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Search Results: 1 - 10 of 33543 matches for " Antonio;Clarke "
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Within-Otolith Variability in Chemical Fingerprints: Implications for Sampling Designs and Possible Environmental Interpretation
Antonio Di Franco, Fabio Bulleri, Antonio Pennetta, Giuseppe De Benedetto, K. Robert Clarke, Paolo Guidetti
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0101701
Abstract: Largely used as a natural biological tag in studies of dispersal/connectivity of fish, otolith elemental fingerprinting is usually analyzed by laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS). LA-ICP-MS produces an elemental fingerprint at a discrete time-point in the life of a fish and can generate data on within-otolith variability of that fingerprint. The presence of within-otolith variability has been previously acknowledged but not incorporated into experimental designs on the presumed, but untested, grounds of both its negligibility compared to among-otolith variability and of spatial autocorrelation among multiple ablations within an otolith. Here, using a hierarchical sampling design of spatial variation at multiple scales in otolith chemical fingerprints for two Mediterranean coastal fishes, we explore: 1) whether multiple ablations within an otolith can be used as independent replicates for significance tests among otoliths, and 2) the implications of incorporating within-otolith variability when assessing spatial variability in otolith chemistry at a hierarchy of spatial scales (different fish, from different sites, at different locations on the Apulian Adriatic coast). We find that multiple ablations along the same daily rings do not necessarily exhibit spatial dependency within the otolith and can be used to estimate residual variability in a hierarchical sampling design. Inclusion of within-otolith measurements reveals that individuals at the same site can show significant variability in elemental uptake. Within-otolith variability examined across the spatial hierarchy identifies differences between the two fish species investigated, and this finding leads to discussion of the potential for within-otolith variability to be used as a marker for fish exposure to stressful conditions. We also demonstrate that a ‘cost’-optimal allocation of sampling effort should typically include some level of within-otolith replication in the experimental design. Our findings provide novel evidence to aid the design of future sampling programs and improve our general understanding of the mechanisms regulating elemental fingerprints.
The Internet of Things and Next-generation Public Health Information Systems  [PDF]
Robert Steele, Andrew Clarke
Communications and Network (CN) , 2013, DOI: 10.4236/cn.2013.53B1002
Abstract: The Internet of things has particularly novel implications in the area of public health. This is due to (1) The rapid and widespread adoption of powerful contemporary Smartphone’s; (2) The increasing availability and use of health and fitness sensors, wearable sensor patches, smart watches, wireless-enabled digital tattoos and ambient sensors; and (3) The nature of public health to implicitly involve connectivity with and the acquisition of data in relation to large numbers of individuals up to population scale. Of particular relevance in relation to the Internet of Things (IoT) and public health is the need for privacy and anonymity of users. It should be noted that IoT capabilities are not inconsistent with maintaining privacy, due to the focus of public health on aggregate data not individual data and broad public health interventions. In addition, public health information systems utilizing IoT capabilities can be constructed to specifically ensure privacy, security and anonymity, as has been developed and evaluated in this work. In this paper we describe the particular characteristics of the IoT that can play a role in enabling emerging public health capabilities; we describe a privacy-preserving IoT-based public health information system architecture; and provide a privacy evaluation.
Transcriptional responses of Burkholderia cenocepacia to polymyxin B in isogenic strains with diverse polymyxin B resistance phenotypes
Slade A Loutet, Flaviana Di Lorenzo, Chelsea Clarke, Antonio Molinaro, Miguel A Valvano
BMC Genomics , 2011, DOI: 10.1186/1471-2164-12-472
Abstract: A heptoseless LPS mutant of B. cenocepacia was passaged through multiple rounds of selection to regain high levels of polymyxin B-resistance. This process resulted in various phenotypic changes in the isolate that could contribute to polymyxin B resistance and are consistent with LPS-independent changes in the outer membrane. The transcriptional response of three B. cenocepacia strains to subinhibitory concentrations of polymyxin B was analyzed using microarray analysis and validated by quantitative Real Time-PCR. There were numerous baseline changes in expression between the three strains in the absence of polymyxin B. In both K56-2 and RSF34, similar transcriptional changes upon treatment with polymyxin B were found and included upregulation of various genes that may be involved in polymyxin B resistance and downregulation of genes required for the synthesis and operation of flagella. This last result was validated phenotypically as both swimming and swarming motility were impaired in the presence of polymyxin B. RSF34 4000B had altered the expression in a larger number of genes upon treatment with polymyxin B than either K56-2 or RSF34, but the relative fold-changes in expression were lower.It is possible to generate polymyxin B-resistant isolates from polymyxin B-sensitive mutant strains of B. cenocepacia, likely due to the multifactorial nature of polymyxin B resistance of this bacterium. Microarray analysis showed that B. cenocepacia mounts multiple transcriptional responses following exposure to polymyxin B. Polymyxin B-regulated genes identified in this study may be required for polymyxin B resistance, which must be tested experimentally. Exposure to polymyxin B also decreases expression of flagellar genes resulting in reduced swimming and swarming motility.Burkholderia cenocepacia belongs to the B. cepacia complex (Bcc), a group of Gram-negative opportunistic pathogens infecting patients with cystic fibrosis (CF) and chronic granulomatous disease [1-3]. The
Contribution towards the knowledge of Rhinotragini (Coleoptera, Cerambycidae). V. Reconsideration of Rhopalessa rubroscutellaris (Tippmann, 1960)
Clarke, Robin O.S.;Martins, Ubirajara R.;Santos-Silva, Antonio;
Papéis Avulsos de Zoologia (S?o Paulo) , 2012, DOI: 10.1590/S0031-10492012002200001
Abstract: corrections to the revision of rhopalessa bates, 1873 (clarke et al. 2011), with the transfer of two species to a new genus, rashelapso: r. durantoni (pe?aherrera-leiva & tavakilian, 2004) comb. nov., and r. schmidi sp. nov. (previously considered to be conspecific with ommata (rhopalessa) rubroscutellaris tippmann, 1960 by the authors). ommata (rhopalessa) rubroscutellaris is now considered a junior synonym of laedorcari fulvicollis (lacordaire, 1868).
