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Search Results: 1 - 10 of 419 matches for " Annamaria Molino "
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The rehabilitation of a reservoir: A new methodological approach for calculating the sustainable useful storage capacity  [PDF]
Annamaria De Vincenzo, Bruno Molino
Agricultural Sciences (AS) , 2013, DOI: 10.4236/as.2013.48A007

Present work introduces the sustainable useful storage capacity as the minimum storage capacity able to satisfy the water demand for drinkable, industrial and irrigational purposes and necessary in order to overcome water deficit situations which, at least in Central Southern Italy, occur in the summer, when agricultural demand is really high. Sediment volumes to be removed from the reservoir bottom will be calculated as the difference between the current and the sustainable useful storage capacities of the reservoir in study. The calculation methodology of the useful sustainable storage capacity, based on the reservoir water balance between inflows at the reservoir and water demand, has been applied to the Camastra reservoir (Basilicata, Southern Italy), for which numerous reliable data including more than 40 years of inflows and water supplied volumes and data relative to 7 bathymetric surveys are available. Result analysis shows that this methodology, at least in the study case, enables sediment quantities to be removed more sustainably from a technical, economical and environmental point of view.

Mammary Paget's disease occurring after mastectomy
Monica Giovannini, Carmelo D'Atri, Quirino Piubello, Annamaria Molino
World Journal of Surgical Oncology , 2006, DOI: 10.1186/1477-7819-4-51
Abstract: We here describe a case of Paget's disease occurring on the thoracic wall site of a previous simple mastectomy, and also briefly summarise the most important aspects leading to a diagnosis of mammary Paget's disease.To the best of our knowledge, this is the first reported case of mammary Paget's disease occurring after mastectomy. The absence of the nipple/areola complex obviously raised some questions concerning whether it was mammary or extra-mammary Paget's disease, and how it could occur in the absence of the nipple/areola complex.Mammary Paget's disease occurs exclusively on the nipple/areola complex from where it may spread on to surrounding skin. Extramammary Paget's disease occurs most commonly in the anogenital region but can arise in any area of skin and mucosa.Mammary Paget's disease accounts for 2–3% of neoplastic conditions of the breast and in most cases (82–92% in several studies) tumour cells have spread to the skin of the nipple and areola from underlying invasive carcinoma or ductal carcinoma in situ [1-3]. The neoplasm associated with mammary Paget's disease, which may or may not be palpable, is usually centrally located (within 2 cm of the areola) but occasionally may be more peripherally sited [1,2]. In cases where a mass is palpable, invasive carcinoma is likely to be found. Conversely, cases of mammary Paget's disease with no palpable mass are more likely to have ductal carcinoma in situ only (66% of cases in one study) [2].Mammary Paget's disease has been reported in the male breast with no evidence that the disease behaves differently, although the numbers of cases reported are small [4].This paper describes a case of Paget's disease occurred on the thoracic wall where simple mastectomy was performed many years before.A 57-year-old woman underwent simple mastectomy (according to Madden procedure) and axillary dissection on 7 December 1995. She reported the appearance of eczema of the nipple-areola complex some years before, and the presence
Bone Marrow Micrometastases in Breast Cancer Patients: A Long-Term Follow-up Study
Annamaria Molino,Monica Giovannini,Rocco Micciolo,Alessandra Auriemma
Clinical Medicine : Oncology , 2008,
Abstract: In 125 early breast cancer patients who underwent multiple bone marrow aspirates, there was no significant difference in terms of disease-free and overall survival after a median follow-up of 163 months between the patients with or without micrometastasis at the time of primary surgery. However, when the time-dependent evolution of the bone marrow aspirates was taken into account, some evidence for a longer disease-free and overall survival was found for the patients with negative bone marrow.
