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Search Results: 1 - 10 of 135 matches for " Annelise Casellato "
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Dissecting Emerging Aspects of Regulatory Circuitry in Man and Mice: Regulatory T Cell Biology  [PDF]
Tania Rahman, Md. Ferdous Seraj, Annelise Casellato
Advances in Bioscience and Biotechnology (ABB) , 2018, DOI: 10.4236/abb.2018.99031
Abstract: Regulatory T cells (Treg), a component of adaptive immunity, are well known for their immunosuppressive roles and their ability to maintain the balance between the immunological and pathological reactions. Treg have been shown to provide protective responses and their depletion has resulted severe pathology in some pathogen infections. The work presented here has unravelled the potential of regulatory cells in the immune system including different repertoir of Treg cell subsets, markers to distinguish them, Treg suppression mechanisms in the pathogenesis of various infections and summarize different mouse models depleting Tregs. These findings would help set up future avenues of research to elucidate a key mechanism of action of these cells and provide new therapeutic insights for pathogenesis and also for broader antibacterial/antiviral/antiproliferative immunity.
Unravelling the Functions of Regulatory T Cells during Infection  [PDF]
Tania Rahman, Md Ferdous Seraj, Annelise Casellato
Open Journal of Medical Microbiology (OJMM) , 2018, DOI: 10.4236/ojmm.2018.84011
Abstract: Accumulating evidences have suggested that Treg have an active role in the regulation of immunity to infection. Treg suppress not only autoimmune responses but also other immune responses for instance, during acute infections, against commensal microbes in inflammatory diseases or during chronic illness. Treg have been shown to limit exacerbated inflammation to avoid collateral tissue damage. Treg are also suggested to provide early protective responses in some viral infections as the permitting timely entry of effector cells in infected tissue. Furthermore, Treg have been shown to contribute to form memory pool after resolution of infection. In this review, we survey and analysis our current knowledge and relative dynamics of Treg in a wide range of infection settings and elaborate the examples in which these cells are of critical importance in conferring tolerance, suppressing pathogenesis, inducing protection and optimizing immunity to eliminate infection.
EPR and semi-empirical studies as tools to assign the geometric structures of FeIII isomer models for transferrins
Scarpellini, Marciela;Casellato, Annelise;Bortoluzzi, Adailton J.;Vencato, Ivo;Mangrich, Antonio S.;Neves, Ademir;Machado, Sérgio P.;
Journal of the Brazilian Chemical Society , 2006, DOI: 10.1590/S0103-50532006000800020
Abstract: the reaction of fe(clo4)3.nh2o with n,n'-bis[(2-hydroxybenzyl)-n,n' -bis(1-methylimidazole-2-yl-methyl)]ethylenediamine (h2bbimen) affords two geometric isomers, a and b, of the complex cation [fe(bbimen)]+, which were fully characterized by ir and uv-visible spectroscopies, esi mass spectrometry, molar conductivity measurements, cyclic voltammetry, spectroelectrochemistry and epr spectroscopy. the geometry of one of these isomers has been clearly demonstrated through x-ray crystallographic analysis. it crystallizes in the monoclinic system, space group p21/c, a = 14.104 (3), b = 15.626 (3), c = 13.291 (3) ?, b = 98.07 (3)o, z = 4, r1 = 6.35% and wr2 = 20.57%. the electrochemical properties of [fe(bbimen)]+ (-0.58 v versus nhe) are quite similar to those of transferrins (-0.52 v versus nhe) and indicate that it is a good model for the redox potential of these metalloenzymes. epr spectroscopy was the only spectroscopic technique able to differentiate the isolated isomers a and b. epr studies revealed that isomer a is better described as a rhombically distorted (e/d @ 0.33) high-spin feiii complex (g1 @ 4.1 with a shoulder at g2 @ 9.0), while the spectrum of b has a set of lines at g1 @ 3.0, g2 @ 3.6 and g3 @ 5.1, in addition to the line at g1 @ 4.2 and a shoulder at g2 @ 9.0, which have been ascribed to feiii complexes in axial symmetry (e/d @ 0.22). semi-empirical theoretical studies, combined with epr data, were essential to the proposition of the geometric structures of a and b.
