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Effect of lipopenic and hypotensive treatment on homocysteine levels in type 2 diabetics
Mabrouka El Oudi, Zied Aouni, Haroun Ouertani, et al
Vascular Health and Risk Management , 2010, DOI: http://dx.doi.org/10.2147/VHRM.S8240
Abstract: t of lipopenic and hypotensive treatment on homocysteine levels in type 2 diabetics Original Research (3839) Total Article Views Authors: Mabrouka El Oudi, Zied Aouni, Haroun Ouertani, et al Published Date May 2010 Volume 2010:6 Pages 327 - 332 DOI: http://dx.doi.org/10.2147/VHRM.S8240 Mabrouka El Oudi1, Zied Aouni1, Haroun Ouertani2, Chakib Mazigh2, Salem Machghoul1 1Département de biochimie, 2Service d’endocrinologie, H pital militaire de Tunis, 1008 Montfleury, Tunisie Aim: Evaluate the effect of lipopenic and hypotensive treatment on homocysteine levels. Methods: We recruited 145 type 2 diabetics and 130 control subjects. Thirty-seven diabetics had no complications, 54 had microvascular complications and 54 had macrovascular complications. We determined the parameters homocysteine of lipid, vitamin B12, triglycerides, and folates for all subjects. Associated treatments used one or more of the following drugs, statin, fibrate, angiotensin-converting enzyme inhibitor and beta-blockers. Results: Hyperhomocysteinemia was present in 35.6% of patients. Diabetics had elevated serum levels of triglycerides (P < 0.001), homocysteine (P < 0.01), folates (P < 0.01) and vitamin B12 (P < 0.001). A strong association was found between type 2 diabetes and hyperhomocysteinemia (P < 0.001). Diabetics with associated treatment had elevated homocysteine, vitamin B12 and folate levels when compared to diabetes-free controls. For diabetics with macrovascular complications, we found significant differences in homocysteine (P = 0.010) and folate (P = 0.014) between those taking associated drugs and those who did not. For diabetics with microvascular complications, a significant difference was found in folate only (P = 0.012). Conclusion: Drugs used for hypertension and hyperlipidemia may have an effect on homocysteine levels, for this reason the interaction between drug action and homocysteine levels should be taken into consideration.
Effect of lipopenic and hypotensive treatment on homocysteine levels in type 2 diabetics
Mabrouka El Oudi,Zied Aouni,Haroun Ouertani,et al
Vascular Health and Risk Management , 2010,
Abstract: Mabrouka El Oudi1, Zied Aouni1, Haroun Ouertani2, Chakib Mazigh2, Salem Machghoul11Département de biochimie, 2Service d’endocrinologie, H pital militaire de Tunis, 1008 Montfleury, TunisieAim: Evaluate the effect of lipopenic and hypotensive treatment on homocysteine levels.Methods: We recruited 145 type 2 diabetics and 130 control subjects. Thirty-seven diabetics had no complications, 54 had microvascular complications and 54 had macrovascular complications. We determined the parameters homocysteine of lipid, vitamin B12, triglycerides, and folates for all subjects. Associated treatments used one or more of the following drugs, statin, fibrate, angiotensin-converting enzyme inhibitor and beta-blockers.Results: Hyperhomocysteinemia was present in 35.6% of patients. Diabetics had elevated serum levels of triglycerides (P < 0.001), homocysteine (P < 0.01), folates (P < 0.01) and vitamin B12 (P < 0.001). A strong association was found between type 2 diabetes and hyperhomocysteinemia (P < 0.001). Diabetics with associated treatment had elevated homocysteine, vitamin B12 and folate levels when compared to diabetes-free controls. For diabetics with macrovascular complications, we found significant differences in homocysteine (P = 0.010) and folate (P = 0.014) between those taking associated drugs and those who did not. For diabetics with microvascular complications, a significant difference was found in folate only (P = 0.012). Conclusion: Drugs used for hypertension and hyperlipidemia may have an effect on homocysteine levels, for this reason the interaction between drug action and homocysteine levels should be taken into consideration.Keywords: type 2 diabetes, complications, homocysteine, hypolipemiant drug, hypotensive drug
Endothelial Nitric Oxyde Synthase Gene Polymorphisms in a Tunisian Deep Vein Thrombosis Group  [PDF]
Nedra Grira, Nadia Ben Abdelhafidh, Manel Ayoub, Rihab Sendesni, Bochra Adib, Najla Stambouli, Salah Othmani, Zied Aouni, Chakib Mazigh
Journal of Biosciences and Medicines (JBM) , 2016, DOI: 10.4236/jbm.2016.49004
