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Search Results: 1 - 10 of 13277 matches for " Anthony Nelson "
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Evaluation and Management of Male Urinary Incontinence
Anthony R. Stone,Roscoe S. Nelson
The Scientific World Journal , 2004, DOI: 10.1100/tsw.2004.86
Matrices and finite Alexander quandles
Gabriel Murillo,Sam Nelson,Anthony Thompson
Mathematics , 2005,
Abstract: We describe an algorithm for determining whether a finite quandle is isomorphic to an Alexander quandle by finding all possible Alexander presentations of the quandle. We give an implementation of this algorithm in Maple.
Patterns of mineral lick visitation by lowland tapir (Tapirus terrestris) and lowland paca (Cuniculus paca) in a western amazonian rainforest in Ecuador
Link,Andres; Di Fiore,Anthony; Galvis,Nelson; Fleming,Erin;
Mastozoolog?-a neotropical , 2012,
Abstract: we studied the temporal patterns of mineral lick use by lowland tapir (tapirus terrestris) and paca (cuniculus paca) at the tiputini biodiversity station, a lowland rain forest in amazonian ecuador. using 24-hour camera and video traps set at two different mineral licks, we documented the frequency of mineral lick use and the influence of weather and lunar conditions on mineral lick visitations by the two species. based on 888 nights of mineral lick monitoring, we found that both tapirus terrestris and cuniculus paca visit the licks frequently throughout the year. mineral-lick visitation was not a seasonal behaviour, but rather was influenced heavily by short-term environmental correlates (e.g., dry weather). although visits by tapir and paca occurred strictly at night, neither lunar phase generally nor the period of lunar visibility each night influenced visitation patterns. this study documents the use of mineral licks by two neotropical mammals and suggests that these areas provide key resources to multiple species of mammals in the neotropics.
Andres Link,Anthony Di Fiore,Nelson Galvis,Erin Fleming
Mastozoolog?-a neotropical , 2012,
Abstract: Este estudio describe los patrones temporales de visita a saladeros por el tapir (Tapirus terrestris) y la paca (Cuniculus paca) en la Estación de Biodiversidad Tiputini, un bosque húmedo tropical en la Amazonía ecuatoriana. Por medio de cámaras trampa ubicadas en dos saladeros documentamos la frecuencia de visita a estos lugares por tapires y pacas, y evaluamos la posible influencia de condiciones del clima y del ciclo lunar en sus patrones de visita y uso de los saladeros. A partir de 888 noches de muestreo de los saladeros, se encontró que tanto Tapirus terrestris como Cuniculus paca visitan los saladeros frecuentemente durante todas las épocas del a o. La visita a los saladeros por estas especies no fue estacional, sino que estuvo fuertemente influida por factores climáticos a más corto plazo (p.e., días secos). Las visitas de tapires y pacas a los saladeros tuvieron lugar casi exclusivamente durante la noche, y ni el ciclo lunar ni la presencia visible de la luna parecieron influir sobre los patrones de visita de estas especies. Este estudio documenta el uso de saladeros por estas dos especies de mamíferos neotropicales, contribuyendo a la hipótesis que sostiene que los saladeros son áreas importantes para múltiples especies de mamíferos del Nuevo Mundo.
The Las Campanas Distant Cluster Survey - The Catalog
Anthony H. Gonzalez,Dennis Zaritsky,Julianne J. Dalcanton,Amy Nelson
Physics , 2001, DOI: 10.1086/322541
Abstract: We present an optically-selected catalog of 1073 galaxy cluster and group candidates at 0.30.3, with a false-detection rate of 30%. At z=0.3 we probe down to the level of poor groups while by z=0.8 we detect only the most massive systems (sigma>1000 km/s). We also present a supplemental catalog of 112 candidates that fail one or more of the automated selection criteria, but appear from visual inspection to be bona fide clusters.
