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Search Results: 1 - 10 of 16720 matches for " Anna-Christina; "
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Swedish advanced home care: organizational structure and implications of adopting this care model in Brazilian health care system
Perroca, Marcia Galan;Ek, Anna-Christina;
Revista Latino-Americana de Enfermagem , 2004, DOI: 10.1590/S0104-11692004000600002
Abstract: the purpose of this paper was to describe the organization of the advanced home care program provided in a region of sweden and to discuss some benefits and implications of this model adoption in brazilian settings. data triangulation as interview, observation and questionnaire was used. thirty two professionals participated in this study. the organizational structure, working method, home visits, and related health resources were described. the investigated model presented both clear effectiveness and versatility; therefore feasible to be adopted in brazilian settings improving their population health care. doubtless, the improvement of life quality and security are the best benefits this model of care can provide.
Sensitivity to heat in MS patients: a factor strongly influencing symptomology - an explorative survey
Gullvi Flensner, Anna-Christina Ek, Olle S?derhamn, Anne-Marie Landtblom
BMC Neurology , 2011, DOI: 10.1186/1471-2377-11-27
Abstract: A cross-sectional designed survey was undertaken. A questionnaire was sent to MS-patients with an Expanded Disability Status Score (EDSS) in the interval of 0-6.5 and who were between 20 and 65 years of age, living in an eastern region of Sweden (n = 334). Besides occurrence of heat sensitivity (Yes/No) and corresponding questions, the Fatigue Severity Scale (FSS), the MS-related symptom checklist and the Perceived Deficit Questionnaire (PDQ) were included. Data were analysed in relation to data level using Chi-square, Mann Whitney U-test, and Student's t-test. Pearson's and Spearman's correlations were calculated. In the logistic regression analyses (enter) dichotomized MS-symptoms were used as dependent variables, and EDSS, disease-course, time since onset, heat-sensitivity, age and sex (female/male) were independent variables. In the linear regression analyses, enter, mean FSS and summarized PDQ were entered as dependent variables and EDSS, disease-course, time since onset, heat sensitivity, age and sex (female/male) were independent variables.Of the responding patients (n = 256), 58% reported heat sensitivity. The regression analyses revealed heat sensitivity as a significant factor relating not only to fatigue (p < 0.001), but also to several other common MS symptoms such as pain (p < 0.001), concentration difficulties (p < 0.001), and urination urgency (p = 0.009).Heat sensitivity in MS patients is a key symptom that is highly correlated with disabling symptoms such as fatigue, pain, concentration difficulty and urination urgency.Between 60 and 80% of individuals diagnosed with the neurological disease Multiple Sclerosis (MS) have been reported as being sensitive to environmental heat [1]. In a multinational Internet-based survey of MS patients (n = 2 529), 70% reported that high temperatures worsened their MS [2]. Clinically, increased body temperature can result in increased neurological signs and MS symptoms. Blurred vision, known as Uthoff's phenomenon and
Health-related quality of life after vertebral or hip fracture: a seven-year follow-up study
Inger Hallberg, Margareta Bachrach-Lindstr?m, Staffan Hammerby, G?ran Toss, Anna-Christina Ek
BMC Musculoskeletal Disorders , 2009, DOI: 10.1186/1471-2474-10-135
Abstract: Ninety-one women examined two years after a low-energy vertebral or hip fracture were invited to a new examination seven years after the diagnosis. HRQOL was examined using the SF-36 questionnaire and was compared with an age and sex-matched reference group. Physical function was assessed using tests and questionnaires. Bone mineral density was measured. Radiographs of the spine were evaluated using the visual semiquantitative technique. A longitudinal and cross-sectional design was used in this study. Statistical analyses included descriptive statistics, Student's t-tests, ANCOVA, and partial correlation.Sixty-seven women participated. In the 42 women (mean age 75.8, SD 4.7) with vertebral fracture as inclusion fracture, bodily pain had deteriorated between two and seven years and might be explained by new fracture. Remaining pronounced reduction of HRQOL was seen in all domains except general health and mental health at seven-year follow-up in women with vertebral fractures compared to the reference group (p < 0.05). All 25 women (mean age 75.0, SD 4.7) with hip fracture as inclusion fracture had no significant changes in HRQOL between two and seven years and did not differ from the reference group regarding HRQOL after seven years. The vertebral group had significantly lower values for bodily pain, vitality, role-emotional function and mental health compared to the hip group. HRQOL showed a positive relationship between physical activity, static balance and handgrip strength.The long-term reduction of HRQOL in women with vertebral fracture emerged clearly in this study. The relationships between HRQOL and physical performance in women with vertebral and hip fracture raise questions for more research.The global burden of osteoporosis includes considerable numbers of fractures, morbidity, mortality and expenses, due mainly to vertebral, hip and forearm fractures [1-4]. Osteoporosis causes no symptoms except for fractures and their complications. All fractures may l