Estudo espectroscópico de compósito obtido da rea??o no estado sólido entre um complexo mononuclear de vanádio(IV) e caulinita
Rezende, Edivaltris I. P. De;Mangrich, Antonio S.;Mangoni, Ana P.;Scarpellini, Marciela;Casellato, Annelise;Fernández, Tatiana L.;
Química Nova , 2012, DOI: 10.1590/S0100-40422012000200005
Abstract: the use of probes, such as paramagnetic species diluted in diamagnetic materials in epr spectroscopy, and mathematical tools such, as the kubelka-munk function in druv-vis spectroscopy are strategies in the analysis of complex mixtures of solid materials. the results obtained here show that the solid state reaction between the complex, [vo(acac)(bmimapy)] [clo4], bmimapy = [(bis(1-methylimidazole-2-yl)methyl)(2-(pyridyl-2-yl)ethyl) amine] and acac = acetilacetonate, with kaolinite turns possible to obtain anisotropic epr spectrum of the complex with a reasonable level of resolution. the study by druv-vis using the method of second derivative mode of the kubelka-munk function revealed new complex structural arrangements, a solid hitherto unknown.
State's Civil Responsibility and the Process Delay Responsabilidade Civil do Estado e a Morosidade Processual
Filipe Casellato
Revista de Direito dos Monitores da Universidade Federal Fluminense , 2011,
Abstract: The article discusses the evolution of the State's civil responsibility since the Republican Constitution of 1891 until nowadays, analysing it's developments in face of the phenomenom of Process Delay, proposing a new interpretation of the old instruments already included in the Civil Process Code (The Mandado de Seguran a Injunction and the Indemnification Popular Action) to solve the conflicts between the length of a process and the damages it causes to the society, O texto aborda a evolu o do instituto da responsabilidade civil do Estado desde a Constitui o Republicana de 1891 até os dias atuais, analisando seus desdobramentos diante do fen meno da morosidade processual, propondo uma nova interpreta o de instrumentos já consagrados no Código de Processo Civil (Mandado de Seguran a, A o Popular e Indenizatória) para resolver o conflito temporal do processo e os danos que acarreta à sociedade.
Binuclear CuII complexes as catalysts for hydrocarbon and catechol oxidation reactions with hydrogen peroxide and molecular oxygen
Martins, Luciana R.;Souza, Elizabeth T.;Fernandez, Tatiana L.;Souza, Bernardo de;Rachinski, Sílvio;Pinheiro, Carlos B.;Faria, Roberto B.;Casellato, Annelise;Machado, Sérgio P.;Mangrich, Antonio S.;Scarpellini, Marciela;
Journal of the Brazilian Chemical Society , 2010, DOI: 10.1590/S0103-50532010000700009
Abstract: the tridentate ligands hl1, [(2-hydroxybenzyl)(2-(imidazol-2-yl)ethyl)]amine, and hl2, [(2-hydroxybenzyl)(2-(pyridil-2-yl)ethyl]amine, were used to synthesize binuclear cuii complexes, [cu2(l1)2]cl2?2h2o, complex 1, and [cu2(l2)2](clo4)2?1.5h2o, complex 2, in order to obtain catalysts for oxidative processes. both complexes were characterized by elemental analysis, ir, uv-vis and epr spectroscopies. in addition, they were studied by cyclic voltammetry and potentiometric titration in order to investigate their behavior in solution. the crystal structure of complex 1 revealed a binuclear cation where the metal centers are bridged by two phenoxo groups. this arrangement provides a cu...cu distance of 3.043(10) ?, which is similar to the observed for catechol oxidase (2.90 ?). the catalytic reactivities of both complexes were investigated for hydrocarbon and catechol oxidations. complexes 1 and 2 led to low overall hydrocarbon oxidation conversion values of 6.34 % and 7.15 %, respectively. however, for complex 1, only cyclohexanol (cy-oh) and cyclohexanone (cy=o) were isolated as reaction products, with selectivities of 68.1% for cy-oh. this low overall conversion is tentatively attributed to steric hindrance effects produced by the non-coplanar aromatic rings of the ligand scaffolds, which suggest that the access of the hydrocarbon molecule to the binuclear active center is a determinant step in the reaction mechanism. investigation of catecholase activities has shown high efficiencies, with complex 2 being more active than complex 1. it indicates that the pyridine-containing ligand is able to stabilize the intermediate cuicui center which is proposed to be formed in this process. this is corroborated by the strong participation of pyridine in the lumo (lowest unoccupied molecular orbital) of complex 2, which can help to accommodate the additional negative charge when the complex is reduced from cuiicuii to cuicui.
