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Search Results: 1 - 10 of 13704 matches for " Anna Oczkowska "
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Homocysteine and asymmetric dimethylarginine concentrations in the plasma of Alzheimer’s disease patients with varying degrees of dementia  [PDF]
Jolanta Dorszewska, Jolanta Florczak-Wyspiańska, Anna Oczkowska, Mateusz Dezor, Micha? Prendecki, Wojciech Kozubski
Advances in Alzheimer's Disease (AAD) , 2013, DOI: 10.4236/aad.2013.21001

Alzheimer’s disease (AD) is accompanied by elevated levels of homocysteine (Hcy). Homocysteine may induce elevated concentration of asymmetric dimethylarginine (ADMA). Both Hcy and ADMA are the amino acids thought to represent risk factors of vascular diseases. Studies were conducted on the plasma levels of Hcy and methionine (Met), estimated by HPLC with electrochemical detection, as well as on levels of ADMA and arginine (Arg), estimated by HPLC with fluorescent detection, in the AD patients with benign through to severe dementia estimated by MMSE scale and in a control group. The studies disclosed elevated levels of Hcy and ADMA in AD (Hcy, p < 0.001) as compared to controls, as well as in subjects older than 60 years of age (Hcy, p < 0.01). The AD patients with severe dementia have shown elevated levels of Hcy (p < 0.05) as compared to the patients with moderate dementia. The concentration of Metand Arg showed a downward trend in AD patientswith severe dementia. The highest levels of ADMA have been demonstrated in AD patients in the early stages of the disease. In parallel, in AD with varying degrees of dementia and subjects older than 60 years of age a disturbed turnover was observed of Hcy to Met and of Arg to ADMA. Similarly to Hcy, ADMA seems to be a potential risk factor of AD and important factor for progress of dementia.

Mutations of TP53 Gene and Oxidative Stress in Alzheimer’s Disease Patients  [PDF]
Jolanta Dorszewska, Agata Ró?ycka, Anna Oczkowska, Jolanta Florczak-Wyspiańska, Micha? Prendecki, Mateusz Dezor, Izabela Postrach, Pawe? P. Jagodzinski, Wojciech Kozubski
Advances in Alzheimer's Disease (AAD) , 2014, DOI: 10.4236/aad.2014.31004
Abstract: Alzheimer’s disease (AD) leads to the generation of β-amyloid (Aβ), which may damage DNA and thus lead to apoptosis induction by the p53 pathway. Dysfunction of the p53 protein may then be connected with the development of AD. Studies were conducted on 28 AD patients and 30 non-AD controls. Analysis of TP53 mutations in exon 7 was performed on DNA isolated from whole blood and biochemical parameters in the peripheral lymphocytes of these individuals. Our study showed a silent mutation TP53 C708T (21%) [p < 0.05] and a missense mutation TP53 C748A (4%) only in the AD patients. Moreover, in AD patients with the TP53 C748A mutation, the level of 8-oxo-2’- deoxyguanosine (8-oxo2dG) was more than 5 times higher than the average level in this study group. In AD patients with the wild-type TP53 gene, the level of 8-oxo2dG was correlated with the level of protein p53 (R = +0.7388, p < 0.05). The level of the oxoguanine DNA glycosylase 1 (OGG1) protein was similar in AD patients with the silent mutation and the wild-type gene TP53 (p < 0.05) and lower than in the controls. It appears that mutations in exon 7 of TP53 (C748A, C708T) may be associated with pathogenesis of AD.
Interactive Vision and Experimental Traditions: How to Frame the Relationship  [PDF]
Anna Estany
Open Journal of Philosophy (OJPP) , 2013, DOI: 10.4236/ojpp.2013.32046
Abstract: In recent decades, the cognitive view has had a considerable impact on the philosophy of science, and two reasons can for this be identified. First, philosophers have increasingly tended towards naturalistic approaches, as opposed to proposals that are more a priori. Second, the cognitive sciences underwent considerable development in the second half of the twentieth century. Motivated by the cognitive view in the philosophy of science, and within a naturalistic framework, the aim of this paper is to analyze the relationship between two pairs of views. On the one hand, I consider the theoretical and experimental traditions; and on the other, I examine the views of pure and interactive vision. The two pairs belong to two independent debates; one in the philosophy of science (theoretical vs. experimental traditions) and the other in cognitive psychology (pure vs. interactive vision). Theoretical traditions correspond to a conception of science according to which the goal of scientific practice is to formulate theories that represent the world, and in them experiments play only an instrumental role that is always subsidiary to theory. The model of science promoted in the program of logical empiricism is a good example of such a tradition. Experimental traditions, in contrast, challenge that conception of science by attributing a more important role to experimentation, which is said to provide its own path to knowledge.
A pilot study, a specially designed pillow may prevent developmental plagiocephaly by reducing pressure from the infant head  [PDF]
Anna Ohman
Health (Health) , 2013, DOI: 10.4236/health.2013.56A2006

