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Search Results: 1 - 10 of 13716 matches for " Anna Henger "
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A complex pattern of chemokine receptor expression is seen in osteosarcoma
Irene von Luettichau, Stephan Segerer, Alexandra Wechselberger, Mike Notohamiprodjo, Michaela Nathrath, Markus Kremer, Anna Henger, Roghieh Djafarzadeh, Stefan Burdach, Ralf Huss, Peter J Nelson
BMC Cancer , 2008, DOI: 10.1186/1471-2407-8-23
Abstract: The overall level of chemokine receptor mRNA expression was determined using TaqMan RT-PCR of microdissected archival patient biopsy samples. Expression was then verified at the protein level by immunohistochemistry using a series of receptor specific antibody reagents to elucidate the cellular association of expression.Expression at the RNA level was found for most of the tested receptors. CCR1 expression was found on infiltrating mononuclear and polynuclear giant cells in the tumor. Cells associated with the lining of intratumoral vessels were shown to express CCR4. Infiltrating mononuclear cells and tumor cells both showed expression of the receptor CCR5, while CCR7 was predominantly expressed by the mononuclear infiltrate. CCR10 was only very rarely detected in few scattered infiltrating cells.Our data elucidate for the first time the cellular context of chemokine receptor expression in osteosarcoma. This is an important issue for better understanding potential chemokine/chemokine receptor function in the complex biologic processes that underlie the development and progression of osteosarcoma. Our data support the suggested involvement of chemokines and their receptors in diverse aspects of the biology of osteosarcoma, but also contradict aspects of previous reports describing the expression of these receptors in this tumor.Osteosarcoma is a primary tumor of the bone that accounts for 5% of childhood cancers and represents the fifth most frequent tumor in young adults [1]. In 15–20% of cases metastasis are present at the time of diagnosis. An additional 20–25% of the patients develop metastasis during the course of disease and have a very poor prognosis despite achievements in multimodal therapy [1]. Currently osteosarcoma is classified according to histological criteria with osteoblastic, chondroblastic and fibroblastic being the most frequent predominant histological elements [2]. The prognosis for patients is predicted by evaluating their response to preopera
A Molecular Signature of Proteinuria in Glomerulonephritis
Heather N. Reich,David Tritchler,Daniel C. Cattran,Andrew M. Herzenberg,Felix Eichinger,Anissa Boucherot,Anna Henger,Celine C. Berthier,Viji Nair,Clemens D. Cohen,James W. Scholey,Matthias Kretzler
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0013451
Abstract: Proteinuria is the most important predictor of outcome in glomerulonephritis and experimental data suggest that the tubular cell response to proteinuria is an important determinant of progressive fibrosis in the kidney. However, it is unclear whether proteinuria is a marker of disease severity or has a direct effect on tubular cells in the kidneys of patients with glomerulonephritis. Accordingly we studied an in vitro model of proteinuria, and identified 231 “albumin-regulated genes” differentially expressed by primary human kidney tubular epithelial cells exposed to albumin. We translated these findings to human disease by studying mRNA levels of these genes in the tubulo-interstitial compartment of kidney biopsies from patients with IgA nephropathy using microarrays. Biopsies from patients with IgAN (n = 25) could be distinguished from those of control subjects (n = 6) based solely upon the expression of these 231 “albumin-regulated genes.” The expression of an 11-transcript subset related to the degree of proteinuria, and this 11-mRNA subset was also sufficient to distinguish biopsies of subjects with IgAN from control biopsies. We tested if these findings could be extrapolated to other proteinuric diseases beyond IgAN and found that all forms of primary glomerulonephritis (n = 33) can be distinguished from controls (n = 21) based solely on the expression levels of these 11 genes derived from our in vitro proteinuria model. Pathway analysis suggests common regulatory elements shared by these 11 transcripts. In conclusion, we have identified an albumin-regulated 11-gene signature shared between all forms of primary glomerulonephritis. Our findings support the hypothesis that albuminuria may directly promote injury in the tubulo-interstitial compartment of the kidney in patients with glomerulonephritis.
Interactive Vision and Experimental Traditions: How to Frame the Relationship  [PDF]
Anna Estany
Open Journal of Philosophy (OJPP) , 2013, DOI: 10.4236/ojpp.2013.32046
Abstract: In recent decades, the cognitive view has had a considerable impact on the philosophy of science, and two reasons can for this be identified. First, philosophers have increasingly tended towards naturalistic approaches, as opposed to proposals that are more a priori. Second, the cognitive sciences underwent considerable development in the second half of the twentieth century. Motivated by the cognitive view in the philosophy of science, and within a naturalistic framework, the aim of this paper is to analyze the relationship between two pairs of views. On the one hand, I consider the theoretical and experimental traditions; and on the other, I examine the views of pure and interactive vision. The two pairs belong to two independent debates; one in the philosophy of science (theoretical vs. experimental traditions) and the other in cognitive psychology (pure vs. interactive vision). Theoretical traditions correspond to a conception of science according to which the goal of scientific practice is to formulate theories that represent the world, and in them experiments play only an instrumental role that is always subsidiary to theory. The model of science promoted in the program of logical empiricism is a good example of such a tradition. Experimental traditions, in contrast, challenge that conception of science by attributing a more important role to experimentation, which is said to provide its own path to knowledge.
A pilot study, a specially designed pillow may prevent developmental plagiocephaly by reducing pressure from the infant head  [PDF]
Anna Ohman
Health (Health) , 2013, DOI: 10.4236/health.2013.56A2006
Abstract:

