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Search Results: 1 - 10 of 14237 matches for " Anna Karlsson "
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Exploring the Implementation of Individual Care Plans in Relation to Characteristics of Staff  [PDF]
Anna Condelius, Ulf Jakobsson, Staffan Karlsson
Open Journal of Nursing (OJN) , 2016, DOI: 10.4236/ojn.2016.68062
Abstract: The aim was to explore the implementation of individual care plans in municipal elderly care in relation to characteristics of staff. Data regarding characteristics of staff were derived through a questionnaire distributed to all staff working in the care for older people, (N = 908, n = 245) in four municipalities in Sweden. The number of care plans established during a one-year period was collected through a contact person in each municipality. In total 47 individual care plans were established during the study year. Significantly more staff in the municipality that had the most number of established individual care plans agreed that there had been sufficient education (p = 0.017), sufficient time (p = 0.002) and routines established regarding individual care plans (p = 0.014) and had a significantly better job satisfaction (p = 0.001), compared to staff in the other municipalities. Implementation leaders may need to take the working conditions and the perception of available resources among staff into consideration in the on-going process of implementing individual care plans.
Genre, hypertext och etnografiskt perspektiv?
Anna-Malin Karlsson
Human IT: Tidskrift f?r Studier av IT ur ett Humanvetenskapligt Perspektiv , 2003,
Abstract: How and why do the humanities and information technology intersect? Should the humanities accommodate the so-called information society? What is the role of the humanities in relation to nanotechnology, virtual worlds and cmputer games? Does it make sense to build cultural laboratories in the computer? Is there a risk in adopting a non-textual and creative approach to humanities research? What is the responsibility of the humanities in the twenty-first century? These are some of the issues explored in this article. A broad disciplinary context and a number of case studies are employed to sketch a rough outline of an emerging field. It is argued that it is important to both relate to the technology critically and to actively engage in exploring it. Technology is not just a tool used to solve problems but also a cultural and communicative arena. This arena might be seen as a cultural laboratory that can be used in humanities research. In the article, this model is presented as well as a real-world humanities laboratory (HUMlab). But neither virtual nor real laboratories can replace what is most important for the further development of this field, namely that we as humanities scholars allow ourselves to become interested in the technologies that increasingly permeate our lives and our society.
The two neutrophil members of the formylpeptide receptor family activate the NADPH-oxidase through signals that differ in sensitivity to a gelsolin derived phosphoinositide-binding peptide
Huamei Fu, Lena Bj?rkman, Paul Janmey, Anna Karlsson, Jennie Karlsson, Charlotta Movitz, Claes Dahlgren
BMC Cell Biology , 2004, DOI: 10.1186/1471-2121-5-50
Abstract: We report that a cell permeable ten amino acid peptide (PBP10) derived from the phosphatidylinositol 4,5-bisphosphate (PIP2) binding region of gelsolin (an uncapper of actin filaments) blocks granule mobilization as well as secretion of oxygen radicals. The inhibitory effect of PBP10 is, however, receptor specific and affects the FPRL1-, but not the FPR-, induced cellular response. The transient rise in intracellular calcium induced by the active receptors is not affected by PBP10, suggesting that the blockage occurs in a parallel, novel signaling pathway used by FPRL1 to induce oxygen radical production and secretion. Also the FPR can activate neutrophils through a PBP10-sensitive signaling pathway, but this signal is normally blocked by the cytoskeleton.This study demonstrates that the two very closely related chemoattractant receptors, FPR and FPRL1, use distinct signaling pathways in activation of human neutrophils. The PIP2-binding peptide PBP10 selectively inhibits FPRL1-mediated superoxide production and granule mobilization. Furthermore, the activity of this novel PBP10 sensitive pathway in neutrophils is modulated by the actin cytoskeleton network.The molecular basis for cellular recognition of signal molecules is their binding to specific cell surface receptors [1]. Despite large structural differences between the huge numbers of extracellular ligands, many bind to (and activate) specific receptors belonging to a large family of pertussis toxin-sensitive G-protein linked receptors (GPCRs) [2]. These receptors possess a high degree of similarity and although activated by different agonists, they transduce downstream signals that have many common features [3]. Nevertheless, it is clear that there are also important differences between receptor-ligand pairs regarding their functional repertoire [4]. The pattern recognition, formyl peptide receptor (FPR) family, belongs to the larger GPCR group of chemoattractant receptors [5]. The FPR gene family has a comple
Gene expression variation to predict 10-year survival in lymph-node-negative breast cancer
Elin Karlsson, Ulla Delle, Anna Danielsson, Bj?rn Olsson, Frida Abel, Per Karlsson, Khalil Helou