A striving for independence: a qualitative study of women living with vertebral fracture
Inger Hallberg, Anna-Christina Ek, G?ran Toss, Margareta Bachrach-Lindstr?m
BMC Nursing , 2010, DOI: 10.1186/1472-6955-9-7
Abstract: The study design was qualitative. Semi-structured interviews were conducted with ten Swedish women during 2008. Data were analysed using qualitative inductive content analysis.The findings of this study revealed three themes related to the influence on HRQOL and daily life: A threatened independence, i.e. back pain, anxiety, negative impact on self-image and consequences in daily life; Strategies for maintaining independence, i.e. coping, self-care and support; and The importance of maintaining independence, i.e. the ability to perform everyday activities, social interaction and having something meaningful to do. The women were striving for independence or maintaining their independence by trying to manage different types of symptoms and consequences in different ways.HRQOL and daily life were strongly affected in a negative way by the impact of the vertebral fracture. Information from this study may provide new knowledge and understanding of the women's experiences of living with vertebral fracture from an insider's point of view in order to obtain a deeper understanding of the women's everyday life. However, further evaluation is still needed in larger study groups.Vertebral fracture resulting from osteoporosis is very common, and is the most frequent osteoporotic fracture in developed countries [1,2]. Osteoporosis is defined as a systematic skeletal disease characterized by low bone mass and the microarchitectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture [3]. Osteoporosis causes no symptoms besides fractures and their complications. Osteoporosis-related fractures, particularly of the vertebrae and hip, may lead to impaired health-related quality of life (HRQOL) [4-8].During recent decades, cross-sectional studies [9-11] and some follow-up studies [12-14] after vertebral fracture have reported that HRQOL is severely impaired. Few studies examine what it means to live with a vertebral fracture; one de
Quantitative PCR Reveals Strong Spatial and Temporal Variation of the Wasting Disease Pathogen, Labyrinthula zosterae in Northern European Eelgrass (Zostera marina) Beds
Anna-Christina Bockelmann, Verena Tams, Jana Ploog, Philipp R. Schubert, Thorsten B. H. Reusch
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0062169
Abstract: Seagrass beds are the foundation species of functionally important coastal ecosystems worldwide. The world’s largest losses of the widespread seagrass Zostera marina (eelgrass) have been reported as a consequence of wasting disease, an infection with the endophytic protist Labyrinthula zosterae. During one of the most extended epidemics in the marine realm, ~90% of East and Western Atlantic eelgrass beds died-off between 1932 and 1934. Today, small outbreaks continue to be reported, but the current extent of L. zosterae in European meadows is completely unknown. In this study we quantify the abundance and prevalence of the wasting disease pathogen among 19 Z. marina populations in northern European coastal waters, using quantitative PCR (QPCR) with primers targeting a species specific portion of the internally transcribed spacer (ITS1) of L. zosterae. Spatially, we found marked variation among sites with abundances varying between 0 and 126 cells mg?1 Z. marina dry weight (mean: 5.7 L. zosterae cells mg?1 Z. marina dry weight ±1.9 SE) and prevalences ranged from 0–88.9%. Temporarily, abundances varied between 0 and 271 cells mg?1 Z. marina dry weight (mean: 8.5±2.6 SE), while prevalences ranged from zero in winter and early spring to 96% in summer. Field concentrations accessed via bulk DNA extraction and subsequent QPCR correlated well with prevalence data estimated via isolation and cultivation from live plant tissue. L. zosterae was not only detectable in black lesions, a sign of Labyrinthula-induced necrosis, but also occurred in green, apparently healthy tissue. We conclude that L. zosterae infection is common (84% infected populations) in (northern) European eelgrass populations with highest abundances during the summer months. In the light of global climate change and increasing rate of marine diseases our data provide a baseline for further studies on the causes of pathogenic outbreaks of L. zosterae.
