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Search Results: 1 - 10 of 99 matches for " Angelique Walstrom "
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Type I Interferons and Interferon Regulatory Factors Regulate TNF-Related Apoptosis-Inducing Ligand (TRAIL) in HIV-1-Infected Macrophages
Yunlong Huang, Angelique Walstrom, Luwen Zhang, Yong Zhao, Min Cui, Ling Ye, Jialin C. Zheng
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0005397
Abstract: TNF-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family that participates in HIV-1 pathogenesis through the depletion of CD4+ T cells. TRAIL is expressed on the cell membrane of peripheral immune cells and can be cleaved into a soluble, secreted form. The regulation of TRAIL in macrophages during HIV-1 infection is not completely understood. In this study, we investigated the mechanism(s) of TRAIL expression in HIV-1-infected macrophages, an important cell type in HIV-1 pathogenesis. A human monocyte-derived macrophage (MDM) culture system was infected with macrophage-tropic HIV-1ADA, HIV-1JR-FL, or HIV-1BAL strains. TRAIL, predominantly the membrane-bound form, increased following HIV-1 infection. We found that HIV-1 infection also induced interferon regulatory factor (IRF)-1, IRF-7 gene expression and signal transducers and activators of transcription 1 (STAT1) activation. Small interfering RNA knockdown of IRF-1 or IRF-7, but not IRF-3, reduced STAT1 activation and TRAIL expression. Furthermore, the upregulation of IRF-1, IRF-7, TRAIL, and the activation of STAT1 by HIV-1 infection was reduced by the treatment of type I interferon (IFN)-neutralizing antibodies. In addition, inhibition of STAT1 by fludarabine abolished IRF-1, IRF-7, and TRAIL upregulation. We conclude that IRF-1, IRF-7, type I IFNs, and STAT1 form a signaling feedback loop that is critical in regulating TRAIL expression in HIV-1-infected macrophages.
Resilience and Engagement: some thoughts on the magnetic impact of small change
Angelique Edmonds
Transforming Cultures , 2010,
Abstract: This paper considers the gap between knowing and mobilised action and investigates local urban examples where action is mobilised. The purpose of this is to consider what such examples can tell us about the conditions required to mobilise action and hence how to foster those conditions. Making cities sustainable is now a major aim and claim of most cities in the world. A myriad of definitions of sustainable development have been proposed but it has not been easy to find one that simultaneously satisfies economists, ecologists, sociologists, philosophers and policy makers. The problem in part relates to uncertainty about the object of sustainability, rather than the idea itself. What is it that ought to be sustained? It is increasingly internationally recognised that many effective solutions for environmental sustainability have their roots in local action and co-ordination. For that reason capacity within local government and the mobilisation of participation at the local level is a pivotal enabler for change. In the context of the discussion raised by the Cities, Nature Justice Conference and project, this paper focuses on discussion of urban local contexts and discusses the importance of local participation and engagement as critical enablers for mobilised action. Of particular interest in these local contexts, is the movement from a state of awareness of social and environmental issues of sustainability, to an active, constructive awareness that informs changes in behaviour and action that lead to sustainable practices of living.
Ageing and loss
Angelique Myles
University of Toronto Medical Journal , 2010, DOI: 10.5015/utmj.v88i1.1288
Abstract: N/A
Repeatability Estimates Of Sloped Scattered Data
Angelique Waller
Undergraduate Journal of Mathematical Modeling : One + Two , 2009, DOI: 10.5038/2326-3652.2.1.8
Abstract: Repeatability is the variance in data accumulated under fixed conditions. It is important for quality control as it costs both time and money to recalibrate tools and remanufacture machines. This project compares three methods for approximating the repeatability of a sloped scattered data set. The first method uses a linear approximation, the second involves rotating the data points, and the third calculates distance using right triangles. The methods are compared for both precision and ease of use.
