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Search Results: 1 - 10 of 1106 matches for " Antonella Paladini "
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Tramadol Extended-Release for the Management of Pain due to Osteoarthritis
Chiara Angeletti,Cristiana Guetti,Antonella Paladini,Giustino Varrassi
ISRN Pain , 2013, DOI: 10.1155/2013/245346
Abstract: Current knowledge on pathogenesis of osteoarticular pain, as well as the consequent several, especially on the gastrointestinal, renal, and cardiovascular systems, side effects of NSAIDs, makes it difficult to perform an optimal management of this mixed typology of pain. This is especially observable in elderly patients, the most frequently affected by osteoarthritis (OA). Tramadol is an analgesic drug, the action of which has a twofold action. It has a weak affinity to mu opioid receptors and, at the same time, can result in inhibition of the reuptake of noradrenaline and serotonin in nociceptorial descending inhibitory control system. These two mechanisms, “opioidergic” and “nonopioidergic,” are the grounds for contrasting certain types of pain that are generally less responsive to opioids, such as neuropathic pain or mixed OA pain. The extended-release formulation of tramadol has good efficacy and tolerability and acts through a dosing schedule that allows a high level of patients compliance to therapies with a good recovery outcome for the patients' functional status. 1. Background Pain is the most common symptom of osteoarthritis (OA), and, as pain levels rise, patients experience a reduced range of motion with a consequent increase of disability [1]. Pain and function limitations substantially reduce the life quality of people affected by OA. The treatment planning for OA is designed to essentially provide pain relief, to prevent from complications such as muscle atrophy or joint deformities, and to maintain and/or improve the functional status with the final aim to produce a sensible life quality improvement [2]. The effectiveness of pain relief not only may result in a reduction of the intensity of pain itself but can also lead to an improvement of life aspects that are strictly related to pain. As has been widely documented, chronic persistent pain can sensibly reduce the health-related quality of life, causing reduced sleep, interference with social/family relationships [3], activity of daily living and productivity, and increased anxiety and depression [4]. There is, therefore, a general need for optimized pharmacologic treatment strategies in patients with chronic/persistent pain due to OA. A management strategy for such patients also should require individualized therapies that are able to ensure a positive risk/benefit profile. It should also provide analgesia outcomes covering an extended period of time. Tramadol is a centrally acting synthetic analgesic with two mechanisms of action. It involves weak -opioid receptors agonism and
GlideScope and Frova Introducer for Difficult Airway Management
Alessandra Ciccozzi,Chiara Angeletti,Cristiana Guetti,Roberta Papola,Paolo Matteo Angeletti,Antonella Paladini,Giustino Varrassi,Franco Marinangeli
Case Reports in Anesthesiology , 2013, DOI: 10.1155/2013/717928
Abstract: The introduction into clinical practice of new tools for intubation as videolaringoscopia has dramatically improved the success rate of intubation and the work of anesthesiologists in what is considered the most delicate maneuver. Nevertheless intubation difficulties may also be encountered with good anatomical visualization of glottic structures in videolaringoscopia. To overcome the obstacles that may occur both in a difficult provided intubation such as those unexpected, associated endotracheal introducer able to facilitate the passage of the endotracheal tube through the vocal cords into the trachea may be useful. We report 4 cases of difficult intubation planned and unplanned and completed successfully using the GlideScope videolaryngoscope associated with endotracheal Frova introducer. 1. Introduction Difficult airway management is a major task for anesthesiologists [1, 2]. Failure in airway management indeed, is a major cause of mortality and morbidity in the setting of anesthesiology and intensive care units [3, 4]. The GlideScope (GS) is a videolaryngoscope (VLS), the last generation of intubation devices available in clinical practice in the last decade. GS provides an indirect airway view, improves the assessment of Cormack-Lehane score, and does not require a specific training [5, 6]. Recent studies underline the advantages of VLS in the management of predicted difficult airway [7, 8] as well as prehospital emergencies [9]. Unfortunately, the direct laryngeal view provided by VLS does not always assure the correct insertion of endotracheal tube (ETT), due to the 60-degree angle in the distal portion of GS blade, that tends to hamper the passage of the ETT from oropharynx to trachea. To facilitate the placement of the ETT, a rigid stylet shaped with the same angle as the blade, the GlideRite stylet (GRs), has been made up. Recently, the most suitable characteristics of the introducer have been largely debated: gum elastic bougie, rigid stylet, malleable stylet, and several experiences have been published with different endotracheal introducer utilized in combination with VLS to facilitate intubation maneuver [10–14]. We report our clinical experience in 4 patients, three characterized by potential and one by unexpected difficult intubation, in whom videolaryngo-GlideScope (VLGS) combined with Frova bougie has been used to facilitate endotracheal intubation. 2. Case??1 A 61-year-old woman (BMI: 22.6?kg/m2) was urgently admitted to the anesthesiological evaluation before undergoing the intervention of spinal decompression of cervical C3–C6
Guía floral para la ciudad de Mendoza y sus alrededores
Enrique Paladini
Multequina , 1996,
Pain after earthquake
Chiara Angeletti, Cristiana Guetti, Roberta Papola, Emiliano Petrucci, Maria Laura Ursini, Alessandra Ciccozzi, Francesca Masi, Maria Rosaria Russo, Salvatore Squarcione, Antonella Paladini, Joseph Pergolizzi, Robert Taylor, Giustino Varrassi, Franco Marinangeli
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine , 2012, DOI: 10.1186/1757-7241-20-43
Abstract: This observational retrospective study evaluated the prevalence and drug treatment of pain in the five weeks following the L'Aquila earthquake (April 6, 2009).958 triage documents were analysed for patients pain severity, pain type, and treatment efficacy.A third of pain patients reported pain with a prevalence of 34.6%. More than half of pain patients reported severe pain (58.8%). Analgesic agents were limited to available drugs: anti-inflammatory agents, paracetamol, and weak opioids. Reduction in verbal numerical pain scores within the first 24 hours after treatment was achieved with the medications at hand. Pain prevalence and characterization exhibited a biphasic pattern with acute pain syndromes owing to trauma occurring in the first 15 days after the earthquake; traumatic pain then decreased and re-surged at around week five, owing to rebuilding efforts. In the second through fourth week, reports of pain occurred mainly owing to relapses of chronic conditions.This study indicates that pain is prevalent during natural disasters, may exhibit a discernible pattern over the weeks following the event, and current drug treatments in this region may be adequate for emergency situations.