Abstract: Deep vein thrombosis (DVT) is a multi-factorial disease involving both genetic and acquired risk factors. The objective of this study was to determine the frequencies of endothelial nitric oxide synthase (eNOS) gene polymorphisms G894T (rs1799983) and T-786C (rs2070744) to assess the role of these polymorphisms as a potential risk factor in the development of DVT. Methods: In this case-control study, we included 32 patients with deep vein thrombosis (DVT) and 31 healthy control subjects. Clinical characteristics were collected. Lipids plasma concentrations were determined by the colorimetric method. Genotyping for the polymorphisms was performed by restriction fragment length polymorphism (PCR-RFLP) method. Results: We had found that the eNos G894T genotype G/T was significantly increasing the risk of DTV (P = 0.042, OR = 3.9; 95% CI = 1.09 to 13.92). But no association of the eNOS T-786C variant and DVT was found. For the eNOs T-786C polymorphism, the frequency of the T/T genotype was 87.5% in patients (with an allelic frequency of T Allele equal to 91%). No significant difference was noted between the two groups (P > 0.05). Conclusion: The eNOs G894T polymorphism seems to be in association with DVT and may be considered as a risk factor, but this is not the case for the T-786C polymorphism.
Endothelial Nitric Oxide Synthase (eNOS) Glu298Asp Gene Polymorphism (G894T) as a Risk Factor for Type 2 Diabetes Mellitus in the Tunisian Population  [PDF]
Rihab Sendesni, Nedra Grira, Oussama Lamine, Sana Aboulkassem, Manel Ayoub, Nejla Stambouli, Ouertani Haroun, Chakib Mazigh, Zied Aouni
Open Access Library Journal (OALib Journal) , 2018, DOI: 10.4236/oalib.1104171
Abstract:
Introduction: Diabetes mellitus is a chronic disease whose global expansion gives it the characteristics of a pandemic. Diabetes risk factors are well known. In this work we proposed to study the role of genetic polymorphism of the eNOS G894T gene in the development of diabetes on the one hand and of these degenerative complications other. Methods: We conducted a prospective case-control study in which we included 200 subjects divided into 100 patients with type 2 diabetes and 100 controls in apparent good health. For each patient and control we measured lipid parameters, CRP-us and sought the G894T polymorphism of eNOS gene by PCR-RFLP. Results: The analysis of our results shows a statistically significant elevated TG values (p < 10﹣3), Lp (a) (p < 10﹣3), and CRP-us (p < 10﹣3) in type 2 diabetes compared with controls. The mutated genotypes of GT eNOS gene was significantly more frequent in diabetic patients. In our series, we did not notice any significant difference in genotype or allele frequency between diabetics with and without degenerative complications. Conclusion: The G894T polymorphism of eNOS gene appears to be a risk factor of T2DM. His role in the development of degenerative complications remains proved.
Evaluation of Cardiovascular Risk Factors in a Young Adults Tunisian Group  [PDF]
Lamine Oussama, Aboulkacem Sana, Grira Nedra, Ayoub Manel, Sendesni Rihab, El Oudi Mabrouka, Stambouli Nejla, Mazigh Chakib, Aouni Zied
Journal of Biosciences and Medicines (JBM) , 2018, DOI: 10.4236/jbm.2018.63001
Abstract: Introduction: Cardiovascular diseases have become more common in young adults. Their emergence is due to the prevalence of cardiovascular risk factors. The aim of this study is to determine the prevalence of cardiovascular risk factors in a Tunisian young adult group. Material and methods: This is an epidemiological study of 705 Tunisians volunteers, free from any cardiovascular pathology; who are recruited at the Military Hospital of Tunis. Besides the classical cardiovascular risk factors (obesity, dyslipidemia, smoking, alcohol…), we evaluate the level of homocysteinemia and determined the C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene by PCR-RFLP method. Results and conclusions: The mean age of our population is 28.25 ± 9.08 with a male majority (83.8%). We have 43.8% obese subject or overweight, 54.3% smokers and 12.9% alcoholics. The lipid profile showed that 12.6% of the population had hypercholesterolemia and 39.5% had hypoHDLemia, 7.9% had a high lipoprotein(a) concentration. In our study population we found that 10.9% of subjects had an hs-CRP concentration greater than 3 mg/L. Genotyping of the MTHFR gene revealed that 34% of young adults had a mutated genome (CT). The results showed a significant correlation between different factors, such as cholesterolemia and obesity. The prevalence of these risk factors showed the severity of our young people’s health status and imposes a change in the way of Tunisians life.