Reconstructing Tuberculosis Services after Major Conflict: Experiences and Lessons Learned in East Timor
Nelson Martins,Paul M Kelly ,Jocelyn A Grace,Anthony B Zwi
PLOS Medicine , 2006, DOI: 10.1371/journal.pmed.0030383
Abstract: Background Tuberculosis (TB) is a major public health problem in developing countries. Following the disruption to health services in East Timor due to violent political conflict in 1999, the National Tuberculosis Control Program was established, with a local non-government organisation as the lead agency. Within a few months, the TB program was operational in all districts. Methods and Findings Using the East Timor TB program as a case study, we have examined the enabling factors for the implementation of this type of communicable disease control program in a post-conflict setting. Stakeholder analysis was undertaken, and semi-structured interviews were conducted in 2003 with 24 key local and international stakeholders. Coordination, cooperation, and collaboration were identified as major contributors to the success of the TB program. The existing local structure and experience of the local non-government organisation, the commitment among local personnel and international advisors to establishing an effective program, and the willingness of international advisers and local counterparts to be flexible in their approach were also important factors. This success was achieved despite major impediments, including mass population displacement, lack of infrastructure, and the competing interests of organisations working in the health sector. Conclusions Five years after the conflict, the TB program continues to operate in all districts with high notification rates, although the lack of a feeling of ownership by government health workers remains a challenge. Lessons learned in East Timor may be applicable to other post-conflict settings where TB is highly prevalent, and may have relevance to other disease control programs.
A Novel Role for the GTPase-Activating Protein Bud2 in the Spindle Position Checkpoint
Scott A. Nelson, Anthony M. Sanson, Hay-Oak Park, John A. Cooper
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0036127
Abstract: The spindle position checkpoint (SPC) ensures correct mitotic spindle position before allowing mitotic exit in the budding yeast Saccharomyces cerevisiae. In a candidate screen for checkpoint genes, we identified bud2Δ as deficient for the SPC. Bud2 is a GTPase activating protein (GAP), and the only known substrate of Bud2 was Rsr1/Bud1, a Ras-like GTPase and a central component of the bud-site-selection pathway. Mutants lacking Rsr1/Bud1 had no checkpoint defect, as did strains lacking and overexpressing Bud5, a guanine-nucleotide exchange factor (GEF) for Rsr1/Bud1. Thus, the checkpoint function of Bud2 is distinct from its role in bud site selection. The catalytic activity of the Bud2 GAP domain was required for the checkpoint, based on the failure of the known catalytic point mutant Bud2R682A to function in the checkpoint. Based on assays of heterozygous diploids, bud2R682A, was dominant for loss of checkpoint but recessive for bud-site-selection failure, further indicating a separation of function. Tem1 is a Ras-like protein and is the critical regulator of mitotic exit, sitting atop the mitotic exit network (MEN). Tem1 is a likely target for Bud2, supported by genetic analyses that exclude other Ras-like proteins.
Malaria control in Timor-Leste during a period of political instability: what lessons can be learned?
Joao S Martins, Anthony B Zwi, Nelson Martins, Paul M Kelly
Conflict and Health , 2009, DOI: 10.1186/1752-1505-3-11
Abstract: To examine the impact of political upheaval and population displacement in Timor-Leste (2006) on malaria in the country.Case study approach drawing on both qualitative and quantitative methods including document reviews, in-depth interviews, focus group discussions, site visits and analysis of routinely collected data.The conflict had its most profound impact on Dili, the capital city, in which tens of thousands of people were displaced from their homes. The conflict interrupted routine malaria service programs and training, but did not lead to an increase in malaria incidence. Interventions covering treatment, insecticide treated nets (ITN) distribution, vector control, surveillance and health promotion were promptly organized for internally displaced people (IDPs) and routine health services were maintained. Vector control interventions were focused on IDP camps in the city rather than on the whole community. The crisis contributed to policy change with the introduction of Rapid Diagnostic Tests and artemether-lumefantrine for treatment.Although the political crisis affected malaria programs there were no outbreaks of malaria. Emergency responses were quickly organized and beneficial long term changes in treatment and diagnosis were facilitated.Globally, malaria poses a threat to approximately 3.3 billion of the world's population with around 250 million clinical cases annually and more than 1 million deaths, mostly in children under 5 years of age [1].In April and May 2006 serious political instability and violence affected the newly independent Democratic Republic of Timor-Leste. The risk of infectious diseases in conflict-affected settings is increased. Violent conflict causes population displacement and destruction of infrastructure, as well as the reduction or disruption of health services, including routine disease control programs, which can lead to outbreaks [2-5]. Additionally, the lack of clean water supplies, poor sanitation and waste management, overcr