Leptin/HER2 crosstalk in breast cancer: in vitro study and preliminary in vivo analysis
Elena Fiorio, Anna Mercanti, Marianna Terrasi, Rocco Micciolo, Andrea Remo, Alessandra Auriemma, Annamaria Molino, Veronica Parolin, Bruno Di Stefano, Franco Bonetti, Antonio Giordano, Gian Cetto, Eva Surmacz
BMC Cancer , 2008, DOI: 10.1186/1471-2407-8-305
Abstract: Expression of ObR, HER2, phospo-HER2 was assessed by immonoblotting. Physical interactions between ObR and HER2 were probed by immunoprecipitation and fluorescent immunostaining. Expression of leptin and ObR in breast cancer tissues was detected by immunohistochemistry (IHC). Associations among markers studied by IHC were evaluated using Fisher's exact test for count data.HER2 and ObR were coexpressed in all studied breast cancer cell lines. In MCF-7 cells, HER2 physically interacted with ObR and leptin treatment increased HER2 phosphorylation on Tyr 1248. In 59 breast cancers, the presence of leptin was correlated with ObR (the overall association was about 93%). This result was confirmed both in HER2-positive and in HER2-negative subgroups. The expression of leptin or ObR was numerically more frequent in larger (> 10 mm) tumors.Coexpression of HER2 and the leptin/ObR system might contribute to enhanced HER2 activity and reduced sensitivity to anti-HER2 treatments.Recent epidemiological and clinical data confirmed that obesity in postmenopausal women is associated with increased breast cancer risk, development of more aggressive breast tumors and resistance to certain anti-breast cancer treatments [1-4]. The molecular mechanisms of this link are not clear, but several studies in animal and cellular models suggested that excess body weight could promote breast cancer through increased production of an adipocyte-derived hormone leptin [5-7]. The primary function of leptin is to regulate energy balance and food intake by acting in the brain, but the hormone also plays an important role in peripheral organs, modulating fertility, lactation, and immune response [8,9]. Leptin levels in humans correlate with adiposity and are usually higher in females than in males [8].Leptin action is mediated through the transmembrane leptin receptor ObR [10]. The human ObR can be expressed as at least four isoforms with different COOH-terminal cytoplasmic domains [11]. The full (long)
Protective Effects of Many Citrus Flavonoids on Cartilage Degradation Process  [PDF]
Lucia Crascì, Annamaria Panico
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2013, DOI: 10.4236/jbnb.2013.43035
Abstract: The objective of this study was to investigate the effects of many citrus flavanones, such as neoeriocitrin, naringin and neohesperidin, in cartilage degradation. Degenerative joint disease involved degradation of joints, including articular cartilage and subchondral bone. When bone surfaces become less well protected by cartilage, bone may be exposed and damaged. The degradation cartilage is mediated by alteration of the balance between anabolic and catabolic processes, changes in proteolytic enzyme activity, mechanical disruption of the cartilage extracellular matrix (ECM), or a combination of these processes. We examine the capability of neoeriocitrin, naringin and neohesperidin, to inhibit metalloproteinase (MMP)-13, collagenase involved in degradation of cartilage matrix components. Also, we assay the flavonoids effect on reducing of Glycosaminoglycans (GAGs) release, and restore Nitric oxide (NO) levels in explant of human articular cartilage. Our results suggest that neoeriocitrin, naringin and neohesperidin are a potential therapeutic agent to protect cartilage tissue.
Strategies, Performances and Profiling of a Sample of U.S. Universities in 2012  [PDF]
Angela Besana, Annamaria Esposito
Open Journal of Applied Sciences (OJAppS) , 2015, DOI: 10.4236/ojapps.2015.53008
Abstract: The global economic crisis is affecting performances of not-for-profits. At the same time donors are targeted by a pressing good-cause related marketing, so that the competition for philanthropy is particularly keen. U.S. universities can be public, not-for-profit and for-profit. U.S. not-for-profit universities are confronted with different marketing, fundraising and revenue diversification. Above all, marketing concerns customers and their segmentation and their purchasing-power exploitation; fundraising aims to gain the trustworthiness of donors, instead. The aim of this paper is the analysis of the revenue diversification of a sample of 100 U.S. not-for-profit universities according to IRS (Internal Revenue Service) Forms. These 100 U.S. universities had the highest 2012’s revenues for the Guidestar ranking (www.guidestar.org). The cluster analysis gives evidence that the highest gain and the highest solvency are both connected with the implementation of revenue diversification for one profile. The most crowded cluster is the Marketing Expert with the second highest gain.
Supporti tecnologici alla collaborazione mediata dal computer: i collaboration script
Marcello Molino
Form@re : Open Journal per la Formazione in Rete , 2013,
Abstract: La collaborazione di gruppo è un processo complesso e non spontaneo, specialmente quando si svolge attraverso la mediazione del computer. La ricerca nel campo del Computer-Supported Collaborative Learning (CSCL) ha sviluppato vari supporti tecnologici allo scopo di aiutare e guidare verso l’efficacia i processi collaborativi. Questi supporti, ai quali ci si riferisce con il termine di collaboration script, favoriscono e facilitano i processi sociali e cognitivi dell’apprendimento collaborativo strutturando le interazioni tra i partecipanti.