BMC Cancer , 2008, DOI: 10.1186/1471-2407-8-254
Abstract: 46 tumours from node-negative breast cancer patients were studied with gene expression microarrays. A t-test was carried out in order to find a set of genes where the expression might predict clinical outcome. Two classifiers were used for evaluation of the gene lists, a correlation-based classifier and a Voting Features Interval (VFI) classifier. We then evaluated the predictive accuracy of this expression signature on tumour sets from two similar studies on lymph-node negative patients. They had both developed gene expression signatures superior to current methods in classifying node-negative breast tumours. These two signatures were also tested on our material.A list of 51 genes whose expression profiles could predict clinical outcome with high accuracy in our material (96% or 89% accuracy in cross-validation, depending on type of classifier) was developed. When tested on two independent data sets, the expression signature based on the 51 identified genes had good predictive qualities in one of the data sets (74% accuracy), whereas their predictive value on the other data set were poor, presumably due to the fact that only 23 of the 51 genes were found in that material. We also found that previously developed expression signatures could predict clinical outcome well to moderately well in our material (72% and 61%, respectively).The list of 51 genes derived in this study might have potential for clinical utility as a prognostic gene set, and may include candidate genes of potential relevance for clinical outcome in breast cancer. According to the predictions by this expression signature, 30 of the 46 patients may have benefited from different adjuvant treatment than they recieved.The research on these tumours was approved by the Medical Faculty Research Ethics Committee (Medicinska fakultetens forskningsetikkommitté, G?teborg, Sweden (S164-02)).Since the prevalence of breast cancer among women is very high (one out of eight American women is affected in their life
Iron-Restricted Erythropoiesis in a Population of Elderly Hospitalized Anemic Patients  [PDF]
Torbj?rn Karlsson
Open Journal of Blood Diseases (OJBD) , 2012, DOI: 10.4236/ojbd.2012.22006
Abstract: The aim of this observational study was to assess the prevalence of iron-restricted erythropoiesis (IRE) in a population of elderly hospitalized anemic patients. Prevalence of IRE was found to be 41% and the most common clinical diagnoses in such patients were hematologic malignancies and solid tumors. Comparison between patients with IRE and non-IRE patients revealed that mean corpuscular volume, mean corpuscular hemoglobin, iron, and transferrin saturation were significantly lower in the IRE group, whereas no significant difference was found for Hb, transferrin, or ferritin. There was a more pronounced inflammatory response in the IRE group demonstrated by a higher C-reactive protein level.
Iron-Restricted Erythropoiesis in Anaemic Patients with Giant Cell Arteritis and Polymyalgia Rheumatica  [PDF]
Torbj?rn Karlsson
Open Journal of Blood Diseases (OJBD) , 2013, DOI: 10.4236/ojbd.2013.31010

The aim of this observational study was to biochemically characterize the anaemia in GCA (giant cell arteritis) and PMR (polymyalgia rheumatica) patients. Values for mean corpuscular volume, mean corpuscular hemoglobin and soluble transferrin receptor were normal, whereas serum iron and total iron binding capacity (TIBC) were subnormal, and mean ferritin was above the upper reference limit. Iron-restricted erythropoiesis (IRE), defined as a bone marrow smear staining positive for iron in combination with transferrin saturation less than 20%, was present in all patients. All patients exhibited clinical and biochemical signs of active inflammation with elevated C-reactive protein and an increased erythrocyte sedimentation rate.

Genetic Profiling Differentiates Second Primary Tumors from Metastases in Adult Metachronous Soft Tissue Sarcoma
Josefin Fernebro,Ana Carneiro,Anders Rydholm,Henryk A. Domanski,Anna Karlsson, ke Borg,Mef Nilbert
Sarcoma , 2008, DOI: 10.1155/2008/431019
Abstract: Purpose. Patients with soft tissue sarcomas (STS) are at increased risk of second primary malignancies, including a second STS, but distinction between metastases and a second primary STS is difficult. Patients and Methods. Array-based comparative genomic hybridization (aCGH) was applied to 30 multiple STS of the extremities and the trunk wall from 13 patients. Different histotypes were present with malignant fibrous histiocytomas/undifferentiated pleomorphic sarcomas being the predominant subtype. Results. aCGH profiling revealed genetic complexity with multiple gains and losses in all tumors. In an unsupervised hierarchical cluster analysis, similar genomic profiles and close clustering between the first and subsequent STS were identified in 5 cases, suggesting metastatic disease, whereas the tumors from the remaining 8 patients did not cluster and showed only weak pairwise correlation, suggesting development of second primary STS. Discussion. The similarities and dissimilarities identified in the first and second STS suggest that genetic profiles can be used to distinguish soft tissue metastases from second primary STS. The demonstration of genetically different soft tissue sarcomas in the same patient suggests independent tumor origin and serves as a reminder to consider development of second primary STS, which has prognostic and therapeutic implications.
