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Search Results: 1 - 10 of 2120 matches for " Anuja Agarwal "
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Characterization and Biodegradation Studies for Interpenetrating Polymeric Network (IPN) of Chitosan-Amino Acid Beads  [PDF]
Manjusha Rani, Anuja Agarwal, Yuvraj Singh Negi
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2011, DOI: 10.4236/jbnb.2011.21010
Abstract: The paper describes the synthesis of pH sensitive interpenetrating polymeric network (IPN) beads composed of chi-tosan, glycine, glutamic acid, cross linked with glutaraldehyde and their use for controlled drug release. The drug was loaded into beads by varying their composition such as, amount of crosslinker glutaraldehyde, ratio of chitosan, glycine and glutamic acid. The beads were characterized by fourier transform infrared (FTIR) spectroscopy to confirm the cross linking reaction and drug interaction with crosslinked polymer in beads, Scanning Electron Microscopy (SEM) to understand the surface morphology and Differential scanning calorimetry (DSC) to find out the thermal stability of beads. X-Ray Diffraction (XRD) investigation was carried out to determine the crystalline nature of drug after loading into chitosan-glycine-glutamic acid IPN beads. Results indicated amorphous dispersion of chlorpheniramine maleate (CPM) in the polymeric matrix. The swelling behavior of the beads at different time intervals was monitored in solutions of pH 2.0 and pH 7.4. The release experiments were performed in solutions of pH 2.0 and pH 7.4 at 37oC using chlorpheniramine maleate (CPM) as a model drug. The swelling behavior and release of drug were observed to be dependent on pH, degree of cross linking and their composition. The results indicate that the cross linked IPN beads of chitosan-glycine-glutamic acid might be useful as a vehicle for controlled release of drug. The kinetics of drug release from beads was best fitted by Higuchi’s model in which release rate is largely governed by rate of diffusion through the matrix.
Manjusha Rani,Anuja Agarwal,Yuvraj Singh Negi
BioResources , 2010,
Abstract: Chitosan obtained by alkaline deacetylation of chitin is a non-toxic, biocompatible, and biodegradable natural polymer. Chitosan-based hydrogel polymeric beads have been extensively studied as micro- or nano-particulate carriers in the pharmaceutical and medical fields, where they have shown promise for drug delivery as a result of their controlled and sustained release properties, as well as biocompatibility with tissue and cells. To introduce desired properties and enlarge the scope of the potential applications of chitosan, graft copolymerization with natural or synthetic polymers on it has been carried out, and also, various chitosan derivatives have been utilized to form beads. The desired kinetics, duration, and rate of drug release up to therapeutical level from polymeric beads are limited by specific conditions such as beads material and their composition, bead preparation method, amount of drug loading, drug solubility, and drug polymer interaction. The present review summarizes most of the available reports about compositional and structural effects of chitosan-based hydrogel polymeric beads on swelling, drug loading, and releasing properties. From the studies reviewed it is concluded that chitosan-based hydrogel polymeric beads are promising drug delivery systems.
Corrosion aspect of dental implants—An overview and literature review  [PDF]
Anuja Agarwal, Amit Tyagi, Anshuman Ahuja, Nishant Kumar, Nayana De, Himanshu Bhutani
Open Journal of Stomatology (OJST) , 2014, DOI: 10.4236/ojst.2014.42010

The use of metals and their alloys in restorative and implant dentistry dates back to centuries. Titanium (Ti) is one of the most widely used biomaterial for medical implants because of its excellent mechanical properties and exceptional biocompatibility. The good biocompatibility of Ti is related to the thin oxide layer formed on Ti surface. TiO2 is inactive with the surrounding biological environment and quite compatible with living tissues. However, TiO2 layer can be destroyed during movements between implant and bone tissue under loading condition. The localized destruction causes corrosion of the implant, thus, weakening it; and can induce the leak of small metallic particles or ions into living tissues. This article highlights a review of the various aspects of corrosion and biocompatibility of dental titanium implants as well as suprastructures, and the methods to prevent it.

