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Search Results: 1 - 10 of 242 matches for " Antonietta Arcella "
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Sensitivity to cisplatin in primary cell lines derived from human glioma correlates with levels of EGR-1 expression
Antonella Calogero, Antonio Porcellini, Vincenza Lombari, Cinzia Fabbiano, Antonietta Arcella, Massimo Miscusi, Donatella Ponti, Giuseppe Ragona
Cancer Cell International , 2011, DOI: 10.1186/1475-2867-11-5
Abstract: Cytotoxicity assays were performed on cells derived from fresh tumor explants of 18 human cases of malignant glioma. In addition to EGR-1, tumor cultures were investigated for genetic alterations and the expression of cancer regulating factors, related to the p53 pathway.We found that sensitivity to cisplatin correlates significantly with levels of EGR-1 expression in tumors with wild-type p53/INK4a/p16 status.Increased knowledge of the mechanisms regulating EGR-1 expression in wild-type p53/INK4a/p16 cases of glioma may help in the design of new chemotherapeutic strategies for these tumors.Malignant brain tumors of glial origin are highly invasive and poorly sensitive to anti-proliferative drugs, with only 20-30% of patients responding to chemotherapy. The biological basis of drug resistance in these tumors is complex, being dependent to some extent on the genetic make-up of the tumor. The prognostic value of molecular markers has been investigated either retrospectively, in patients treated with standard therapy, or in tumor cells cultured in vitro and exposed to different chemotherapics, but no clear results have emerged [1]. The role of p53 gene status [2], the presence of deletions in the INK4a/INK4b locus coding for the tumor suppressors and cell cycle regulators p16, p15 and p14ARF [3], the MGMT (O6-methylguanine DNA methyltransferase) levels [4] and the levels of expression for several players and regulators of apoptosis [5] were all studied to predict the response of the tumor to specific drugs. The rationale of these studies was that tumor cells react to the genotoxic insult by p53-dependent cell cycle arrest, or by undergoing apoptosis [6]. However, from these studies none of these factors, except MGMT, emerged as a major determinant of chemoresistance [7].Many genes are found to be defective and others are deregulated in gliomas [8]. We have recently found that EGR-1 expression is downregulated in malignant gliomas [9]. EGR-1 encodes a nuclear transcript
LIBERARSE DE LAS RAíCES
Arcella,Luciano;
Praxis Filosófica , 2010,
Abstract: trough this essay the author proposes a critic to the actual principle of the necessity of "roots" for human being. this expression, which has a symbolic character, in the romantic and post romantic german culture, got a peculiar meaning: if became concrete. the man was considered a tree and his highest values were expressed through the dangerous expression "blut und boden" (ground and blood). the consequence was a kind of damnation for the free bourgeois, the citizen of the new urban reality, and specifically the hebrew. now it doesn't mean that the man must not have roots, no past, no traditions, but that, being aware of them, he must be able to get free form them, in spatial like in temporal sense. in order to move in the world, like a nomad, as he always was, to create culture, that means to give the landscape his image and his values.
LA RAGIONE DEI "VISIONARI". IMPORTANZA RELATIVA DEL DATO STORICO NELLA CULTURA RINASCIMENTALE
Arcella,Luciano;
Praxis Filosófica , 2011,
Abstract: in questo saggio si analizza l'atteggiamento di meraviglia di francis yates, che nel suo testo giordano bruno e la tradizione ermetica, indica come fatto singolare l'insensibilità degli antichi sapienti, come dei moderni studiosi, dinanzi alla scoperta del filologo isaac casaubon. questi aveva determinato l'esatta collocazione degli scritti attribuiti a ermete trismegisto, non appartenenti a una antichissima realtà egizia, come credevano i cultori della scienza magica rinascimentale, che traevano dal testo la base del loro quadro del mondo, ma a un ambiente tardo ellenistico. tuttavia, la nuova datazione, nonostante la sua evidenza, non costituì di fatto un evento epocale, non convinse i "visionari" dell'epoca ad abbandonare le loro "fallaci" convinzioni. da questa incongruenza sorge la domanda alla quale si cerca di offrire una possibile soluzione, basata sulla diversa sensibilità dell'uomo rinascimentale rispetto alla nuova umanità, che avrebbe messo definitivamente da parte l'antica visione simbolica del mondo.