Neutrophil Secretion Induced by an Intracellular Ca Rise and Followed by Whole-Cell Patch-Clamp Recordings Occurs Without any Selective Mobilization of Different Granule Populations
Daniel Granfeldt,Olle Harbecke, se Bj rstad,Anna Karlsson,Claes Dahlgren
Journal of Biomedicine and Biotechnology , 2006, DOI: 10.1155/jbb/2006/97803
Abstract: We have investigated calcium-induced secretion in human neutrophils, using a whole-cell patch-clamp technique. Mobilization of subcellular granules to the cell membrane was followed as the change in membrane capacitance (△Cm). Both the magnitude and the kinetics of the response differed between low and high concentrations of Ca2
Mass screening for celiac disease from the perspective of newly diagnosed adolescents and their parents: A mixed-method study
Anna Rosén, Maria Emmelin, Annelie Carlsson, Solveig Hammarroth, Eva Karlsson, Anneli Ivarsson
BMC Public Health , 2011, DOI: 10.1186/1471-2458-11-822
Abstract: All adolescents (n = 145) with screening-detected CD found in a Swedish school-based screening study, and their parents, were invited to this study about one year after diagnosis. In all, 14 focus group discussions were conducted with 31 adolescents and 43 parents. Written narrative was completed by 91 adolescents (63%) and 105 parents (72%), and questionnaires returned by 114 parents (79%). Data were analyzed using qualitative content analysis. In addition, narratives and questionnaire data allowed for quantified measures.Adolescents and parents described how they agreed to participate "for the good of others," without considering consequences for themselves. However, since the screening also introduced a potential risk of having the disease, the invitation was regarded as "an offer hard to resist." For the majority, receiving the diagnosis was described as "a bolt of lightning," but for some it provided an explanation for previous health problems, and "suddenly everything made sense." Looking back at the screening, the predominant attitude was "feeling grateful for being made aware," but some adolescents and parents also expressed "ambivalent feelings about personal benefits." Among parents, 92% supported future CD screening. The most common opinion among both adolescents and parents was that future CD mass screening should be "a right for everyone" and should be offered as early as possible. However, some argued that it should be "only for sufferers" with symptoms, whereas others were "questioning the benefits" of CD mass screening.Although the incentives to participate in the CD screening were partly non-personal, and diagnosis was met with surprise, adolescents and parents felt grateful that they were made aware. They welcomed future CD screening, but suggested that it should be conducted earlier in life. Thus, CD mass screening seemed acceptable to most of those who were diagnosed and their parents.Mass screening programs seek to identify individuals at risk o
A multi-centre cohort study shows no association between experienced violence and labour dystocia in nulliparous women at term
Hafrún Finnbogadóttir, Elisabeth Dejin-Karlsson, Anna-Karin Dykes
BMC Pregnancy and Childbirth , 2011, DOI: 10.1186/1471-2393-11-14
Abstract: A population-based multi-centre cohort study. A self-administrated questionnaire collected at 37 weeks of gestation from nine obstetric departments in Denmark. The total cohort comprised 2652 nulliparous women, among whom 985 (37.1%) met the protocol criteria for dystocia.Among the total cohort, 940 (35.4%) women reported experience of violence, and among these, 66 (2.5%) women reported exposure to violence during their first pregnancy. Further, 39.5% (n = 26) of those had never been exposed to violence before. Univariate logistic regression analysis showed no association between history of violence or experienced violence during pregnancy and labour dystocia at term, crude OR 0.91, 95% CI (0.77-1.08), OR 0.90, 95% CI (0.54-1.50), respectively. However, violence exposed women consuming alcoholic beverages during late pregnancy had increased odds of labour dystocia, crude OR 1.45, 95% CI (1.07-1.96).Our findings indicate that nulliparous women who have a history of violence or experienced violence during pregnancy do not appear to have a higher risk of labour dystocia at term, according to the definition of labour dystocia in this study. Additional research on this topic would be beneficial, including further evaluation of the criteria for labour dystocia.Accumulating knowledge suggests that domestic violence occurring during pregnancy is a serious public health issue due to the risk for adverse maternal and fetal health outcomes [1-3]. Labour dystocia, another serious complication in obstetrics, has also been increasingly highlighted during the past decades [4-9]. Labour dystocia is defined as a slow or difficult labour or childbirth. According to Kjaergaard et al. [10] the term 'dystocia' is frequently used in clinical practice, yet there is no consistency in the use of terminology for prolonged labour or labour dystocia [4,6,11,12]. However, labour dystocia accounts for most interventions during labour [4,6,7]. Although both labour dystocia [4,7] and domestic viol
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