation or reduce self-esteem in those they wish to help. Nevertheless, health promotion interventions, which adopt the conventional discourse or a 'top-down approach', may unintent
Democracia e controle jurídico da constitucionalidade
Freeman, Samuel;
Lua Nova: Revista de Cultura e Política , 1994, DOI: 10.1590/S0102-64451994000100010
Abstract: objections to the institution of judicial review as being incompatible with democracy are examined and refuted. judicial review can be democratically justified, it is argued. this is possible if we conceive it as a previous collective compromise assumed by the citizens in the constitutional choice situation, to the effect that they would not exercise their equal political rights in ways that could put in danger their own condition of bearers of equal citizenship rights.
Tissue engineered devices for ligament repair, replacement and regeneration
JW Freeman
African Journal of Biotechnology , 2009,
Abstract: The anterior cruciate ligament (ACL) is one of five ligaments in the knee that are important for stability and kinematics. It is also the most commonly injured ligament of the knee and due to its poor healing potential, severe damage warrants surgical intervention including complete replacement. Ligaments are longitudinally arranged, complex tissues; the mechanical properties of ligaments are a direct result of their components and the arrangement of these components in the tissue. It is these mechanics that have made ligaments so difficult to replace. Past ACL replacements have had many limitations that prevented their extensive use. These limitations range from mechanical fatigue over time to fraying of the device after implantation. In light of these problems, investigators have begun to pursue a host of new techniques to create a range of viable options for the repair, replacement, and/or regeneration of the ACL. These options include tissue engineered scaffolds with novel designs and specially treated transplanted tissues. In this article, the composition, arrangement, and mechanics of the ACL will be discussed in order to elucidate important aspects of ACL repair and past replacements will be described. Afterwards, novel replacement options that look to solve problems faced by older replacement options will be presented. These devices use a wide variety of materials and designs to replicate ligament mechanics and allow for new tissue regeneration.
Dealing with major depression in general practice
CP Freeman
South African Family Practice , 2012,
Abstract: One in ten South Africans will be diagnosed with major depressive disorder (MDD) at some point in their lives. MDD is a potentially disabling condition that affects many spheres of an individual’s life and leads to marked social and occupational dysfunction. General practitioners are frequently required to diagnose and manage MDD, often in a time-pressured primary healthcare setting. This article aims to provide practitioners with an overview of MDD. It covers aspects of diagnosis, co-morbidity, pharmacology and special patient groups.
Never Again! Genocide and the International Community
Freeman, Michael
Papeles del CEIC , 2007,
Abstract: The term "genocide" refers to the worst of crimes.Yet, although it involves complex social processes withenormous impacts on individuals and societies, it hasbeen rather neglected by social scientists. This is duein part to the fact that the international legaldefinition of "genocide" is unclear and unsatisfactory,and also in part to the methodological problems ofcomparing large-scale events. The article proposes amethodological solution to these problems —involvingthe use of Weber’s ideal type— and offers a criticalreview of the leading explanatory theories ofgenocide. It concludes that these theories offerconsiderable insight into the causation of genocide,although none is wholly convincing. A brief analysis ofthe crisis in Darfur is made to clarify some of theremaining problems in this field./El término "genocidio" alude al peor de los crímenes.Aunque este concepto implica complejos procesossociales que tienen un gran impacto sobre losindividuos y las sociedades, ha sido descuidado por loscientíficos sociales. Esto es debido en parte al hechode que la definición internacional de "genocidio" esconfusa e insatisfactoria, y también en parte aproblemas metodológicos en la comparación de grandessucesos. El artículo propone una solución metodológicaa esos problemas —utilizando los tipos ideales deWeber— y ofrece una revisión crítica de las principalesteorías explicativas del genocidio. El artículo concluyecon la idea de que esas teorías ofrecen unaconsiderable comprensión de las causas del genocidio,aunque ninguna resulta totalmente convincente. Serealiza un breve análisis de la crisis en Darfur con laintención de clarificar algunos de los problemasremanentes en este campo.
Does scarcity lead to better integrated care?
George Freeman
International Journal of Integrated Care , 2003,
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