Clinical Analysis of the Pharmacological Interactions of Clopidogrel and Gender Differences: A Case-Control Study  [PDF]
Bianchi Stefano, Chiara Casellato, Bianchini Erica, Scanavacca Paola
International Journal of Clinical Medicine (IJCM) , 2012, DOI: 10.4236/ijcm.2012.36093
Abstract: Background: Clopidogrel is a prodrug metabolized by cytochrome P450-2C19. Drugs inhibiting this enzyme might reduce its antiplatelet activity. In order to reduce gastrointestinal bleedings, proton-pump inhibitors are usually prescribed in association with clopidogrel. The study aims at assessing the clinical importance of interactions between clopidogrel and inhibitors of CYP2C19. It also aims to evaluate any possible factors that may reduce the therapeutic efficacy of the drug. Particular attention was devoted to possible gender differences in responsiveness to treatment with clopidogrel or clopidogrel plus proton-pump inhibitors. This analysis is a retrospective case-control observational study carried out by the University Hospital of Ferrara. Methods: Subjects were patients who had received clopidogrel from 01-01-2008 to 31-12-2008. For them, we analysed hospital admissions and data of drug prescriptions relative to dispensing of drugs cytochrome P-450-2C19 inhibitors. Patients were subdivided into case and control groups based on the occurrence or not of cardiovascular or cerebrovascular secondary events during therapy with clopidogrel. Results: The study focused on 781 patients, 20.1% of which (n.157) experienced secondary effects. The mean age is 70 years old. Men (67% of the analyzed population) experienced secondary events more than women (OR 1.54; CI 95% 1.04 - 2.28; p < 0.03). 70% of patients took PPIs and we noticed that the risk of secondary events increased by 2.2% with respect to the remaining patients (20.77% vs 18.57%; OR 1.15; CI 0.78 - 1.70; p = NS). Among PPIs, lansoprazole is the most used. For this subgroup the risk is 5.2% higher (risk in those exposed of 23.75% vs 18.57% in those not exposed; or 1.37, 95% CI 0.92 - 2.03; p = NS). The interaction with PPIs is particularly interesting only among women, with a risk 6.3% higher (17.46% exposed, 11.11% non exposed). The risk remains the same among men. Conclusions: Analyzed data show an increase in cardiovascular or cerebral secondary events for patients exposed to PPIs. It also demonstrated the existence of differrent gender in therapeutic response to clopidogrel.
Conference Review - The European Association for Terminology, Third Terminology Summit, Brussels
Annelise Grinsted
Language at Work : Bridging Theory and Practice , 2012,
Abstract: The European Association for Terminology held its Third Summit in Brussels on the 13th and 14th of November, 2006. It was a special summit due to the fact that it was also the celebration of the 10th anniversary of the European Association for Terminology.
Funktions- og v rkt jer til underst ttelse af netbaseret kollaborativ l ring
Annelise Agertoft
Tidsskriftet for Universiteternes Efter- og Videreuddannelse , 2004,
Abstract: F rste gang publiceret i UNEV nr. 2: E-l ringsplatforme - muligheder og potentialer, januar - marts 2004, red. Tom Nyvand og Michael Pedersen. ISSN 1603-5518. Netbaseret kollaborativ l ring er forl b, der didaktisk tager udgangspunkt i de studerende f lles videnskonstruktion. Netbaserede kollaborative l ringsforl b egner sig til proces- og projektorienterede l ringsforl b p universitetsniveau. IKT anvendes b de underst ttende og kvalificerende i disse processer. I artiklen tages afs t i fire centrale handlingstyper for den kollaborative gruppe, og der peges i oversigtsform p hvilke funktioner, v rkt jer og E-l ringssystemer, der i s rlig grad synes at kunne underst tte CSCL (Computer Supported Collaborative Learning). Artiklen kommer ikke ind p administrative funktioner i forbindelse med valg af E-l ringssystem.
Refleksioner over udarbejdelse af test i Blackboard
Annelise Grinsted
Tidsskriftet for Universiteternes Efter- og Videreuddannelse , 2006,
Abstract: F rste gang publiceret i UNEV nr. 7: E-l ring i sprogfag, juni 2006, red. Signe Hvid Maribo og Ole Lauridsen. ISSN 1603-5518. Vi er 2 lektorer, Simon Clement og Annelise Grinsted, der indg r i et p dagogisk udviklingsarbejde som en del af e-l ringsstrategien p Syddansk Universitet, hvor vi skal udvikle 3 former for tests i universitetets valgte l ringssystem, Blackboard, afpr ve disse og derefter evaluere p resultaterne af denne proces. Udarbejdelsen af sp rgsm l i denne form for tests viser sig at kr ve langt flere overvejelser end f rst antaget som fx antal mulige svar, sv rhedsgrad, entydighed, r kkef lge af sp rgsm l, etc.
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