Developmental plagiocephaly (DP) has been an increasing problem since the successful “back to sleep campaign”. The referrals for DP have increased by >400% during the years 2004 to 2008. Many infants spend less time in the prone position nowadays and some of the risk factors for DP are as follows: less than 3 times per day for the tummy time, torticollis and slow achievement of motor milestones. There is a need for better information to the parents but also for other strategies to prevent DP. The aim of this study was to investigate the effect of a special pillow and thus to reduce pressure on the infant head. Method: infants aged zero to two months were included in the study. They were randomized to either intervention group or control group. Head shape was investigated on two occasions, on the second occasion motor development, mobility and muscle function of the neck were also investigated. The parents were asked about tummy time and sleep position. All infants were investigated by the same physical therapist, blinded to group belonging. Result: seven infants had CVAI >3.5 on the last assessment, five of these had not used any method to reduce pressure. Fishers exact test showed a tendency where infants with reduced pressure on the head had less DP (P 0.08). Paired t test showed significant decrease in CVAI for the infants who had had reduced pressure on the head (P 0.01). Among these infants the CVAI was zero for 47% in the last assessment. For the infants who had not had a reduction of pressure on the head, there was no indication of a decrease of CVAI (P 0.45), and only 12% of these infants had a CVAI that was zero in the last assessment. Conclusion: this pilot study shows that a specially designed pillow may prevent DP in young infants. However, a larger sample is needed to confirm or disprove this. The study is planned to go on until there are 200 participants.

Models, AmI-Creator and A-Methodology for Ambient Intelligence Environments  [PDF]
Anna Chambers
Journal of Software Engineering and Applications (JSEA) , 2014, DOI: 10.4236/jsea.2014.74030

The current paper introduces an approach to a development of Ambient Intelligence domain-based software systems from scratch. The presented approach is based on models. The paper also presents the domain-related models expressing different levels of abstractions and stages of the development. The approach refers to a Model-Driven Development of Ambient Intelligence which was suggested at AmI-07-Ambient Intelligence conference. The approach is presented as a standard with its feasible realization. It starts from modeling of a content of the future AmI-dedicated software system and concludes by mapping the graphical concepts into a final code. A process proving feasibility and correctness of the approach is provided through a dedicated research methodology. Its process comprises an identification of needs in a speedy development of the systems. It is followed by studying of the currently available techniques capable of supporting the development and an experimenting with them. It continues by finding a solution, verified by its validation and concludes by an identification of the further perspectives. The developed approach presents a common way of a communication amongst stakeholders participating in creating of AmI-based environments. Such communication involves the notations of AmI-Creator—a Domain-Specific Language of Ambient Intelligence domain. Every part of DSL corresponds to a demonstration of A-methodology expressing a step-by-step guidance for the development. The methodology comprises two parts dedicated to providing semantics for DSL through studying of Ambient Intelligence domain ontology; and development of actual environments. A validity of the working proposition is confirmed by three examples. The further challenges refer to an extension of the presented work by other frameworks and expansion to a development of different domains with complex organizations.

