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Search Results: 1 - 10 of 73342 matches for " Ant?nio Carlos Martins;Proietti "
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Les es dermatológicas em pacientes infectados pelo vírus linfotrópico humano de células T do tipo 1 (HTLV-1)
Nobre Vandack,Guedes Antnio Carlos Martins,Proietti Fernando Augusto,Stanciolli Edel
Revista da Sociedade Brasileira de Medicina Tropical , 2005,
Abstract: O vírus linfotrópico humano de células T do tipo 1 (HTLV-1) é o primeiro retrovírus isolado do ser humano. Descreveu-se, em pouco tempo, o seu papel etiológico em algumas doen as, com destaque para a leucemia/linfoma de células T do adulto (ATLL), a mielopatia associada ao HTLV-1/paraparesia espástica tropical (HAM/TSP) e a uveíte associada ao HTLV-1 (HAU). Na década de 90, o HTLV-1 foi associado a eczema grave da infancia, conhecido como dermatite infecciosa (DI). Desde ent o, diversos outros tipos de les es cutaneas têm sido observados em pacientes infectados pelo HTLV-1, em especial, nos doentes de HAM/TSP ou de ATLL. Porém, mesmo portadores assintomáticos do vírus apresentam doen as dermatológicas. Excetuando-se a dermatite infecciosa, n o há les o da pele específica da infec o pelo HTLV-1. Aqui, os autores apresentam as principais les es dermatológicas descritas em pacientes infectados pelo HTLV-1, destacando o valor epidemiológico e clínico desses achados.
Les?es dermatológicas em pacientes infectados pelo vírus linfotrópico humano de células T do tipo 1 (HTLV-1)
Nobre, Vandack;Guedes, Antnio Carlos Martins;Proietti, Fernando Augusto;Stanciolli, Edel;Martins, Marina Lobato;Serufo, José Carlos;Antunes, Carlos Maurício;Grossi, Maria Aparecida;Lambertucci, José Roberto;,;
Revista da Sociedade Brasileira de Medicina Tropical , 2005, DOI: 10.1590/S0037-86822005000100009
Abstract: human t-cell lymphotropic vírus type i (htlv-1) was the first human retrovírus described. some time after its discovery a group of diseases were related to this vírus, such as, adult t-cell leukemia lymphoma (atll), htlv-1 associated myelopathy/tropical spastic paraparesis (ham/tsp) and htlv-1 associated uveitis (hau). in the nineties, htlv-1 was associated to a severe eczema of children, called infective dermatitis (id). since then, several other skin manifestations have been observed in htlv-1-infected individuals, particularly in patients with atll or ham/tsp. however, according to some reports, dermatologic lesions are also common in asymptomatic htlv-1 carriers. besides id, all other skin lesions reported are nonspecific. the aim of this review is to outline the dermatologic manifestations reported in htlv-1 infected patients, emphasizing the clinical and epidemiological value of these findings.
Myelopathy and adult T-cell leukemia associated with HTLV-1 in a young patient with hearing loss as the initial manifestation of disease
Gon?alves, Denise Utsch;Felipe, Lílian;Carneiro-Proietti, Anna Bárbara;Guedes, Antnio Carlos;Martins-Filho, Olindo Assis;Lambertucci, José Roberto;
Revista da Sociedade Brasileira de Medicina Tropical , 2009, DOI: 10.1590/S0037-86822009000300018
Abstract: a young male developed hearing loss, vertigo, headache and facial palsy. neurological examination did not show any abnormalities. two years later, cervical lymphadenopathy, hepatosplenomegaly and atypical lymphocytes in peripheral blood revealed leukemia. at the same time, acquired ichthyosis was observed. subsequently, neurological abnormalities revealed myelopathy associated with htlv-1, due to vertical transmission.
Infec??o e doen?a pelos vírus linfotrópicos humanos de células T (HTLV-I/II) no Brasil
Carneiro-Proietti, Anna Bárbara F.;Ribas, Jo?o Gabriel Ramos;Catalan-Soares, Bernadette C.;Martins, Marina L.;Brito-Melo, Gustavo E. A.;Martins-Filho, Olindo A.;Pinheiro, S?nia R.;Araújo, Abelardo de Queiroz-Campos;Galv?o-Castro, Bernardo;Oliveira, Maria S. Pombo de;Guedes, Antnio Carlos;Proietti, Fernando Augusto;
Revista da Sociedade Brasileira de Medicina Tropical , 2002, DOI: 10.1590/S0037-86822002000500013
Abstract: htlv-i/ii infection is present in all regions of brazil, but its prevalence varies according to the geographical area, being higher in bahia, pernambuco and pará. it has been estimated that brazil has the highest absolute number of infected individuals in the world. blood donors screening and research conducted with special groups (indigenous population of brazil, iv drug users and pregnant women) are the major sources of information about these viruses in our country. htlv-i causes adult t cell leukemia/lymphoma (atll), htlv associated myelopathy/tropical spastic paraparesis (ham/tsp), htlv associated uveitis (hau), dermatological and immunological abnormalities. htlv-ii is not consistently associated with any disease. diagnosis is established using screening (enzymatic assays, agglutination) and confirmatory (western blot, pcr) tests. the viruses are transmitted by blood and contaminated needles, by sexual relations and from mother to child, especially by breast feeding. prevention efforts should focus on education of positive blood donors, infected mothers and iv drug users.