Current European Labyrinthula zosterae Are Not Virulent and Modulate Seagrass (Zostera marina) Defense Gene Expression
Janina Brakel, Franziska Julie Werner, Verena Tams, Thorsten B. H. Reusch, Anna-Christina Bockelmann
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0092448
Abstract: Pro- and eukaryotic microbes associated with multi-cellular organisms are receiving increasing attention as a driving factor in ecosystems. Endophytes in plants can change host performance by altering nutrient uptake, secondary metabolite production or defense mechanisms. Recent studies detected widespread prevalence of Labyrinthula zosterae in European Zostera marina meadows, a protist that allegedly caused a massive amphi-Atlantic seagrass die-off event in the 1930's, while showing only limited virulence today. As a limiting factor for pathogenicity, we investigated genotype×genotype interactions of host and pathogen from different regions (10–100 km-scale) through reciprocal infection. Although the endophyte rapidly infected Z. marina, we found little evidence that Z. marina was negatively impacted by L. zosterae. Instead Z. marina showed enhanced leaf growth and kept endophyte abundance low. Moreover, we found almost no interaction of protist×eelgrass-origin on different parameters of L. zosterae virulence/Z. marina performance, and also no increase in mortality after experimental infection. In a target gene approach, we identified a significant down-regulation in the expression of 6/11 genes from the defense cascade of Z. marina after real-time quantitative PCR, revealing strong immune modulation of the host's defense by a potential parasite for the first time in a marine plant. Nevertheless, one gene involved in phenol synthesis was strongly up-regulated, indicating that Z. marina plants were probably able to control the level of infection. There was no change in expression in a general stress indicator gene (HSP70). Mean L. zosterae abundances decreased below 10% after 16 days of experimental runtime. We conclude that under non-stress conditions L. zosterae infection in the study region is not associated with substantial virulence.
Volatile Emissions from Compressed Tissue
Francesca Dini, Rosamaria Capuano, Tillan Strand, Anna-Christina Ek, Margareta Lindgren, Roberto Paolesse, Corrado Di Natale, Ingemar Lundstr?m
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0069271
Abstract: Since almost every fifth patient treated in hospital care develops pressure ulcers, early identification of risk is important. A non-invasive method for the elucidation of endogenous biomarkers related to pressure ulcers could be an excellent tool for this purpose. We therefore found it of interest to determine if there is a difference in the emissions of volatiles from compressed and uncompressed tissue. The ultimate goal is to find a non-invasive method to obtain an early warning for the risk of developing pressure ulcers for bed-ridden persons. Chemical analysis of the emissions, collected in compresses, was made with gas-chromatography – mass spectrometry and with a chemical sensor array, the so called electronic nose. It was found that the emissions from healthy and hospitalized persons differed significantly irrespective of the site. Within each group there was a clear difference between the compressed and uncompressed site. Peaks that could be certainly deemed as markers of the compression were, however, not identified. Nonetheless, different compounds connected to the application of local mechanical pressure were found. The results obtained with GC-MS reveal the complexity of VOC composition, thus an array of non-selective chemical sensors seems to be a suitable choice for the analysis of skin emission from compressed tissues; it may represent a practical instrument for bed side diagnostics. Results show that the adopted electronic noses are likely sensitive to the total amount of the emission rather than to its composition. The development of a gas sensor-based device requires then the design of sensor receptors adequate to detect the VOCs bouquet typical of pressure. This preliminary experiment evidences the necessity of studies where each given person is followed for a long time in a ward in order to detect the insurgence of specific VOCs pattern changes signalling the occurrence of ulcers.