A specially designed pillow may be used as treatment for young infants with developmental plagiocephaly  [PDF]
Anna ?hman
Health (Health) , 2013, DOI: 10.4236/health.2013.512280

Developmental plagiocephaly has increased since the back to sleep campaign and is nowadays a rather common condition in infants. Prevention is the best way to decrease this problem, therefore, tools for treatment are needed. This case description of two children who dropped out from a study of a specially designed pillow indicates that the Mimos pillow may work as the treatment in young infants with developmental plagiocephaly.

Beighton Scores for Healthy Infants at the Age of Three Months  [PDF]
Anna ?hman
Open Journal of Therapy and Rehabilitation (OJTR) , 2015, DOI: 10.4236/ojtr.2015.32006
Abstract: Objective: To investigate the incidence of hypermobility in infants at the age of three months. Method: Eighty-one healthy infants aged three months were examined using the Beighton score. The spine was excluded for practical reasons; due to this the highest possible Beighton score for the participants in this study was 8. Also ankle dorsiflexion and the big toe were examined. Results: The mean score on the Beighton scale was 2.7; median was 2.0 and the range was 0 to 6. Almost half of the infants scored at least 4 on the Beighton scale. T test showed no gender difference. Neither was there any difference between right and left sides. Conclusions: Infants at the age of three months have high mobility in the distal joints, ankle dorsiflexion, thumb and little finger. It is rare to find hypermobility in elbows and knees at this age.
A Craniometer with a Headband Can Be a Reliable Tool to Measure Plagiocephaly and Brachycephaly in Clinical Practice  [PDF]
Anna ?hman
Health (Health) , 2016, DOI: 10.4236/health.2016.812128
Abstract: Objective: The aim of the study was to determine the intra- and inter-reliability for measuring infants with plagiocephaly and brachycephaly with a craniometer when using a marked headband as landmarks. Subjects: Six physiotherapists and eight infants participated in the study. Methods: The physiotherapists measured all infants twice; each infant was measured with the same headband and craniometer. The physiotherapists were blinded to measurements carried out by their colleagues. The infants with their parents changed places in the room to minimize the possibility that the physiotherapists would remember their first measurements of any infant. Results: There was a high intra- and inter-reliability, for intra-reliability ICC 0.96 to 0.99 and for inter-reliability ICC 0.98. Conclusion: It is possible to achieve a high intra- and inter-reliability when using a headband and craniometer when measuring cranial vault asymmetry for plagiocephaly and cephalic ratio for brachycephaly.
The Role of an Implicit Assumption of Causality in the Methodology of Empirical Research  [PDF]
Anna Storozhuk
Open Journal of Philosophy (OJPP) , 2018, DOI: 10.4236/ojpp.2018.83022
Abstract: The purpose of the article is to point out the causal ladenness of empirical data in the social sciences. This is a kind of theory ladenness, representing implicit assumptions about the deterministic nature of political processes. The nonlinear and chaotic nature of social phenomena requires the collection of data not only about the current state of the system, but also about the evolution of the system. Using an example, we illustrate that the conclusions made on the basis of information about the final state can be very different from the conclusions made on the basis of monitoring the dynamics of the system. Low-importance factors can have big consequences in a chaotic case and, vice versa, there takes place fading of causality: considerable efforts can lead to more than modest results. For the successful management of political life, it is important to be able to identify the impacts that lead to great consequences.
Forming Stages of Polycrystalline TiN Films Depending on the Nitrogen Concentration in Mixed Gas  [PDF]
Anna L. Kameneva
Materials Sciences and Applications (MSA) , 2011, DOI: 10.4236/msa.2011.21002
Abstract: The influence of nitrogen concentration in mixed gas on temperature conditions, structure and phase composition of the TiN film deposited by arc spraying has been investigated. By electron microscopic investigations and X-ray diffraction phase analysis was recognized forming stages and structuring process of the film with main cubic phase (111) TiN. It was discovered that forming stages and process of structuring of ion-plasma TiN films are affected by both film temperature and its rate of heating.
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