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Search Results: 1 - 10 of 118654 matches for " Annie T. Darilay "
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Factors Affecting Glomerular Filtration Rate, as Measured by Iohexol Disappearance, in Men with or at Risk for HIV Infection
Joseph B. Margolick, Lisa P. Jacobson, George J. Schwartz, Alison G. Abraham, Annie T. Darilay, Lawrence A. Kingsley, Mallory D. Witt, Frank J. Palella
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0086311
Abstract: Objective Formulae used to estimate glomerular filtration rate (GFR) underestimate higher GFRs and have not been well-studied in HIV-infected (HIV(+)) people; we evaluated the relationships of HIV infection and known or potential risk factors for kidney disease with directly measured GFR and the presence of chronic kidney disease (CKD). Design Cross-sectional measurement of iohexol-based GFR (iGFR) in HIV(+) men (n = 455) receiving antiretroviral therapy, and HIV-uninfected (HIV(?)) men (n = 258) in the Multicenter AIDS Cohort Study. Methods iGFR was calculated from disappearance of infused iohexol from plasma. Determinants of GFR and the presence of CKD were compared using iGFR and GFR estimated by the CKD-Epi equation (eGFR). Results Median iGFR was higher among HIV(+) than HIV(?) men (109 vs. 106 ml/min/1.73 m2, respectively, p = .046), and was 7 ml/min higher than median eGFR. Mean iGFR was lower in men who were older, had chronic hepatitis C virus (HCV) infection, or had a history of AIDS. Low iGFR (≤90 ml/min/1.73 m2) was associated with these factors and with black race. Other than age, factors associated with low iGFR were not observed with low eGFR. CKD was more common in HIV(+) than HIV(?) men; predictors of CKD were similar using iGFR and eGFR. Conclusions iGFR was higher than eGFR in this population of HIV-infected and -uninfected men who have sex with men. Presence of CKD was predicted equally well by iGFR and eGFR, but associations of chronic HCV infection and history of clinically-defined AIDS with mildly decreased GFR were seen only with iGFR.
Contexts of diffusion: Adoption of research synthesis in Social Work and Women's Studies
Laura Sheble,Annie T. Chen
Computer Science , 2014,
Abstract: Texts reveal the subjects of interest in research fields, and the values, beliefs, and practices of researchers. In this study, texts are examined through bibliometric mapping and topic modeling to provide a birds eye view of the social dynamics associated with the diffusion of research synthesis methods in the contexts of Social Work and Women's Studies. Research synthesis texts are especially revealing because the methods, which include meta-analysis and systematic review, are reliant on the availability of past research and data, sometimes idealized as objective, egalitarian approaches to research evaluation, fundamentally tied to past research practices, and performed with the goal informing future research and practice. This study highlights the co-influence of past and subsequent research within research fields; illustrates dynamics of the diffusion process; and provides insight into the cultural contexts of research in Social Work and Women's Studies. This study suggests the potential to further develop bibliometric mapping and topic modeling techniques to inform research problem selection and resource allocation.
A Peptide of SPARC Interferes with the Interaction between Caspase8 and Bcl2 to Resensitize Chemoresistant Tumors and Enhance Their Regression In Vivo
Mahbuba Rahman, Annie P. K. Chan, Isabella T. Tai
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0026390
Abstract: SPARC, a matricellular protein with tumor suppressor properties in certain human cancers, was initially identified in a genome-wide analysis of differentially expressed genes in chemotherapy resistance. Its exciting new role as a potential chemosensitizer arises from its ability to augment the apoptotic cascade, although the exact mechanisms are unclear. This study further examines the mechanism by which SPARC may be promoting apoptosis and identifies a smaller peptide analogue with greater chemosensitizing and tumor-regressing properties than the native protein. We examined the possibility that the apoptosis-enhancing activity of SPARC could reside within one of its three biological domains (N-terminus (NT), the follistatin-like (FS), or extracellular (EC) domains), and identified the N-terminus as the region with its chemosensitizing properties. These results were not only confirmed by studies utilizing stable cell lines overexpressing the different domains of SPARC, but as well, with a synthetic 51-aa peptide spanning the NT-domain. It revealed that the NT-domain induced a significantly greater reduction in cell viability than SPARC, and that it enhanced the apoptotic cascade via its activation of caspase 8. Moreover, in chemotherapy resistant human colon, breast and pancreatic cancer cells, its chemosensitizing properties also depended on its ability to dissociate Bcl2 from caspase 8. These observations translated to clinically significant findings in that, in-vivo, mouse tumor xenografts overexpressing the NT-domain of SPARC had significantly greater sensitivity to chemotherapy and tumor regression, even when compared to the highly-sensitive SPARC-overexpressing tumors. Our results identified an interplay between the NT-domain, Bcl2 and caspase 8 that helps augment apoptosis and as a consequence, a tumor's response to therapy. This NT-domain of SPARC and its 51-aa peptide are highly efficacious in modulating and enhancing apoptosis, thereby conferring greater chemosensitivity to resistant tumors. Our findings provide additional insight into mechanisms involved in chemotherapy resistance and a potential novel therapeutic that specifically targets this devastating phenomenon.