Inhibition of cell growth by EGR-1 in human primary cultures from malignant glioma
Antonella Calogero, Vincenza Lombari, Giorgia De Gregorio, Antonio Porcellini, Severine Ucci, Antonietta Arcella, Riccardo Caruso, Franco Gagliardi, Alberto Gulino, Gaetano Lanzetta, Luigi Frati, Dan Mercola, Giuseppe Ragona
Cancer Cell International , 2004, DOI: 10.1186/1475-2867-4-1
Abstract: Low levels of EGR-1 protein were found in all primary cultures examined, with lower values present in grade IV tumors and in cultures carrying wild-type copies of p53 gene. The levels of EGR-1 protein were significantly correlated to the amount of intracellular fibronectin, but only in tumors carrying wild-type copies of the p53 gene (R = 0,78, p = 0.0082). Duplication time, plating efficiency, colony formation in agarose, and contact inhibition were also altered in the p53 mutated tumor cultures compared to those carrying wild-type p53. Growth arrest was achieved in both types of tumor within 1–2 weeks following infection with a recombinant adenovirus overexpressing EGR-1 but not with the control adenovirus.Suppression of EGR-1 is a common event in gliomas and in most cases this is achieved through down-regulation of gene expression. Expression of EGR-1 by recombinant adenovirus infection almost completely abolishes the growth of tumor cells in vitro, regardless of the mutational status of the p53 gene.EGR-1 encodes a nuclear phosphoprotein that binds to DNA and regulates transcription through a GC-rich consensus sequence [1-4]. EGR-1 is involved in the regulation of cell responses to a wide array of stimuli such as mitogens, growth factors and stress stimuli [5-7]. Recent studies have shown that EGR-1 expression is altered in several types of neoplasia, compared to normal tissue [1,8,9]. Gene deletion or EGR-1 mutations have been reported in sporadic hematological malignancies [10]. EGR-1 expression has been found to be either decreased or undetectable in human breast cancer tissue and small cell lung carcinoma [11,12]. EGR-1 is altered in a different manner in prostate cancer, where higher levels of EGR-1 expression are found correlated to more advanced stages of malignancy [13]. Later studies confirmed in two independent mouse models that EGR-1 up-regulates tumor progression [14,15]. From these various studies it is clear that EGR-1 is involved in regulation of
Enhancing Metaphor and Metonymy Comprehension in Children with High-Functioning Autism Spectrum Disorder  [PDF]
Sergio Melogno, Maria Antonietta Pinto
Psychology (PSYCH) , 2014, DOI: 10.4236/psych.2014.511148
Abstract:

This article addresses how to enhance metaphor and metonymy comprehension in children with high-functioning autism spectrum disorder (HF-ASD), who are known to have difficulties with figurative language. After considering some major issues on typical development and in HF-ASD, and some studies on treatment in this specific domain, the authors describe an intervention methodology that can be used in schools and clinics. This methodology is based on two main points: 1) the explicit teaching of strategies for understanding metaphors and 2) activities for enhancing the abstraction of semantic features in metaphors and metonymies. The authors show how these devices can make complex processes such as figurative language comprehension more concrete for children with HF-ASD.

Autobiografia, storia e politica nella trattatistica di Tristano Caracciolo Autobiography, history, and politics in the literary production of Tristano Caracciolo
Antonietta Iacono
Reti Medievali Rivista , 2012, DOI: 10.6092/1593-2214/360
Abstract: Questo articolo considera la atipica produzione letteraria dell’umanista Tristano Caracciolo (Napoli, 1437-1522) e analizza la sua controversa collocazione nel contesto politico e culturale napoletano tra la fine del secolo XV e l’inizio del XVI. Nel De vitae auctoris actae notitia, le sue memorie, e in altri lavori di taglio autobiografico e storico, Caracciolo, membro della nobiltà napoletana, indirizza la propria attenzione su eventi di grande importanza per la storia di Napoli e del suo regno. L’articolo mostra il ritratto di un intellettuale che non si sentiva completamente schierato con la dinastia regnante e restava fedele al mos maiorum, antico e austero, della nobiltà cittadina. The essay considers the atypical literary production of the humanist Tristano Caracciolo (Naples, 1437-1522) and analyses Caracciolo's controversial standing into political and cultural sphere of Naples between the end of XV century and the beginning of XVI century. In the De vitae auctoris actae notitia, his memoirs, and in other autobiographical and historical works, Caracciolo, member of Neapolitan nobility, focuses on events of major importance for history of Naples and its Kingdom. The essay shows the portrait of an intellectual who felt himself not entirely close to the reigning dynasty and was faithful to the native and austere mos maiorum of the Neapolitan nobility.
Analysis of some parameters related to the hydraulic infiltration of a silty-loam soil subjected to organic and mineral fertilizer systems in Southern Italy
Antonietta Napolitano
Italian Journal of Agronomy , 2011, DOI: 10.4081/ija.2011.e19
Abstract: This experiment was carried out to detect the most linear process to calculate the hydraulic conductivity, with the aim to classify the soil of experimental station of the Unit for Research in Cultivations Alternative to Tobacco (CAT), locate in South Italy (Scafati, Province of Salerno), subject to different types of manure: compost and mineral fertilizer. The field tests were made by a system measuring infiltration by double, inner and outer ring, inserted into the ground. Each ring was supplied with a constant level of water from external bottle (3 cm), and hydraulic conductivity is determined when the water flow rate in the inner ring is constant. Four areas, two fertilized by mineral fertilizer (areas I and III) and two amended with compost (areas II and IV) at two depths, 5 and 10 cm (H1-H2), were analysed. The parameters were recorded at the following dates: on 18th and 19th September 2009, respectively, at 5 and 10 cm of depth (H1-H2) in area I; on 7th and 8th October 2009 in area II; on 13th and 14th October 2009 in area III; on 16th and 17th October 2009 in area IV. The effect of compost, used one time only, is present in all parameters, even if with a low statistical significance (P<0.01-0.05). This biomass stores a better water reserve [g (100 g)–1)-Δθ] and causes a lower avidity for water (bibacity) and a better speed of percolation (Ks) of exceeding water. The organic matter decreased the variability of soil along field. The studied soil showed to be almost permeable and not having any serious problem concerning rain intensity.
