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Search Results: 1 - 10 of 88 matches for " Anxiolytic "
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Nootropic Activity of Caralluma fimbriata Extract in Mice  [PDF]
Ramaswamy Rajendran, Digambar Balkrishna Ambikar, Rakesh Arun Khandare, Vrushali Dattatraya Sannapuri, Niraj Sudhakar Vyawahare, Paul Clayton
Food and Nutrition Sciences (FNS) , 2014, DOI: 10.4236/fns.2014.52019

We investigated the effects of a standardized extract of Caralluma fimbriata Wall (CFE) on learning and memory in mice using various behavioural models. Unusually, CFE exerts both nootropic and anxiolytic effects.

A rapid solid supported synthesis of 4-amino-5-(pyridin-4-YL)-4H-1,2,4-triazol-3-thiol and its derivatives
46. Shahana Ehsan, Sahar Sarfraz, Bushra Khan, Syeda Mona Hassan, Munawar Iqbal
Chemistry Internatioanl , 2016,
Abstract: 1,2,4-Triazoles and its substituted derivatives were synthesized since these compounds are known for their excellent antibacterial, antifungal, anti-tubercular, antioxidant, anticancer, anti-inflammatory, analgesic, anticonvulsant and anxiolytic activities. 1,2,4-triazole and substituted derivatives of 1,2,4-triazole were synthesized using solid state microwave irradiation technique and synthesized compounds were characterized by UV-Visible, FTIR and GC-MS techniques and in future study the biological activities of synthesized compounds will studied.
A systematic updated review of scientifically tested selected plants used for anxiety disorders
Sharma A, Cardoso-Taketa A, García G, Villarreal ML
Botanics: Targets and Therapy , 2012, DOI: http://dx.doi.org/10.2147/BTAT.S20593
Abstract: systematic updated review of scientifically tested selected plants used for anxiety disorders Review (1919) Total Article Views Authors: Sharma A, Cardoso-Taketa A, García G, Villarreal ML Published Date September 2012 Volume 2012:2 Pages 21 - 39 DOI: http://dx.doi.org/10.2147/BTAT.S20593 Received: 02 June 2012 Accepted: 24 July 2012 Published: 07 September 2012 Ashutosh Sharma, Alexandre Cardoso-Taketa, Griselda García, María Luisa Villarreal Centro de Investigación en Biotecnología, Universidad Autónoma del Estado de Morelos, Cuernavaca, Mexico Abstract: The aim of this review is to provide a summary on multidisciplinary scientific information obtained from medicinal plants used worldwide to treat anxiety, focusing on pharmacological and clinical studies. The bibliographical investigation was carried out by consulting five peer-reviewed worldwide database publications for references, and patents. The information gathered on plants with attributed anxiolytic properties are presented as follows: (1) plant extracts with anxiolytic properties evaluated in animal models; (2) plants with clinical trials; (3) identified active compounds in plants that have been assayed in animal models; (4) mechanism of action of anxiolytic plant extracts and compounds; and (5) registered patents for anxiolytic plant preparations. We recorded 112 plant species belonging to 63 botanical families for which the anxiolytic properties had been tested in animal models. Eleven plant species to treat general anxiety disorders as well as eleven species to treat anxiety-associated conditions, had been documented by clinical trials. Thirty-three registers for active compounds belonging to five general types of secondary metabolites had also been recorded. The mechanism of action at the central nervous system level had been determined in 33 plant species, either in their extracts or isolated compounds. Forty-seven patent registrations for plant preparations to be used for the treatment of anxiety were included.
Gadekar Dayanand H.,Jain Sourabh,Malik K Jitender
International Research Journal of Pharmacy , 2011,
Abstract: The hydro-alcoholic extract of Boerhaavia diffusa of leaves was investigated for evaluation of exhibited anxiolytic activity in rats at a dose 100 and 200 mg/kg by p.o. route for Elevated Plus Maze test, Hole Board Test, Ketamine induced Sleep and Haloperidol Induced Catalepsy method.. Results of in-vivo activity lead to the conclusion that the hydro-alcoholic of Boerhaavia diffusa showed predominantly significant activity which is compared to the standard drug Diazepam (0.5mg/kg).
