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Search Results: 1 - 10 of 167 matches for " Annelies Vanderper "
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Glucose Tolerance and Left Ventricular Pressure-Volume Relationships in Frequently Used Mouse Strains
Wouter Oosterlinck,Annelies Vanderper,Willem Flameng,Paul Herijgers
Journal of Biomedicine and Biotechnology , 2011, DOI: 10.1155/2011/281312
Abstract: We investigated glucose tolerance and left ventricular contractile performance in 4 frequently used mouse strains (Swiss, C57BL/6J, DBA2, and BalbC) at 24 weeks. Glucose tolerance was tested by measuring blood glucose levels in time after intraperitoneal glucose injection (2 mg/g body weight). Left ventricular contractility was assessed by pressure-conductance analysis. Peak glucose levels and glucose area under the curve were higher (all <.05) in C57BL/6J (418±65 mg/dL and 813±100 mg·h/dL) versus Swiss (237±66 mg/dL and 470±126 mg·h/dL), DBA2 (113±20 mg/dL and 304±49 mg·h/dL, <.01), and BalbC mice (174±55 mg/dL and 416±70 mg·h/dL). Cardiac output was higher (all <.05) in Swiss (14038±4530 μL/min) versus C57BL/6J (10405±2683 μL/min), DBA2 (10438±3251 μL/min), and BalbC mice (8466±3013 μL/min). Load-independent left ventricular contractility assessed as recruitable stroke work (PRSW) was comparable in all strains. In conclusion, glucose tolerance and load-dependent left ventricular performance parameters were different between 4 mice background strains, but PRSW was comparable.
Angiotensin-converting enzyme inhibition and food restriction restore delayed preconditioning in diabetic mice
Gerry Van der Mieren, Ines Nevelsteen, Annelies Vanderper, Wouter Oosterlinck, Willem Flameng, Paul Herijgers
Cardiovascular Diabetology , 2013, DOI: 10.1186/1475-2840-12-36
Abstract: Hypoxic preconditioning was induced in C57Bl6-mice (WT), leptin deficient ob/ob (model for type II diabetes) and double knock-out (DKO) mice with combined leptin and LDL-receptor deficiency (model for metabolic syndrome). Twenty-four hours later, 30 min of regional ischemia was followed by 60 min reperfusion. Left ventricular contractility and infarct size were studied. The effect of 12 weeks food restriction or angiotensin-converting enzyme inhibition (ACE-I) on this was investigated. Differences between groups were analyzed for statistical significance by student's t-test or one-way ANOVA followed by a Fisher's LSD post hoc test. Factorial ANOVA was used to determine the interaction term between preconditioning and treatments, followed by a Fisher's LSD post hoc test. Two-way ANOVA was used to determine the relationship between infarct size and contractility (PRSW). A value of p<0.05 was considered significant.Left ventricular contractility is reduced in ob/ob compared with WT and even further reduced in DKO. ACE-I improved contractility in ob/ob and DKO mice. After ischemia/reperfusion without preconditioning, infarct size was larger in DKO and ob/ob versus WT. Hypoxic preconditioning induced a strong protection in WT and a partial protection in ob/ob mice. The preconditioning potential was lost in DKO. Twelve weeks of food restriction or ACE-I restored the preconditioning potential in DKO and improved it in ob/ob.Delayed preconditioning is restored by food restriction and ACE-I in case of type II diabetes and the metabolic syndrome.