Developmental plagiocephaly (DP) has been an increasing problem since the successful “back to sleep campaign”. The referrals for DP have increased by >400% during the years 2004 to 2008. Many infants spend less time in the prone position nowadays and some of the risk factors for DP are as follows: less than 3 times per day for the tummy time, torticollis and slow achievement of motor milestones. There is a need for better information to the parents but also for other strategies to prevent DP. The aim of this study was to investigate the effect of a special pillow and thus to reduce pressure on the infant head. Method: infants aged zero to two months were included in the study. They were randomized to either intervention group or control group. Head shape was investigated on two occasions, on the second occasion motor development, mobility and muscle function of the neck were also investigated. The parents were asked about tummy time and sleep position. All infants were investigated by the same physical therapist, blinded to group belonging. Result: seven infants had CVAI >3.5 on the last assessment, five of these had not used any method to reduce pressure. Fishers exact test showed a tendency where infants with reduced pressure on the head had less DP (P 0.08). Paired t test showed significant decrease in CVAI for the infants who had had reduced pressure on the head (P 0.01). Among these infants the CVAI was zero for 47% in the last assessment. For the infants who had not had a reduction of pressure on the head, there was no indication of a decrease of CVAI (P 0.45), and only 12% of these infants had a CVAI that was zero in the last assessment. Conclusion: this pilot study shows that a specially designed pillow may prevent DP in young infants. However, a larger sample is needed to confirm or disprove this. The study is planned to go on until there are 200 participants.

Models, AmI-Creator and A-Methodology for Ambient Intelligence Environments  [PDF]
Anna Chambers
Journal of Software Engineering and Applications (JSEA) , 2014, DOI: 10.4236/jsea.2014.74030
Abstract:

The current paper introduces an approach to a development of Ambient Intelligence domain-based software systems from scratch. The presented approach is based on models. The paper also presents the domain-related models expressing different levels of abstractions and stages of the development. The approach refers to a Model-Driven Development of Ambient Intelligence which was suggested at AmI-07-Ambient Intelligence conference. The approach is presented as a standard with its feasible realization. It starts from modeling of a content of the future AmI-dedicated software system and concludes by mapping the graphical concepts into a final code. A process proving feasibility and correctness of the approach is provided through a dedicated research methodology. Its process comprises an identification of needs in a speedy development of the systems. It is followed by studying of the currently available techniques capable of supporting the development and an experimenting with them. It continues by finding a solution, verified by its validation and concludes by an identification of the further perspectives. The developed approach presents a common way of a communication amongst stakeholders participating in creating of AmI-based environments. Such communication involves the notations of AmI-Creator—a Domain-Specific Language of Ambient Intelligence domain. Every part of DSL corresponds to a demonstration of A-methodology expressing a step-by-step guidance for the development. The methodology comprises two parts dedicated to providing semantics for DSL through studying of Ambient Intelligence domain ontology; and development of actual environments. A validity of the working proposition is confirmed by three examples. The further challenges refer to an extension of the presented work by other frameworks and expansion to a development of different domains with complex organizations.