Subcorneal pustular dermatosis and thymoma: An association or a coincidence?
Agarwal Anuja,Shivaswamy K,Raja Barani,Thappa Devinder
Indian Journal of Dermatology , 2006,
Abstract: A 36-year-old male came to us with a six months history of a generalized, itchy, pus-filled eruption and a change in voice of five months duration. Healthy looking male on cutaneous examination revealed numerous isolated and grouped vesicles and vesiculopustules ranging from 5-10 mm on both normal and erythematous skin over the face, trunk, buttocks and extremities. Both flaccid and tense vesicles were seen along with some of them coalescing to form circinate or polycyclic patterns with crusting. Most of these lesions showed hypopyon formation. Nikolsky′s sign and bulla-spread sign were negative. Histopathology and direct immunofluorescence substantiated our clinical diagnosis of subcorneal pustular dermatosis (SCPD). On investigation, he was found to have thymoma. We herewith report an association of SCPD with thymoma in this case report, not yet reported in the literature.
Subclinical changes of oral mucosa in Hansen’s disease – a histopathological and immunohistochemical study
N Anuja
Biology and Medicine , 2011,
Abstract: Leprosy is a crippling disease with an associated social stigma. The disease is widely prevalent in India, which is oneof the endemic areas for the disease. Its oral manifestations though described, is very rare. Twenty established casesof leprosy from various hospitals were taken up in the study. Thirteen were in the lepromatous variety and sevenwere in the tuberculoid variety. None of the cases had any oral lesions. Biopsies were taken from the buccal mucosaand histopathological sections were studied by Hematoxylin and eosin, Wade-fite and S-100 immunoperoxidasestain. The results showed positivity for Mycobacterium leprae in 5 cases of lepromatous leprosy by Wade fittechnique. S-100 immunoperoxidase stain revealed nerve changes in the form of fragmentation in cases positive forMycobacterium leprae. These findings show that even in the absence of clinically observable oral lesions, tissuechanges in oral tissues do happen in some cases of leprosy and the causative organism Mycobacterium leprae canbe demonstrated.
Residual efficacy of seed dressing chemicals during storage
Indian Phytopathology , 2012,
Non-conventional techniques for management of Aspergillus flavus aflatoxins and preservation of rice grain quality during storage
Indian Phytopathology , 2011,
Abstract: Antifungal efficacy of non-conventional and safe treatments were evaluated against aflatoxin producing fungus Aspergillus flavus using bioassay and as dressings during storage for different types of rice grains. The radial growth of the fungus Aspergillus flavus was restricted on PDA medium with increasing concentration of different treatments viz., turmeric, cloves and potassium sorbate using food poison technique. Turmeric treatment @ 0.1% (dry seed dressing) gave 43 per cent control followed by 36 and 27 per cent control in potassium sorbate and clove treatments, respectively. At 0.4% concentration, clove treatment gave 100 per cent control of A. flavus followed by 53 and 51 per cent control in potassium sorbate and turmeric treatments, respectively. Exposure to microwave heat for 2 min at 100% power retained the moisture content of grains and inhibited more than 50% fungal growth without adversely affecting the cooking quality of rice grains. The cooking quality of stored rice grains also remained unaffected irrespective of different treatments and storage conditions even after 15 months of storage. The occurrence of fungi including A. flavus increased during successive storage irrespective of the rice types up to 12 months of storage. High fungal incidence was recorded in unpolished rice grain (51.5%) followed by polished rice grain (43.0%) and whole paddy grain (5.5%). Amongst the storage conditions, 20.1% and 13.1% incidence of A. flavus was recorded on grains stored under godown conditions at a rice mill and those stored in the scientific seed stores, respectively. Fungal incidences of 20.4% and 12.8% were found associated with grains stored in jute bags and polylined jute bags, respectively. Treatment with potassium sorbate, turmeric, cloves and microwave heat exhibited 67.3, 62.7, 37.3, and 5.9 percent control of A. flavus, respectively during storage for 15 months under ambient conditions.
Profile of Ectopic Pregnancy in Tertiary Level Hospital in Uttarakhand, India  [PDF]
Neeta Bansal, Anuja Nanda, Vineeta Gupta
Open Journal of Obstetrics and Gynecology (OJOG) , 2015, DOI: 10.4236/ojog.2015.54026

Introduction: Ectopic pregnancy is an emergency in obstetric wards and a significant cause of maternal morbidity and mortality. Incidences of ectopic pregnancy are increasing. Life can be saved with quickness and alertness. Objective: The objective of this study is to find out and evaluate the incidence, clinical presentation, risk factors, and management outcomes of ectopic pregnancies at Sri Guru Ram Rai Institute of Medical and Health Sciences (SGRRIMHS), Dehradun, Uttarakhand, India. Method: We did a retrospective study of the patients admitted in our hospital (SMI Hospital, SGRRIMHS) and study period was January 1, 2004 to December 31, 2013. Medical records were studied for management, total admission in obstetric wards, total births. Data were collected with the aid of data-entry forms designed for study. There were 4040 ANC patients admitted, out of which 202 cases were ectopic pregnancies. The relevant data collected were analyzed with SPSS for Windows. Result: Ectopic pregnancy constituted 5.0% of all ANC cases admitted in our Hospital. The mean age of patients was 25±2 years, 192 of 202 (95.04%) had ruptured pregnancies, and remaining 10 (4.96%) were unruptured. The commonest clinical presentation was abdominal pain (162 of 20280.19%). The commonest (120 of 202, 59.4%) cause was past history of induced abortion. 4 deaths (1.98%) were recorded. Conclusion: Ecotopic pregnancy is common and recognized cause of maternal morbidity and mortality. It is a recognized risk of induced abortion.

Biocontrol of Meloidogyne incognita in Lycopersicon esculentum with AM Fungi and Oil Cakes
Anuja Bharadwaj,Satyawati Sharma
Plant Pathology Journal , 2006,
Abstract: Currently chemical pesticides are the major means to control nematode-induced diseases but they are neither economical nor ecofriendly. Alternative methods are being sought to reduce the amount of chemical pesticides required. Arbuscular mycorrhizal fungi have been reported to reduce the infestation of root-knot nematodes on vegetable crops. Amendment of soil with some oil cakes has been found effective. A study was conducted on exploitation of the combined effect of AM with three different oil cakes Azadirachta indica, Brassica campestris and Ricinus communis oil cakes in controlling the root knot nematode Meloidogyne incognita. Combined use of AMF and cakes resulted in reducing the galling and nematode multiplication thus improving the plant growth and yield. The best results pertaining to AM root infection, nematode reproduction and plant growth and yield were obtained with the combination of AMF and R. communis oil cake.
Letterer siwe disease
George Anuja,Yogirajan K
Indian Journal of Dermatology, Venereology and Leprology , 2001,
Abstract: A 1-year-old boy presented with recurrent pyoderma-like lesions and purulent ear discharge of 6 months duration. The biopsy helped to confirm Letterer Siwe disease. Purpuric lesion on palms and soles which is a reputedly lethal sign of the disease was also present in the child who died within a few days.
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