Angiotensin-converting enzyme inhibition and food restriction in diabetic mice do not correct the increased sensitivity for ischemia-reperfusion injury
Gerry Van der Mieren, Ines Nevelsteen, Annelies Vanderper, Wouter Oosterlinck, Willem Flameng, Paul Herijgers
Cardiovascular Diabetology , 2012, DOI: 10.1186/1475-2840-11-89
Abstract: C57Bl6/J wild type (WT) mice, leptin deficient ob/ob (model for type II diabetes) and double knock-out (LDLR-/-;ob/ob, further called DKO) mice with combined leptin and LDL-receptor deficiency (model for metabolic syndrome) were used. The effects of 12?weeks food restriction or ACE-I on infarct size and load-independent left ventricular contractility after 30?min regional cardiac ischemia were investigated. Differences between groups were analyzed for statistical significance by Student’s?t-test or factorial ANOVA followed by a Fisher’s LSD post hoc test.Infarct size was larger in ob/ob and DKO versus WT. Twelve weeks of ACE-I improved pre-ischemic left ventricular contractility in ob/ob and DKO. Twelve weeks of food restriction, with a weight reduction of 35-40%, or ACE-I did not reduce the effect of IR.ACE-I and food restriction do not correct the increased sensitivity for cardiac IR-injury in mouse models of type II diabetes and the metabolic syndrome.The number of patients with diabetes and the metabolic syndrome increases in Western societies and reaches epidemic proportions [1,2]. At present, diabetes affects approximately 250 million people worldwide and by 2025 this is expected to increase to over 380 million, with type II diabetes accounting for 90-95% of them. Prevalence is expected to increase most in Asia and Africa with the majority of patients in 2030 being found there [2]. The prevalence of the metabolic syndrome currently exceeds 20% of individuals who are over 20?years of age and 40% of the population older than 40?years [1]. Heart failure is the leading cause of mortality in people with type II diabetes. The incidence of myocardial infarction in diabetic patients is twice that of the general population [3,4]. They are at increased risk for mortality and post-ischemic complications [3,4]. Infarct size for a given ischemic insult is larger in diabetic mice than in controls [5-7]. This, on top of diabetic cardiomyopathy [8,9], contributes to progressi
“The Gong Gong Was Beaten” —Adamorobe: A “Deaf Village” in Ghana and Its Marriage Prohibition for Deaf Partners
Annelies Kusters
Sustainability , 2012, DOI: 10.3390/su4102765
Abstract: Adamorobe is a village in Ghana where the historical presence of a hereditary form of deafness resulted in a high number of deaf inhabitants. Over the centuries, a local sign language emerged, which is used between deaf and hearing people in everyday life, rendering Adamorobe into a unique place of inclusion of deaf people. However, in 1975, a law was introduced to reduce the number of deaf people in Adamorobe: deaf people cannot marry each other in order to avoid deaf offspring. In the long term, this law threatens the linguistic and cultural diversity in this village where the use of sign language is omnipresent and where deaf people are perceived as fully productive and worthy members of society. This article is structured around two sets of tensions in the village, Firstly, hearing people’s acceptance and inclusion of the deaf inhabitants, versus the wish to live in a village with no (or less) deaf people. Secondly, there is a tension between deaf people’s subjection to, and resistance against, the law, this is a tension that can be observed in the existence of relationships between deaf partners, and abortions when these unions lead to pregnancies.
Towards a better understanding of the role of psychological variables in arthritis outcome research
Annelies Boonen
Arthritis Research & Therapy , 2010, DOI: 10.1186/ar2922
Abstract: We are disturbed not (only) by events, but (also) by the views which we take of them.(Epictetus, born 55 AD)Likely, the majority of rheumatologists have been trained in the belief that health outcomes are mainly explained by biomedical factors related to the disease. In the previous issue of Arthritis Research and Therapy, the biomedical model is challenged by the article of Brionez and coworkers [1]. The authors show that the total explained variation of the Bath Ankylosing Spondylitis Functional Index increased from 32% to 56% when adding various psychological variables (depression, coping and beliefs about controllability) to the demographic and clinical variables. Although the Bath Ankylosing Spondylitis Functional Index and other patient-reported outcome measures have been criticized by experts in ankylosing spondylitis because of their subjective nature, this paper helps to understand mechanisms underlying these effects and quantifies the magnitude of their influence.Psychology is the discipline that attempts to understand the role of mental functions in individual and social behavior. In medicine, psychology became more widely integrated when the biopsychosocial model of disease was adopted by the World Health Organization, through the approval of the International Classification of Functioning, Disability and Health (ICF) (Figure 1) as the framework and classification of health.In the biopsychosocial model, functioning and health results from a complex interplay of the health components - body functions and structures, activities and participation - and the contextual factors - environmental factors and personal factors [2]. In the ICF, psychological variables can be found either within the body functions or within the personal factors. Depression, as in the study by Brionez and coworkers [1], is part of the body functions (emotional function) - and as such can be the direct consequence of the health condition or an emotional reaction to the presence of the
Panathenaeum. Een Gronings studentenblad in de begintijd van de Nederlandse studentenpers (1842-1843)
Annelies Noordhof
TS·> Tijdschrift voor Tijdschrift-studies , 2010,
Abstract: In the historiography of the university the development of the student journals has rarely been the subject of research. These journals written by and for students, which first appeared in 1825, nevertheless did have an important role for student life. In this article, one of the early student journals, Panathenaeum, which appeared in Groningen in 1842 and 1843, will be studied in order to illustrate some aspects of the so-called early student press (1825-1855). These aspects are respectively the literary elements, the significance of the student journal for local student life and the contribution of the student journal to a growing awareness of a national student community.