Review of Research , 2013,
Abstract: The present study was designed to evaluate the neuropsychopharmacological effects (anxiolytic) of Aegle marmelos extract. These effects were compared with standard drugs of their class (Diazepam). Aegle marmelos extract showed anxiolytic activity in elevated plus-maze and Y-maze models. A. marmelos extract administration at both the doses (100 mg/Kg, 200 mg/Kg, p.o) significantly increased open arm activity in EPM by increasing time spent and number of entries into open arms and decreased the number of visits in Y-maze, as compared to those of control. Effect of higher dose was more than lower dose. This anxiolytic effect was achieved without any impairment in motor co-ordination in contrast to diazepam which has skeletal muscle relaxant activity at antianxiety dose. Present study shows that Aegle marmelos possess anxiolytic properties. All these effects could be attributed a number of phytoconstituents including flavonoids, quercetin, tannic acid, phenols, eugenol, marmesinin, ascorbic acid, skimmianine and saponin.
Anxiogenic Effects of an Aqueous Crude Extract of Cryptolepis sanguinolenta (Periplocaceae) in Mice
Charles Ansah,Evans A.A. Mfoafo,Eric Woode,Mahama Duwiejua
International Journal of Pharmacology , 2008,
Abstract: We studied the behavioural effects of the aqueous extract of Cryptolepis sanguinolenta (cryptolepis) in mice based on findings of a sedative action of cryptolepis in the pentobarbitone-induced sleeping-time model and the reported traditional use in the management of insomnia. Cryptolepis (100, 300 and 1000 mg kg-1, p.o) was evaluated in the elevated plus maze, open field and the hole board. We assessed entries and the time spent in the two arms of the elevated plus maze, entries and the time spent in the centre, periphery and corners of the open field and head-dipping behavior in the hole board. Cryptolepis (100, 300 and 1000 mg kg-1) significantly (p<0.05) increased the time spent in the closed arms of the elevated plus-maze, increased the time spent (p<0.001) in the corners of the open field apparatus and decreased head-dipping (p<0.01) behaviour in the hole board. The effects of cryptolepis were similar to that of caffeine used as a reference anxiogenic but completely opposite to that of diazepam, a typical anxiolytic. Present findings indicate that cryptolepis has an anxiogenic-like effect in mice.
Anxiolytic and Antidepressant Effects of a Leaf Extract of Palisota hirsuta K. Schum. (Commelinaceae) in Mice
E. Woode,E. Boakye-Gyasi,N. Amidu,C. Ansah
International Journal of Pharmacology , 2010,
Abstract: The effect of a 70% (v/v) ethanolic leaf extract of Palisota hirsuta, a traditional West African plant used for CNS disorders and pain, in animal models of anxiety and depression-the open field test, the light/dark box, the Elevated plus Maze (EPM), the Forced Swimming Test (FST) and Tail Suspension Test (TST) has been reported. P. hirsuta (30-300 mg kg-1) treated mice exhibited anxiolytic activity in all the anxiety models used by significantly increasing the percentage of center entries and the percentage time spent in the center of the open field. P. hirsuta also significantly increased the time spent in the lit area in comparison to the time spent in the dark area of the light/dark box. In the EPM, it significantly increased open arm activity which was completely reversed by flumazenil (3 mg kg-1), a specific antagonist of the GABAA benzodiazepine receptor complex. In the antidepressant test, the extract also dose-dependently reduced the duration of immobility in both the FST (ED50: 114.55±72.69 mg kg-1) and TST (70.42±0.06 mg kg-1). Pretreatment with α-methydopa (400 mg kg-1; 3 h; p.o.), reserpine (1 mg kg-1; 24 h; s.c.) or a combination of the two drugs attenuated the anti-immobility effects of both imipramime and the extract but not fluoxetine. Neither the extract nor the standard drugs used modified motor performance on the rotarod test at all doses tested. These results suggest that the extract has anxiolytic and antidepressant-like effects in the models employed possibly by GABAergic activation and/or effect on monoamine levels in the CNS.