The Distribution of an Index of Dissimilarity for Two Samples from a Uniform Population  [PDF]
Giovanni Girone, Antonella Nannavecchia
Applied Mathematics (AM) , 2013, DOI: 10.4236/am.2013.47140

In this paper the authors study the sample behavior of the Gini’s index of dissimilarity in the case of two samples of equal size drawn from the same uniform population. The paper present the analytical results obtained for the exact distribution of the index of dissimilarity for sample sizes n 8. This result was obtained by expressing the index of dissimilarity as a linear combination of spacings of the pooled sample. The obtained results allow to achieve the exact expressions of the moments for any sample size and, therefore, to highlight the main features of the sampling distributions of the index of dissimilarity. The present study can enhance inferential statistical aspects about one of the main contributions of Gini.

The Distribution of the Concentration Ratio for Samples from a Uniform Population  [PDF]
Giovanni Girone, Antonella Nannavecchia
Applied Mathematics (AM) , 2015, DOI: 10.4236/am.2015.61007
Abstract: In the present paper we derived, with direct method, the exact expressions for the sampling probability density function of the Gini concentration ratio for samples from a uniform population of size n = 6, 7, 8, 9 and 10. Moreover, we found some regularities of such distributions valid for any sample size.
Human Mobility Control and Labour Market of Migrants in Sicily the Case Study of the Cara of Mineo  [PDF]
Antonella Elisa Castronovo
Open Journal of Social Sciences (JSS) , 2015, DOI: 10.4236/jss.2015.32023
Abstract: This paper analyses human mobility control in Sicily, linking it with immigrants’ employment segregation. The focus is on the Cara of Mineo that, since 2011, has represented one of the most important “laboratory” in order to observe the effects of Italian migration governance. The study is supported by several interviews to stakeholders and to migrant farm hands. The first aim is to show how a place designed to contain the mobility of people [1] can be seen as area where the migration movements are intersected with the economic needs of local context.
Intelligence, Globalization, Complex and Multi-Level Society  [PDF]
Antonella Colonna Vilasi
Open Journal of Political Science (OJPS) , 2018, DOI: 10.4236/ojps.2018.81004
Abstract: The information activity is based on the security needs. National Security is a concept that refers to the idea of a Nation not only in purely ethnic terms of nationality but?also?in the wider sense of defense as a center for political, economic, social and cultural imputations. According to a simplistic vision of National Security, typical of an old constitutionalist doctrine, defense from external threats and the maintenance of internal order are of primary importance. In contemporary Nations, international and regional organizations, legal entities under international law and an ever-increasing international structure of international relations made the system unprecedented and complex. The concept of National Security involves all the activities, citizens and tangible and intangible assets, culture and cultural identity.
The Intelligence Cycle  [PDF]
Antonella Colonna Vilasi
Open Journal of Political Science (OJPS) , 2018, DOI: 10.4236/ojps.2018.81003
Abstract: Focusing on the Information Cycle, reference is made to the distribution architectures and the pathways that the various Intelligence products (journals, reports, alerts, forecasts) produce to the Administration (Intelligence Cycle). An introduction to any study on the Information loop needs a brief digression to clarify concepts such as data, news, and information. Events mean any event or action that has been established to be true and/or has occurred and whose knowledge is assigned an information value; the information is the unclear cognition of a fact and/or a significant event related to topics of interest; information, in turn, is the product resulting from data following a frame of processing, analysis, interpretation, comparison, reasoned integration and evaluation.
The Italian Intelligence from the Pre-Unification Period to the First World War  [PDF]
Antonella Colonna Vilasi
Open Journal of Political Science (OJPS) , 2018, DOI: 10.4236/ojps.2018.81005
Abstract: In the newly formed Kingdom of Italy the first Intelligence operations were focused on the public order protection and the citizens’ security. This analytical, theory-building article examines the pre-existing core of the Italian Intelligence from the pre-unitarian Italian States to the First World War from a different perspective, evaluating the culturally transmitted factors that influence politico-military elites, security communities, and decision-makers.
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