Correlation between Inflammatory Markers and Lipid Parameters in a Tunisian Coronary Artery Disease Group  [PDF]
Rihab Sendesni, Dhaker Lahidheb, Manel Ayoub, Nedra Grira, Dhekra Lafi, Nejla Stambouli, Mabrouka El Oudi, Ezzedine Ghazouani, Habib Haouala, Zied Aouni, Chakib Mazigh
Open Access Library Journal (OALib Journal) , 2016, DOI: 10.4236/oalib.1102635
Abstract:
Aims: To evaluate the relationship between inflammatory biomarkers and lipid parameters in a Tunisian coronary artery disease group. Material and Methods: In the study, we have included 122 subjects with acute coronary syndrome (ACS) confirmed by coronary angiography, selected among patients admitted to the cardiology department and 162 subjects free of any cardiovascular disease, recruited from medical and paramedical volunteers. Lipid parameters, high sensitivity CRP (hsCRP) and proinflammatory cytokines (IL6, IL8 and TNFα) were determined for all patients and controls. Results: A highly significant difference (P < 103) was noted between the mean of the hsCRP in coronary patients (14.65 ± 9.81 mg/L) compared to controls (1.63 ± 1.75 mg/L). We note also a significant difference between the means of IL6 in the diseased population (11.56 ± 8.23 pg/mL) compared to controls (2.5 ± 0.84 pg/mL) with a value of P < 103. The hsCRP values are inversely correlated with the HDLc values. No association was found between IL 8 and the various lipid parameters. Patients having high IL6 values had higher levels of CT and CT/HDLc ratio. This correlation is statistically significant. Regarding TNFα, there is a positive and significant correlation with CT and LDLc. Conclusion: Significant correlation was found between inflammatory markers and lipids profile. This may explain the role of inflammation in the development of cardiovascular disease.
Evaluation of Cardiovascular Risk Factors in Tunisian Coronary Patients  [PDF]
Grira Nadra, Sandesni Rihab, Lamine Ossama, Aboulkassem Sana, Ayoub Manel, El Oudi Mabrouka, Stambouli Najla, Lahidheb Thaker, Haouala Habib, Mazigh Chakib, Aouni Zied
Open Access Library Journal (OALib Journal) , 2018, DOI: 10.4236/oalib.1104214
Abstract:
Introduction: Ischemic heart disease ranked among the leading causes of death worldwide. Several biological and genetic risk factors associated with acute coronary syndrome. By addressing the risk factors, it is possible to prevent most of the cardiovascular diseases and contribute to the reduction of complications of acute coronary syndrome. Material and Methods: Our study is a prospective study that was conducted to the main military hospital of instruction of Tunis. Recruitment involved 122 coronary (n = 122) and 705 controls (n = 705) totaling a population of 827 subjects. Data collection concerned socio-demographic characteristics, anthropometric measurements, habits and lifestyle, health status and biological assessment. Results: Our study reported a high prevalence of cardiovascular classic risk factor particularly overweight (62.3%), diabetes (63.1%) and hypertension (50%). In 55% of coronary patients, moderate to intermediate hyperhomocysteinemia was found, but it appears to be an independent risk factor. The results of our study show a significant difference in the genotypic frequencies of the C677T mutation in the MTHFR gene between the two populations, cases and controls. Conclusion: Acute coronary syndromes are the leading cause of sudden death in adults. The evaluation of risk factors after acute coronary syndrome episode is essential for a better management according to the recommendations of learned societies and standards of good practice.