Living in a Bottomless Pit: Households’ Responses to Land Subsidence, an Example from Indonesia  [PDF]
Erlis Saputra, Tejo Spit, Annelies Zoomers
Journal of Environmental Protection (JEP) , 2019, DOI: 10.4236/jep.2019.101001
Abstract: Land subsidence has severe physical and economic implications for both areas and people. Numerous scholars have shown that land subsidence has had massive impacts at global, national and regional levels, and that the impacts were usually responded to by the government. However, little attention has been paid to what land subsidence means to people’s daily lives and how much it costs them. To fill that gap, this article draws on empirical research carried out in three areas in Indonesia to provide a better understanding of what land subsidence means to households, and how they respond to the consequences and how much it costs them to do so. An analysis of a survey of 330 households shows that they have been suffering from various severities of impacts of land subsidence for an extended period. Whereas some of the households respond to the impacts by making small preparations or adapting to the damages, others can do nothing due to a lack of money and their continuously declining earning capacity. Thus, the affected households are effectively throwing money into a bottomless pit. We argue that these households must escape the vicious circle caused by land subsidence by increasing their income capacity or even abandoning the affected areas.
Role of PPAR in Hepatic Carbohydrate Metabolism
Annelies Peeters,Myriam Baes
PPAR Research , 2010, DOI: 10.1155/2010/572405
Abstract: Tight control of storage and synthesis of glucose during nutritional transitions is essential to maintain blood glucose levels, a process in which the liver has a central role. PPAR is the master regulator of lipid metabolism during fasting, but evidence is emerging for a role of PPAR in balancing glucose homeostasis as well. By using PPAR ligands and PPAR mice, several crucial genes were shown to be regulated by PPAR in a direct or indirect way. We here review recent evidence that PPAR contributes to the adaptation of hepatic carbohydrate metabolism during the fed-to-fasted or fasted-to-fed transition in rodents. 1. Introduction 1.1. PPAR Peroxisome proliferator-activated receptor (PPAR ) is a nuclear receptor and master regulator of lipid metabolism. In the liver of rodents, PPAR is an important orchestrator of the switch from the fed to the fasted condition via activation of fatty acid catabolism by mitochondrial, microsomal, and peroxisomal -oxidation in order to maintain energy homeostasis during fasting and to protect cells from lipid overload [1–4]. Fasting periods are characterized by increased hepatic fatty acid influx, which bears similarities with high fat feeding. Moreover, PPAR functions as a fatty acid sensor and mediates the remodeling of hepatic lipid metabolism via the induction of several genes, like fatty acid transporters, fatty acid activation genes, and key enzymes of the fatty acid oxidation (FAO) pathways [4]. Besides inducing FAO, PPARα also stimulates the synthesis of ketone bodies from fatty acids [4], which in the fasted state serve as fuel for many extrahepatic organs, such as muscle [5]. In this way, fatty acids are preferentially utilized as fuel in periods of fasting. The transactivation potential of PPAR can be stimulated either by PPAR ligands or by the presence of high levels of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1 ), as occurs during fasting [6]. Moreover, the induction/suppression of PPAR target genes will also depend on PPAR expression levels which are in part autoregulated [6]. Since nonesterified fatty acids are known ligands for PPAR , elevated plasma free fatty acids (FFAs) could be expected to act as endogenous PPARα ligands during fasting and to mediate the fasting-induced metabolic effects. Surprisingly, it was shown that this activation of hepatic PPAR does not occur by plasma FFAs [6, 7], but by fatty acids synthesized in hepatocytes de novo [7, 8]. Hepatic PPAR rather than PPAR was shown to be responsive to elevated fasting plasma FFAs levels
Does Migration Lead to Development? Or is it Contributing to a Global Divide?
Annelies Zoomers,Gery Nijenhuis
Societies , 2012, DOI: 10.3390/soc2030122
Abstract: This article aims to show that the benefits of international migration (often presented as a ‘global flow’) very much depend on the positionality of the areas involved, as well as the regional particularities. It is argued that countries producing south-north migration or diasporic states are in a more favorable position to benefit from international migration than countries that are mainly involved in south-south migration. In addition, the opportunity to benefit from international migration very much depends on geographical particularities. For example, international migration in the context of Latin America/USA is in many respects not comparable to what is happening in Africa, Asia, the EU and the Gulf States. Even though international migration is often described in terms of a growing connectedness in the age of globalization, it progresses also hand in hand with new gaps and regional divides.
Lexical Description of Signs — Linguistic Benefits of a Geometric Dependency Model Description lexicale des signes — Intérêts linguistiques d’un modèle géométrique à dépendances
Michael Filhol,Annelies Braffort
Traitement Automatique des Langues , 2009,
Abstract: This article deals with formal representation of sign language lexicons. Present models are based on systematic parameter specification, which we think lacks flexibility. We suggest an adaptable model based on a sequential and geometric approach. Then we discuss a graphical representation for it that allows for a clearer view of the descriptions’ structures and dependencies. We give hints on the benefits we see in the model onto two different domains: sign language synthesis and data base driven studies of sign languages
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