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Search Results: 1 - 10 of 364 matches for " Annamaria Panico "
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Protective Effects of Many Citrus Flavonoids on Cartilage Degradation Process  [PDF]
Lucia Crascì, Annamaria Panico
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2013, DOI: 10.4236/jbnb.2013.43035
Abstract: The objective of this study was to investigate the effects of many citrus flavanones, such as neoeriocitrin, naringin and neohesperidin, in cartilage degradation. Degenerative joint disease involved degradation of joints, including articular cartilage and subchondral bone. When bone surfaces become less well protected by cartilage, bone may be exposed and damaged. The degradation cartilage is mediated by alteration of the balance between anabolic and catabolic processes, changes in proteolytic enzyme activity, mechanical disruption of the cartilage extracellular matrix (ECM), or a combination of these processes. We examine the capability of neoeriocitrin, naringin and neohesperidin, to inhibit metalloproteinase (MMP)-13, collagenase involved in degradation of cartilage matrix components. Also, we assay the flavonoids effect on reducing of Glycosaminoglycans (GAGs) release, and restore Nitric oxide (NO) levels in explant of human articular cartilage. Our results suggest that neoeriocitrin, naringin and neohesperidin are a potential therapeutic agent to protect cartilage tissue.
Toxicity and Carcinogenicity Mechanisms of Fibrous Antigorite
Venera Cardile,Laura Lombardo,Elena Belluso,Annamaria Panico,Silvana Capella,Michael Balazy
International Journal of Environmental Research and Public Health , 2007, DOI: 10.3390/ijerph2007010001
Abstract: We studied the effects of fibrous antigorite on mesothelial MeT-5A and monocyte-macrophage J774 cell lines to further understand cellular mechanisms induced by asbestos fibers leading to lung damage and cancer. Antigorite is a mineral with asbestiform properties, which tends to associate with chrysotile or tremolite, and frequently occurs as the predominant mineral in the veins of several serpentinite rocks found abundantly in the Western Alps. Particles containing antigorite are more abundant in the breathing air of this region than those typically found in urban ambient air. Exposure of MeT-5A and J774 cells to fibrous antigorite at concentrations of 5-100 μg/ml for 72 hr induced dose-dependent cytotoxicity. Antigorite also stimulated the ROS production, induced the generation of nitrite and PGE2. MeT-5A cells were more sensitive to antigorite than J774 cells. The results of this study revealed that the fibrous antigorite stimulates cyclooxygenase and formation of hydroxyl and nitric oxide radicals. These changes represent early cellular responses to antigorite fibers, which lead to a host of pathological and neoplastic conditions because free radicals and PGE2 play important roles as mediators of tumor pathogenesis. Understanding the mechanisms of the cellular responses to antigorite and other asbestos particles should be helpful in designing rational prevention and treatment approaches.
Fluoro-edenite Fibers Induce Expression of Hsp70 and Inflammatory Response
Venera Cardile,Laura Lombardo,Elena Belluso,Annamaria Panico,Marcella Renis,Antonio Gianfagna,Michael Balazy
International Journal of Environmental Research and Public Health , 2007, DOI: 10.3390/ijerph2007030001
Abstract: Many asbestos-like mineral fibers have been detected in the air of mountainous and volcanic areas of Italy and other parts of the world. These fibers have been suspected to be the cause of increased incidences of lung cancer and other lung diseases in these areas. However, the mechanisms of the cellular response and defense following exposure to these microscopic fibers have not been characterized. We continue to study these mechanisms to be able to propose preventive strategies in large populations. The objective of the present study was to determine comparatively biological responses of mesothelial Met-5A and monocyte-macrophage J774 cells following exposure to two types of fluoro-edenite fibers having low and high iron content (labeled 19 and 27, respectively) obtained from Biancavilla (Sicily, Italy). The reference fiber was a non-iron fibrous tremolite from Val di Susa (Piemonte, Italy). The cells were treated with 5, 50, and 100 μg of fibrous matter per 1 ml for 72 hr. We identified several key mechanisms by which cells responded and counteracted the injury induced by these fibers. The fibers caused induction of the heat shock protein 70 (Hsp70), stimulated formation of reactive oxygen species (detected by using DCFH-DA as a fluorescent probe) and NO? (measured as nitrite). Exposure of cells to the fibers induced lactate dehydrogenase activity and decreased viability. The fluoro-endenite type 27 was the most potent fiber tested, which indicated that iron and possibly manganese contribute significantly to this fiber toxicity. The J774 cells were more sensitive to fluoro-edenite than Met-5A cells suggesting that the primary site of the fiberinduced inflammatory response could be the macrophage rather than the pulmonary epithelium. Fluoro-edenite produces more biological alterations with respect to non-iron tremolite. Hsp70 and free radicals could be important factors in the context of mineral fiber-induced acute lung injury leading possibly to mutagenic effects. We anticipate that pharmacological blockade of the fiber-dependent cellular responses could in long term offer preventive approach to combat lung diseases induced by these fibers.