Families, Friends, and the Neighborhood of Older Adults: Evidence from Public Housing in Singapore
Treena Wu,Angelique Chan
Journal of Aging Research , 2012, DOI: 10.1155/2012/659806
Abstract: Introduction. This empirical paper examines how the Housing Development Board (HDB) public housing neighborhood influences older urban Singaporeans' social interactions and ameliorates social isolation. Methods. Using 4,542 observations of noninstitutionalized urban adults aged 60 and above, ordered logistic regressions are run to determine the predictors of isolation while controlling for physical health and demographics. Results. 87% of older Singaporeans reside in public housing apartments while 13% reside in private market housing. The main predictor of social isolation is living alone and the second main predictor is coresidence with adult children. The relationship between coresidence with adult children and isolation is mediated when controlling for older adult functional limitations. The public apartment neighborhood and daily participation in public neighborhood events have substantial effects on reducing the risk of isolation. Older adult contact with friends alleviates isolation more than contact with non-coresiding relatives. Conclusion. Findings suggest that the public neighborhood-built environment in Singapore plays a positive role in the social interactions of the elderly. Knowledge of the factors that decrease the risk of social isolation will have implications for studying morbidity and mortality among the elderly. 1. Introduction In newly industrialized economies (NIE) in Asia, economic growth and demographic changes are leading to longer life and smaller family size. In Asia, given the Confucian beliefs of filial piety, it has been traditionally expected that the younger members of the family provide time, money, goods, and instrumental and emotional support for older adults. However, with later marriage and lower fertility, it is now more likely that older adults in Asian NIE have smaller families and a higher likelihood of living alone. As a consequence elders in urban settings may have fewer social interactions as they age. However it is not necessarily the case that late life is characterized by social isolation. Individuals can adapt to the aging process with changes in their behavior and the environment. Older adults may compensate for a loss of social interaction when their families become smaller by interacting more with friends and neighbors who are in close physical proximity. This may especially be the case for the oldest old with functional limitations who may not only be neighborhood-based but neighborhood-bound. We hypothesize that in the Singapore densely populated city state the built neighborhood environment
Foil Diffuser Investigation with GEANT4
Joseph M. Fabritius II,Konstantin Borozdin,Peter Walstrom
Physics , 2013,
Abstract: An investigation into the appropriate materials for use as a diffuser foil in electron radiography was undertaken in GEANT4. Simulations were run using various refractory materials to determine a material of appropriate Z number such that energy loss is minimal. The plotted results of angular spread and energy spread are shown. It is concluded that higher Z number materials such as tungsten, tantalum, platinum or uranium could be used as diffuser materials. Also, an investigation into the handling of bremsstrahlung, multiple coulomb scattering, and ionization in GEANT4 was performed.
Relating debt and currency crises -- towards a general equilibrium approach
Angelique Herzberg,Frederik S Herzberg
Mathematics , 2006,
Abstract: This short paper proposes a simple general equilibrium approach within a Markov-switching regime to explain how asymmetric information between lenders and speculators may lead to currency crises. The paper concludes by providing necessary as well as sufficient conditions for special cases.
Work resumption at the price of distrust: a qualitative study on return to work legislation in the Netherlands
Nicole Hoefsmit, Angelique de Rijk, Inge Houkes
BMC Public Health , 2013, DOI: 10.1186/1471-2458-13-153
Abstract: This qualitative study was based on in-depth interviews with 8 employees and 8 employers. Employees reported sick for 1.5-20 months for various reasons. Interviews were analysed using an interpretative approach and pattern matching.Cooperation was lacking early during sick leave. Later on there were regular meetings, but employers decided about RTW without consulting the employees. Particularly employers were motivated to cooperate during the first year, while employees were especially motivated during the second. This could be understood by experienced dependence; employees (first year) and employers (second year) did not consider cooperation to be important for achieving medical recovery (employees) or RTW (employers). These divergent goals may be understood by personal norms about the timing of medical recovery and RTW. Legislation was particularly effective regarding employer behaviour in year 1 and employee behaviour in year 2. Employees distrusted their employers during the first year, while employers reported to distrust the employees during the second year. Besides, employees and employers experienced a moderate ability to cooperate. This could be understood particularly by having moderate knowledge about legislation. The RDIC model appeared to be valid to understand the cases studied, but the additional factor distrust also played a role.Legislation appeared to support cooperation, but awareness of a mutual dependence, trust, knowledge about the legislation and personal norms regarding recovery and RTW are also important. Professionals such as occupational physicians should support this to attain a degree of cooperation that is necessary for effective RTW.