A specially designed pillow may be used as treatment for young infants with developmental plagiocephaly  [PDF]
Anna ?hman
Health (Health) , 2013, DOI: 10.4236/health.2013.512280
Abstract:

Developmental plagiocephaly has increased since the back to sleep campaign and is nowadays a rather common condition in infants. Prevention is the best way to decrease this problem, therefore, tools for treatment are needed. This case description of two children who dropped out from a study of a specially designed pillow indicates that the Mimos pillow may work as the treatment in young infants with developmental plagiocephaly.

Beighton Scores for Healthy Infants at the Age of Three Months  [PDF]
Anna ?hman
Open Journal of Therapy and Rehabilitation (OJTR) , 2015, DOI: 10.4236/ojtr.2015.32006
Abstract: Objective: To investigate the incidence of hypermobility in infants at the age of three months. Method: Eighty-one healthy infants aged three months were examined using the Beighton score. The spine was excluded for practical reasons; due to this the highest possible Beighton score for the participants in this study was 8. Also ankle dorsiflexion and the big toe were examined. Results: The mean score on the Beighton scale was 2.7; median was 2.0 and the range was 0 to 6. Almost half of the infants scored at least 4 on the Beighton scale. T test showed no gender difference. Neither was there any difference between right and left sides. Conclusions: Infants at the age of three months have high mobility in the distal joints, ankle dorsiflexion, thumb and little finger. It is rare to find hypermobility in elbows and knees at this age.
A Craniometer with a Headband Can Be a Reliable Tool to Measure Plagiocephaly and Brachycephaly in Clinical Practice  [PDF]
Anna ?hman
Health (Health) , 2016, DOI: 10.4236/health.2016.812128
Abstract: Objective: The aim of the study was to determine the intra- and inter-reliability for measuring infants with plagiocephaly and brachycephaly with a craniometer when using a marked headband as landmarks. Subjects: Six physiotherapists and eight infants participated in the study. Methods: The physiotherapists measured all infants twice; each infant was measured with the same headband and craniometer. The physiotherapists were blinded to measurements carried out by their colleagues. The infants with their parents changed places in the room to minimize the possibility that the physiotherapists would remember their first measurements of any infant. Results: There was a high intra- and inter-reliability, for intra-reliability ICC 0.96 to 0.99 and for inter-reliability ICC 0.98. Conclusion: It is possible to achieve a high intra- and inter-reliability when using a headband and craniometer when measuring cranial vault asymmetry for plagiocephaly and cephalic ratio for brachycephaly.
The Role of an Implicit Assumption of Causality in the Methodology of Empirical Research  [PDF]
Anna Storozhuk
Open Journal of Philosophy (OJPP) , 2018, DOI: 10.4236/ojpp.2018.83022
Abstract: The purpose of the article is to point out the causal ladenness of empirical data in the social sciences. This is a kind of theory ladenness, representing implicit assumptions about the deterministic nature of political processes. The nonlinear and chaotic nature of social phenomena requires the collection of data not only about the current state of the system, but also about the evolution of the system. Using an example, we illustrate that the conclusions made on the basis of information about the final state can be very different from the conclusions made on the basis of monitoring the dynamics of the system. Low-importance factors can have big consequences in a chaotic case and, vice versa, there takes place fading of causality: considerable efforts can lead to more than modest results. For the successful management of political life, it is important to be able to identify the impacts that lead to great consequences.
Forming Stages of Polycrystalline TiN Films Depending on the Nitrogen Concentration in Mixed Gas  [PDF]
Anna L. Kameneva
Materials Sciences and Applications (MSA) , 2011, DOI: 10.4236/msa.2011.21002
Abstract: The influence of nitrogen concentration in mixed gas on temperature conditions, structure and phase composition of the TiN film deposited by arc spraying has been investigated. By electron microscopic investigations and X-ray diffraction phase analysis was recognized forming stages and structuring process of the film with main cubic phase (111) TiN. It was discovered that forming stages and process of structuring of ion-plasma TiN films are affected by both film temperature and its rate of heating.
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