Anticonvulsant and Anxiolytic Effects of Calcium Channel Blockers in Mice
S. Umukoro,R.B. Ashorobi,E.E. Essein
Journal of Medical Sciences , 2006,
Abstract: This study reports on the anticonvulsant and anxiolytic effects of two well-known calcium channel antagonists, verapamil and nifedipine in mice. The anticonvulsant effect of these drugs was screened utilizing strychnine animal seizure model. The anxiolytic effect of these compounds was assessed using elevated plus maze paradigm. The results of the study showed that verapamil (5-20 mg kg-1, i.p) and nifedipine (5-10 mg kg-1, i.p) exhibited anticonvulsant activity as evidenced by their ability to prolong the onset of seizures produced by strychnine (1 mg kg-1, i.p) in mice. Verapamil (20 mg kg-1) offered 100% protection against convulsions or death induced by strychnine. Similar effects were observed in animals pretreated with 10 mg kg-1 of nifedipine. In the anxiolytic test, verapamil, but not nifedipine significantly (p<0.05) modified the number of entries in a similar manner to diazepam in the elevated plus maze paradigm. Taken together, these findings suggest that verapamil possess both anticonvulsant and anxiolytic effects, whilst nifedipine only exhibited anticonvulsant activity in mice.
Anxiety-Behavior Modulated by Ventral Medial Prefrontal Cortex of Rats Submitted to the Vogel Conflict Test Involves a Local NMDA Receptor and Nitric Oxide  [PDF]
Sabrina F. Lisboa, Francisco S Guimar?es, Leonardo B.M Resstel
Journal of Behavioral and Brain Science (JBBS) , 2011, DOI: 10.4236/jbbs.2011.13024
Abstract: It was demonstrated in the Vogel conflict test (VCT) that the ventral portion of medial prefrontal cortex (vMPFC) of rats is involved with anxiety behavior. Moreover, the vMPFC local glutamatergic and nitrergic system interaction is involved in modulation of fear conditioning, a model of anxiety. To better understand the role of the MPFC-glutamatergic and nitrergic system on the VTC behavior response, male Wistar rats (250 g) were water deprived for 48 h before the VCT. After 24 h of water deprivation, they were subjected to an initial 3-min non-punished (pre-test) drinking session. Twenty-four hours later bilateral microinjections of NMDA-antagonist LY235959 (4 nmol/200 nL), the specific nNOS inhibitor N-Propyl-L-arginine (N-Propyl –0.08 nmol/200 nL), the NO scavenger Carboxi-PTIO (C-PTIO, 2 nmol/200 nL) or 200nL of vehicle were applied in the vMPFC. After 10 min, the animals were submitted to 3-min punished-licking session. LY235959 increased the number of punished licks. Similar to LY235959, both N-Propyl and C-PTIO also increased the number of punished licks. No changes were observed when LY235959, N-Propyl and C-PTIO were micro- injected into vMPFC surrounding structures such as the cingulate cortex area 1, the corpus callosum and the tenia tecta. In control experiments these drugs did not change neither the number of unpunished licks nor had any effect in the tail-flick test. The results show that NO signaling in the vMPFC can modulate anxiety-behavior in the VCT by control punished behavior. Moreover, this NO modulation could be associated with local glutamatergic activation through NMDA receptors.
O modelo de aten??o à saúde e o uso de ansiolíticos entre mulheres
Carvalho, Lúcia de Fátima;Dimenstein, Magda;
Estudos de Psicologia (Natal) , 2004, DOI: 10.1590/S1413-294X2004000100014
Abstract: this work discusses the chemical dependence of anxiolytic drugs by women, analyzing the relation between women, drug, and public health service. the participants were seventeen women, all of them anxiolytic users, attending public health service at the city of natal, rio grande do norte, brazil. a semi-structured interview was used as research instrument, associated with methodological analysis of user's speeches. we consider that health service, usually available and produced for this kind of patient, with generalized prescription and utilization of anxiolytics, is taking women to dependence on these drugs. we observed also that the relation between these elements reinforces woman's medicalization, and affects their health/disease process.
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