Contribui??o para o estudo dos Rhinotragini (Coleoptera, Cerambycidae): IV. Rhopalessa bates, 1873
Clarke, Robin O.S.;Martins, Ubirajara R.;Santos-Silva, Antonio;
Papéis Avulsos de Zoologia (S?o Paulo) , 2011, DOI: 10.1590/S0031-10492011002100001
Abstract: the genus rhopalessa is revised and divided into two groups: the clavicornis-group with r. clavicornis (bates, 1873), r. demissa (melzer, 1934), r. hirticollis (zajciw, 1958), r. moraguesi (tavakilian & pe?aherrera-leiva, 2003), r. pilosicollis (zajciw, 1966) and r. subandina sp. nov.; and the rubroscutellaris-group with r. durantoni (pe?aherrera-leiva & tavakilian, 2004) and r. rubroscutellaris (tippmann, 1960). two species were synonymyzed with r. clavicornis: ommata (rhopalessa) nigrotarsis fisher, 1937 and ommata (rhopalessa) nigricollis zajciw, 1969.
Contribui??o para o estudo dos Rhinotragini (Coleoptera, Cerambycidae). II. Revis?o de Ommata White, 1855
Santos-Silva, Antonio;Martins, Ubirajara R.;Clarke, Robin O.S.;
Papéis Avulsos de Zoologia (S?o Paulo) , 2010, DOI: 10.1590/S0031-10492010003900001
Abstract: the genus ommata is reviewed and divided into four genera: ommata sensu strictu, acatinga gen. nov. (type species odontocera (?) maia newman, 1841), etimasu gen. nov. (type species ommata cosmipes pe?aherrera-leiva & tavakilian, 2003) and pyrpotyra gen. nov. (type species ommata (ommata) paradisiaca tippmann, 1953). five new species are described: ommata nigricollis (brazil, espírito santo), ommata andina (bolivia), pyrpotyra pytinga (brazil, pará), p. capixaba (brazil, espírito santo), and p. paraensis (brazil, pará). the following species were transferred from ommata to the new genera, besides the type species: acatinga boucheri (tavakilian & pe?aherrera-leiva, 2005), comb. nov.; a. gallardi (pe?aherrera-leiva & tavakilian, 2004), comb. nov.; a. quinquemaculata (zajciw, 1966), comb. nov.; pyrpotyra albitarsis (galileo & martins, 2010), comb. nov.
Contribui??o para o estudo dos Rhinotragini (Coleoptera, Cerambycidae). III: Oxyommata Zajciw, 1970 e novo gênero oriundo da divis?o de Xenocrasis Bates, 1873
Santos-Silva, Antonio;Clarke, Robin O. S.;Martins, Ubirajara R.;
Papéis Avulsos de Zoologia (S?o Paulo) , 2011, DOI: 10.1590/S0031-10492011001000001
Abstract: oxyommata zajciw, 1970 and o. collaris (audinet-serville, 1833) are redescribed and commented uppon. a new genus from the division of xenocrasis bates, 1873 is described, and three species are allocated in to it: x. fulvicollis (lacordaire, 1868); x. pubipennis (fisher, 1952); and x. vestitipennis zajciw, 1963. a key to the species of the new genus is added.
Prediction in several conventional contexts
Bertrand Clarke,Jennifer Clarke
Statistics Surveys , 2012,
Abstract: We review predictive techniques from several traditional branches of statistics. Starting with prediction based on the normal model and on the empirical distribution function, we proceed to techniques for various forms of regression and classification. Then, we turn to time series, longitudinal data, and survival analysis. Our focus throughout is on the mechanics of prediction more than on the properties of predictors.
Standardising Outcomes in Paediatric Clinical Trials
Mike Clarke
PLOS Medicine , 2008, DOI: 10.1371/journal.pmed.0050102
Abstract:
Doing New Research? Don't Forget the Old
Mike Clarke
PLOS Medicine , 2004, DOI: 10.1371/journal.pmed.0010035
Abstract:
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