The dynamics of maps tangent to the identity and with non-vanishing index
Laura Molino
Mathematics , 2005,
Abstract: Let f be a germ of holomorphic self-map of C^2 at the origin O tangent to the identity, and with O as a non-dicritical isolated fixed point. A parabolic curve for f is a holomorphic f-invariant curve, with O on the boundary, attracted by O under the action of f. It has been shown that if the characteristic direction [v] has residual index not belonging to Q^+, then there exist parabolic curves for f tangent to [v]. In this paper we prove, with a different method, that the conclusion still holds just assuming that the residual index is not vanishing (at least when f is regular along [v]).
Adjuvant chemotherapy of pT1a and pT1b breast carcinoma: results from the NEMESI study
Stefania Gori, Matteo Clavarezza, Salvatore Siena, Jennifer Foglietta, E Tarenzi, Monica Giordano, Annamaria Molino, Claudio Graiff, Vittorio Fusco, Oscar Alabiso, Editta Baldini, Teresa Gamucci, Giuseppe Altavilla, Davide Dondi, Marco Venturini
BMC Cancer , 2012, DOI: 10.1186/1471-2407-12-158
Abstract: To evaluate the variables that determined the choice of adjuvant chemotherapy and the type of chemotherapy delivered in pT1a-pT1b BC, we analysed the small tumours enrolled in the NEMESI study.Out of 1,894 patients with pathological stage I-II BC enrolled in NEMESI, 402 (21.2%) were pT1a-pT1b. Adjuvant chemotherapy was delivered in 127/402 (31.59%). Younger age, grading G3, high proliferative index, ER-negative and HER2-positive status were significantly associated with the decision to administer adjuvant chemotherapy. An anthracycline without taxane regimen was administered in 59.1% of patients, anthracycline with taxane in 24.4%, a CMF-like regimen in 14.2% and taxane in 2.4%. Adjuvant chemotherapy was administered in 88.4% triple-negative and 73.46% HER2-positive pT1a-pT1b BC. Adjuvant trastuzumab was delivered in 30/49 HER2-positive BC (61.2%).Adjuvant chemotherapy was delivered in 31.59% T1a-pT1b BC treated at 63 Italian oncological centres from January 2008 to June 2008. The choice to deliver chemotherapy was based on biological prognostic factors. Anthracycline-based chemotherapy was administered in 83.5% patients.
The Evolutionary Processes of Canine Coronaviruses
Annamaria Pratelli
Advances in Virology , 2011, DOI: 10.1155/2011/562831
Abstract: Since the first identification of the virus in 1971, the disease caused by canine coronavirus (CCoV) has not been adequately investigated, and the role that the virus plays in canine enteric illness has not been well established. Only after the emergence in 2002 of SARS in human has new attention been focused on coronaviruses. As a consequence of the relatively high mutation frequency of RNA-positive stranded viruses, CCoV has evolved and, with the biomolecular techniques developed over the last two decades, new virus strains, serotypes, and subtypes have been identified in infected dogs. Considering the widespread nature of CCoV infections among dog populations, several studies have been carried out, focusing upon the epidemiological relevance of these viruses and underlining the need for further investigation into the biology of CCoVs and into the pathogenetic role of the infections. This paper reports the evolutionary processes of CCoVs with a note onto recent diagnostic methods. 1. Coronaviruses: Genome and Structure Coronaviruses (CoVs), a genus in the Coronaviridae family, order Nidovirales, are large, enveloped, RNA viruses that cause highly prevalent diseases in humans and domestic animals. CoVs are spherical enveloped particles about 100–120?nm in diameter with a capped, polyadenylated single-stranded, positive-sense genomic RNA 27.6 to 31?kb in length, the largest known RNA virus genome. The 5′ end of the genome consists of a 65 to 98?nt sequence, termed the leader RNA, that is also present at the 5′ end of all subgenomic mRNAs. An untranslated region (UTR) of 200 to 400?nts follows this leader sequence. At the 3′ end of the RNA genome is another UTR of 200 to 500?nts followed by a poly(A) sequence of variable length. Both 5′- and 3′-UTRs are important for RNA replication and transcription. The remaining genomic sequence includes different open reading frames (ORFs) which differ markedly among coronaviruses in number, nt sequence, genes order, and in method of expression. At the 5′ end of each gene, all CoVs have a common intergenic sequence of about 7 bases which is essential for the formation of subgenomic RNAs [1]. The first two-thirds of the genome consists of two partially overlapping ORFs, ORF1a and ORF1b. These ORFs are translated into a polyprotein which is the precursor both of the viral RNA-dependent RNA polymerase and of proteases. The one-third in the 3′ end of the genome contains ORFs encoding for the major structural proteins, spike (S), envelope (E), membrane (M), and nucleocapsid (N) proteins. These ORFs are interspersed with
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