Immunological Profile of HTLV-1-Infected Patients Associated with Infectious or Autoimmune Dermatological Disorders
Jordana Grazziela Alves Coelho-dos-Reis equal contributor,Livia Passos equal contributor,Mariana Costa Duarte,Marcelo Grossi Araújo,Ana Carolina Campi-Azevedo,Andréa Teixeira-Carvalho,Vanessa Peruhype-Magalh?es,Bruno Caetano Trindade,Raquel dos Santos Dias,Marina Lobato Martins,Anna Barbara de Freitas Carneiro-Proietti,Antnio Carlos Guedes,Denise Utsch Gon?alves,Olindo Assis Martins-Filho
PLOS Neglected Tropical Diseases , 2013, DOI: 10.1371/journal.pntd.0002328
Abstract: In the present study, the frequency, the activation and the cytokine and chemokine profile of HTLV-1 carriers with or without dermatological lesions were thoroughly described and compared. The results indicated that HTLV-1-infected patients with dermatological lesions have distinct frequency and activation status when compared to asymptomatic carriers. Alterations in the CD4+HLA-DR+, CD8+ T cell, macrophage-like and NKT subsets as well as in the serum chemokines CCL5, CXCL8, CXCL9 and CXCL10 were observed in the HTLV-1-infected group with skin lesions. Additionally, HTLV-1 carriers with dermatological skin lesions showed more frequently high proviral load as compared to asymptomatic carriers. The elevated proviral load in HTLV-1 patients with infectious skin lesions correlated significantly with TNF-α/IL-10 ratio, while the same significant correlation was found for the IL-12/IL-10 ratio and the high proviral load in HTLV-1-infected patients with autoimmune skin lesions. All in all, these results suggest a distinct and unique immunological profile in the peripheral blood of HTLV-1-infected patients with skin disorders, and the different nature of skin lesion observed in these patients may be an outcome of a distinct unbalance of the systemic inflammatory response upon HTLV-1 infection.
O Instituto de Coimbra e o Ensino Secundário em Portugal na Primeira República. O caso particular das Ciências Físico-Químicas
António J. Leonardo,Décio R. Martins,Carlos Fiolhais
Revista Portuguesa de Educa??o , 2012,
Abstract: Se analiza la reforma de la educación secundaria en Portugal después de 1905 y durante la Primera República sobre la base de la revista O Instituto, publicada por la sociedad literaria y científica Instituto de Coimbra (IC), con énfasis en el estudio de la Física y Química. Se discuten algunos de los textos de miembros de IC, como Bernardino Machado, Adolfo Coelho y Costa Lobo, que participaron en las reformas emprendidas. Hacemos hincapié en las relaciones entre Portugal y Espa a en el ámbito de la educación, en particular el artículo de Rubén Landa, profesor espa ol que fue comisionado en 1918 para estudiar la educación secundaria en Portugal. Esta visita se produjo como resultado de un estudio solicitado por el gobierno espa ol en la educación pública portuguesa, establecida en 1914 por la portuguesa Alice Pestana, profesora de la Instituición Libré de Ense anza (ILE), en Madrid. En ambos estudios se elogió el sistema educativo portugués. Sin embargo, esta ense anza era sólo para un peque o número de estudiantes.
Teor de água, temperatura do ambiente e conserva??o de sementes de ipê-roxo
Martins, Leila;Lago, Antnio Augusto do;Andrade, Antnio Carlos Silva de;
Revista árvore , 2012, DOI: 10.1590/S0100-67622012000200001
Abstract: tabebuia impetiginosa is a tree species of high economical, ornamental and medicinal value. its seeds present short viability period and they are difficult to be stored. thus, the objective of this study was to study the ideal conditions of moisture water content and storage temperature for preservation of tabebuia impetiginosa seeds for one year. firstly, the initial moisture content of the seed was determined (18.3%) and a sample was taken. the remaining seeds were submitted to drying with air circulation at 30°c, in order to obtain seeds with the water contents of 12.5, 8.4 and 4.2%. after that, the samples were stored in chambers at -10°c and 20°c and evaluated at the beginning and after 90, 180, 270 and 360 days of storage regarding percentage of germination and seedling emergence in sand. the experiment was set up in a complete random design, in a 4 x 2 factorial design with four treatments (water contents) before storage, and eight treatments (four water content x 2 thermal conditions) in each evaluation period during storage. means were compared by the tukey test at 5%. the preservation of tabebuia impetiginosa seeds is favored by maintaining them with moisture degrees ranging from 4.2 and 12.5%, at -10°c, and from 4.2 to 8.4% at 20°c.
