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Search Results: 1 - 10 of 32253 matches for " Antonio Iacone "
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Megadoses of Sodium Ascorbate Efficiently Kill HL60 Cells in Vitro: Comparison with Arsenic Trioxide  [PDF]
Domenico Mastrangelo, Lauretta Massai, Giuseppe Fioritoni, Antonio Iacone, Paolo Di Bartolomeo, Patrizia Accorsi, Tiziana Bonfini, Michela Muscettola, Giovanni Grasso
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.48162
Abstract:

Arsenic Trioxide (ATO) is widely acknowledged as the treatment of choice for Acute Promyelocytic Leukemia (APL). It is a “two-sided” drug since it can induce differentiation or kill APL and other tumor cells according to the dosage. Part of the cytotoxic effects of ATO on APL cells is due to its pro-oxidant activity, a characteristic which ATO shares with a number of other compounds, including high doses of ascorbate (ASC). In a comparative investigation on the cytotoxic effects of both ATO and ASC on HL60 (APL) cell lines, in Vitro, we have been able to confirm the known cytotoxic effects of ATO, but, more importantly, we have demonstrated that ASC is significantly more effective than ATO, in killing these cancer cells in Vitro, when the concentrations are maintained within the millimolar (mM) range, i.e. the range of plasma concentrations at which ASC induces oxidative damage to tumor cells. Since these plasma levels can be reached only by the intravenous administration of high doses of ASC, we propose that intravenous high doses of ASC may represent a potentially revolutionary new approach in the management of APL.

Origin and aims of the ESTM (European School of Transfusion Medicine)
U. Rossi,A. Iacone
Drugs and Cell Therapies in Hematology , 2012, DOI: 10.4081/dcth.2012.1s.15
Abstract: The birth of the ESTM (European School of Transfusion Medicine) may well be considered the fulfilment of the wishes expressed in Roma by Leone Lattes in 1935, at the eve of the birth of the International Society of Blood Transfusion (ISBT). ESTM has been the result of a series of study documents and discussions on the teaching of Transfusion Medicine, originated by the Council of Europe (in 1963 and 1985) and developed (from 1990 to 1994 and later) by the ISBT within its European Regional Congresses and by the Italian Society of Transfusion Medicine (SIITS-AICT, later converted into SIMTI) through its “Symposia for European Cooperation”, following the recommendation issued, in 1989, at the end of the ISBT 1st European Regional Congress in Lugano...
Fish assemblage in a dammed tropical river: an analysis along the longitudinal and temporal gradients from river to reservoir
Terra, Bianca de Freitas;Santos, Alex Braz Iacone dos;Araújo, Francisco Gerson;
Neotropical Ichthyology , 2010, DOI: 10.1590/S1679-62252010000300004
Abstract: we analysed changes in the fish assemblage structure along a longitudinal gradient of the paraíba do sul river and funil reservoir. we tested the hypothesis that shifts from lotic to lentic environment affect the richness and structure of the assemblage which are modulated by seasonal rainfall changes. standardised monthly samplings were carried out from october 2006 to september 2007 in four zones: 1) river upstream from the reservoir; 2) upper part of the reservoir; 3) lower part of the reservoir, and 4) river downstream from the reservoir. fishes were caught using gillnets deployed for 15 hours. we collected a total of 4550 specimens, representing 35 species and 5 orders. the highest richness and diversity were recorded in zone 2, the transitional zone between river and reservoir. in this ecotone, lotic and lentic species overlap. greater abundance and biomass was recorded in the river upstream from the reservoir (zone 1); however, there are no differences between the zones in the structure of assemblages during the wet season. during the dry season, the assemblage structure is more differentiated between zones, although no differences in abundance and biomass occur. the seasonal flow of the river is the major driving factor to influence the fish assemblage structure along the longitudinal gradient from the river to the reservoir.
Influence of the river flow on the structure of fish assemblage along the longitudinal gradient from river to reservoir
Santos, Alex Braz Iacone;Terra, Bianca de Freitas;Araújo, Francisco Gerson;
Zoologia (Curitiba) , 2010, DOI: 10.1590/S1984-46702010000500010
Abstract: changes in fish assemblage structure along a longitudinal gradient of the paraíba do sul river and funil reservoir were studied to detect distribution patterns and the seasonal influence of the inflowing river. fish were caught by gill nets in three zones (riverine, transition and lentic) during two seasons (dry and wet). a total of 3,721 individuals were captured, comprising five orders, 14 families, 27 genera and 33 species. five species were non-native and amounted to 17.7% of the total number of individuals. the 10 most abundant species were used to assess spatial-temporal patterns. plagioscion squamosissimus (heckel, 1840), oligosarcus hepsetus (curvier, 1829) and metynnis maculatus (kner, 1858) were widely distributed in both seasons. astyanax bimaculatus (linnaeus, 1758), cichla kelberi kullander & ferreira, 2006 and geophagus brasiliensis (quoy & gaimard, 1824) had higher abundance in the dry season, occurring mainly in the lentic zone. by contrast, the benthopelagics pimelodus maculatus la cèpede, 1803 and astyanax parahybae (eigenmann, 1908) and the benthics hoplosternum littorale (hancock, 1828) and hypostomus auroguttatus kner, 1854 had higher abundance in the wet season, with the two first species occurring mainly in the riverine zone, and latter two species in the transition zone. the highest diversity for both seasons was recorded in the transition zone, which is an ecotone that allows the co-existence of both riverine and lentic species. a major shift in assemblage structure occurred along the longitudinal gradient due to changes in discharge of the inflowing river, with increased fish abundance in the riverine zone caused by increased habitat availability in wet season, and the reverse of this situation in the dry season.
Who Meets the Standrads: A Multidimensional Approach  [PDF]
Antonio Villar
Modern Economy (ME) , 2011, DOI: 10.4236/me.2011.24069
Abstract: We consider here the evaluation of the performance of a society with respect to a given set of targets. We provide a characterization of an intuitive evaluation formula that consists of the mean of the shares of the achievements in the targets. The criterion so obtained permits one not only to endogenously determine who meets the standards and who does not, but also to quantify the degree of fulfilment. Two empirical illustrations are provided: the compliance of the European Union Stability and Growth Pact, on the one hand, and the evaluation of research excellence in the Spanish universities, on the other hand.
The Educational Development Index: A Multidimensional Approach to Educational Achievements through PISA  [PDF]
Antonio Villar
Modern Economy (ME) , 2013, DOI: 10.4236/me.2013.45042
Abstract:

This paper proposes a multidimensional index that summarizes three relevant aspects of the educational achievements, out of the data provided by the PISA Report, concerning reading abilities of 15-year-old students from 65 countries. The three aspects considered are: performance, equity, and quality. The Educational Development Index (EDI) is the geometric mean of the normalized values of those three variables. We analyse the distribution of the variables that approach those three aspects and the resulting index, relative to the corresponding means of the OECD countries.

The Factorizational Theory of Finite Asymptotic Expansions in the Real Domain: A Survey of the Main Results  [PDF]
Antonio Granata
Advances in Pure Mathematics (APM) , 2015, DOI: 10.4236/apm.2015.51001
Abstract:

After studying finite asymptotic expansions in real powers, we have developed a general theory for expansions of type (*)\"\" ,x x0 where the ordered n-tuple \"\" forms an asymptotic scale at x0 , i.e.\"\" as x x0, 1 i n 1,

The Role of Asymptotic Mean in the Geometric Theory of Asymptotic Expansions in the Real Domain  [PDF]
Antonio Granata
Advances in Pure Mathematics (APM) , 2015, DOI: 10.4236/apm.2015.52013
Abstract:

We call “asymptotic mean” (at +∞) of a real-valued function \"\" the number, supposed to exist, \"\", and highlight its role in the geometric theory of asymptotic expansions in the real domain of type (*) \"\" where the comparison functions \"\", forming an asymptotic scale at +∞, belong to one of the three classes having a definite “type of variation” at +∞, slow, regular or rapid. For regularly varying comparison functions we can characterize the existence of an asymptotic expansion (*) by the nice property that a certain quantity F(t) has an asymptotic mean at +∞. This quantity is defined via a linear differential operator in f and admits of a remarkable geometric interpretation as it measures the ordinate of the point wherein that special curve \"\", which has a contact of order n -

Chronic Achilles Tendinopathy in Runners: Relationship between Pain and Tendon Vascularity and Efficacy and Safety of the Radial Extracorporeal Shock Wave Therapy  [PDF]
Antonio Ammendolia
Case Reports in Clinical Medicine (CRCM) , 2015, DOI: 10.4236/crcm.2015.46044
Abstract:
Few studies report the possible correlation pain-paratendon microvascularity during the painful phase of the chronic Achilles tendinopathy and the efficacy of the radial shock wave therapy re-spect to other therapies. The aim of the present longitudinal, controlled study is to demonstrate the variation of the tendon micro vascularization in athletes affected by Achilles tendinopathy and the efficacy and safety of the radial extracorporeal shock wave therapy. Twelve elite runners with Achilles tendinopathy were compared with 12 healthy amateurs, both treated by radial extracorporeal shock wave therapy in 3 sessions (1/every 3 days). VAS scale was used for pain evaluation at one and six months after treatment and a Color and Power Doppler echography was performed to observe the paratendon microvascularity before the beginning of the treatment and at one and six months after. One month after the beginning of the treatment, it was observed a decrease of the hypervascularity in all 12 subjects with tendinopathy and no variation in the control group participants. Clinically, 80% of patients referred pain relief and they were able to return to sports activity. The decrease of the paratendon microvascularity confirms the correlation between the disappearance of the pain and the normalization of the vascularity in the athletes. Moreover, radial extracorporeal shock wave therapy consented a quickly pain relief and returned to the sport. These results confirmed the efficacy and safety of this physical therapy that it could be considered a good therapeutic choice in the treatment of the chronic Achilles tendinopathy.
Analytic Theory of Finite Asymptotic Expansions in the Real Domain. Part II-C: Constructive Algorithms for Canonical Factorizations and a Special Class of Asymptotic Scales  [PDF]
Antonio Granata
Advances in Pure Mathematics (APM) , 2015, DOI: 10.4236/apm.2015.58047
Abstract: This part II-C of our work completes the factorizational theory of asymptotic expansions in the real domain. Here we present two algorithms for constructing canonical factorizations of a disconjugate operator starting from a basis of its kernel which forms a Chebyshev asymptotic scale at an endpoint. These algorithms arise quite naturally in our asymptotic context and prove very simple in special cases and/or for scales with a small numbers of terms. All the results in the three Parts of this work are well illustrated by a class of asymptotic scales featuring interesting properties. Examples and counterexamples complete the exposition.
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