Peripheral T-cell Lymphoma with Cyclin D1 overexpression: a case report
Gabriella Aquino, Renato Franco, Fioravante Ronconi, Annamaria Anniciello, Luigi Russo, Annarosaria De Chiara, Luigi Panico
Diagnostic Pathology , 2012, DOI: 10.1186/1746-1596-7-79
Abstract: The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1117747619703769Peripheral T-cell lymphomas (PTCLs) represent an heterogeneous group of non-Hodgkin's lymphomas (NHL), characterized by poor outcome, accounting approximately for 10%-15% of all non-Hodgkin lymphomas in the western countries, and with an higher prevalence in Asia [1,2]. Peripheral T-cell lymphomas derive from lymphocytes at the post-thymic stage of maturation. According to recent WHO (World Health Organization) classification more than 20 biologically and clinically distinct entities of Peripheral T-cell lymphomas have been described, such as Peripheral T-cell lymphomas Not Otherwise Specified (NOS), angioimmunoblastic T-cell lymphoma (AITL), natural killer/T-cell lymphoma, adult T-cell leukemia/lymphoma (ATLL) and anaplastic large-cell lymphoma (ALCL), the most common ones [3]. Cutaneous lymphomas represent a distinct entity of T lymphomas according to WHO, because same of those show even an indolent course [4]. Unlike other non-Hodgkin's lymphomas, only two subtypes of Peripheral T-cell lymphomas are characterized by disease-defining genetic abnormalities, such as the t(2;5)(p23;q35) in anaplastic large-cell lymphoma and DNA integration of human T-lymphotropic virus 1 (HTLV1) in adult T-cell leukemia/lymphoma [5,6]. Peripheral T-cell lymphomas- Not Otherwise Specified account approximatively for 60-70% of T-cell lymphomas and it cannot be furtherly classified on the basis of morphology, phenotype, and conventional molecular studies, representing often a diagnosis of exclusion with respect to other T cell lymphomas histotypes [7].Cyclin D1 is well-established human oncogene, frequently deregulated in cancer, playing a specific role in cancer phenotype characterization and disease progression [8]. Cyclin D1 over-expression is often due to chromosomal aberration. Among lymphomas, translocation (11;14)(q13;q32) is typically observed in mantle cell lymph
Las causas de la crisis de deuda en Europa y el papel de la integración regional
Panico, Carlo;
Investigación económica , 2010,
Abstract: the paper examines the main explanations of the recent speculative attacks against the government debts of some european monetary union (emu) countries. it argues that the attacks have been favored by the faults in the institutional organization of the emu and concludes that it is inevitable to complete the process of regional integration in the euro area. only these reforms can offer some emu countries a way out from the current unsustainable situation and avoid further problems. the emu should set up a european fiscal agency to make the process of coordination between monetary and fiscal policies pragmatic and effective, a european development agency to counter-act the inevitable widening of the gaps between the richer and poorer economies, and a permanent monetary stabilization funds to discourage in advance any speculative attack against the euro economies.