Dabigatran in the Treatment of Extensive Cerebral Venous Thrombosis: A Case Report  [PDF]
Viviane Maria Vedana, Luiz Carlos Porcello Marrone, Nathalia Guarienti Missima, William Alves Martins, Camila Simeoni, Luisa Franciscatto, Ricardo Bernardi Soder, Antnio Carlos Huf Marrone
World Journal of Neuroscience (WJNS) , 2018, DOI: 10.4236/wjns.2018.81003
Abstract: Background: Cerebral venous thrombosis (CVT) is a rare type of cerebrovascular disease associated with a 15% rate of death or function dependence. The mainstay of treatment for CVT is systemic anticoagulation, despite venous hemorrhagic infarction. Vitamin K antagonists have long been the only available option for anticoagulation; however, the past few years have brought the development of many new target-specific drugs, collectively called non-vitamin K antagonist oral anticoagulants (NOACs). Although emerging evidence suggests NOACs have an acceptable safety and tolerability profile in CVT, there are limited data available and no randomized controlled trials have been performed to date. Case Presentation: This describes the case of a patient with CVT occurring during an infection who was successfully treated with a NOAC, dabigatran, after a difficult time on warfarin. Conclusions: A case of extensive and deep CVT was identified. Dabigatran 150 mg treatment twice daily in this patient resulted in no additional damage to the brain. This case study illustrates that the use of NOACs such as dabigatran can be safe and effective in patients with CVT.
Métodos para estimar a forragem consumível em pastagem de capim-elefante
Cóser Antnio Carlos,Martins Carlos Eugênio,Deresz Fermino,Freitas Ary Ferreira de
Pesquisa Agropecuária Brasileira , 2003,
Abstract: O objetivo deste trabalho foi avaliar a eficiência e a confiabilidade de métodos para estimar a forragem consumível em pastagem de capim-elefante (Pennisetum purpureum Schumach.). Foram usados o método do rendimento visual comparativo (MRVC) e o método do pastejo simulado (PSIM). Foram realizadas amostragens em 20 de mar o e 5 de abril de 2001, com um e quatro observadores para PSIM e MRVC, respectivamente. As estimativas obtidas foram analisadas por meio de regress o linear da produ o de matéria seca em raz o dos padr es estimados e as médias comparadas pelo teste F, a 1% de probabilidade. N o houve diferen a entre os métodos. Tanto o MRVC como o PSIM podem ser recomendados para estimar a forragem potencialmente consumível em pastagem de capim-elefante. O treinamento dos avaliadores torna-se decisivo, especialmente quando o MRVC estiver sendo utilizado.
Dynamics of Protein Phosphatase Gene Expression in Corbicula fluminea Exposed to Microcystin-LR and to Toxic Microcystis aeruginosa Cells
José Carlos Martins,Jo?o Machado,António Martins,Joana Azevedo,Luís OlivaTeles,Vitor Vasconcelos
International Journal of Molecular Sciences , 2011, DOI: 10.3390/ijms12129172
Abstract: This study investigated the in vivo effects of microcystins on gene expression of several phosphoprotein phosphatases (PPP) in the freshwater clam Corbicula fluminea with two different exposure scenarios. Clams were exposed for 96 h to 5 μg L ?1 of dissolved microcystin-LR and the relative changes of gene expression of three different types of PPP (PPP1, 2 and 4) were analyzed by quantitative real-time PCR. The results showed a significant induction of PPP2 gene expression in the visceral mass. In contrast, the cyanotoxin did not cause any significant changes on PPP1 and PPP4 gene expression. Based on these results, we studied alterations in transcriptional patterns in parallel with enzymatic activity of C. fluminea for PPP2, induced by a Microcystis aeruginosa toxic strain (1 × 10 5 cells cm ?3) during 96 h. The relative changes of gene expression and enzyme activity in visceral mass were analyzed by quantitative real-time PCR and colorimetric assays respectively. The clams exhibited a significant reduction of PPP2 activity with a concomitant enhancement of gene expression. Considering all the results we can conclude that the exposure to an ecologically relevant concentration of pure or intracellular microcystins (-LR) promoted an in vivo effect on PPP2 gene expression in C. fluminea.
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