2-Metoksi stradiol-bis-Sulfamaat ontwrig mikrotubulien netwerk, stuit selsiklus en induseer apoptose in ‘n esofagus karsinoom sellyn
T.V. Mqoco,Sumari Marais,Annie M. Joubert
Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie , 2012, DOI: 10.4102/satnt.v31i1.321
Sponge-associated bacteria of Lakshadweep coral reefs, India: resource for extracellular hydrolytic enzymes  [PDF]
Annie Feby, Shanta Nair
Advances in Bioscience and Biotechnology (ABB) , 2010, DOI: 10.4236/abb.2010.14043
Abstract: Sponges (Phylum: Porifera) is one of the major groups in the Lakshadweep coral reefs. These sponges harbor diverse bacteria with metabolic potentiality. From biodiversity to biotechnological prospecting, scientific investigations related to sponge associated microorganisms have expanded, but remain rather limited to few geographic locations. In this study, culturable bacteria associated with two demosponges viz Dysidea granulosa, Sigmadocia fibulata and the ambient water were screened for commercially important enzymes such as amylase, protease, gelatinase, lipase, deoxyribonucleic, phosphatase and urease. Amylase and phosphatase were the predominant enzymes produced by >80% of sponge-associated bacteria compared to the ambient water. Nearly 50% of the sponge-associated bacteria expressed multiple enzymatic activities (> 4) with variation in the percentage of expression of individual enzymes. More than 65% of the culturable heterotrophic bacteria associated with sponges were Gammaproteobacteria. The order Vibrionales was the main source for multiple enzyme production. Sponge associated bacteria formed more closely related clusters than the water isolates based upon their activity pattern. High recovery of sponge-associated bacteria with multiple enzymatic activities suggest that these versatile bacteria are yet unexploited potential for bioprospecting.
Review: Gram Negative Bacteria in Brewing  [PDF]
Paradh Ashtavinayak, Hill Annie Elizabeth
Advances in Microbiology (AiM) , 2016, DOI: 10.4236/aim.2016.63020
Abstract: Gram negative aerobic bacteria such as Acetic Acid Bacteria, which include Acetobacter and Gluconobacter, have historically caused significant problems to brewers. Although incidences of spoilage have recently reduced as a result of improvements in beer packaging, these bacteria are still a concern in dispense systems in pub breweries, public houses and cask conditioned beers. Gram negative facultative bacteria of the genus Zymomonas can spoil primed cask conditioned beer and cider. There is a wide range of Enterobacteraeceace which are found within brewery environments and they serve as indicator microorganisms for hygiene and sanitation. Gram negative strictly anaerobic bacteria such as Pectinatus and Megasphaera have recently emerged as a significant threat due to the improvement in reduction of oxygen levels in beer and an increase in production of unpasteurised beer. Pectinatus and Megasphaera are sensitive to routine cleaning agents used in breweries, but they can survive and proliferate in biofilms eventually causing spoilage of beer. This review focuses on Gram negative aerobic, facultative anaerobic and strictly anaerobic brewery related spoilage bacteria.
Benjamin & Schmitt: uma arqueologia da exce??o
Dymetman, Annie;
Lua Nova: Revista de Cultura e Política , 2001, DOI: 10.1590/S0102-64452001000200006
Abstract: situated at opposed poles of the ideological and cultural life in the twenties and thirties of the last century. walter benjamin and carl schmitt are protagonists in a complex play of affinity and repulsion on the level of their basic conceptions, which are built around the theme of excess. the author proposes an hermeneutic of excess.
Doris Salcedo: Shibboleth
Annie Tse
Opticon1826 , 2008, DOI: 10.5334/opt.040821
Abstract: Doris Salcedo’s Shibboleth begins with an inconspicuous crack at the entrance of Tate Modern, inviting the viewer to follow its meandering course which runs 167 meters down the full length of the Turbine Hall. This encourages visitors to walk meditatively along the widening chasm, in contrast to a very different journey down Carsten Holler’s slides in a previous exhibition last year, also in the Turbine Hall, where all thought was suspended during the exhilarating descent. Shibboleth is groundbreaking – not only in the literal sense but also because it is the first time in Tate Modern’s history that a work of art has been embedded in the building itself, leaving a permanent mark after the crack is filled at the end of the exhibition in April.
Anne Renoult, Andrée Viollis, Une femme journaliste
Annie Rouquier
Genre & Histoire , 2008,
Abstract: Andrée Viollis (1870-1950), une des journalistes les plus connues entre les deux guerres, figure marquante de l'information et du grand reportage, témoin de nombreux événements politiques de la scène planétaire pendant le premier XXe siècle, est tombée aujourd'hui dans l'oubli ou presque, au contraire d'un Albert Londres, auquel on pourrait la comparer. Anne Renoult mène une enquête biographique, sollicitée par la double problématique du succès et de l'oubli et guidée par le parcours prof...
Robert Delpire : l’art d’un éditeur d’art
Annie Renonciat
Strenae : Recherches sur les Livres et Objets Culturels de l'Enfance , 2010, DOI: 10.4000/strenae.72
Abstract: évoquant récemment son métier d’éditeur d’ouvrages photographiques dans le Journal des arts, à propos du livre de William Klein sur New York qu’il a publié en 1956, Robert Delpire mettait l’accent sur le r le décisionnaire du photographe en minimisant le sien : Je crois que le métier d’éditeur est modeste. Il y a un artiste d’un c té, un artisan de l’autre, il ne faut jamais trahir cette relation. L’un des objectifs de notre dossier thématique vise précisément à examiner cette relation, m...
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