Doing masculinity, not doing health? a qualitative study among dutch male employees about health beliefs and workplace physical activity
Petra Verdonk, Hannes Seesing, Angelique de Rijk
BMC Public Health , 2010, DOI: 10.1186/1471-2458-10-712
Abstract: In the Fall of 2008, we interviewed 13 white Dutch male employees aged 23-56 years. The men worked in a wide range of professions and occupational sectors and all interviewees had been offered a workplace physical activity program. Interviews lasted approximately one to one-and-a-half hour and addressed beliefs about health and lifestyle behaviours including workplace physical activity, as well as normative beliefs about masculinity. Thematic analysis was used to analyze the data.Two normative themes were found: first, the ideal man is equated with being a winner and real men are prepared to compete, and second, real men are not whiners and ideally, not vulnerable. Workplace physical activity is associated with a particular type of masculinity - young, occupied with looks, and interested in muscle building. Masculine norms are related to challenging health while taking care of health is feminine and, hence, something to avoid. Workplace physical activity is not framed as a health measure, and not mentioned as of importance to the work role.Competitiveness and nonchalant attitudes towards health shape masculine ideals. In regards to workplace physical activity, some men resist what they perceive to be an emphasis on muscled looks, whereas for others it contributes to looking self-confident. In order to establish a greater reach among vulnerable employees such as ageing men, worksite health promotion programs including workplace physical activity may benefit from greater insight in the tensions between health behaviours and masculinity.A large body of literature points towards sex differences in health and illness. These biological health outcomes occur in a pattern of gendered social interactions, namely expectations of how men and women should behave, and in practices that treat men and women of various ages, ethnic and social classes differently [1,2]. Research must therefore address both sex and gender [3,4]. In many countries, including the Netherlands, men's lif
Stress Management Based on Trait-Anxiety Levels and Sleep Quality in Middle-Aged Employees Confronted with Psychosocial Chronic Stress  [PDF]
Marion Trousselard, Dominique Steiler, Angelique Lebreton, Pascal Van Beers, Catherine Drogout, Josiane Denis, Mounir Chennaoui, Frédéric Canini
Psychology (PSYCH) , 2014, DOI: 10.4236/psych.2014.51013
Abstract:

A stress management program using cardiac coherence was implemented after an organizational downsizing. The study was conducted in nine voluntary workers in order to evaluate the efficiency of the program. A baseline evaluation was conducted on psychological variables (anxiety, perceived-stress, wellbeing and sleep), endocrine assessments (urinary cortisol excretion, alpha-amylase and salivary concentrations) and physiological recordings (sleep and heart rate variability). The low number of participants was due to the intrusive approach in collecting physiological and endocrine variables. The program consisted of ten sessions of cardiac coherence training during a 3-month follow-up period. At the end of the training sequence, subjects were once again exposed to the same evaluation battery. A decrease in perceived stress and a subsequent increase in well-being were observed. Sleep quality improved as suggested by the results of the subjective and objective measurements. For the entirety of the results, improvements were higher in subjects with high vs. low trait-anxiety scoring. The pattern of results for subjects prone to a high level of trait-anxiety suggested that stress and sleep are related to each other in a bidirectional way: increased anxiety is associated to poor sleep and stress reduction improves both anxiety and sleep. On the basis of these results, we suggest that trait-anxiety can be used as an indicator of which employees should be given priority for stress management intervention. We will also highlight the interest of operationally physiological recordings, used outside the laboratory, for measuring objective improvements due to this stress management intervention, as quality of sleep.

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