Lyman-alpha Forest Tomography from Background Galaxies: The First Megaparsec-Resolution Large-Scale Structure Map at z>2
Khee-Gan Lee,Joseph F. Hennawi,Casey Stark,J. Xavier Prochaska,Martin White,David J. Schlegel,Anna-Christina Eilers,Andreu Arinyo-i-Prats,Nao Suzuki,Rupert A. C. Croft,Karina I. Caputi,Paolo Cassata,Olivier Ilbert,Bianca Garilli,Anton M. Koekemoer,Vincent Le Brun,Olivier Le Fèvre,Dario Maccagni,Peter Nugent,Yoshiaki Taniguchi,Lidia A. M. Tasca,Laurence Tresse,Gianni Zamorani,Elena Zucca
Physics , 2014, DOI: 10.1088/2041-8205/795/1/L12
Abstract: We present the first observations of foreground Lyman-$\alpha$ forest absorption from high-redshift galaxies, targeting 24 star-forming galaxies (SFGs) with $z\sim 2.3-2.8$ within a $5' \times 15'$ region of the COSMOS field. The transverse sightline separation is $\sim 2\,h^{-1}\mathrm{Mpc}$ comoving, allowing us to create a tomographic reconstruction of the 3D Ly$\alpha$ forest absorption field over the redshift range $2.20\leq z\leq 2.45$. The resulting map covers $6\,h^{-1}\mathrm{Mpc} \times 14\,h^{-1}\mathrm{Mpc}$ in the transverse plane and $230\,h^{-1}\mathrm{Mpc}$ along the line-of-sight with a spatial resolution of $\approx 3.5\,h^{-1}\mathrm{Mpc}$, and is the first high-fidelity map of large-scale structure on $\sim\mathrm{Mpc}$ scales at $z>2$. Our map reveals significant structures with $\gtrsim 10\,h^{-1}\mathrm{Mpc}$ extent, including several spanning the entire transverse breadth, providing qualitative evidence for the filamentary structures predicted to exist in the high-redshift cosmic web. Simulated reconstructions with the same sightline sampling, spectral resolution, and signal-to-noise ratio recover the salient structures present in the underlying 3D absorption fields. Using data from other surveys, we identified 18 galaxies with known redshifts coeval with our map volume enabling a direct comparison to our tomographic map. This shows that galaxies preferentially occupy high-density regions, in qualitative agreement with the same comparison applied to simulations. Our results establishes the feasibility of the CLAMATO survey, which aims to obtain Ly$\alpha$ forest spectra for $\sim 1000$ SFGs over $\sim 1 \,\mathrm{deg}^2$ of the COSMOS field, in order to map out IGM large-scale structure at $\langle z \rangle \sim 2.3$ over a large volume $(100\,h^{-1}\mathrm{Mpc})^3$.
Escritores-fantasma e comércio de trabalhos científicos na internet: a ciência em risco
Grieger, Maria Christina Anna;
Revista da Associa??o Médica Brasileira , 2007, DOI: 10.1590/S0104-42302007000300023
Abstract: frauds in scientific production are not a rare phenomenon, even in the medical field. among these frauds are some types of authorship misconduct, such as plagiarism and ghostwriting sponsored by pharmaceutical industries. another type of misconduct, which is particularly detrimental to science, is the ecommerce of scientific works, which has been growing and frequently shown in the press. objective: to analyze the e-commerce of scientific papers and the means by which these services are offered. methods: eighteen brazilian web sites that offer elaboration of scientific papers were selected. a request for the elaboration of a final essay for a forged post-graduatie course was sent to each of them. the research requested had already been completed, consequently technical, ethical and bibliographical characteristics were already known to the author. results: ten enterprises accepted the order and, except for one, they have not objected to the conditions imposed: field research, approval by an ethics committee on research and use of the vancouver norms. six have not replied and two have not accepted the order alleging that they had no co-workers available for the task. conclusions: e-commerce of scientific papers is a fact which can negatively interfere in the ethical, scientific and professional development of graduate and post-graduate students, as well as in scientific production by adulterating data and information found in literature. a new approach is recommended, especially when evaluating final essays.
Authorship: an ethical dilemma of science
Grieger, Maria Christina Anna;
Sao Paulo Medical Journal , 2005, DOI: 10.1590/S1516-31802005000500008
Abstract: context and objective: the scientific and technological progress that has taken place since the 1960s has brought an ever-growing volume of scientific research, and inflation in co-authorship. over this period, it has been observed that an increasing number of publications have listed authors or co-authors whose participation in the published research was minimal or even nonexistent. the objective of this work was to analyze reports in the literature regarding misconduct in authorship: its types, chief causes, consequences and ethical guidelines; and to outline proposals for greater ethical commitment in scientific publication. design and setting: narrative review undertaken at faculdade de medicina de itajubá, minas gerais, brazil. methods: analysis of publications about authorship using the medline, lilacs and scielo databases. results and conclusions: frequent types of misconduct were gift authorship and divided and redundant publications. the chief causes of these practices seem to be the pressure exerted by academia and the desire for social and professional development. such factors have brought an increase in unethical behavior. this bias in science continues despite the criteria defined by the international committee of medical journal editors, the vancouver group. recommendations: various actions are proposed for educational institutions, research development agencies, regulatory agencies and professional associations. the aim is to establish an evaluation policy that gives primacy to the quality of publications and sets ethical principles for scientific research.
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