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Search Results: 1 - 10 of 3459 matches for " Angelo Leone "
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A Community Welfare Model Interdependent with Productive, Civil Economy Clusters: A New Approach  [PDF]
Gaetano Giunta, Giovanni Giunta, Liliana Leone, Domenico Marino, Gaspare Motta, Angelo Righetti, Domenico Marino
Modern Economy (ME) , 2014, DOI: 10.4236/me.2014.58084
Abstract:

In this paper we will present a new model of social policy related with productive, civil economy clusters able to generate an evolved community welfare, currently experimented in the area of the Strait of Messina. The approach is based on anthropological postulates much more complex than the concept of homo oeconomicus and it focuses on mesoscopic socio-economic-ecological systems. The theoretical description is supported by a mathematical model completely self-consistent and therefore is able to generate predictions easily verifiable through experimental measurements. The logical scheme is based on the idea that local, human and economic development feeds on and amplifies social capital, peoples instrumental freedoms and the economic resources of the analyzed clusters.

Expression of Nitric Oxide Synthase in Inflamed Gingival Tissue: Immunohistochemical and Image Analysis
Angelo Leone,Maria Laura Uzzo,Giovanni Francesco Spatola,Tomasz Konopka
Research Journal of Biological Sciences , 2007,
Abstract: We have used 12 Epulis taken during surgical operation and as control, some normal gingival specimen. The aim was to clarify the relationship between the degree of inflammation and NO production in several cases of Epulis, exhibiting different degree of inflammatory process and verifying the presence of cells involved in NO production. From the immuhistochemical data in our possession we can conclude that NO is one of the factor which module the pathogenecity degree of Epulis.
COX-2 Expression in the Inflamed Gingival Tissues: Immunohistochemistry, Cytochemistry and Biochemistry Tests
Angelo Leone,Elvira Farina-Lipari,Aldo Gerbino,Francesco Burruano
Research Journal of Biological Sciences , 2007,
Abstract: Prostaglandins (PG) are chemical mediators for most physiological and pathological responses, including cytoprotection of the gastric mucosa, blood coagulation, inflammation and pain (1, 2, 3). E2 Prostaglandins (PG2) play an important role in the pathogenesis of periodontal diseases, since PG2 determines vasodilatation and increased vascular permeability, oedema and erythema. Therefore, it is not surprising to find high levels of PG2 in inflamed gingival tissues. Indeed, in inflamed gingival tissue, PG2 levels of the Gingival Fluid (GCF) are known to be higher in periodontitis than in healthy gingiva. Moreover, in different parodontitis the high PG2 level of the GCF is related to periodontal ligament loss. The pathogenensis of the periodontitis can be due to the high PG2 activation of the Matrix Metal-Protease (MMP), which is synthesized by monocytes and fibroblasts. Consequently, destruction of connective tissue on a large scale takes place. The aim of this research is two-fold: To test the COX-2 expression in the human epulis and study its involvement in the PG2 synthesis and to find a alternative terapy to treat gingival diseases.
Expression of Cyclooxygenase-1 and Cyclooxygenase-2 in normal and pathological human oral mucosa
Annamaria Mauro,Luana Lipari,Angelo Leone,Silvia Tortorici
Folia Histochemica et Cytobiologica , 2010,
Abstract: Cyclooxigenase (COX) is the rate-limiting enzyme for the conversion of arachidonic acid (AA) to prostaglandins(PGs). Two isoforms of COX have been identified: COX-1 is constitutively expressed in many cells and is involved in cellhomeostasis, angiogenesis and cell-cell signalling; COX-2 is not expressed in normal condition however it is stronglyexpressed in inflammation. The oral cavity is costantly exposed to physical and chemical trauma that could lead to mucosalreactions such as hyperplasia, dysplasia and cancer. Early diagnosis is the most important issue to address for a positiveoutcome of oral cancer; therefore it would be useful to identify molecular markers whose expression is associated with thevarious stages of oral cancer progression. Since COX enzyme has been involved, with different mechanisms, in the developmentand progression of malignancies we decided to investigate the expression and localization of COX-1 and COX-2in normal human oral mucosa and three different pathologies (hyperplasia, dysplasia and carcinoma) by immunohistochemistryand RT-PCR. COX-1 mRNA and protein have been detected already in normal oral mucosa and their expressionprogressively increases from normal samples towards hyperplasia, dysplasia and finally carcinoma. On the contrary,COX-2 is not expressed in the normal tissue, starts to be expressed in hyperplasia, reaches the maximum activation in dysplasiaand then starts to be downregulated in carcinoma.