LA LINGUA ITALIANA PARLATA E SCRITTA DAGLI STUDENTI USBECHI: ANALISI DI POSSIBILI INTERFERENZE DELLA LORO LINGUA MADRE.
Antonietta Gobbis
Italiano LinguaDue , 2011, DOI: 10.6092/2037-3597/1231
Abstract: In questo breve saggio ci proponiamo di illustrare le peculiarità dell’italiano parlato in Uzbekistan dagli studenti dell’Università delle Lingue Mondiali di Tashkent, dove chi scrive presta servizio come Lettore ministeriale dal gennaio del 2008. Dalle nostre osservazioni si evince come la L1 e la prima lingua straniera studiata a scuola, l’inglese, possono interferire durante il processo di apprendimento della lingua italiana. I due gruppi linguistici più consistenti all’interno dei corsi di italiano della scrivente sono rappresentati dagli usbechi e dai russi e per questo motivo l’analisi sarà limitata ad essi. Il nostro non vuole essere un mero studio comparativo delle lingue usbeca, russa e italiana ma intende evidenziare le maggiori difficoltà linguistiche che incontrano gli studenti di italiano in Uzbekistan, in particolare nelle prime fasi dell’interlingua, e suggerire alcune strategie per superarle. Spoken and written italian by uzbek students: an analysis of possible interferences from their native language The following brief essay discusses Italian usage by students of the Uzbek State University of World Languages, where the author has been working as Lecturer for the Italian Foreign Office since January 2008. The thesis of this article is that the students’ native language and the first foreign language studied at school, English, interfere with the process of learning Italian. The two largest language groups in the author’s classes are Uzbek und Russian and the analysis is restricted to interference problems from them. It is not an exhaustive comparative study of Uzbek, Russian and Italian, but investigates the main difficulties that Italian learners in Uzbekistan have and suggests some ways to overcome them.
Recovery of Biomolecules from Food Wastes — A Review
Antonietta Baiano
Molecules , 2014, DOI: 10.3390/molecules190914821
Abstract: Food wastes are produced by a variety of sources, ranging from agricultural operations to household consumption. About 38% occurs during food processing. At present, the European Union legislation encourages the exploitation of co-products. This valorisation can be achieved through the extraction of high-value components such as proteins, polysaccharides, fibres, flavour compounds, and phytochemicals, which can be re-used as nutritionally and pharmacologically functional ingredients. Extraction can proceed according to solid-liquid extraction, Soxhlet extraction, pressurized fluid extraction, supercritical fluid extraction, ultrasound-assisted extraction, microwave-assisted extraction, pulsed electric field extraction, and enzyme-assisted extraction. Nevertheless, these techniques cannot be used indiscriminately and their choice depends on the type of biomolecules and matrix, the scale processing (laboratory or industrial), the ratio between production costs and economic values of the compounds to be extracted. The vegetable wastes include trimmings, peelings, stems, seeds, shells, bran, residues remaining after extraction of oil, starch, sugar, and juice. The animal-derived wastes include wastes from bred animals, wastes from seafood, wastes from dairy processing. The recovered biomolecules and by-products can be used to produce functional foods or as adjuvants in food processing or in medicinal and pharmaceutical preparations. This work is an overview of the type and amounts of food wastes; food waste legislation; conventional and novel techniques suitable for extracting biomolecules; food, medicinal and pharmaceutical uses of the recovered biomolecules and by-products, and future trends in these areas.
Regulation of Glial Cell Functions by PPAR- Natural and Synthetic Agonists
Antonietta Bernardo,Luisa Minghetti
PPAR Research , 2008, DOI: 10.1155/2008/864140
Abstract: In the recent years, the peroxisome proliferator-activated receptor- (PPAR-), a well known target for type II diabetes treatment, has received an increasing attention for its therapeutic potential in inflammatory and degenerative brain disorders. PPAR- agonists, which include naturally occurring compounds (such as long chain fatty acids and the cyclopentenone prostaglandin 15-deoxy Δ12,14 prostaglandin J2), and synthetic agonists (among which the thiazolidinediones and few nonsteroidal anti-inflammatory drugs) have shown anti-inflammatory and protective effects in several experimental models of Alzheimer's and Parkinson's diseases, amyotrophic lateral sclerosis, multiple sclerosis and stroke, as well as in few clinical studies. The pleiotropic effects of PPAR- agonists are likely to be mediated by several mechanisms involving anti-inflammatory activities on peripheral immune cells (macrophages and lymphocytes), as well as direct effects on neural cells including cerebral vascular endothelial cells, neurons, and glia. In the present article, we will review the recent findings supporting a major role for PPAR- agonists in controlling neuroinflammation and neurodegeneration through their activities on glial cells, with a particular emphasis on microglial cells as major macrophage population of the brain parenchyma and main actors in brain inflammation.
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