Supersonic Flutter of a Spherical Shell Partially Filled with Fluid  [PDF]
Mohamed Menaa, Aouni A. Lakis
American Journal of Computational Mathematics (AJCM) , 2014, DOI: 10.4236/ajcm.2014.43014
Abstract:

In the present study, a hybrid ?nite element method is applied to investigate the dynamic behavior of a spherical shell partially filled with fluid and subjected to external supersonic airflow. The structural formulation is a combination of linear spherical shell theory and the classic finite element method. In this hybrid method, the nodal displacements are derived from exact solution of spherical shell theory rather than approximated by polynomial functions. Therefore, the number of elements is a function of the complexity of the structure and it is not necessary to take a large number of elements to get rapid convergence. Linearized first-order potential (piston) theory with the curvature correction term is coupled with the structural model to account for aerodynamic loading. It is assumed that the fluid is incompressible and has no free surface effect. Fluid is considered as a velocity potential at each node of the shell element where its motion is expressed in terms of nodal elastic displacements at the ?uid-structure interface. Numerical simulation is done and vibration frequencies are obtained. The results are validated using numerical and theoretical data available in literature. The investigation is carried out for spherical shells with different boundary conditions, geometries, filling ratios, flow parameters, and radius to thickness ratios. Results show that the spherical shell loses its stability through coupled-mode flutter. This proposed hybrid finite element method can be used efficiently for analyzing the flutter of spherical shells employed in aerospace structures at less computational cost than other commercial FEM software.

An Augmented Framework for Practical Development of Construction Robots
Khaled Zied
International Journal of Advanced Robotic Systems , 2008,
Abstract: The use of robotic systems in performing construction tasks has great potential; however the development of such systems remains problematic. This is due to the lack of a suitable feasibility analysis that can help the decision makers to justify the use of robots and problems in the development process of the system itself. The multidisciplinary and complex nature of construction robotic systems requires a robust development framework for such systems. An augmented framework for the development of construction robots is explained in detail and practically applied to the Star lifter robotic system which is mainly designed to carry heavy tools for construction tasks. The framework consists of two models; the feasibility analysis model and the development process model. The feasibility analysis principles, methodology and tools are explained and discussed in detail. Systems Engineering model is used in the development of the system which allows complete analysis of the system hardware and software components. The purpose of the current project is to develop a general purpose robot that can be employed to perform different jobs to justify its use economically. The presented tools and processes can be utilised in the development of any similar systems.
A robust system for melanoma diagnosis using heterogeneous image databases  [PDF]
Khaled Taouil, Zied Chtourou, Nadra Ben Romdhane
Journal of Biomedical Science and Engineering (JBiSE) , 2010, DOI: 10.4236/jbise.2010.36080
Abstract: Early diagnosis of melanoma is essential for the fight against this skin cancer. Many melanoma detection systems have been developed in recent years. The growth of interest in telemedicine pushes for the development of offsite CADs. These tools might be used by general physicians and dermatologists as a second advice on submission of skin lesion slides via internet. They also can be used for indexation in medical content image base retrieval. A key issue inherent to these CADs is non-heterogeneity of databases obtained with different apparatuses and acquisition techniques and conditions. We hereafter address the problem of training database heterogeneity by developing a robust methodology for analysis and decision that deals with this problem by accurate choice of features according to the relevance of their discriminative attributes for neural network classification. The digitized lesion image is first of all segmented using a hybrid approach based on morphological treatments and active contours. Then, clinical descriptions of malignancy signs are quantified in a set of features that summarize the geometric and photometric features of the lesion. Sequential forward selection (SFS) method is applied to this set to select the most relevant features. A general regression network (GRNN) is then used for the classification of lesions. We tested this approach with color skin lesion images from digitized slides data base selected by expert dermatologists from the hospital “CHU de Rouen-France” and from the hospital “CHU Hédi Chaker de Sfax-Tunisia”. The performance of the system is assessed using the index area (Az) of the ROC curve (Receiver Operating Characteristic curve). The classification permitted to have an Az score of 89,10%.
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