Expression of cyclooxygenase-1 and cyclooxygenase-2 in normal and pathological human oral mucosa.
Annamaria Mauro,Luana Lipari,Angelo Leone,Silvia Tortorici
Folia Histochemica et Cytobiologica , 2011, DOI: 10.5603/4169
Abstract: Cyclooxigenase (COX) is the rate-limiting enzyme for the conversion of arachidonic acid (AA) to prostaglandins (PGs). Two isoforms of COX have been identified: COX-1 is constitutively expressed in many cells and is involved in cell homeostasis, angiogenesis and cell-cell signalling; COX-2 is not expressed in normal condition however it is strongly expressed in inflammation. The oral cavity is constantly exposed to physical and chemical trauma that could lead to mucosal reactions such as hyperplasia, dysplasia and cancer. Early diagnosis is the most important issue to address for a positive outcome of oral cancer; therefore it would be useful to identify molecular markers whose expression is associated with the various stages of oral cancer progression. Since COX enzyme has been involved, with different mechanisms, in the development and progression of malignancies we decided to investigate the expression and localization of COX-1 and COX-2 in normal human oral mucosa and three different pathologies (hyperplasia, dysplasia and carcinoma) by immunohistochemistry and RT-PCR. COX-1 mRNA and protein have been detected already in normal oral mucosa and their expression progressively increases from normal samples towards hyperplasia, dysplasia and finally carcinoma. On the contrary, COX-2 is not expressed in the normal tissue, starts to be expressed in hyperplasia, reaches the maximum activation in dysplasia and then starts to be downregulated in carcinoma.
Passive Smoking and Infectious Disease: A Serious Hazard for Cardiovascular System  [PDF]
Aurelio Leone
International Journal of Clinical Medicine (IJCM) , 2011, DOI: 10.4236/ijcm.2011.25090
Abstract: Exposure to passive smoking is usually associated with heavy changes in both function and structure of the cardiovascular system at different levels: coronary circulation, heart metabolism, myocardial muscle. These changes may be transient but may have characteristics of irreversibility. Major determinant of cardiovascular alterations is hypoxia due to tobacco products of the environment although a large number of alterations affect immune t-cells and antibody response. All infectious diseases which involve cardiovascular system, including some tropical patterns, particularly Chagas disease, are adversely influenced as a consequence of a continuous although irregular exposure to passive smoking, which worsens the degree of cardiac muscle alterations at different levels like myocardium, coronary arteries and both these structures. Therefore, exposure to passive smoking must be avoided for those individuals suffering from infectious diseases of the heart whatever factor can be responsible.
Functional Aspects of Adrenocholinergic and Peptidergic Innervation about Prostate and Seminal Vesicles in Mammals: A Review
Aldo Gerbino,Luana Lipari,Annamaria Mauro,Angelo Leone,Salvatore Provenzano,Maria Buscemi
Research Journal of Biological Sciences , 2012,
Abstract: This study was aimed to explain the functional role of the mediation in the organs of the male reproductive system (prostate and seminal vesicles of rat and hamster), representing through the visualization of adrenergic fibres (Falck method), cholinergic fibres (Martinez-Rodriguez method) and by immunohistochemical methods to detect the P substance and the CGRP (PAP) in glandular structures. The adrenocholinergic and peptidergic mediators have a growing interest for their synergic action in the control of contractility, vasodilatation and most likely, of the secretory activity of the epithelium, probably expressed by endocrine-paracrinous mechanisms.