Revista Galega de Economía , 2012,
Abstract: The concept of rationality is crucial in economics. Different notions of rationality have accompanied its long journey, from that implied in classical economics to those proposed by neoclassical theory since 1870s. The paper also discusses the meaning of rationality in rational choice theory, the contributions of Simon on "bounded rationality" and the different lines of research of experimental economics, behavioural economics and neuronomics. During this long journey the literature has underlined the existence of several problems, some of which can be so summarised: is it possible to consider scientifically satisfactory a theory that moves from assumptions, like those on the behaviour of utility, whose validity cannot be empirically verified?, is the description of human psychology implied by the different versions of the neoclassical theory acceptable?, is it possible to overlook the influence of social interactions on individual choice?, is it possible to overlook that it may be not adequate or convenient to examine the working of the whole economic system as the sum of the behaviour of the individual agents? The paper argues that these problems have not yet found a satisfactory solution and that it may be convenient to go back to the contributions of Keynes, Sraffa and Myrdal during the 1920s and 1930s to develop adequate and competent answers.
Las causas de la crisis de deuda en Europa y el papel de la integración regional
Carlo Panico
Investigación económica , 2010,
Strategies, Performances and Profiling of a Sample of U.S. Universities in 2012  [PDF]
Angela Besana, Annamaria Esposito
Open Journal of Applied Sciences (OJAppS) , 2015, DOI: 10.4236/ojapps.2015.53008
Abstract: The global economic crisis is affecting performances of not-for-profits. At the same time donors are targeted by a pressing good-cause related marketing, so that the competition for philanthropy is particularly keen. U.S. universities can be public, not-for-profit and for-profit. U.S. not-for-profit universities are confronted with different marketing, fundraising and revenue diversification. Above all, marketing concerns customers and their segmentation and their purchasing-power exploitation; fundraising aims to gain the trustworthiness of donors, instead. The aim of this paper is the analysis of the revenue diversification of a sample of 100 U.S. not-for-profit universities according to IRS (Internal Revenue Service) Forms. These 100 U.S. universities had the highest 2012’s revenues for the Guidestar ranking (www.guidestar.org). The cluster analysis gives evidence that the highest gain and the highest solvency are both connected with the implementation of revenue diversification for one profile. The most crowded cluster is the Marketing Expert with the second highest gain.
Effective Action and Holography in 5D Gauge Theories
Panico, Giuliano;Wulzer, Andrea
High Energy Physics - Phenomenology , 2007, DOI: 10.1088/1126-6708/2007/05/060
Abstract: We apply the holographic method to 5D gauge theories on the warped interval. Our treatment includes the scalars associated with the fifth gauge field component, which appear as 4D Goldstone bosons in the holographic effective action. Applications are considered to two classes of models in which these scalars play an important role. In the Composite-Higgs (and/or Gauge-Higgs Unification) scenario, the scalars are interpreted as the Higgs field and we use the holographic recipe to compute its one-loop potential. In AdS/QCD models, the scalars are identified with the mesons and we compute holographically the Chiral Perturbation Theory Lagrangian up to p^4 order. We also discuss, using the holographic perspective, the effect of including a Chern-Simons term in the 5D gauge Lagrangian. We show that it makes a Wess-Zumino-Witten term to appear in the holographic effective action. This is immediately applied to AdS/QCD, where a Chern-Simons term is needed in order to mimic the Adler-Bardeen chiral anomaly.
Nucleon Form Factors from 5D Skyrmions
Panico, Giuliano;Wulzer, Andrea
High Energy Physics - Phenomenology , 2008, DOI: 10.1016/j.nuclphysa.2009.04.004
Abstract: Several aspects of hadron physics are well described by a simple 5D effective field theory. Baryons arise in this scenario as "large" (and therefore calculable) 5D skyrmions. We extend and refine the existing analysis of this 5D soliton, which is fairly non-trivial due to the need of numerical methods. We perform the complete quantization of those collective coordinates which are relevant for computing the static observables like the nucleon form factors. We compare the result with simple expectations about large-N_c QCD and with the experimental data. An agreement within 30% is found.
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