Comparative in silico analysis identifies bona fide MyoD binding sites within the Myocyte Stress 1 gene promoter
Samir Ounzain, Caroline S Dacwag, Nilesh J Samani, Anthony N Imbalzano, Nelson W Chong
BMC Molecular Biology , 2008, DOI: 10.1186/1471-2199-9-50
Abstract: Analysis of MS1 expression in differentiating C2C12 muscle cells demonstrated a temporal differentiation dependent up-regulation in ms1 mRNA. An in silico comparative sequence analysis identified two conserved putative myogenic regulatory domains within the proximal 1.5 kbp of 5' upstream sequence. Co-transfecting C2C12 myoblasts with ms1 promoter/luciferase reporters and myogenic regulatory factor (MRF) over-expression plasmids revealed specific sensitivity of the ms1 promoter to MyoD. Subsequent mutagenesis and EMSA analysis demonstrated specific targeting of MyoD at two distinct E-Boxes (E1 and E2) within identified evolutionary conserved regions (ECRs, α and β). Chromatin immunoprecipitation (ChIP) analysis indicates that co-ordinated binding of MyoD at E-Boxes located within ECRs α and β correlates with the temporal induction in ms1 mRNA.These findings suggest that the tissue specific and differentiation dependent up-regulation in ms1 mRNA is mediated by temporal binding of MyoD at distinct evolutionary conserved E-Boxes within the ms1 5' upstream sequence. We believe, through its activation of ms1, this is the first study to demonstrate a direct link between MyoD activity and SRF transcriptional signalling, with clear implications for the understanding of muscle determination, differentiation and regeneration.During mammalian embryogenesis, the development of skeletal muscle is mediated by a co-ordinated series of events that begins with commitment of mesodermal precursor cells to the skeletal muscle lineage, followed by myoblast fusion and the subsequent progression of a programme of muscle specific gene expression [1-3]. A specialised group of transcription factors control this process of myogenic specification and differentiation. These factors, designated the myogenic regulatory factors (MRFs), include four basic helix-loop-helix (bHLH) E-Box binding proteins: MyoD, Myf5, Myogenin and MRF4 [4]. During development MyoD and Myf5 dictate myoblast specificatio
The full genome sequence of three strains of Jamestown Canyon virus and their pathogenesis in mice or monkeys
Richard S Bennett, Jacob T Nelson, Anthony K Gresko, Brian R Murphy, Stephen S Whitehead
Virology Journal , 2011, DOI: 10.1186/1743-422x-8-136
Abstract: We have completed the sequence of three isolates of JCV collected in geographically diverse locations over a 57 year time span. The nucleotide identity for the three strains is 90, 83, and 85% for the S, M, and L segments respectively whereas the percent identify for the predicted amino acid sequences of the N, NSS, M poly, GN, NSM, GC, and L proteins was 97, 91, 94, 98, 91, 94, and 97%, respectively. In Swiss Webster mice, each JCV isolate exhibits low neuroinvasiveness but high infectivity. Two of the three JCV isolates were highly neurovirulent after IC inoculation whereas one isolate, JCV/03/CT, exhibited low neurovirulence. In rhesus monkeys, JCV infection is accompanied by a low-titered viremia, lack of clinical disease, but a robust neutralizing antibody response.The first complete sequence of JCV is reported for three separate isolates, and a relatively high level of amino acid sequence conservation was observed even for viruses isolated 57 years apart indicating that the virus is in relative evolutionary stasis. JCV is highly infectious for mice and monkeys, and these animals, especially mice, represent useful experimental hosts for further study.Jamestown Canyon virus (JCV), family Bunyaviridae, is a mosquito-borne pathogen endemic in the United States and Canada and considered an emerging threat to public health [1]. JCV is a member of the California serogroup of viruses in the genus Orthobunyavirus and contains three genome segments, small (S), medium (M), and large (L) consisting of a single strand of negative-sense RNA. JCV was first isolated from Culiseta inornata mosquitoes collected near Jamestown Canyon, northwest of Boulder, CO [2]. The serogroup contains members found on five continents that include human pathogens such as La Crosse (LACV) and snowshoe hare viruses in North America; Guaroa virus in North and South America; Inkoo and Tahyna viruses in Europe; and Lumbo virus in Africa.JCV is distributed over a large geographic range, including muc
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