Mandibulary Eosinophilic Granuloma: Case Series
Silvia Tortorici,Francesco Burruano,Emiliano Maresi,Luigi Caradonna,Paolo Difalco Angelo Leone,Maria Buscemi,Aldo Gerbino
Research Journal of Medical Sciences , 2012,
Abstract: Eosinophilic granuloma is a proliferation of Langerhans cells in the bones that most commonly involving the skeletal system. The disease generally affects children or young adults with predominance in males and it is characterized by a single or multiple skeletal lesions. This study describes a few cases of mandibular Eosinophilic Granuloma and the effects of surgical curettage of lesions.
COX-2 Expression in the Inflamed Gingival Tissues: Immunohistochemistry, Cytochemistry and Biochemistry Tests
Angelo Leone,Elvira Farina-Lipari,Aldo Gerbino,Francesco Burruano,Silvia Tortorici,Maria Buscemi
Research Journal of Biological Sciences , 2012,
Abstract: Prostaglandins (PG) are chemical mediators for most physiological and pathological responses, including cytoprotection of the gastric mucosa, blood coagulation, inflammation and pain (1, 2, 3). E2 Prostaglandins (PG2) play an important role in the pathogenesis of periodontal diseases, since PG2 determines vasodilatation and increased vascular permeability, oedema and erythema. Therefore, it is not surprising to find high levels of PG2 in inflamed gingival tissues. Indeed, in inflamed gingival tissue, PG2 levels of the Gingival Fluid (GCF) are known to be higher in periodontitis than in healthy gingiva. Moreover, in different parodontitis the high PG2 level of the GCF is related to periodontal ligament loss. The pathogenensis of the periodontitis can be due to the high PG2 activation of the Matrix Metal-Protease (MMP), which is synthesized by monocytes and fibroblasts. Consequently, destruction of connective tissue on a large scale takes place. The aim of this research is two-fold: To test the COX-2 expression in the human epulis and study its involvement in the PG2 synthesis and to find a alternative terapy to treat gingival diseases.
Influência do sexo na evolu o imediata e a médio prazo após a interven o coronariana percutanea primária e análise dos fatores independentes de risco para óbito ou eventos
Peixoto Rodrigo Trajano Sandoval,Peixoto Edison Carvalho Sandoval,Sena Marcello Augustus,Tedeschi Angelo Leone
Arquivos Brasileiros de Cardiologia , 2006,
Abstract: OBJETIVO: Determinar os fatores de risco para óbito e eventos e a influência do sexo na evolu o intra-hospitalar e aos seis meses, de pacientes internados nas 12 horas iniciais do infarto agudo do miocárdio (IAM) com supradesnivelamento de ST, tratados com interven o coronariana percutanea primária. MéTODOS: Foram considerados 199 pacientes consecutivos, entre 07/1998 e 12/2000, com IAM e sem choque cardiogênico, sendo avaliada a evolu o intra-hospitalar e em seis meses. RESULTADOS: As características clínicas eram semelhantes entre os grupos, exceto que as mulheres, que eram mais idosas que os homens (67,04 ± 11,53 x 59,70 ± 10,88, p < 0,0001). A mortalidade intra-hospitalar foi maior no sexo feminino (9,1% x 1,5%, p = 0,0171), assim como a incidência de eventos maiores (12,1% x 3,0%, p = 0,0026). A diferen a de mortalidade persistia em seis meses (12,1% x 1,5%, p = 0,0026). Na análise multivariada predisseram óbito: sexo feminino e octogenários e eventos e/ou angina estável: doen a multiarterial e disfun o ventricular grave. CONCLUS O: Sexo feminino e octogenários foram fatores independentes relacionados à mortalidade seis meses após a interven o coronariana percutanea primária.
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